Israel Nelken Lab

ELSC Members

Milton and Brindell Gottlieb Chair in Brain Science
Laboratory of Auditory Neurophysiology

We study the auditory system using a combination of behavioral, electrophysiological and imaging techniques, mostly in animal models but also in humans.

Sounds and the Brain

We investigate the transformation of sound from a physical phenomenon to a perceptual experience. Initial neural representations in the ascending auditory system closely correlate with the momentary physical characteristics of sounds. However, by the time signals reach the midbrain, they begin to integrate increasingly rich contextual information. In the primary auditory cortex, sound responses are profoundly influenced not only by spectro-temporal context but also by the animal’s actions, the specific task at hand, and the level of attention and engagement.

We propose that these representations form part of an inner model of the world, which is essential for decision-making in sound-guided behaviors and serves as the foundation for the perception of sounds. 

Here is a sample of our recent and ongoing projects:

Context-dependent sound representations in auditory cortex >>

Early sound exposure and sound preferences in mice     >>

Sound-guided behavior and neural dynamics in auditory cortex of freely-moving rats >>

Representation of actions in auditory cortex: insights from reinforcement learning and deep neural networks >>

Envelope Phone-alt

Israel Nelken

Professor

Email: israel.nelken@mail.huji.ac.il
Phone: +972-2-6584229
Fax: +972-2-6586077
Israel Nelken
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 2, Room 1207, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
Milton and Brindell Gottlieb Chair in Brain Science
Laboratory of Auditory Neurophysiology

We study the auditory system using a combination of behavioral, electrophysiological and imaging techniques, mostly in animal models but also in humans.

Sounds and the Brain

We investigate the transformation of sound from a physical phenomenon to a perceptual experience. Initial neural representations in the ascending auditory system closely correlate with the momentary physical characteristics of sounds. However, by the time signals reach the midbrain, they begin to integrate increasingly rich contextual information. In the primary auditory cortex, sound responses are profoundly influenced not only by spectro-temporal context but also by the animal’s actions, the specific task at hand, and the level of attention and engagement.

We propose that these representations form part of an inner model of the world, which is essential for decision-making in sound-guided behaviors and serves as the foundation for the perception of sounds. 

Here is a sample of our recent and ongoing projects:

Context-dependent sound representations in auditory cortex >>

Early sound exposure and sound preferences in mice     >>

Sound-guided behavior and neural dynamics in auditory cortex of freely-moving rats >>

Representation of actions in auditory cortex: insights from reinforcement learning and deep neural networks >>

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Dina Moshitch
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Lital Summer
Lab administrative officer
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Moran Aharoni
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Samira Souffi
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Alex Kazakov
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Kamini Sehrawat
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B.Sc. Student
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Maciej Jankowski
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Ori Brook
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Yael Bitterman
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Roi Kliper
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Yaron Rotman
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Nadav Amir
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Tamar Regev
Mor
Mor Harpaz
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Shahar Mendelssohn
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Yehuda Albeck
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Bshara Awwad
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Jonathan Rubin
ELSC-background-010
Dina Farkas
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Omer Bar-Yosef
ELSC-Seminars-General
Nevo Taaseh
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Nachum Ulanovsky
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Tohar Sion Yarden
ELSC-Seminars-General
Alon Fishbach
ELSC-Seminars-General
Amit Yaron
ELSC-Seminars-General
Ayelet Shapira
ELSC-Seminars-General
Dana Barniv
ELSC-Seminars-General
Eyal Wigderson
ELSC-Seminars-General
Flora Antunes
ELSC-Seminars-General
Gal Chechik
ELSC-Seminars-General
Itai Hershenhoren
ELSC-Seminars-General
Leila Khouri
ELSC-Seminars-General
Liora Las
ELSC-Seminars-General
Livia de Hoz
ELSC-Seminars-General
Mor Nahum
ELSC-Seminars-General
Gideon Rothschild
Sehrawat, K., Nelken, I.

Sound preferences in mice are sex-dependent

bioRxiv (2024)

Polterovich, A., Jankowski, M.M., Niediek, J., Kazakov, A., Nelken, I.

