Hagai Bergman Lab

ELSC Members

Simone and Bernard Guttman Chair in Brain Research

The French Friends Parkinson’s Laboratory

Our research group use physiological (multiple electrode) tools to explore the computation physiology of the basal ganglia, their disorders and therapy. We record the activity of several neurons in the different basal ganglia nuclei during behavioral tasks and over the wake-sleep cycle. We do it before and after induction of disease-like state (e.g., Parkinson’s disease, schizophrenia) in animal models and in human patients undergoing deep brain stimulation (DBS) procedures. Our goal is to provide better understanding of the physiology and pathophysiology of the basal ganglia, and to use this understanding to develop better methods for treatment (eg closed-loop DBS).

Nadav Amir

Undergraduate Student

Shiran Katabi

PhD Student

Halen Baker

MSc Student

Salam Qukal

MSc Student

Aviv Mizrahi-Kliger

MD-PhD Student

Nir Asch

MD-PhD Student

Orilia Ben Yishay Nizri

MD-PhD Student

Sharon Friman PhD

Managing and Administration

Uri Werner-Reiss

Lab Manager

Shai Heiman Grosberg

PhD Student

Pnina Rapel

PhD Student

Gennadiy Fonar

Post Doc

Jing Guang

Post Doc

Lily Iskhakova

Post Doc

Alexander Kaplan

PhD Student

Dan Valsky

PhD Student

Daniel Sand

PhD Student

Noa Rahamim

PhD Student

Odeya Marmor

PhD Student

Shimon Firman

Liu X, Xu Y, Bergman H, Li S, Wang W.

A systematic review of Twiddler’s syndrome: a hardware-related complication of deep brain stimulation

Neurosurg Rev. (2021)

Sand D, Arkadir D, Abu Snineh M, Marmor O, Israel Z, Bergman H, Hassin-Baer S, Israeli-Korn S, Peremen Z, Geva AB, Eitan R.

Deep Brain Stimulation Can Differentiate Subregions of the Human Subthalamic Nucleus Area by EEG Biomarkers

Front Syst Neurosci. (2021)

Iskhakova, L. P. Rappel, G. Fonar , O. Marmor, R. Paz , Z. Israel , R. Eitan, H. Bergman

Frequency matters: Up- and Down-Regulation of Dopamine Tone Induces Similar Frequency Shifts in Cortico-Basal Ganglia Beta Oscillations

bioRxiv (2021)

Mizrahi-Kliger, A. D., A. Kaplan, Z. Israel, M. Deffains, and H. Bergman.

‘Basal ganglia beta oscillations during sleep underlie Parkinsonian insomnia

Proc Natl Acad Sci U S A. (2020)

Valsky D, Heiman Grosberg S, Israel Z, Boraud T, Bergman H, Deffains M.

What is the true discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia?

Elife (2020)

Nir Asch, Yehuda Herschman, Rotem Maoz, Carmel Aurbach-Asch, Dan Valsky, Muneer Abu-Snineh, David Arkadir, Eduard Linetsky, Renana Eitan, Odeya Marmor, Hagai Bergman and Zvi Israel;

Independently Together: Subthalamic Theta and Beta Opposite Roles in Predicting Parkinson’s Tremor

Brain communications (2020)

Benady A, Zadik S, Eimerl D, Heymann S, Bergman H, Israel Z, Raz A.

Sedative drugs modulate the neuronal activity in the subthalamic nucleus of parkinsonian patients

Sci Rep. (2020)

L. Iskhakova, P. Rappel, M. Deffains, G. Fonar, O. Marmor, R. Paz, Z. Israel, R. Eitan & H. Bergman

Modulation of dopamine tone induces frequency shifts in cortico-basal ganglia beta oscillations

Nat Commun 12, 7026 (2021)

Jing Guang, Halen Baker, Orilia Ben-Yishay Nizri, Shimon Firman, Uri Werner-Reiss, Vadim Kapuller, Zvi Israel & Hagai Bergman

Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity

npj Parkinson’s Disease (2021)

Kaplan, A., Mizrahi-Kliger, A.D., Israel, Z. et al.

Dissociable roles of ventral pallidum neurons in the basal ganglia reinforcement learning network

Nat Neurosci 23, 556–564 (2020)

Menchón, J.M., Real, E., Alonso, P. et al.

