Gamma oscillations in cortex have been extensively studied with relation to behavior in both humans and animal models; however, their computational role in the processing of behaviorally relevant signals is still not clear. One oft-overlooked characteristic of gamma oscillations is their spatial distribution over the cortical space and the computational consequences of such an organization. Here, we advance the proposal that the spatial organization of gamma oscillations is of major importance for their function. The interaction of specific spatial distributions of oscillations with the functional topography of cortex enables select amplification of neuronal signals, which supports perceptual and cognitive processing.