Task-related activity in auditory cortex enhances sound representation

bioRxiv (2024)

Omri David Gilday, Benedikt Praegel, Ido Maor, Tav Cohen, Israel Nelken, Adi Mizrahi

Surround suppression in mouse auditory cortex underlies auditory edge detection

PLoS Computational Biology (2023)

Bshara Awwad, Maciej M. Jankowski, Ana Polterovich, Sapir Bashari, Israel Nelken

Extensive representation of sensory deviance in the responses to auditory gaps in unanesthetized rats

Current Biology (2023)

Maciej M. Jankowski, Ana Polterovich, Alex Kazakov, Johannes Niediek, Israel Nelken

An automated, low-latency environment for studying the neural basis of behavior in freely moving rats

BMC Biology (2023)

Maciej M. Jankowski , Mousa Karayanni, Mor Harpaz, Ana Polterovich , Israel Nelken

A Rapid Anterior Auditory Processing Stream Through the Insulo-Parietal Auditory Field in the Rat

bioRxiv (2023)

Rajendran VG, Tsdaka Y, Keung TY, Schnupp JWH, Nelken I.

Rats synchronize predictively to metronomes

iScience, in press (2023)

Tamar I Regev, Geffen Markusfeld, Leon Y Deouell, Israel Nelken

Context sensitivity across multiple time scales with a flexible frequency bandwidth

Cerebral Cortex 32 (1), 158-175 (2022)

Tohar S. Yarden, Adi Mizrahi, Israel Nelken

Context-Dependent Inhibitory Control of Stimulus-Specific Adaptation

Journal of Neuroscience. 42(23): 4629-4651 (2022)

Mousa Karayanni & Israel Nelken

Extrinsic rewards, intrinsic rewards, and non-optimal behavior

Journal of Computational Neuroscience volume 50, pages139–143 (2022)

Nadav Amir, Naftali Tishby, Israel Nelken

A simple model of the attentional blink and its modulation by mental training

PLOS Computational Biology, e1010398 (2022)

Mor Harpaz, Maciej M. Jankowski, Leila Khouri, Israel Nelken

Emergence of abstract sound representations in the ascending auditory system

Progress in Neurobiology, Volume 202, 102049, ISSN 0301-0082 (2021)

Lior Madmoni, Shir Tibor, Israel Nelken, Boaz Rafaely

The Effect of Partial Time-Frequency Masking of the Direct Sound on the Perception of Reverberant Speech

IEEE/ACM Transactions on Audio, Speech, and Language Processing, 29, 2037-2047 (2021)

Bshara Awwad, Maciej M Jankowski, Israel Nelken

Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex

Cerebral Cortex Volume 30, Issue 8, August 2020, Pages 4465–4480 (2020)

Israel Nelken

From neurons to behavior: the view from auditory cortex

Current Opinion in Physiology 18, 37-41 (2020)

Meng Wang, Xiang Liao, Ruijie Li, Shanshan Liang, Ran Ding, Jingcheng Li, Jianxiong Zhang, Wenjing He, Ke Liu, Junxia Pan, Zhikai Zhao, Tong Li, Kuan Zhang, Xingyi Li, Jing Lyu, Zhenqiao Zhou, Zsuzsanna Varga, Yuanyuan Mi, Yi Zhou, Junan Yan, Shaoqun Zeng, Jian K. Liu, Arthur Konnerth, Israel Nelken, Hongbo Jia & Xiaowei Chen

Single-neuron representation of learned complex sounds in the auditory cortex

Nature Communications 11 (1), 1-14 (2020)

Huang,Shun-Ho, Shmoel,Nava, Jankowski, Maciej M., Erez, Hadas, Sharon,Aviv, Abu-Salah,Wesal, Nelken,Israel, Weiss,Aryeh, Spira,Micha E.