A prospective international multi-center study on safety and efficacy of deep brain stimulation for resistant obsessive-compulsive disorder

Mol Psychiatry (2019)

Snineh MA, Hajyahya A, Linetsky E, Eitan R, Bergman H, Israel Z, Arkadir D

A Real-Life Search for the Optimal Set of Conversion Factors to Levodopa-Equivalent-Dose in Parkinson’s Disease Patients on Polytherapy

Journal of Parkinson's Disease (2019)

Eitan R, Arkadir D, Linetsky E, Bick AS, Gilad M, Freedman S, Bergman H, Israel Z

Deep brain stimulation for obsessive compulsive disorder: case report of the first OCD patient in Israel

Harefua, Issue 158, Volume 7, Pages 418-422 (2019)

Shamir RR, Duchin Y, Kim J, Patriat R, Marmor O, Bergman H, Vitek JL, Sapiro G, Bick A, Eliahou R, Eitan R, Israel Z, Harel N

Microelectrode Recordings Validate the Clinical Visualization of Subthalamic-Nucleus Based on 7T Magnetic Resonance Imaging and Machine Learning for Deep Brain Stimulation Surgery

Neurosurgery, 84, no. 3, 749–757 (2019)

Marmor O, Rappel P, Valsky D, Bick AS, Arkadir D, Linetzky E, Peled O, Tamir I, Bergman H, Israel Z, Eitan R

Movement context modulates neuronal activity in motor and limbic-associative domains of the human parkinsonian subthalamic nucleus

Neurobiology of Disease, 104716 (2019)

Ben Engelhard, Ran Darshan, Nofar Ozeri-Engelhard, Zvi Israel, Uri Werner-Reiss, David Hansel, Hagai Bergman, Eilon Vaadia

Neuronal activity and learning in local cortical networks are modulated by the action-perception state

bioRxiv (2019)

Marc Deffains, Hagai Bergma

Parkinsonism & Related Disorders (2019)

Valsky D, Blackwell K, Tamir I, Eitan R, Bergman H, Israel Z

Real-time machine learning classification of pallidal borders during deep brain stimulation surgery

Journal of Neural Engineering (2019)

Rappel P, Grosberg S, Arkadir D, Linetsky E, Abu Snineh M, Bick AS, Tamir I, Valsky D, Marmor O, Abo Foul Y, Peled O, Gilad M, Daudi C, Ben-Naim S, Bergman H, Israel Z, Eitan R.

Theta‐alpha oscillations characterize emotional subregion in the human ventral subthalamic nucleus

Movement Disorders (2019) (2019)

Wichmann T, Bergman H, DeLong MR

Basal ganglia, movement disorders and deep brain stimulation: advances made through non-human primate research

Journal of Neural Transmission, Volume 125, Issue 3, pp 419–430 (2018)

Mizrahi-Kliger, Kaplan, Israel and Bergman

De-synchronization of slow oscillations in the basal ganglia during natural sleep

PNAS, 115 (18) E4274-E4283 (2018)

Deffains M, Iskhakova L, Katabi S, Israel Z, Bergman H.

Longer β oscillatory episodes reliably identify pathological subthalamic activity in Parkinsonism

Movement disorders. 33(10):1609-1618 (2018)

Ashkan K, Rogers P, Bergman H, Ughratdar I

Insights into the mechanisms of deep brain stimulation

Nature Reviews Neurology, volume 13, pages 548–554 (2017)

Marmor O, Valsky D, Joshua M, Bick AS, Arkadir D, Tamir I, Bergman H, Israel Z, Eitan R.

Local vs. volume conductance activity of field potentials in the human subthalamic nucleus

Journal of Neurophysiology 117(6):2140-2151 (2017)

Israel, Z, Bergman H.

Location, location, location: Validating the position of deep brain stimulation electrodes.

Movement disorders, Volume 31, Issue 3, Pages 259-259 (2016)

Schechtman, E, Noblejas M I, Mizrahi AD, Dauber O, Bergman H.

Pallidal spiking activity reflects learning dynamics and predicts performance.

PNAS, 113 (41) E6281-E6289 (2016)

Deffains, M, Iskhakova L, Bergman H.

Stop and Think about Basal Ganglia Functional Organization: The Pallido-Striatal “Stop” Route.

Neuron, Volume 89, Issue 2, Pages 237-239 (2016)

Deffains, Iskhakova, Katabi, Haber, Israel & Bergman

Subthalamic, not striatal, activity correlates with basal ganglia downstream activity in normal and parkinsonian monkeys

eLife 2016;5:e16443 (2016)

Soreq, L., Salomonis, N., Guffanti, A., Bergman, H., Israel, Z. and Soreq, H.

Whole transcriptome RNA sequencing data from blood leukocytes derived from Parkinson’s disease patients prior to and following deep brain stimulation treatment

Genomics Data, Volume 3, Pages 57-60 (2015)

Soreq, L., Guffanti, A., Salomonis, N., Simchovitz, A., Israel, Z., Bergman, H. and Soreq, H.

Long Non-Coding RNA and Alternative Splicing Modulations in Parkinson’s Leukocytes Identified by RNA Sequencing

Plos computational biology, 10(3):e1003517 (2014)

Soreq, L., Bergman, H., Israel, Z. and Soreq, H.

Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson’s patients leukocytes

BMC Genomics, 14:478 (2013)

Adler A, Katabi S, Finkes I, Prut Y, Bergman H

Different correlation patterns of cholinergic and GABAergic interneurons with striatal projection neurons

Frontiers in Systems Neuroscience, 7:47 (2013)

Adler A, Finkes I, Katabi S, Prut Y, Bergman H

Encoding by Synchronization in the Primate Striatum

Journal of Neuroscience, 33 (11) 4854-4866 (2013)

Engelhard B, Ozeri N, Israel Z, Bergman H, Vaadia E.

