Eran Meshorer Lab

ELSC Members

Arthur Gutterman Family Chair in Stem Cell Biology Endowment Fund

Epigenetics, stem cells, & neurons

The Meshorer lab is studying

1. Epigenetic regulation in stem cells and differentiation;
2. Neurodegenerative diseases (e.g. HD) using pluripotent stem cell models;
3. Paleo-epigenetics: reconstructing DNA methylation in archaic genomes.

Malka Nissim-Rafinia PhD

Lab Manager

Ayelet - Hashahar Cohen

Research Associate (Teacher-Researcher)

Elad Dvir

Joint PhD student with Sagiv Shifman

Tzukit Tal

Joint student with TEVA

Walaa Oweis

PhD Student

Tamar Segal

PhD Student

Avital Pushett

PhD Student

Ziv Brodie

PhD Student

Shira Siegel

MSc Student

Eden Mishne

MSc Student

Rivka Masar

MSc Student

Shira Horev

MSc Student

Shalhevet Klemfner

Graduate student

Yoav Mathov, Malka Nissim-Rafinia, Chen Leibson, Nir Galun, Tomas Marques-Bonet, Arye Kandel, Meir Liebergal, Eran Meshorer, Liran Carmel

Inferring DNA methylation in non-skeletal tissues of ancient specimens

Nature Ecology & Evolution, 1-13 (2024)

Leader Y, Lev Maor G, Sorek M, Shayevitch R, Hussein M, Hameiri O, Tammer L, Zonszain J, Keydar I, Hollander D, Meshorer E, Ast G.

The upstream 5′ splice site remains associated to the transcription machinery during intron synthesis

Nat Commun. (2021)

Bar S, Vershkov D, Keshet G, Lezmi E, Meller N, Yilmaz A, Yanuka O, Nissim-RafiniaM, Meshorer E, Eldar-Geva T, Benvenisty N.

Identifying regulators of parental imprinting by CRISPR/Cas9 screening in haploid human embryonic stem cells

Nat Commun. (2021)

Gokhman, D., M. Nissim-Rafinia, L. Agranat-Tamir, G. Housman, R. Garcia-Perez, E. Lizano, O. Cheronet, S. Mallick, M. A. Nieves-Colon, H. Li, S. Alpaslan-Roodenberg, M. Novak, H. Gu, J. M. Osinski, M. Ferrando-Bernal, P. Gelabert, I. Lipende, D. Mjungu, I. Kondova, R. Bontrop, O. Kullmer, G. Weber, T. Shahar, M. Dvir-Ginzberg, M. Faerman, E. E. Quillen, A. Meissner, Y. Lahav, L. Kandel, M. Liebergall, M. E. Prada, J. M. Vidal, R. M. Gronostajski, A. C. Stone, B. Yakir, C. Lalueza-Fox, R. Pinhasi, D. Reich, T. Marques-Bonet, E. Meshorer, and L. Carmel.

Differential DNA methylation of vocal and facial anatomy genes in modern humans

Nat Commun (2020)

Pattabiraman S, Azad GK, Amen T, Brielle S, Park JE, Sze SK, Meshorer E, Kaganovich D.

Vimentin protects differentiating stem cells from stress

Sci Rep. (2020)

Meshorer E, Plath K.

Chromatin and Nuclear Architecture in Stem Cells

Stem Cell Reports (2020)

Lim PSL, Meshorer E.

Organization of the Pluripotent Genome

Cold Spring Harb Perspect Biol (2020)

Lim PSL, Meshorer E.

Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome

Nat Struct Mol Biol. (2020)

Harikumar A, Lim PSL, Nissim-Rafinia M, Park JE, Sze SK, Meshorer E.

Embryonic Stem Cell Differentiation Is Regulated by SET through Interactions with p53 and β-Catenin

Stem Cell Reports (2020)

Ben-Ami R, Klochendler A, Seidel M, Sido T, Gurel-Gurevich O, Yassour M, Meshorer E, Benedek G, Fogel I, Oiknine-Djian E, Gertler A, Rotstein Z, Lavi B, Dor Y, Wolf DG, Salton M, Drier Y; Hebrew University-Hadassah COVID-19 diagnosis team

Large-scale implementation of pooled RNA extraction and RT-PCR for SARSCoV-2 detection

Clin Microbiol Infect. (2020)

Danny Bavli, Xue Sun, Chen Kozulin, Dena Ennis, Alex Motzik, Alva Biran, Shlomi Brielle, Adi Alajem, Eran Meshorer, Amnon Buxboim, Oren Ram

CloneSeq: A highly sensitive analysis platform for the characterization of 3D-cultured single-cell-derived clones

Developmental Cell, ISSN 1534-5807, (2021)

Sorek, M., Oweis, W., Nissim-Rafinia, M. Maman M, Simon S, Hession CC, Adiconis X, Simmons SK, Sanjana NE, Shi X, Lu C, Pan JQ, Xu X, Pouladi MA, Ellerby LM, Zhang F, Levin JZ, Meshorer E.

Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity

Genome Biol 22, 73 (2021)

Pablo Aurelio Gómez-García, Stephanie Portillo-Ledesma, Maria Victoria Neguembor, Martina Pesaresi, Walaa Oweis, Talia Rohrlich, Stefan Wieser, Eran Meshorer, Tamar Schlick, Maria Pia Cosma, Melike Lakadamyali

Mesoscale Modeling and Single-Nucleosome Tracking Reveal Remodeling of Clutch Folding and Dynamics in Stem Cell Differentiation

Cell Reports, Volume 34, Issue 2, 2021, 108614, ISSN 2211-1247 (2021)

Hanan, M., Simchovitz, A., Yayon, N., Vaknine, S., Cohen-Fultheim, R., Karmon, M., Madrer, N., Rohrlich, T.M., Maman, M., Bennett, E.R., Greenberg, D.S., Meshorer, E., Levanon, E.Y., Soreq, H. & Kadener, S.

