Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging

Specific mutations in the human gene encoding lamin A or in the lamin A – processing enzyme, Zmpste24, cause premature aging. New data on mice and humans suggest that these mutations affect adult stem cells by interfering with the Notch and Wnt signaling pathways.

Authors: Meshorer E and Gruenbaum Y
Year of publication: 2008
Journal: Journal of Cell Biology, vol. 181 no. 1 9-13

Link to publication:


“Working memory”