Inducing Gamma Oscillations and Precise Spike Synchrony by Operant Conditioning via Brain-Machine Interface

Neuron; 77(2):361-75 (2013)

Soreq, L., Salomonis, N., Bronstein, M., Greenberg, D.S., Israel, Z. Bergman, H. and Soreq, H.

Small RNA sequencing-microarray analyses in Parkinson leukocytes reveal deep brain stimulation-induced splicing changes that classify brain region transcriptomes

Frontiers in Molecular Neuroscience, 6, article 10, 20 pp (2013)

BenMoyal-Segal, L., Soreq, L., Ben-Shaul, Y., Ben-Ari, S., Ben-Moshe, T., Aviel, S., Bergman, H. and Soreq, H.

Adaptive Alternative Splicing Correlates with Less Environmental Risk of Parkinsonism

Neurodegenerative Disease 9, 87-98 (2012)

Soreq, L., Israel, Z., Greenberg, D.S., Bergman, H. and Soreq, H.

Deep brain stimulation induces rapidly reversible transcript changes in Parkinson’s leucocytes

Journal of cellular and molecular medicine 16, 1496-1507 (2012)

Soreq, L., Greenberg, D.S., Bergman, H., Israel, Z. and Soreq, H.

Exon Arrays Reveal Alternative Splicing Aberrations in Parkinson’s Disease Leukocytes

Neurodegenerative Disease 10, 203-206 (2012)

Soreq, L., Ben-Shaul, Y., Israel, Z., Bergman, H. and Soreq, H.

Meta-analysis of genetic and environmental Parkinson’s disease models reveals a common role of mitochondrial protection pathways

Neurobiology of Disease, Volume 45, Issue 3, Pages 1018-1030 (2012)

R.R. Shamir, A. Zaidel, L. Joskowicz, H. Bergan, Z. Israel

Microelectrode Recording Duration and Spatial Density Constraints for Automatic Targeting of the Subthalamic Nucleus

Stereotactic and Functional Neurosurgery 90(5):325-335 (2012)

Adler A, Katabi S, Finkes I, Israel Z, Prut Y, Bergman H.

Temporal convergence of dynamic cell assemblies in the striato-pallidal network

Journal of Neuroscience, 32 (7) 2473-2484; (2012)

Rosin B, Slovik M, Mitelman R, Rivlin-Etzion M, Haber SN, Israel Z, Vaadia E, Bergman H.

Closed-loop deep brain stimulation is superior in ameliorating Parkinsonism

Neuron, 72(2), 370-384 (2011)

Adler, A, Joshua M, Rivlin-Etzion M, Mitelman R, Marmor O, Prut Y, Bergman H.

Neurons in both pallidal segments change their firing properties similarly prior to closure of the eyes.

Journal of neurophysiology. 103(1):346-59 (2010)

Joshua, M. Adler, A. and Bergman, H.

Novelty encoding by the output neurons of the basal ganglia

Frontiers in Systems Neuroscience 8;3:2 (2010)

Zaidel A, Spivak A, Grieb B, Bergman H, Israel Z.

Subthalamic span of beta-oscillations predicts deep brain stimulation efficacy for Parkinson’s patients

Brain. 133(Pt 7):2007-21 (2010)

Mitelman, R, Joshua M, Adler A, Bergman H.

A noninvasive, fast and inexpensive tool for the detection of eye open/closed state in primates

Journal of Neuroscience Methods, Volume 178, Issue 2, Pages 350-356 (2009)

Joshua, M, Adler A, Rosin B, Vaadia E, Bergman H.

Encoding of probabilistic rewarding and aversive events by pallidal and nigral neurons.

Journal of neurophysiology, Volume 101, Issue 2, Pages 758-772 (2009)

Joshua M, Adler A, Prut Y, Vaadia E, Wickens JR, Bergman H.

Synchronization of midbrain dopaminergic neurons is enhanced by rewarding events

Neuron. 62(5):695-704 (2009)

Joshua, M, Adler, A. and Bergman, H.

The dynamics of dopamine in control of motor behavior

Current Opinion in Neurobiology, Volume 19, Issue 6, Pages 615-620 (2009)

Soreq L, Israel Z, Bergman H, Soreq H.

Advanced microarray analysis highlights modified neuro-immune signaling in nucleated blood cells from Parkinson’s disease patients

J Neuroimmunol. 2008 Sep 15;201-202:227-36. (2008)

Neta Zach, Dorrit Inbar, Yael Grinvald, Hagai Bergman and Eilon Vaadia

Emergence of novel representations in primary motor cortex and premotor neurons during associative learning

Journal of Neuroscience 17 September 2008, 28 (38) 9545-9556; (2008)

Parush N, Arkadir D, Nevet A, Morris G, Tishby N, Nelken I, Bergman H.