A Parkinson’s disease CircRNAs Resource reveals a link between circSLC8A1 and oxidative stress

EMBO Mol Med (2020)

Yoav Mathov, Daniel Batyrev, Eran Meshorer, Liran Carmel

Harnessing epigenetics to study human evolution

Current Opinion in Genetics & Development Pages 23-29, ISSN 0959-437X (2020)

Imke K. Mandemaker, Di Zhou, Serena T. Bruens, Dick H. Dekkers, Pernette J. Verschure, Raghu R. Edupuganti, Eran Meshorer, Jeroen A. Demmers, Jurgen A. Marteijn

Histone H1 eviction by the histone chaperone SET reduces cell survival following DNA damage

Journal of Cell Science jcs.235473 (2020)

Batyrev D, Lapid E, Carmel L, Meshorer E

Predicted Archaic 3D Genome Organization Reveals Genes Related to Head and Spinal Cord Separating Modern from Archaic Humans

Cells, 9(1), 48 (2020)

Lezmi E, Weissbein U, Golan-Lev T, Nissim-Rafinia M, Meshorer E, Benvenisty N.

The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation

Stem Cell Reports 2020;S2213-6711(20)30186-7. (2020)

Goldshtein et al.

Transcription Factor Binding in Embryonic Stem Cells Is Constrained by DNA Sequence Repeat Symmetry

Biophysical Journal (2020)

Gokhman D, Agranat L, Housman G, Nissim-Rafinia M, Colon MN, Gu H, Ferrando M, Gelabert P, Lipende I, Quillen EE, Meissner A, Stone AC, Pusey AE, Mjungu D, Kandel L, Liebergall M, Prada ME, Vidal JM, Krause J, Yakir B, Reich D, Fox CL, Marques-Bonet T, Eran Meshorer and Liran Carmel

Extensive Regulatory Changes in Genes Affecting Vocal and Facial Anatomy Separate Modern from Archaic Humans

BioRxiv (2019)

Mallm JP, Windisch P, Biran A, Gal Z, Schumacher S, Glass R, Herold-Mende C, Meshorer E, Barbus M, Rippe K

Glioblastoma initiating cells are sensitive to histone demethylase inhibition due to epigenetic deregulation

International Journal of Cancer (2019)

Schlesinger S and Meshorer E

Open chromatin, epigenetic plasticity and nuclear organization in pluripotency

Developmental Cell, Volume 48, Issue 2, 28 January 2019, Pages 135-150 (2019)

Cohen-Carmon D, Sorek M, Lerner V, Nissim-Rafinia M, Yarom Y, Meshorer E

Progerin-Induced Transcriptional Changes in Huntington’s Disease Human Pluripotent Stem Cell-Derived Neurons

Molecular Neurobiology (2019)

Gokhman D, Mishol N, de Manuel M, de Juan D, Shuqrun J, Meshorer E, Marques-Bonet T, Rak Y, Carmel L.

Reconstructing Denisovan Anatomy Using DNA Methylation Maps

Cell, Volume 179, Issue 1, Pages 180-192.e10 (2019)

Gold A, Eini L, Nissim-Rafinia M, Viner R, Ezer S, Erez K, Aqaqe N, Hanania R, Milyavsky M, Meshorer E, Goldberg M

Spironolactone inhibits the growth of cancer stem cells by impairing DNA damage response

Oncogene, volume 38, pages 3103–3118 (2019)

Viegas JO, Meshorer E

The Princess and the P: Pluripotent Stem Cells and P-Bodies

Cell Stem Cell (2019), Volume 25, Issue 5, Pages 589-591 (2019)

Azad GK, Ito K, Sailaja BS, Biran A, Nissim-Rafinia M, Brown DT, Takizawa T and Meshorer E

PARP1-dependent eviction of the linker histone H1 mediates immediate early gene expression during neuronal activation

Journal of Cell Biology, 217(2):473-481 (2018)

Schlesinger S, Kaffe B, Melcer S, Aguilera JDA, Mundackal DS, Kaplan T and Meshorer E

A hyperdynamic H3.3 nucleosome marks promoter regions in pluripotent embryonic stem cells

Nucleic Acids Research, Volume 45, Issue 21, 1 December 2017, Pages 12181–12194 (2017)

Edupuganti RR, Harikumar A, Aaronson Y, Biran A, Sailaja BS, Nissim-Rafinia M, Azad GK, Cohen MM, Park JE, Shivalila CS, Markoulaki S, Sze SK, Jaenisch R and Meshorer E

Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation

Stem Cell Reports, Volume 9, Issue 4, Pages 1291-1303 (2017)

Harikumar A, Edupuganti RR, Sorek M, Azad GK, Markoulaki S, Sehnalová P, Legartová S, Bártová E, Farkash-Amar S, Jaenisch R, Alon U and Meshorer E

An endogenously tagged fluorescent fusion protein library in mouse embryonic stem cells

Stem Cell Reports, Volume 9, Issue 4, 10 October 2017, Pages 1304-1314 (2017)

Gokhman, D, Meshorer E, Carmel L.

Epigenetics: It’s Getting Old. Past Meets Future in Paleoepigenetics.

Trends in Ecology & Evolution, Volume 31, Issue 4, Pages 290-300 (2016)

Aaronson, Y, Livyatan I, Gokhman D, Meshorer E.

Systematic identification of gene family regulators in mouse and human embryonic stem cells.

Nucleic Acids Research, Volume 44, Issue 9, Pages 4080–4089 (2016)

Torres CM, Biran A,S, Burney MJ, Patel H, Henser-Brownhill T, Cohen AS, Li Y, Ben Hamo R, Nye E, Spencer-Dene B, Chakravarty P, Efroni S, Matthews N, Misteli T, Meshorer E and Scaffidi P

The linker histone H1.0 determines epigenetic and functional intratumor heterogeneity

Science, Vol 353, Issue 6307 30 September 2016 (2016)

Livyatan I, Aaronson Y, Gokhman D, Ashkenazi R and Meshorer E

BindDB: an integrated database and webtool platform for “reverse-ChIP” epigenomic analysis

Cell Stem Cell, LETTER| VOLUME 17, ISSUE 6, P647-648, DECEMBER 03, 2015 (2015)

Harikumar A and Meshorer E

Chromatin remodeling and bivalent histone modifications in embryonic stem cells

EMBO reports, 16, 1609-1619 (2015)

Alajem A, Biran A, Harikumar A, Sailaja BS, Aaronson Y, Livyatan I, Nissim-Rafinia M, Sommer AG, Mostoslavsky G, Gerbasi VR, Golden DE, Datta A, Sze SK and Meshorer E

Differential Association of Chromatin Proteins Identifies BAF60a/SMARCD1 as a regulator of embryonic stem cell differentiation.

