Hermona Soreq Lab

ELSC Members

Charlotte Slesinger Chair In Cancer Studies, Emeritus
Soreq Lab

Hermona Soreq was trained at The Hebrew University, The Weizmann Institute of Science, Tel Aviv University and the Rockefeller University. She joined The Hebrew University in 1986, holds a University Slesinger Chair and is a founding member of ELSC. Soreq’s research pioneered the application of molecular biology and genomics to the study of cholinergic signaling, with a recent focus on its RNA processing regulation and on signaling changes. She is the elected President of the International Organization of Cholinergic Mechanisms and served as the elected Dean of the Faculty of Science in 2005-2008. Soreq has authored hundreds of publications, including 60 published in Science, Nature, PNAS, Neuron and other high-impact journals. Notably, 25 of Soreq’s trainees are currently faculty members in Israeli universities (in Jerusalem, Tel Aviv, Haifa, the Galilee and Beer Sheva) and international ones (UC Berkeley, Maryland, Ann Arbor, Paris, Tours, Gottingen, London). Others are post-doctoral fellows, employed by government and private biotechnology organizations and companies involved in Life Sciences, or are presently PhD students in her lab.

Soreq’s studies address the molecular regulators of acetylcholine (ACh) functioning, with a recent focus on Non-coding RNAs, especially MicroRNAs (miRs) and transfer RNA fragments (tRFs), which have rapidly emerged as global regulators of gene expression, yet the full scope of their roles in brain and body functioning remains largely unknown. She combines advanced sequencing technologies with computational neuroscience and cell culture and transgenic engineering tools to investigate miR and tRF functions in the healthy and diseased brain, with a focus on ACh-related processes. Her studies discovered cholinergic brain-to-body regulation of anxiety and inflammation and found “CholinomiR” and “CholinotRF” silencers of multiple genes that compete with each other on suppressing inflammation, anxiety and metabolic targets and controlling epilepsy. Studying such small RNA interactions with a focus on sex- and age-related differences, Soreq tests CholinomiR- and CholinotRF-based intervention with diseases involving impaired ACh signaling. In engineered mice, Soreq found that CholinomiR levels increase under stress, inflammation, ischemic stroke and obesity, whereas in Alzheimer’s brains she found massive CholinomiRs decline, accompanying modifications in alternative splicing and transcript processing that differs from those occurring in Parkinson’s disease brains. In human volunteers, she found cholinergic-associated pulse increases under fear of terror, and elevated trait anxiety, blood pressure and inflammation under inherited interference with acetylcholinesterase (AChE)-targeting CholinomiRs, with recently shown sex-related differences. Soreq studies the molecular regulators of cholinergic signaling, with a focus on non-coding RNAs and stress-related diseases.

Hermona Soreq

Professor Emeritus

Phone: +972-2-6585109
Fax: +972-2-6520258
Address: The Alexander Silberman Institute of Life Sciences, Room no. 1-420, Wing A, Fourth Floor
Charlotte Slesinger Chair In Cancer Studies, Emeritus
Soreq Lab

Hermona Soreq was trained at The Hebrew University, The Weizmann Institute of Science, Tel Aviv University and the Rockefeller University. She joined The Hebrew University in 1986, holds a University Slesinger Chair and is a founding member of ELSC. Soreq’s research pioneered the application of molecular biology and genomics to the study of cholinergic signaling, with a recent focus on its RNA processing regulation and on signaling changes. She is the elected President of the International Organization of Cholinergic Mechanisms and served as the elected Dean of the Faculty of Science in 2005-2008. Soreq has authored hundreds of publications, including 60 published in Science, Nature, PNAS, Neuron and other high-impact journals. Notably, 25 of Soreq’s trainees are currently faculty members in Israeli universities (in Jerusalem, Tel Aviv, Haifa, the Galilee and Beer Sheva) and international ones (UC Berkeley, Maryland, Ann Arbor, Paris, Tours, Gottingen, London). Others are post-doctoral fellows, employed by government and private biotechnology organizations and companies involved in Life Sciences, or are presently PhD students in her lab.

