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Home » Publications » Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase

Genomic dissection reveals locus response to stress for mammalian acetylcholinesterase

The mammalian acetylcholinesterase (ACHE) locus was investigated using computational predictive methods and experiments of reverse transcription polymerase chain reaction (RT-PCR). Computational analysis identified two genes downstream to ACHE, an inversely oriented arsenite resistance gene homologue (ARS), and a novel previously unidentified gene (PIX), co-oriented with ACHE. Experimental evidence shows coregulation of murine ACHE and ARS following confined swim, indicating coordinated locus response to stress, that is possibly mediated by altered cholinergic neurotransmission.

Authors: Grant AD, Shapira M, Soreq H.

Year of publication: 2001

Journal: Cell Mol Neurobiol. 2001 Dec;21(6):783-97.

Link to publication:

https://www.ncbi.nlm.nih.gov/pubmed/12043848

Labs:

Hermona Soreq

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