The mammalian acetylcholinesterase (ACHE) locus was investigated using computational predictive methods and experiments of reverse transcription polymerase chain reaction (RT-PCR). Computational analysis identified two genes downstream to ACHE, an inversely oriented arsenite resistance gene homologue (ARS), and a novel previously unidentified gene (PIX), co-oriented with ACHE. Experimental evidence shows coregulation of murine ACHE and ARS following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission.
Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase
Authors: Grant AD, Shapira M, Soreq H.
Year of publication: 2001
Journal: Cell Mol Neurobiol. 2001 Dec;21(6):783-97.
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