Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase

The mammalian acetylcholinesterase (ACHE) locus was investigated using computational predictive methods and experiments of reverse transcription polymerase chain reaction (RT-PCR). Computational analysis identified two genes downstream to ACHE, an inversely oriented arsenite resistance gene homologue (ARS), and a novel previously unidentified gene (PIX), co-oriented with ACHE. Experimental evidence shows coregulation of murine ACHE and ARS following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission.

Authors: Grant AD, Shapira M, Soreq H.
Year of publication: 2001
Journal: Cell Mol Neurobiol. 2001 Dec;21(6):783-97.

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