Immunohistological and Ultrastructural Study of the Inflammatory Response to Perforated Polyimide Cortical Implants: Mechanisms Underlying Deterioration of Electrophysiological Recording Quality

Frontiers in neuroscience 14, 926 (2020)

Nadav Amir, Reut Suliman-Lavie, Maayan Tal, Sagiv Shifman, Naftali Tishby, Israel Nelken

Value-complexity tradeoff explains mouse navigational learning

PLOS Computational Biology 16(12): e1008497 (2020)

Oren Amsalem, James King, Michael Reimann, Srikanth Ramaswamy, Eilif Muller, Henry Markram, Israel Nelken, Idan Segev

Dense Computer Replica of Cortical Microcircuits Unravels Cellular Underpinnings of Auditory Surprise Response

bioRxiv (2020)

Kenneth W. Latimer, Dylan Barbera, Michael Sokoletsky, Bshara Awwad, Yonatan Katz, Israel Nelken, Ilan Lampl, Adriene L. Fairhall, Nicholas J. Priebe

Multiple Timescales Account for Adaptive Responses across Sensory Cortices

The Journal of Neuroscience (2020)

Busche, M A, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT.

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo.

Nat Neurosci (2019)

Regev, TI, Nelken I, Deouell LY.

Evidence for Linear but Not Helical Automatic Representation of Pitch in the Human Auditory System.

Journal of Cognitive Neuroscience Early Access p.1-17 (2019)

Alainde Cheveigné, Israel Nelken

Filters: When, Why, and How (Not) to Use Them

Neuron 102 (2), 280-293 (2019)

Carsten H. Tischbirek, Takahiro Noda, Manabu Tohmi, Antje Birkner, Israel Nelken, Arthur Konnerth

In Vivo Functional Mapping of a Cortical Column at Single-Neuron Resolution

Cell Reports 27 (5), 1319-1326. e5 (2019)

Atlan G, Terem A, Peretz-Rivlin N, Sehrawat K, Gonzales BJ, Pozner G, Tasaka G-i, Goll Y, Refaeli R, Zviran O, Lim BK, Groysman M, Goshen I, Mizrahi A, Nelken I, Citri A,

The claustrum supports resilience to distraction

Current Biology, Volume 28, Issue 17, 10 September 2018, Pages 2752-2762 (2018)

Polterovich A, Jankowski MM, Nelken I.

Deviance sensitivity in the auditory cortex of freely moving rats

PLoS One. 13(6):e0197678 (2018)

de Hoz, L, Gierej D, Lioudyno V, Jaworski J, Blazejczyk M, Cruces-Solís H, Beroun A, Lebitko T, Nikolaev T, Knapska E, Nelken I, Kaczmarek L.

Blocking c-Fos Expression Reveals the Role of Auditory Cortex Plasticity in Sound Frequency Discrimination Learning.

Cerebral Cortex, Volume 28, Issue 5, Pages 1645–1655 (2018)

Kazakov A, Jankowski MM, Nelken I.

Acoustic recordings data from an echoic environment and a toolkit for its analysis

Data Brief. 21:1451-1457 (2018)

Kazakov, A, Nelken I.

Acoustic calibration in an echoic environment.

Journal of Neuroscience Methods Volume 309, Pages 60-70 (2018)

Yarden TS, Nelken I.

Stimulus-specific adaptation in a recurrent network model of primary auditory cortex

PLoS Comput Biol. 3(3):e1005437 (2017)

Li J, Liao X, Zhang J, Wang M, Yang N, Zhang J, Lv G, Li H, Lu J, Ding R, Li X, Guang Y, Yang Z, Qin H, Jin W, Zhang K, He C, Jia H, Zeng S, Hu Z, Nelken I, Chen X.

Primary Auditory Cortex is Required for Anticipatory Motor Response

Cereb Cortex; 27(6):3254-3271 (2017)

Keskin AD, Kekuš M, Adelsberger H, Neumann U, Shimshek DR, Song B, Zott B, Peng T, Förstl H, Staufenbiel M, Nelken I, Sakmann B, Konnerth A, Busche M A.

BACE inhibition-dependent repair of Alzheimer’s pathophysiology

Proc Natl Acad Sci U S A. 114(32):8631-8636 (2017)

Israel Nelken

Neural Population Coding of Natural Sounds in Non-flying Mammals

Oxford Research Encyclopedia of Neuroscience (2017)

Jonathan Rubin, Nahum Ulinovsky, Israel Nelken and Naftali Tishby

The Representation of Prediction Error in Auditory Cortex

PLoS Comput Biol 12(8) e1005058 (2016)

Wigderson, E, Nelken I, Yarom Y.