Cell Reports, Volume 10, Issue 12, 31 March 2015, Pages 2019-2031 (2015)

Moussaieff A, Rouleau M, Kitsberg D, Cohen M, Levy G, Barasch D, Nemirovski A, Shen-Orr S, Laevsky I, Amit M, Bomze D, Elena-Herrmann B, Scherf T, Nissim-Rafinia M, Kempa S, Itskovitz-Eldor J, Meshorer E, Aberdam D, Nahmias Y.

Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells

Cell Metabolism, Volume 21, Issue 3, Pages 392-402 (2015)

Yearim A, Gelfman S, Shayevitch R, Melcer S, Glaich O, Mallm JP, Nissim-Rafinia M, Cohen A, Rippe K, Meshorer E and Ast G

HP1 Is Involved in Regulating the Global Impact of DNA Methylation on Alternative Splicing

Cell Reports Volume 10, Issue 7, Pages 1122-1134 (2015)

Kfir N, Glaich O, Lev-Maor G, Alajem A, Datta A, Sze SK, Meshorer E and Ast G

SF3B1 Association with Chromatin Determines Splicing Outcomes

Cell Reports, Volume 11, Issue 4, Pages 618-629 (2015)

Shahar OD, Kalousi A, Eini L, Fisher B, Weiss A, Darr J, Mazina O, Bramson S, Kupiec M, Eden A, Meshorer E, Mazin AV, Brino L, Goldberg M and Soutoglou E

A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair

Nucleic Acids Research, Volume 42, Issue 9, Pages 5689–5701 (2014)

Schlesinger S, Meshorer E and Goff SP

Asynchronous transcriptional silencing of individual retroviral genomes in embryonic cells

Retrovirology, 11:31 (2014)

Ben-David U, Biran A, Scaffidi P, Herold-Mende C, Boehringer M, Meshorer E and Benvenisty N

Elimination of undifferentiated cancer cells by pluripotent stem cell inhibitors

Journal of Molecular Cell Biology, Volume 6, Issue 3, Pages 267–269 (2014)

Bodaker M, Meshorer E, Mitrani E and Louzoun Y

Bioinformatics, Volume 30, Issue 3, Pages 406–413 (2014)

Bošković A, Eid A, Pontabry J, Ishiuchi T, Spiegelhalter C, Ram EVS, Meshorer E and Torres-Padilla ME

Higher chromatin mobility supports totipotency and precedes pluripotency in vivo

Genes & Dev. 28: 1042-1047 (2014)

Raviv S, Bharti K, Rencus-Lazar S, Cohen-Tayar Y, Schyr R, Evantal N, Meshorer E, Zilberberg A, Grebe R, Rosin-Arbesfeld R, Lauderdale J, Lutty G, Arnheiter H and Ashery-Padan R

PAX6 Regulates Melanogenesis in the Retinal Pigmented Epithelium through Feed-Forward Regulatory Interactions with MITF

PLoS Genetics, 10(5):e1004360 (2014)

Gokhman D, Lavi E, Prüfer K, Fraga MF, Riancho JA, Kelso J, Pääbo S, Meshorer E* and Carmel L*

Reconstructing the DNA methylation maps of the Neandertal and the Denisovan

Science, Vol 344, Issue 6183 02 May 2014 (2014)

Alvarez-Saavedra M, De Repentigny Y, Lagali P, Ram EV, Yan K, Hashem E, Ivanochko D, Huh M, Doo Y, Mears A, Todd M, Corcoran C, Bassett E, Tokarew N, Kokavec J, Majumder R, Ioshikhes I, Wallace V, Kothary R, Meshorer E, Stopka T, Skoultchi A and Picketts D

Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation

Nature Communications, volume 5, Article number: 4181 (2014)

Blumberg A, Sailaja BS, Kundaje A, Levin L, Dadon S, Shmorak S, Shaulian S, Meshorer E and Mishmar D

Transcription Factors Bind Negatively Selected Sites within Human mtDNA Genes

Genome Biology and Evolution, Volume 6, Issue 10, Pages 2634–2646 (2014)

Deng T, Zhu I, Zhang S, Leng F, Cherukuri S, Hansen L, Mariño-Ramírez L, Meshorer E, Landsman D and Bustin M

HMGN1 Modulates Nucleosome Occupancy and DNase I Hypersensitivity at the CpG Island Promoters of Embryonic Stem Cells

Molecular and Cellular Biology, 33(16):3377-89 (2013)

Gokhman D, Livyatan I, Sailaja BS, Melcer S and Meshorer E

Multilayered chromatin analysis reveals E2f, Smad and Zfx as transcriptional regulators of histones

Nature Structural & Molecular Biology, volume 20, pages 119–126 (2013)

Livyatan I, Harikumar A, Nissim-Rafinia M, Duttagupta R, Gingeras TR and Meshorer E

Non-polyadenylated transcription in embryonic stem cells reveals novel non-coding RNA related to pluripotency and differentiation

Nucleic Acids Research, Volume 41, Issue 12, Pages 6300–6315 (2013)

Efroni S, Meerzaman D, Schaefer CF, Greenblum S, Soo-Lyu M, Hu Y, Cultraro C, Meshorer E, Buetow KH

Systems analysis utilising pathway interactions identifies sonic hedgehog pathway as a primary biomarker and oncogenic target in hepatocellular carcinoma

IET Systems Biology, Volume: 7 , Issue: 6, Pages: 243 - 251 (2013)

Biran A and Meshorer E

Chromatin and Genome Organization in Reprogramming

Stem Cells, Volume 30, Issue 9, Pages 1793-1799 (2012)

Dutta B, Adav SS, Koh CG, Lim SK, Meshorer E and Sze SK

Elucidating the temporal dynamics of chromatin-associated protein release upon DNA digestion by quantitative proteomic approach

Journal of Proteomics, Volume 75, Issue 17, Pages 5493-5506 (2012)

Melcer S, Hezroni H, Rand E, Nissim-Rafinia M, Stewart C, Skoultchi A, Bustin M and Meshorer E

Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation

Nature Communications volume 3, Article number: 910 (2012)

Shahar O, Raghu Ram EVS, Shimshoni E, Hareli S, Meshorer E and Goldberg M

Live imaging of induced and controlled DNA double-strand break formation reveals extremely low repair by homologous recombination in human cells

Oncogene, volume 31, pages 3495–3504 (2012)

Cohen-Carmon D and Meshorer E

Polyglutamine (polyQ) disorders The chromatin connection

Nucleus, Volume 3, Issue 5, Pages 433-441 (2012)

Sommer CA, Christodoulou C, Gianotti-Sommer A, Shen SS, Sailaja BS, Hezroni H, Meshorer E, Kotton DN and Mostoslavsky G.