Encoding by response duration in the basal ganglia

J Neurophysiol. 2008 Dec;100(6):3244-52. (2008)

Lilach Soreq, Adi Gilboa-Geffen, Sonia Berrih-Aknin, Paul Lacoste, Ariel Darvasi, Eyal Soreq, Hagai Bergman, and Hermona Soreq

Identifying alternative hyper-splicing signatures in MG-thymoma by exon arrays

PLoS One. 2008; 3(6): e2392. (2008)

Rivlin-Etzion M, Marmor O, Saban G, Rosin B, Haber SN, Vaadia E, Prut Y, Bergman H.

Low-pass filter properties of basal ganglia cortical muscle loops in the normal and MPTP primate model of parkinsonism

J Neurosci. 2008 Jan 16;28(3):633-49. (2008)

Joshua, M, Adler A, Mitelman R, Vaadia E, Bergman H.

Midbrain dopaminergic neurons and striatal cholinergic interneurons encode the difference between reward and aversive events at different epochs of probabilistic classical conditioning trials.

Journal of Neuroscience, 28 (45) 11673-11684 (2008)

Joshua, M, Elias S, Levine O, Bergman H.

Quantifying the isolation quality of extracellularly recorded action potentials.

Journal of Neuroscience Methods, Volume 163, Issue 2, Pages 267-282 (2007)

Elias, S, Joshua M, Goldberg JA, Heimer G, Arkadir D, Morris G, Bergman H.

Statistical properties of pauses of the high-frequency discharge neurons in the external segment of the globus pallidus.

Journal of Neuroscience, 27 (10) 2525-2538 (2007)

Ben-Shaul Y, Benmoyal-Segal L, Ben-Ari S, Bergman H, Soreq H.

Adaptive acetylcholinesterase splicing patterns attenuate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice

Eur J Neurosci. 2006 Jun;23(11):2915-22. (2006)

Morris, Nevet, Arkadir, Vaadia and Bergman

Midbrain dopamine neurons encode decisions for future action

Nature Neuroscience volume 9, pages 1057–1063 (2006)

Paz R, Nathan C, Boraud T, Bergman H, Vaadia E.

Acquisition and generalization of visuomotor transformations by nonhuman primates

Exp Brain Res. 2005 Feb;161(2):209-19. (2005)

Rony Paz, Chen Natan, Thomas Boraud, Hagai Bergman and Eilon Vaadia

Emerging patterns of neuronal responses in supplementary and primary motor areas during sensorimotor adaptation

Journal of Neuroscience 23 November 2005, 25 (47) 10941-10951; (2005)

Ben-Shaul Y, Bergman H, Soreq H.

Identifying subtle interrelated changes in functional gene categories using continuous measures of gene expression

Bioinformatics. 2005 Apr 1;21(7):1129-37. Epub 2004 Nov 18. (2005)

Morris G, Arkadir D, Nevet A, Vaadia E, Bergman H.

Coincident but distinct messages of midbrain dopamine and striatal tonically active neurons

Neuron. 43(1):133-43. (2004)

Bar-Gad I, Elias S, Vaadia E, Bergman H.

Complex locking rather than complete cessation of neuronal activity in the globus pallidus of a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primate in response to pallidal microstimulation

J Neurosci. 2004 Aug 18;24(33):7410-9. (2004)

Arkadir D, Morris G, Vaadia E, Bergman H.

Independent coding of movement direction and reward prediction by single pallidal neurons

J Neurosci. 2004 Nov 10;24(45):10047-56. (2004)

Goldberg JA, Rokni U, Boraud T, Vaadia E, Bergman H.

Spike synchronization in the cortex/basal-ganglia networks of Parkinsonian primates reflects global dynamics of the local field potentials

J Neurosci. 2004 Jun 30;24(26):6003-10. (2004)

Bar-Gad I, Heimer G, Ritov Y, Bergman H.

Functional correlations between neighboring neurons in the primate Globus Pallidus are weak or nonexistent

J Neurosci. 23(10):4012-6. (2003)

Bar-Gad I, Morris G, Bergman H.

Information processing, dimensionality reduction and reinforcement learning in the basal ganglia

Prog Neurobiol. 71(6):439-73. (2003)

Paz R, Boraud T, Natan C, Bergman H, Vaadia E.

Preparatory activity in motor cortex reflects learning of local visuomotor skills

Nat Neurosci. 2003 Aug;6(8):882-90. (2003)

Goldberg JA, Boraud T, Maraton S, Haber SN, Vaadia E, Bergman H.

Enhanced synchrony among primary motor cortex neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson’s disease

J Neurosci. 2002 Jun 1;22(11):4639-53. (2002)

Steinberg O, Donchin O, Gribova A, Cardosa de Oliveira S, Bergman H, Vaadia E.

Neuronal populations in primary motor cortex encode bimanual arm movements

Eur J Neurosci. 2002 Apr;15(8):1371-80. (2002)

Donchin O, Gribova A, Steinberg O, Mitz AR, Bergman H, Vaadia E.