Early multisensory integration of self and source motion in the auditory system.

Proc Natl Acad Sci U S A, 113(29): 8308–8313 (2016)

Grimm, S, Escera C, Nelken I.

Early indices of deviance detection in humans and animal models.

Biological Psychology Volume 116, Pages 23-27 (2016)

Itai Hershenhoren, Israel Nelken

Detection of Tones Masked by Fluctuating Noise in Rat Auditory Cortex

Cerebral Cortex 27 (11), 5130-5143 (2016)

Busche MA, Kekuš M, Adelsberger H, Noda T, Förstl H, Nelken I, Konnerth A.

Rescue of long-range circuit dysfunction in Alzheimer’s disease models

Nat Neurosci. 2015 Nov;18(11):1623-30. (2015)

Slomowitz E, Styr B, Vertkin I, Milshtein-Parush H, Nelken I, Slutsky M, Slutsky I.

Interplay between population firing stability and single neuron dynamics in hippocampal networks

https://doi.org/10.7554/eLife.04378 (2015)

Khouri L, Nelken I.

Detecting the unexpected

Curr Opin Neurobiol. 2015 Dec;35:142-7. (2015)

Barniv D, Nelken I.

Auditory Streaming as an Online Classification Process with Evidence Accumulation

PLoS One. 2015 Dec 15;10(12):e0144788. (2015)

Moshitch D, Nelken I.

Using Tweedie distributions for fitting spike count data

J Neurosci Methods. 2014 Mar 30;225:13-28. (2014)

Grodzinsky Y., Nelken I.

The neural code that makes us human

Science. 2014 Feb 28;343(6174):978-9. (2014)

Itai Hershenhoren, Nevo Taaseh, Flora M. Antunes and Israel Nelken

Intracellular correlates of stimulus-specific adaptation

Journal of Neuroscience 26 February 2014, 34 (9) 3303-3319. (2014)

de Hoz L, Nelken I.

Frequency tuning in the behaving mouse: different bandwidths for discrimination and generalization

PLoS One. 2014 Mar 14;9(3):e91676. (2014)

Israel Nelken, Jennifer Bizley, Shihab A. Shamma, and Xiaoqin Wang

Auditory cortical processing in real-world listening: the auditory system going real

J Neurosci. 2014 Nov 12; 34(46): 15135–15138. (2014)

Nelken I, Bizley J, Shamma SA, Wang X.

Auditory cortical processing in real-world listening: the auditory system going real

J Neurosci. 2014 Nov 12;34(46):15135-8. (2014)

Xu X, Yu X, He J, Nelken I.

Across-ear stimulus-specific adaptation in the auditory cortex

Front Neural Circuits. 2014 Jul 30;8:89. (2014)

Moshitch D, Nelken I.

The Representation of Interaural Time Differences in High-Frequency Auditory Cortex

Cereb Cortex. 2016 Feb;26(2):656-68. (2014)

Nelken I.

Stimulus-specific adaptation and deviance detection in the auditory system: experiments and models

Biol Cybern. 2014 Oct;108(5):655-63. (2014)

A postdoctoral position is available in the field of auditory perception under the supervision of Prof. Israel Nelken. Click here for more information.
Honors:
1985 The A. Heller prize for excellence in Research Thesis
1991 Fullbright fellowship
1994 The Bergmann Memorial Research Grant (concurrently with BSF grant No. 93-00057)
1999 Research prize of the Faculty of Medicine, Hebrew University – Hadassah Medical School.
2000 Bernard Katz Lecturer for the year 2000
2008 Michael Bruno prize, administered by Yad-Hanadiv foundation
2015 Rector prize for excellence in research and teaching
2016 The Michael Landau prize for the Sciences and Research
2021 Humboldt research prize
Envelope Phone-alt

Israel Nelken

Professor

Email: israel.nelken@mail.huji.ac.il
Phone: +972-2-6584229
Fax: +972-2-6586077
Israel Nelken
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 2, Room 1207, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401

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