Residual Expression of Reprogramming Factors Affects the Transcriptional Program and Epigenetic Signatures of Induced Pluripotent Stem Cells

PLoS ONE 7(12): e51711 (2012)

Sailaja BS, Cohen-Carmon D, Zimmerman G, Soreq H and Meshorer E

Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4

PNAS, 109 (52) E3687-E3695 (2012)

Farkash-Amar S, David Y, Polten A, Hezroni H, Eldar Y, Meshorer E, Yakhini Z and Simon I

Systematic Determination of Replication Activity Type Highlights Interconnections between Replication, Chromatin Structure and Nuclear Localization

PLoS ONE 7(11): e48986 (2012)

Mattout A, Biran A and Meshorer E

Global epigenetic changes during somatic cell reprogramming to iPS cell

Journal of Molecular Cell Biology, Volume 3, Issue 6, Pages 341–350 (2011)

Hezroni H, Tzchori I, Davidi A, Mattout A, Biran A, Nissim-Rafinia M, Westphal H and Meshorer E

H3K9 histone acetylation predicts pluripotency and reprogramming capacity of ES cells

Nucleus, Volume 2, Issue 4, Pages 300-309 (2011)

Gaspar-Maia A, Alajem A, Meshorer E and Ramalho-Santos M

Open chromatin in pluripotency and reprogramming

Nature Reviews Molecular Cell Biology, volume 12, pages 36–47 (2011)

Nissim-Rafinia M and Meshorer E

Photobleaching Assays (FRAP & FLIP) to Measure Chromatin Protein Dynamics in Living Embryonic Stem Cells

J. Vis. Exp. (52), e2696 (2011)

Hezroni H, Sailaja BS and Meshorer E

The Journal of Biological Chemistry, 286, 35977-35988 (2011)

Mattout, A and Meshorer E

Chromatin plasticity and genome organization in pluripotent embryonic stem cells

Current Opinion in Cell Biology, Volume 22, Issue 3, Pages 334-341 (2010)

Gaspar-Maia A, Alajem A, Polesso F, Sridharan R, Mason MJ, Heidersbach A, Ramalho-Santos J, McManus MT, Plath K, Meshorer E, Ramalho-Santos M

Chd1 regulates open chromatin and pluripotency of embryonic stem cells

Nature, volume 460, pages 863–868 (2009)

Schwartz S, Meshorer E and Ast G

Chromatin organization marks exon-intron structure

Nature Structural & Molecular Biology volume 16, pages 990–995 (2009)

Efroni, S, Melcer S, Nissim-Rafinia M and Meshorer E

Stem cells do play with dice: A statistical physics view of transcription

Cell Cycle, Volume 8, Issue 1, Pages 43-48 (2009)

Raghu Ram EVS and Meshorer E

Transcriptional competence in pluripotency

Genes & Dev. 23: 2793-2798 (2009)

Takizawa T and Meshorer E

Chromatin and nuclear architecture in the nervous system

Trends in Neurosciences, Volume 31, Issue 7, Pages 343-352 (2008)

Efroni S, Duttagupta R, Cheng J, Dehghani H, Hoeppner DJ, Dash C, Bazett-Jones DP, Le Grice S, McKay RDG, Buetow KH, Gingeras TR, Misteli T, Meshorer E

Global Transcription in Pluripotent Embryonic Stem Cells

Cell Stem Cell, Volume 2, Issue 5, Pages 437-447 (2008)

Meshorer E and Gruenbaum Y

Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging

Journal of Cell Biology, vol. 181 no. 1 9-13 (2008)

Meshorer E

Imaging chromatin in embryonic stem cells

StemBook (2008)

Meshorer E

Chromatin in embryonic stem cell neuronal differentiation

Histology and Histopathology, 22, 311-319 (2007)

Meshorer E, Yellajoshula D, George E, Scambler PJ, Brown D and Misteli T

Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells

Developmental Cell, Volume 10, Issue 1, Pages 105-116 (2006)

Meshorer E and Soreq H

Virtues and woes of AChE alternative splicing in stress-related neuropathologies

Trends in Neurosciences,Volume 29, Issue 4, Pages 216-224 (2006)

Meshorer E, Biton I, Ben-Shaul Y, Assaf Y, Soreq H and Cohen Y

Chronic cholinergic imbalances promote brain diffusion and transport abnormalities

The FASEB Journal, Vol. 19, No. 8 (2005)

Salmon A1, Erb C, Meshorer E, Ginzberg D, Adani Y, Rabinovitz I, Amitai G, Soreq H.

Muscarinic modulations of neuronal anticholinesterase responses

Chem Biol Interact. 2005 Dec 15;157-158:105-13. Epub 2005 Nov 11. (2005)

Meshorer E, Bryk B, Toiber D, Cohen J, Podoly E, Dori A and Soreq H

SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA

Molecular Psychiatry, 10, 985–997 (2005)

Meshorer E, Toiber D, Zurel D, Sahly I, Dori A, Cagnano E, Schreiber L, Grisaru D, Tronche F and Soreq H

Combinatorial Complexity of 5′ Alternative Acetylcholinesterase Transcripts and Protein Products

The Journal of Biological Chemistry, 279, 29740-29751 (2004)

Meshorer E, Erb C, Gazit R, Pavlovsky L, Kaufer D, Friedman A, Glick D, Ben-Arie N and Soreq H

Alternative Splicing and Neuritic mRNA Translocation Under Long-Term Neuronal Hypersensitivity

Science, Vol. 295, Issue 5554, pp. 508-512 (2002)

Stoilov P, Meshorer E, Gencheva M, Glick D, Soreq H and Stamm S

Defects in Pre-mRNA Processing as Causes of and Predisposition to Diseases

DNA and Cell Biology, Vol. 21, No. 11 (2002)

Meshorer E and Soreq H

Pre‐mRNA splicing modulations in senescence

Aging Cell, Volume 1, Issue 1, Pages 10-16 (2002)