Single-unit activity related to bimanual arm movements in the primary and supplementary motor cortices

J Neurophysiol. 2002 Dec;88(6):3498-517. (2002)

A. Gribova, O. Donchin, H. Bergman, E. Vaadia, S. Cardoso de Oliveira

Timing of bimanual movements in human and non-human primates in relation to neuronal activity in primary motor cortex and supplementary motor area

Experimental Brain Research October 2002, Volume 146, Issue 3, pp 322–335 (2002)

Raz A, Frechter-Mazar V, Feingold A, Abeles M, Vaadia E, Bergman H.

Activity of pallidal and striatal tonically active neurons is correlated in mptp-treated monkeys but not in normal monkeys

J Neurosci. 2001 Feb 1;21(3):RC128. (2001)

Bar-Gad I, Ritov Y, Vaadia E, Bergman H.

Failure in identification of overlapping spikes from multiple neuron activity causes artificial correlations

J Neurosci Methods. 2001 May 30;107(1-2):1-13. (2001)

O. Donchin, A. Gribova, O. Steinberg, H. Bergman, Cardoso S. de Oliveira, E. Vaadia

Local field potentials related to bimanual movements in the primary and supplementary motor cortices

Experimental Brain Research 140(1):46-55 (2001)

Cardoso de Oliveira S, Gribova A, Donchin O, Bergman H, Vaadia E.

Neural interactions between motor cortical hemispheres during bimanual and unimanual arm movements

Eur J Neurosci. 2001 Dec;14(11):1881-96. (2001)

Raz A, Vaadia E, Bergman H.

Firing patterns and correlations of spontaneous discharge of pallidal neurons in the normal and tremulous MPTP Vervet model of Parkinsonism

J Neurosci. 20(22):8559-71. (2000)

Slovin H, Abeles M, Vaadia E, Haalman I, Prut Y, Bergman H.

Frontal cognitive impairments and saccadic deficits in low-dose MPTP-treated monkeys

J Neurophysiol. 1999 Feb;81(2):858-74. (1999)

Prut Y, Vaadia E, Bergman H, Haalman I, Slovin H, Abeles M.

Spatiotemporal structure of cortical activity: properties and behavioral relevance

J Neurophysiol. 1998 Jun;79(6):2857-74. (1998)

Bergman H, Feingold A, Nini A, Raz A, Slovin H, Abeles M, Vaadia E.

Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates

Trends Neurosci. 1998 Jan;21(1):32-8. (1998)

Bergman H, Raz A, Feingold A, Nini A, Nelken I, Hansel D, Ben-Pazi H, Reches A.

Physiology of MPTP tremor

Mov Disord. 1998;13 Suppl 3:29-34. (1998)

Raz A, Feingold A, Zelanskaya V, Vaadia E, Bergman H.

Neuronal synchronization of tonically active neurons in the striatum of normal and Parkinsonian primates

J Neurophysiol; 76(3):2083-8. (1996J Neurophysiol; 76(3):2083-8.)

Seidemann E, Meilijson I, Abeles M, Bergman H, Vaadia E.

Simultaneously recorded single units in the frontal cortex go through sequences of discrete and stable states in monkeys performing a delayed localization task

J Neurosci. 1996 Jan 15;16(2):752-68. (1996)

Abeles M, Bergman H, Gat I, Meilijson I, Seidemann E, Tishby N, Vaadia E.

Cortical activity flips among quasi-stationary states

Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8616-20. (1995)

Vaadia E, Haalman I, Abeles M, Bergman H, Prut Y, Slovin H, Aertsen A.

Dynamics of neuronal interactions in monkey cortex in relation to behavioural events

Nature. 1995 Feb 9;373(6514):515-8. (1995)

Nini A, Feingold A, Slovin H, Bergman H.

Neurons in the globus pallidus do not show correlated activity in the normal monkey, but phase-locked oscillations appear in the MPTP model of Parkinsonism

J Neurophysiol; 74(4):1800-5. (1995)

Abeles M, Prut Y, Bergman H, Vaadia E.

Synchronization in neuronal transmission and its importance for information processing

Prog Brain Res. 1994;102:395-404. (1994)

Bergman H, Wichmann T, Karmon B, DeLong MR.

The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism

J. of Neurophysiology. 72: 507-520 (1994)

Ahissar E, Vaadia E, Ahissar M, Bergman H, Arieli A, Abeles M.

Dependence of cortical plasticity on correlated activity of single neurons and on behavioral context

Science. 1992 Sep 4;257(5075):1412-5. (1992)

Ahissar M, Ahissar E, Bergman H, Vaadia E.

Encoding of sound-source location and movement: activity of single neurons and interactions between adjacent neurons in the monkey auditory cortex

J Neurophysiol. 1992 Jan;67(1):203-15. (1992)

Aertsen A, Vaadia E, Abeles M, Ahissar E, Bergman H, Karmon B, Lavner Y, Margalit E, Nelken I, Rotter S.