Soreq’s studies address the molecular regulators of acetylcholine (ACh) functioning, with a recent focus on Non-coding RNAs, especially MicroRNAs (miRs) and transfer RNA fragments (tRFs), which have rapidly emerged as global regulators of gene expression, yet the full scope of their roles in brain and body functioning remains largely unknown. She combines advanced sequencing technologies with computational neuroscience and cell culture and transgenic engineering tools to investigate miR and tRF functions in the healthy and diseased brain, with a focus on ACh-related processes. Her studies discovered cholinergic brain-to-body regulation of anxiety and inflammation and found “CholinomiR” and “CholinotRF” silencers of multiple genes that compete with each other on suppressing inflammation, anxiety and metabolic targets and controlling epilepsy. Studying such small RNA interactions with a focus on sex- and age-related differences, Soreq tests CholinomiR- and CholinotRF-based intervention with diseases involving impaired ACh signaling. In engineered mice, Soreq found that CholinomiR levels increase under stress, inflammation, ischemic stroke and obesity, whereas in Alzheimer’s brains she found massive CholinomiRs decline, accompanying modifications in alternative splicing and transcript processing that differs from those occurring in Parkinson’s disease brains. In human volunteers, she found cholinergic-associated pulse increases under fear of terror, and elevated trait anxiety, blood pressure and inflammation under inherited interference with acetylcholinesterase (AChE)-targeting CholinomiRs, with recently shown sex-related differences. Soreq studies the molecular regulators of cholinergic signaling, with a focus on non-coding RNAs and stress-related diseases.

Photo - Katarzyna Winek
Katarzyna Winek
Post Doc
ELSC-Tamara-Zorbaz
Tamara Zorbaz
Post Doc
ELSC-Seminars-General
Gilli Moshitzky
PhD Student
ELSC-Yonat-Tzur
Yonat Tzur
PhD Student
Photo - Nimrod Madrer
Nimrod Madrer
PhD Student
shani
Shani Vaknine
PhD Student
studen-Dana-Shulman-2---yonatan
Dana Shulman
MSc Student
ELSC-Seminars-General
Or Yakov
MSc Student
ELSC-Serafima-Dubnov
Serafima Dubnov
MSc Student
ELSC-David-Greenberg
David Greenberg
Research Fellow
ELSC-Ester-Bennett
Ester Bennett
Lab Manager
ELSC-Petra-Pollins
Petra Pollins
Secretary
ELSC-Arik-Monash
Arik Monash
PhD Student
ELSC-Seminars-General
Mor Hanan
Naomi Niederhoffer
Naomi Niederhoffer
ELSC-Nadav-Yayon
Nadav Yayon
Screen Shot 2019-02-17 at 8.35.44 PM
Alon Simchovitz
Moshitzky, G., Shoham, S., Madrer, N., Husain, A.M., Greenberg, D.S., Yirmiya, R., Ben-Shaul, Y. & Soreq, H.

Biomolecules (2020)

Hanan, M., Simchovitz, A., Yayon, N., Vaknine, S., Cohen-Fultheim, R., Karmon, M., Madrer, N., Rohrlich, T.M., Maman, M., Bennett, E.R., Greenberg, D.S., Meshorer, E., Levanon, E.Y., Soreq, H. & Kadener, S.

EMBO Mol Med (2020)

Meydan, C., Madrer, N. and Soreq, H.

Frontiers in Immunology (2020)

Winek, K., Lobentanzer, S., Nadorp, B., Dubnov, S., Dames, C., Moshitzky, G., Hotter, B., Meisel, C., Greenberg, D.S., Shifman, S., Klein, J., Shenhar-Tsarfaty, S., Meise S. & Soreq, H.

medRxiv (2020)

Yayon, N., Amsalem, O., Dudai, A., Yakov, O., Adam, G., Tessier-Lavigne, M., Renier, N., Segev, I., London, M., & Soreq, H.

bioRxiv (2020)

Dudai A, Yayon N, Lerner V, Tasaka Gi, Deitcher Y, et al.

PLOS Biology 18(2): e3000613 (2020)

Moshitzky, G.; Shoham, S.; Madrer, N.; Husain, A.M.; Greenberg, D.S.; Yirmiya, R.; Ben-Shaul, Y.; Soreq, H.

Biomolecules 10, 848 (2020)

Madrer N, Soreq H.

FEBS Lett. 10.1002/1873-3468.13789 (2020)

Raber, J., Arzy, S., Boulanger-Bertolus, J., Depue, B., Haas, H.E., Hofmann, S.G., Kangas, M., Kensinger, E., LeDoux, J., Lowry, C.A., Marusak, H.A., Minnier, J., Mouly, A., Muehlberger, A., Norrholm, S.D., Peltonen, K., Pinna, G., Rabinak, C., Shiban, Y., Soreq, H., van der Kooij, M., Weingast, L.T., Yamashita, P. & Boutros, S.W.