Lev-Lehman E, Evron T, Broide RS, Meshorer E, Ariel I, Seidman S and Soreq H

Synaptogenesis and myopathy under acetylcholinesterase overexpression

Journal of Molecular Neuroscience, Volume 14, Issue 1–2, pp 93–105 (2000)

Sigalevich P, Meshorer E, Helman Y and Cohen Y

Transition from Anaerobic to Aerobic Growth Conditions for the Sulfate-Reducing Bacterium Desulfovibrio oxyclinae Results in Flocculation

Appl. Environ. Microbiol. 66:5005-5012 (2000)

Prokocimer M, Davidovich M, Nissim-Rafinia M, Wiesel-Motiuk N, Bar D, Barkan R, Meshorer E and Gruenbaum Y

Nuclear lamins: key regulators of nuclear structure and activities

Journal of Cellular and Molecular Medicine, Volume 13, Issue 6, Pages 1059-1085 (2009)

Honors:
2019 'Breakthrough of the Year’ Award by Science for Gokhman et al. Cell, 2019

2018 Coordinator, Marie Curie ITN Project award (‘EpiSyStem’)

2016 Gold Medal Award from the 1st Faculty of Medicine, Charles University, Prague, Czech Republic

2016 Named the Arthur Gutterman Chair for Stem Cell Research

2015 Vigevani Research Prize, Israel-Italy (with Prof. Giuseppe Testa, Milano)

2013 Zelman Cowen Award for Biomedical Research, Hebrew University and University of Sydney

2012 Hestrin Prize for an outstanding young researcher, Israel Society for Biochemistry and Molecular Biology

2012 Klachky Prize for the advancement of science, Hebrew University

Website:
Lab Website
Lab Facebook Page

Eran Meshorer

Professor

Email: eran.meshorer@mail.huji.ac.il

Phone: +972-2-6585161

Eran Meshorer CV

Eran Meshorer

@meshorer1

Address: Department of Genetics, The Institute of Life Sciences, Silberman Building, Room 2-541. The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram. Yael Riback, Lab administrator, 02-6585144

http://meshorerlab.huji.ac.il/

Arthur Gutterman Family Chair in Stem Cell Biology Endowment Fund

Epigenetics, stem cells, & neurons

The Meshorer lab is studying

People

Dina Moshitch

Lab Manager

Lital Summer

Lab administrative officer

Samira Souffi

Post Doc

Mousa Karayanni

PhD Student

Sapir Bashari

Ph.D. Student

Nimrod Agassi

M.Sc. Student

Alon Dotan

B.Sc. Student

Ana Polterovich

Alex Kazakov

Moran Aharoni

Kamini Sehrawat

Arthur Berrou

Maciej Jankowski

Johannes Niediek

Ori Brook

Yael Bitterman

Itai Hershenhoren

Yehuda Albeck

Bshara Awwad

Jonathan Rubin

Dina Farkas

Flora Antunes

Eyal Wigderson

Dana Barniv

Ayelet Shapira

Amit Yaron

Alon Fishbach

Tohar Sion Yarden

Shahar Mendelssohn

Mor Harpaz

Tamar Regev

Leila Khouri

Liora Las

Livia de Hoz

Mor Nahum

Nachum Ulanovsky

Nevo Taaseh

Omer Bar-Yosef

Roi Kliper

Gal Chechik

Yaron Rotman

Nadav Amir

Gideon Rothschild

Publications

S Bashari, MM Jankowski, I Nelken

The representation of regularity and randomness in auditory cortex of awake rats

bioRxiv (2025)

J Niediek, MM Jankowski, A Polterovich, A Kazakov, I Nelken

Insular cortex encodes task alignment

bioRxiv (2024)

Gilday D. O., Praegel B., Maor I., Cohen T., Nelken I., Mizrahi A.

Surround suppression in mouse auditory cortex underlies auditory edge detection

PLoS Computational Biology (2023)

Yarden. T., Mizrahi. A., Nelken I.

Context-Dependent Inhibitory Control of Stimulus-Specific Adaptation

Journal of Neuroscience. (2022)

Rajendran VG, Tsdaka Y, Keung TY, Schnupp JWH, Nelken I.

Rats synchronize predictively to metronomes

iScience, in press (2023)

Polterovich, A., Jankowski, M.M., Niediek, J., Kazakov, A., Nelken, I.

bioRxiv (2024)

Sehrawat, K., Nelken, I.

Sound preferences in mice are sex-dependent

bioRxiv (2024)

Maciej M. Jankowski , Mousa Karayanni, Mor Harpaz, Ana Polterovich , Israel Nelken

A Rapid Anterior Auditory Processing Stream Through the Insulo-Parietal Auditory Field in the Rat

bioRxiv (2023)

Kenneth W. Latimer, Dylan Barbera, Michael Sokoletsky, Bshara Awwad, Yonatan Katz, Israel Nelken, Ilan Lampl, Adriene L. Fairhall, Nicholas J. Priebe

Multiple Timescales Account for Adaptive Responses across Sensory Cortices

The Journal of Neuroscience (2020)

Maciej M. Jankowski, Ana Polterovich, Alex Kazakov, Johannes Niediek, Israel Nelken

An automated, low-latency environment for studying the neural basis of behavior in freely moving rats

BMC Biology (2023)

Bshara Awwad, Maciej M. Jankowski, Ana Polterovich, Sapir Bashari, Israel Nelken

Extensive representation of sensory deviance in the responses to auditory gaps in unanesthetized rats

Current Biology (2023)

Oren Amsalem, James King, Michael Reimann, Srikanth Ramaswamy, Eilif Muller, Henry Markram, Israel Nelken, Idan Segev

Dense Computer Replica of Cortical Microcircuits Unravels Cellular Underpinnings of Auditory Surprise Response

bioRxiv (2020)

Atlan G. Terem A. Peretz-Rivlin N., Sehrawat, K. Gonzales, B., Goll Y., Pozner G., Tasaka G., Goll Y., Rafaeli R., Zviran O., Lim B., Groysman M., Goshen I, Mizrahi A., Nelken I., Citri A.

The claustrum supports resilience to distraction

Current Biology (2018)

Mizrahi A., Shalev A. Nelken I.

Single neuron and population coding of natural sounds in auditory cortex

Current Opinion in Neurobiology (2014)

Rothschild G, Cohen L, Mizrahi A, Nelken I.