Neural interactions in the frontal cortex of a behaving monkey: signs of dependence on stimulus context and behavioral state

J Hirnforsch. 1991;32(6):735-43. (1991)

H Bergman, T Wichmann, MR DeLong

Reversal of experimental parkinsonism by lesions of the subthalamic nucleus

Science, Vol. 249, Issue 4975, pp. 1436-1438 (1990)

Vaadia E, Bergman H, Abeles M.

Neuronal activities related to higher brain functions–theoretical and experimental implications

IEEE Trans Biomed Eng. 1989 Jan;36(1):25-35. (1989)

Honors:
Michael Bruno Memorial Award in 2003

Baruch Rapport prize for excellence in bio-medical research in 2013

the Rotchild prize in life science 2016

Website:
https://basalganglia.huji.ac.il

Gallery:

Hagai Bergman

Professor

Email: hagaibe@ekmd.huji.ac.il

Phone: +972-2-6757388

Fax: +972-2-6439736

Hagai Bergman

@hb_cell

Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 3, Room 1304 Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401

https://basalganglia.huji.ac.il

Simone and Bernard Guttman Chair in Brain Research

The French Friends Parkinson’s Laboratory

People

Dina Moshitch

Lab Manager

Lital Summer

Lab administrative officer

Samira Souffi

Post Doc

Mousa Karayanni

PhD Student

Sapir Bashari

Ph.D. Student

Nimrod Agassi

M.Sc. Student

Alon Dotan

B.Sc. Student

Ana Polterovich

Alex Kazakov

Moran Aharoni

Kamini Sehrawat

Arthur Berrou

Maciej Jankowski

Johannes Niediek

Ori Brook

Yael Bitterman

Itai Hershenhoren

Yehuda Albeck

Bshara Awwad

Jonathan Rubin

Dina Farkas

Flora Antunes

Eyal Wigderson

Dana Barniv

Ayelet Shapira

Amit Yaron

Alon Fishbach

Tohar Sion Yarden

Shahar Mendelssohn

Mor Harpaz

Tamar Regev

Leila Khouri

Liora Las

Livia de Hoz

Mor Nahum

Nachum Ulanovsky

Nevo Taaseh

Omer Bar-Yosef

Roi Kliper

Gal Chechik

Yaron Rotman

Nadav Amir

Gideon Rothschild

Publications

S Bashari, MM Jankowski, I Nelken

The representation of regularity and randomness in auditory cortex of awake rats

bioRxiv (2025)

J Niediek, MM Jankowski, A Polterovich, A Kazakov, I Nelken

Insular cortex encodes task alignment

bioRxiv (2024)

Gilday D. O., Praegel B., Maor I., Cohen T., Nelken I., Mizrahi A.

Surround suppression in mouse auditory cortex underlies auditory edge detection

PLoS Computational Biology (2023)

Yarden. T., Mizrahi. A., Nelken I.

Context-Dependent Inhibitory Control of Stimulus-Specific Adaptation

Journal of Neuroscience. (2022)

Rajendran VG, Tsdaka Y, Keung TY, Schnupp JWH, Nelken I.

Rats synchronize predictively to metronomes

iScience, in press (2023)

Polterovich, A., Jankowski, M.M., Niediek, J., Kazakov, A., Nelken, I.

bioRxiv (2024)

Sehrawat, K., Nelken, I.

Sound preferences in mice are sex-dependent

bioRxiv (2024)

Maciej M. Jankowski , Mousa Karayanni, Mor Harpaz, Ana Polterovich , Israel Nelken

A Rapid Anterior Auditory Processing Stream Through the Insulo-Parietal Auditory Field in the Rat

bioRxiv (2023)

Kenneth W. Latimer, Dylan Barbera, Michael Sokoletsky, Bshara Awwad, Yonatan Katz, Israel Nelken, Ilan Lampl, Adriene L. Fairhall, Nicholas J. Priebe

Multiple Timescales Account for Adaptive Responses across Sensory Cortices

The Journal of Neuroscience (2020)

Maciej M. Jankowski, Ana Polterovich, Alex Kazakov, Johannes Niediek, Israel Nelken

An automated, low-latency environment for studying the neural basis of behavior in freely moving rats

BMC Biology (2023)

Bshara Awwad, Maciej M. Jankowski, Ana Polterovich, Sapir Bashari, Israel Nelken

Extensive representation of sensory deviance in the responses to auditory gaps in unanesthetized rats

Current Biology (2023)

Oren Amsalem, James King, Michael Reimann, Srikanth Ramaswamy, Eilif Muller, Henry Markram, Israel Nelken, Idan Segev

Dense Computer Replica of Cortical Microcircuits Unravels Cellular Underpinnings of Auditory Surprise Response

bioRxiv (2020)

Atlan G. Terem A. Peretz-Rivlin N., Sehrawat, K. Gonzales, B., Goll Y., Pozner G., Tasaka G., Goll Y., Rafaeli R., Zviran O., Lim B., Groysman M., Goshen I, Mizrahi A., Nelken I., Citri A.