Neuroscience & Biobehavioral Reviews (2019)

Soreq H

Front. Young Minds. (2019)

Lobentanzer S, Hanin G, Klein J, Soreq H

Cell Reports, Volume 29, Issue 3, Pages 764-777 (2019)

Lackie RE, Razzaq AR, Farhan SMK, Qiu LR, Moshitzky G, Beraldo FH, Lopes MH, Maciejewski A, Gros R, Fan J, Choy WY, Greenberg DS, Martins VR, Duennwald ML, Lerch JP, Soreq H, Prado VF, Prado MAM

Journal of Neurochemistry (2019)

Simchovitz A, Hanan M, Niederhoffer N, Madrer N, Yayon N, Bennett ER, Greenberg DS, Kadener S, Soreq H

The FASEB Journal (2019)

Tejera D, Mercan D, Sanchez-Caro JM, Hanan M, Greenberg D, Soreq H, Latz E, Golenbock D, Heneka MT

The EMBO Journal, 38: e101064 (2019)

Salinas J, Lin H, Aparico HJ, Huan T, Liu C, Rong J, Beiser A, Himali JJ, Freedman JE, Larson MG, Rosand J, Soreq H, Levy D, Seshadri S

PLoS ONE 14(8) (2019)

Aylar Tafazzoli, Andreas J Forstner, David Broadley, Andrea Hofmann, Silke Redler, Lynn Petukhova, Kathrin A Giehl, Roland Kruse, Bettina Blaumeiser, Markus Boehm, Marta Bertolini, Alfredo Rossi, Natalie Garcia Bartels, Gerhard Lutz, Hans Wolff, Ulrike Blume-Peytavi, Hermona Soreq, Angela M Christiano, Natalia V Botchkareva, Markus M Nöthen, Regina C Betz

Journal of Investigative Dermatology, Volume 138, Issue 3, Pages 549-556 (2018)

Georgia Kalozoumi, Olga Kel-Margoulis, Elizabeth Vafiadaki, David Greenberg, Hélène Bernard, Hermona Soreq, Antoine Depaulis, Despina Sanoudou

PLoS ONE 13(8): e0201742 (2018)

N Yayon, A Dudai, N Vrieler, O Amsalem, M London, H Soreq

Scientific Reports, volume 8, Article number: 4311 (2018)

Geula Hanin, Nadav Yayon, Yonat Tzur, Rotem Haviv, Estelle R Bennett, Shiran Udi, Yoganathan R Krishnamoorthy, Eleni Kotsiliti, Rivka Zangen, Ben Efron, Joseph Tam, Orit Pappo, Eyal Shteyer, Eli Pikarsky, Mathias Heikenwalder, David S Greenberg, Hermona Soreq

Gut; 67:1124-1134 (2018)

Chanan Meydan, Uriya Bekenstein, and Hermona Soreq

Frontiers in molecular neuroscience, vol. 11, 189 (2018)

Jade-Emmanuelle Deshaies, Lulzim Shkreta, Alexander J Moszczynski, Hadjara Sidibé, Sabrina Semmler, Aurélien Fouillen, Estelle R Bennett, Uriya Bekenstein, Laurie Destroismaisons, Johanne Toutant, Quentin Delmotte, Kathryn Volkening, Stéphanie Stabile, Anaïs Aulas, Yousra Khalfallah, Hermona Soreq, Antonio Nanci, Michael J Strong, Benoit Chabot, Christine Vande Velde

Brain, Volume 141, Issue 5, Pages 1320–1333 (2018)

Shaheen, M., Schindler, L., Saar-Ashkenazy, R., Odeh, K.B., Soreq, H., Friedman, A. & Kirschbaum, C.

Psychophysiology e13271 (2018)

Barbash, S, Garfinkel BP, Maoz R, Simchovitz A, Nadorp B, Guffanti A, Bennett ER, Nadeau C, Turk A, Paul L, Reda T, Li Y, Buchman AS, Greenberg DS, Seitz A, Bennett DA, Giavalisco P, Soreq H.

Neurobiology of Disease Volume 106, Pages 1-13 (2017)

Maoz R, Garfinkel BP, Soreq H.

Adv Exp Med Biol. 2017;978:337-361 (2017)