Elevated correlations in neuronal ensembles of mouse auditory cortex following parturition

J Neurosci. (2013)

Nadav Amir, Naftali Tishby, Israel Nelken

A simple model of the attentional blink and its modulation by mental training

PLOS Computational Biology, e1010398 (2022)

Mousa Karayanni & Israel Nelken

Extrinsic rewards, intrinsic rewards, and non-optimal behavior

Journal of Computational Neuroscience volume 50, pages139–143 (2022)

Lior Madmoni, Shir Tibor, Israel Nelken, Boaz Rafaely

The Effect of Partial Time-Frequency Masking of the Direct Sound on the Perception of Reverberant Speech

IEEE/ACM Transactions on Audio, Speech, and Language Processing, 29, 2037-2047 (2021)

Nadav Amir, Reut Suliman-Lavie, Maayan Tal, Sagiv Shifman, Naftali Tishby, Israel Nelken

Value-complexity tradeoff explains mouse navigational learning

PLOS Computational Biology 16(12): e1008497 (2020)

Carsten H. Tischbirek, Takahiro Noda, Manabu Tohmi, Antje Birkner, Israel Nelken, Arthur Konnerth

In Vivo Functional Mapping of a Cortical Column at Single-Neuron Resolution

Cell Reports 27 (5), 1319-1326. e5 (2019)

Huang,Shun-Ho, Shmoel,Nava, Jankowski, Maciej M., Erez, Hadas, Sharon,Aviv, Abu-Salah,Wesal, Nelken,Israel, Weiss,Aryeh, Spira,Micha E.

Immunohistological and Ultrastructural Study of the Inflammatory Response to Perforated Polyimide Cortical Implants: Mechanisms Underlying Deterioration of Electrophysiological Recording Quality

Frontiers in neuroscience 14, 926 (2020)

Meng Wang, Xiang Liao, Ruijie Li, Shanshan Liang, Ran Ding, Jingcheng Li, Jianxiong Zhang, Wenjing He, Ke Liu, Junxia Pan, Zhikai Zhao, Tong Li, Kuan Zhang, Xingyi Li, Jing Lyu, Zhenqiao Zhou, Zsuzsanna Varga, Yuanyuan Mi, Yi Zhou, Junan Yan, Shaoqun Zeng, Jian K. Liu, Arthur Konnerth, Israel Nelken, Hongbo Jia & Xiaowei Chen

Single-neuron representation of learned complex sounds in the auditory cortex

Nature Communications 11 (1), 1-14 (2020)

Israel Nelken

From neurons to behavior: the view from auditory cortex

Current Opinion in Physiology 18, 37-41 (2020)

Israel Nelken

Neural Population Coding of Natural Sounds in Non-flying Mammals

Oxford Research Encyclopedia of Neuroscience (2017)

Itai Hershenhoren, Israel Nelken

Detection of Tones Masked by Fluctuating Noise in Rat Auditory Cortex

Cerebral Cortex 27 (11), 5130-5143 (2016)

Alainde Cheveigné, Israel Nelken

Filters: When, Why, and How (Not) to Use Them

Neuron 102 (2), 280-293 (2019)

Eban E., Rothschild G., Mizrahi A., Nelken I., Elidan G.

Dynamic copula networks for modeling real-valued time series

Artificial Intelligence and Statistics (2013)

Tamar I Regev, Geffen Markusfeld, Leon Y Deouell, Israel Nelken

Context sensitivity across multiple time scales with a flexible frequency bandwidth

Cerebral Cortex 32 (1), 158-175 (2022)

Rothschild G, Nelken I, Mizrahi A.

Functional organization and population dynamics in the mouse primary auditory cortex

Nat Neurosci. 2010 Mar;13(3):353-60. (2010)

Mor Harpaz, Maciej M. Jankowski, Leila Khouri, Israel Nelken

Emergence of abstract sound representations in the ascending auditory system

Progress in Neurobiology, Volume 202, 102049, ISSN 0301-0082 (2021)

Bshara Awwad, Maciej M Jankowski, Israel Nelken

Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex

Cerebral Cortex Volume 30, Issue 8, August 2020, Pages 4465–4480 (2020)

Regev, TI, Nelken I, Deouell LY.

Evidence for Linear but Not Helical Automatic Representation of Pitch in the Human Auditory System.

Journal of Cognitive Neuroscience Early Access p.1-17 (2019)

Busche, M A, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT.

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo.

Nat Neurosci (2019)

Kazakov, A, Nelken I.

Acoustic calibration in an echoic environment.

Journal of Neuroscience Methods Volume 309, Pages 60-70 (2018)

Kazakov A, Jankowski MM, Nelken I.

Acoustic recordings data from an echoic environment and a toolkit for its analysis

Data Brief. 21:1451-1457 (2018)

de Hoz, L, Gierej D, Lioudyno V, Jaworski J, Blazejczyk M, Cruces-Solís H, Beroun A, Lebitko T, Nikolaev T, Knapska E, Nelken I, Kaczmarek L.

Blocking c-Fos Expression Reveals the Role of Auditory Cortex Plasticity in Sound Frequency Discrimination Learning.

Cerebral Cortex, Volume 28, Issue 5, Pages 1645–1655 (2018)

Polterovich A, Jankowski MM, Nelken I.

Deviance sensitivity in the auditory cortex of freely moving rats

PLoS One. 13(6):e0197678 (2018)

Keskin AD, Kekuš M, Adelsberger H, Neumann U, Shimshek DR, Song B, Zott B, Peng T, Förstl H, Staufenbiel M, Nelken I, Sakmann B, Konnerth A, Busche M A.

BACE inhibition-dependent repair of Alzheimer’s pathophysiology

Proc Natl Acad Sci U S A. 114(32):8631-8636 (2017)

Li J, Liao X, Zhang J, Wang M, Yang N, Zhang J, Lv G, Li H, Lu J, Ding R, Li X, Guang Y, Yang Z, Qin H, Jin W, Zhang K, He C, Jia H, Zeng S, Hu Z, Nelken I, Chen X.

Primary Auditory Cortex is Required for Anticipatory Motor Response

Cereb Cortex; 27(6):3254-3271 (2017)

Yarden TS, Nelken I.

Stimulus-specific adaptation in a recurrent network model of primary auditory cortex

PLoS Comput Biol. 3(3):e1005437 (2017)

Grimm, S, Escera C, Nelken I.

Early indices of deviance detection in humans and animal models.

Biological Psychology Volume 116, Pages 23-27 (2016)

Wigderson, E, Nelken I, Yarom Y.