The claustrum supports resilience to distraction

Current Biology (2018)

Mizrahi A., Shalev A. Nelken I.

Single neuron and population coding of natural sounds in auditory cortex

Current Opinion in Neurobiology (2014)

Rothschild G, Cohen L, Mizrahi A, Nelken I.

Elevated correlations in neuronal ensembles of mouse auditory cortex following parturition

J Neurosci. (2013)

Nadav Amir, Naftali Tishby, Israel Nelken

A simple model of the attentional blink and its modulation by mental training

PLOS Computational Biology, e1010398 (2022)

Mousa Karayanni & Israel Nelken

Extrinsic rewards, intrinsic rewards, and non-optimal behavior

Journal of Computational Neuroscience volume 50, pages139–143 (2022)

Lior Madmoni, Shir Tibor, Israel Nelken, Boaz Rafaely

The Effect of Partial Time-Frequency Masking of the Direct Sound on the Perception of Reverberant Speech

IEEE/ACM Transactions on Audio, Speech, and Language Processing, 29, 2037-2047 (2021)

Nadav Amir, Reut Suliman-Lavie, Maayan Tal, Sagiv Shifman, Naftali Tishby, Israel Nelken

Value-complexity tradeoff explains mouse navigational learning

PLOS Computational Biology 16(12): e1008497 (2020)

Carsten H. Tischbirek, Takahiro Noda, Manabu Tohmi, Antje Birkner, Israel Nelken, Arthur Konnerth

In Vivo Functional Mapping of a Cortical Column at Single-Neuron Resolution

Cell Reports 27 (5), 1319-1326. e5 (2019)

Huang,Shun-Ho, Shmoel,Nava, Jankowski, Maciej M., Erez, Hadas, Sharon,Aviv, Abu-Salah,Wesal, Nelken,Israel, Weiss,Aryeh, Spira,Micha E.

Immunohistological and Ultrastructural Study of the Inflammatory Response to Perforated Polyimide Cortical Implants: Mechanisms Underlying Deterioration of Electrophysiological Recording Quality

Frontiers in neuroscience 14, 926 (2020)

Meng Wang, Xiang Liao, Ruijie Li, Shanshan Liang, Ran Ding, Jingcheng Li, Jianxiong Zhang, Wenjing He, Ke Liu, Junxia Pan, Zhikai Zhao, Tong Li, Kuan Zhang, Xingyi Li, Jing Lyu, Zhenqiao Zhou, Zsuzsanna Varga, Yuanyuan Mi, Yi Zhou, Junan Yan, Shaoqun Zeng, Jian K. Liu, Arthur Konnerth, Israel Nelken, Hongbo Jia & Xiaowei Chen

Single-neuron representation of learned complex sounds in the auditory cortex

Nature Communications 11 (1), 1-14 (2020)

Israel Nelken

From neurons to behavior: the view from auditory cortex

Current Opinion in Physiology 18, 37-41 (2020)

Israel Nelken

Neural Population Coding of Natural Sounds in Non-flying Mammals

Oxford Research Encyclopedia of Neuroscience (2017)

Itai Hershenhoren, Israel Nelken

Detection of Tones Masked by Fluctuating Noise in Rat Auditory Cortex

Cerebral Cortex 27 (11), 5130-5143 (2016)

Alainde Cheveigné, Israel Nelken

Filters: When, Why, and How (Not) to Use Them

Neuron 102 (2), 280-293 (2019)

Eban E., Rothschild G., Mizrahi A., Nelken I., Elidan G.

Dynamic copula networks for modeling real-valued time series

Artificial Intelligence and Statistics (2013)

Tamar I Regev, Geffen Markusfeld, Leon Y Deouell, Israel Nelken

Context sensitivity across multiple time scales with a flexible frequency bandwidth

Cerebral Cortex 32 (1), 158-175 (2022)

Rothschild G, Nelken I, Mizrahi A.

Functional organization and population dynamics in the mouse primary auditory cortex

Nat Neurosci. 2010 Mar;13(3):353-60. (2010)

Mor Harpaz, Maciej M. Jankowski, Leila Khouri, Israel Nelken

Emergence of abstract sound representations in the ascending auditory system

Progress in Neurobiology, Volume 202, 102049, ISSN 0301-0082 (2021)

Bshara Awwad, Maciej M Jankowski, Israel Nelken

Synaptic Recruitment Enhances Gap Termination Responses in Auditory Cortex

Cerebral Cortex Volume 30, Issue 8, August 2020, Pages 4465–4480 (2020)

Regev, TI, Nelken I, Deouell LY.

Evidence for Linear but Not Helical Automatic Representation of Pitch in the Human Auditory System.

Journal of Cognitive Neuroscience Early Access p.1-17 (2019)

Busche, M A, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT.

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo.

Nat Neurosci (2019)

Kazakov, A, Nelken I.

Acoustic calibration in an echoic environment.

Journal of Neuroscience Methods Volume 309, Pages 60-70 (2018)

Kazakov A, Jankowski MM, Nelken I.