Early multisensory integration of self and source motion in the auditory system.

Proc Natl Acad Sci U S A, 113(29): 8308–8313 (2016)

Jonathan Rubin, Nahum Ulinovsky, Israel Nelken and Naftali Tishby

The Representation of Prediction Error in Auditory Cortex

PLoS Comput Biol 12(8) e1005058 (2016)

Barniv D, Nelken I.

Auditory Streaming as an Online Classification Process with Evidence Accumulation

PLoS One. 2015 Dec 15;10(12):e0144788. (2015)

Khouri L, Nelken I.

Detecting the unexpected

Curr Opin Neurobiol. 2015 Dec;35:142-7. (2015)

Slomowitz E, Styr B, Vertkin I, Milshtein-Parush H, Nelken I, Slutsky M, Slutsky I.

Interplay between population firing stability and single neuron dynamics in hippocampal networks

https://doi.org/10.7554/eLife.04378 (2015)

Busche MA, Kekuš M, Adelsberger H, Noda T, Förstl H, Nelken I, Konnerth A.

Rescue of long-range circuit dysfunction in Alzheimer’s disease models

Nat Neurosci. 2015 Nov;18(11):1623-30. (2015)

Nelken I.

Stimulus-specific adaptation and deviance detection in the auditory system: experiments and models

Biol Cybern. 2014 Oct;108(5):655-63. (2014)

Moshitch D, Nelken I.

The Representation of Interaural Time Differences in High-Frequency Auditory Cortex

Cereb Cortex. 2016 Feb;26(2):656-68. (2014)

Xu X, Yu X, He J, Nelken I.

Across-ear stimulus-specific adaptation in the auditory cortex

Front Neural Circuits. 2014 Jul 30;8:89. (2014)

Nelken I, Bizley J, Shamma SA, Wang X.

Auditory cortical processing in real-world listening: the auditory system going real

J Neurosci. 2014 Nov 12;34(46):15135-8. (2014)

Israel Nelken, Jennifer Bizley, Shihab A. Shamma, and Xiaoqin Wang

Auditory cortical processing in real-world listening: the auditory system going real

J Neurosci. 2014 Nov 12; 34(46): 15135–15138. (2014)

de Hoz L, Nelken I.

Frequency tuning in the behaving mouse: different bandwidths for discrimination and generalization

PLoS One. 2014 Mar 14;9(3):e91676. (2014)

Itai Hershenhoren, Nevo Taaseh, Flora M. Antunes and Israel Nelken

Intracellular correlates of stimulus-specific adaptation

Journal of Neuroscience 26 February 2014, 34 (9) 3303-3319. (2014)

Grodzinsky Y., Nelken I.

The neural code that makes us human

Science. 2014 Feb 28;343(6174):978-9. (2014)

Moshitch D, Nelken I.

Using Tweedie distributions for fitting spike count data

J Neurosci Methods. 2014 Mar 30;225:13-28. (2014)

Nelken I, de Cheveigné A.

An ear for statistics

Nat Neurosci. 2013 Apr;16(4):381-2. (2013)

Nelken I, Yaron A, Polterovich A, Hershenhoren I.

Stimulus-specific adaptation beyond pure tones

Adv Exp Med Biol. 2013;787:411-8. (2013)

Eitan Globerson, and Israel Nelken

The neuro-pianist

Front Syst Neurosci. 2013; 7: 35. (2013)

Chechik G, Nelken I.

Auditory abstraction from spectro-temporal features to coding auditory entities

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18968-73. (2012)

Nelken I.

Predictive information processing in the brain: the neural perspective

Int J Psychophysiol. 2012 Feb;83(2):253-5. (2012)

Yaron A, Hershenhoren I, Nelken I.

Sensitivity to Complex Statistical Regularities in Rat Auditory Cortex

Neuron. 2012 Nov 8;76(3):603-15. (2012)

Grienberger C, Adelsberger H, Stroh A, Milos RI, Garaschuk O, Schierloh A, Nelken I, Konnerth A.

Sound-evoked network calcium transients in mouse auditory cortex in vivo

J Physiol. 2012 Feb 15;590(4):899-918. (2012)

Zohar O, Shackleton TM, Nelken I, Palmer AR, Shamir M.

First spike latency code for interaural phase difference discrimination in the guinea pig inferior colliculus

J Neurosci. 2011 Jun 22;31(25):9192-204. (2011)

Chen X, Leischner U, Rochefort NL, Nelken I, Konnerth A.

Functional mapping of single spines in cortical neurons in vivo

Nature. 2011 Jun 26;475(7357):501-5. (2011)

Israel Nelken

Music and the auditory brain: where is the connection?

Front Hum Neurosci. 2011; 5: 106. (2011)

Taaseh N, Yaron A, Nelken I.

Stimulus-specific adaptation and deviance detection in the rat auditory cortex

PLoS One. 2011;6(8):e23369. (2011)

Asadollahi A, Endler F, Nelken I, Wagner H.

Neural correlates of binaural masking level difference in the inferior colliculus of the barn owl (Tyto alba)

Eur J Neurosci. 2010 Aug;32(4):606-18. (2010)

Nahum M, Nelken I, Ahissar M.

Stimulus uncertainty and perceptual learning: similar principles govern auditory and visual learning

Vision Res. 2010 Feb 22;50(4):391-401. (2010)

Antunes FM, Nelken I, Covey E, Malmierca MS.

Stimulus-specific adaptation in the auditory thalamus of the anesthetized rat

PLoS One. 2010 Nov 19;5(11):e14071. (2010)

Nelken I.

Inhibitory plasticity in auditory cortex

Neuron. 2009 Jun 11;62(5):605-7. (2009)

Winkler I, Denham SL, Nelken I.

Modeling the auditory scene: predictive regularity representations and perceptual objects

Trends Cogn Sci. 2009 Dec;13(12):532-40. (2009)

Merav Ahissar , Mor Nahum , Israel Nelken and Shaul Hochstein

Reverse hierarchies and sensory learning

Philosophical transactions of the Royal Society of London. Series B, Biological sciences (2009)

Andrew J King, Israel Nelken

Unraveling the principles of auditory cortical processing: can we learn from the visual system?

Nature Neuroscience volume 12, pages 698–701 (2009) (2009)

Parush N, Arkadir D, Nevet A, Morris G, Tishby N, Nelken I, Bergman H.

Encoding by response duration in the basal ganglia

J Neurophysiol. 2008 Dec;100(6):3244-52. (2008)

Las L, Shapira AH, Nelken I.

Functional gradients of auditory sensitivity along the anterior ectosylvian sulcus of the cat

J Neurosci. 2008 Apr 2;28(14):3657-67. (2008)

Nahum M, Nelken I, Ahissar M.

Low-level information and high-level perception: the case of speech in noise

PLoS Biol. 2008 May 20;6(5):e126. (2008)

Israel Nelken and Omer Bar-Yosef

Neurons and objects: the case of auditory cortex

Front Neurosci. 2008 Jul; 2(1): 107–113. (2008)

Nelken I, Bizley JK, Nodal FR, Ahmed B, King AJ, Schnupp JW.

Responses of auditory cortex to complex stimuli: functional organization revealed using intrinsic optical signals

J Neurophysiol. 2008 Apr;99(4):1928-41. (2008)

Gordon N, Shackleton TM, Palmer AR, Nelken I.

Responses of neurons in the inferior colliculus to binaural disparities: Insights from the use of Fisher information and mutual information

J Neurosci Methods. 2008 Apr 30;169(2):391-404. (2008)

Yuval-Greenberg S, Tomer O, Keren AS, Nelken I, Deouell LY.

Transient induced gamma-band response in EEG as a manifestation of miniature saccades

Neuron. 2008 May 8;58(3):429-41. (2008)

Y. Bitterman, R. Mukamel, R. Malach, I. Fried & I. Nelken

Ultra-fine frequency tuning revealed in single neurons of human auditory cortex

Nature volume 451, pages 197–201 (10 January 2008) (2008)

Nelken I, Chechik G.

Information theory in auditory research

Hear Res. 2007 Jul;229(1-2):94-105. (2007)

Israel Nelken, Nachum Ulanovsky

Mismatch negativity and stimulus-specific adaptation in animal models

Journal of Psychophysiology 21(3-4):214-223 (2007)

Bizley JK, Nodal FR, Bajo VM, Nelken I, King AJ.

Physiological and anatomical evidence for multisensory interactions in auditory cortex

Cereb Cortex. 2007 Sep;17(9):2172-89. (2007)

Alex Loebel, Israel Nelken, and Misha Tsodyks

Processing of sounds by population spikes in a model of primary auditory cortex

Front Neurosci. 2007 Nov; 1(1): 197–209. (2007)

Omer Bar-Yosef and Israel Nelken

The Effects of Background Noise on the Neural Responses to Natural Sounds in Cat Primary Auditory Cortex

Front Comput Neurosci. 2007; 1: 3. (2007)

Israel Nelken, Merav Ahissar

High-Level and Low-Level Processing in the Auditory System: The Role of Primary Auditory Cortex

IOS Press (2006)

Chechik G, Anderson MJ, Bar-Yosef O, Young ED, Tishby N, Nelken I.

Reduction of information redundancy in the ascending auditory pathway

Neuron. 2006 Aug 3;51(3):359-68. (2006)

Moshitch D, Las L, Ulanovsky N, Bar-Yosef O, Nelken I.

Responses of neurons in primary auditory cortex (A1) to pure tones in the halothane-anesthetized cat

J Neurophysiol. 2006 Jun;95(6):3756-69. (2006)

Nelken I, Chechik G, Mrsic-Flogel TD, King AJ, Schnupp JW.

Encoding stimulus information by spike numbers and mean response time in primary auditory cortex

J Comput Neurosci. 2005 Oct;19(2):199-221. (2005)

Bizley JK, Nodal FR, Nelken I, King AJ.

Functional Organization of Ferret Auditory Cortex

Cereb Cortex. 2005 Oct;15(10):1637-53. (2005)

Liora Las, Edward A. Stern and Israel Nelken

Representation of tone in fluctuating maskers in the ascending auditory system

Journal of Neuroscience 9 February 2005, 25 (6) 1503-1513; (2005)

Griffiths TD, Warren JD, Scott SK, Nelken I, King AJ.

Cortical processing of complex sound: a way forward?

Trends Neurosci. 2004 Apr;27(4):181-5. (2004)

Nelken I, Bizley JK, Nodal FR, Ahmed B, Schnupp JW, King AJ.

Large-scale organization of ferret auditory cortex revealed using continuous acquisition of intrinsic optical signals

J Neurophysiol. 2004 Oct;92(4):2574-88. (2004)

Nachum Ulanovsky, Liora Las, Dina Farkas and Israel Nelken

Multiple time scales of adaptation in auditory cortex neurons

Journal of Neuroscience 17 November 2004, 24 (46) 10440-10453; (2004)

Nelken I.

Processing of complex stimuli and natural scenes in the auditory cortex

Curr Opin Neurobiol. 2004 Aug;14(4):474-80. (2004)

Fishbach A, Yeshurun Y, Nelken I.

Neural model for physiological responses to frequency and amplitude transitions uncovers topographical order in the auditory cortex

J Neurophysiol. 2003 Dec;90(6):3663-78. (2003)

Israel Nelken, Alon FishbachLiora LasNachum UlanovskyDina Farkas

Primary auditory cortex of cats: feature detection or something else?

Biological Cybernetics November 2003, Volume 89, Issue 5, pp 397–406 (2003)

Ulanovsky N, Las L, Nelken I.

Processing of low-probability sounds by cortical neurons

Nat Neurosci. 2003 Apr;6(4):391-8. (2003)

Open Positions

A postdoctoral position is available in the field of auditory perception under the supervision of Prof. Israel Nelken. Click here for more information.

Additional Information

Honors:
1985 The A. Heller prize for excellence in Research Thesis
1991 Fullbright fellowship
1994 The Bergmann Memorial Research Grant (concurrently with BSF grant No. 93-00057)
1999 Research prize of the Faculty of Medicine, Hebrew University – Hadassah Medical School.
2000 Bernard Katz Lecturer for the year 2000
2008 Michael Bruno prize, administered by Yad-Hanadiv foundation
2015 Rector prize for excellence in research and teaching
2016 The Michael Landau prize for the Sciences and Research
2021 Humboldt research prize

Israel Nelken

Professor

Email: israel.nelken@mail.huji.ac.il

Phone: +972-2-6584229

Fax: +972-2-6586077

Israel Nelken

Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 2, Room 1207, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401