Acoustic recordings data from an echoic environment and a toolkit for its analysis

Data Brief. 21:1451-1457 (2018)

de Hoz, L, Gierej D, Lioudyno V, Jaworski J, Blazejczyk M, Cruces-Solís H, Beroun A, Lebitko T, Nikolaev T, Knapska E, Nelken I, Kaczmarek L.

Blocking c-Fos Expression Reveals the Role of Auditory Cortex Plasticity in Sound Frequency Discrimination Learning.

Cerebral Cortex, Volume 28, Issue 5, Pages 1645–1655 (2018)

Polterovich A, Jankowski MM, Nelken I.

Deviance sensitivity in the auditory cortex of freely moving rats

PLoS One. 13(6):e0197678 (2018)

Keskin AD, Kekuš M, Adelsberger H, Neumann U, Shimshek DR, Song B, Zott B, Peng T, Förstl H, Staufenbiel M, Nelken I, Sakmann B, Konnerth A, Busche M A.

BACE inhibition-dependent repair of Alzheimer’s pathophysiology

Proc Natl Acad Sci U S A. 114(32):8631-8636 (2017)

Li J, Liao X, Zhang J, Wang M, Yang N, Zhang J, Lv G, Li H, Lu J, Ding R, Li X, Guang Y, Yang Z, Qin H, Jin W, Zhang K, He C, Jia H, Zeng S, Hu Z, Nelken I, Chen X.

Primary Auditory Cortex is Required for Anticipatory Motor Response

Cereb Cortex; 27(6):3254-3271 (2017)

Yarden TS, Nelken I.

Stimulus-specific adaptation in a recurrent network model of primary auditory cortex

PLoS Comput Biol. 3(3):e1005437 (2017)

Grimm, S, Escera C, Nelken I.

Early indices of deviance detection in humans and animal models.

Biological Psychology Volume 116, Pages 23-27 (2016)

Wigderson, E, Nelken I, Yarom Y.

Early multisensory integration of self and source motion in the auditory system.

Proc Natl Acad Sci U S A, 113(29): 8308–8313 (2016)

Jonathan Rubin, Nahum Ulinovsky, Israel Nelken and Naftali Tishby

The Representation of Prediction Error in Auditory Cortex

PLoS Comput Biol 12(8) e1005058 (2016)

Barniv D, Nelken I.

Auditory Streaming as an Online Classification Process with Evidence Accumulation

PLoS One. 2015 Dec 15;10(12):e0144788. (2015)

Khouri L, Nelken I.

Detecting the unexpected

Curr Opin Neurobiol. 2015 Dec;35:142-7. (2015)

Slomowitz E, Styr B, Vertkin I, Milshtein-Parush H, Nelken I, Slutsky M, Slutsky I.

Interplay between population firing stability and single neuron dynamics in hippocampal networks

https://doi.org/10.7554/eLife.04378 (2015)

Busche MA, Kekuš M, Adelsberger H, Noda T, Förstl H, Nelken I, Konnerth A.

Rescue of long-range circuit dysfunction in Alzheimer’s disease models

Nat Neurosci. 2015 Nov;18(11):1623-30. (2015)

Nelken I.

Stimulus-specific adaptation and deviance detection in the auditory system: experiments and models

Biol Cybern. 2014 Oct;108(5):655-63. (2014)

Moshitch D, Nelken I.

The Representation of Interaural Time Differences in High-Frequency Auditory Cortex

Cereb Cortex. 2016 Feb;26(2):656-68. (2014)

Xu X, Yu X, He J, Nelken I.

Across-ear stimulus-specific adaptation in the auditory cortex

Front Neural Circuits. 2014 Jul 30;8:89. (2014)

Nelken I, Bizley J, Shamma SA, Wang X.

Auditory cortical processing in real-world listening: the auditory system going real

J Neurosci. 2014 Nov 12;34(46):15135-8. (2014)

Israel Nelken, Jennifer Bizley, Shihab A. Shamma, and Xiaoqin Wang

Auditory cortical processing in real-world listening: the auditory system going real

J Neurosci. 2014 Nov 12; 34(46): 15135–15138. (2014)

de Hoz L, Nelken I.

Frequency tuning in the behaving mouse: different bandwidths for discrimination and generalization

PLoS One. 2014 Mar 14;9(3):e91676. (2014)

Itai Hershenhoren, Nevo Taaseh, Flora M. Antunes and Israel Nelken

Intracellular correlates of stimulus-specific adaptation

Journal of Neuroscience 26 February 2014, 34 (9) 3303-3319. (2014)

Grodzinsky Y., Nelken I.

The neural code that makes us human

Science. 2014 Feb 28;343(6174):978-9. (2014)

Moshitch D, Nelken I.

Using Tweedie distributions for fitting spike count data

J Neurosci Methods. 2014 Mar 30;225:13-28. (2014)

Nelken I, de Cheveigné A.

An ear for statistics

Nat Neurosci. 2013 Apr;16(4):381-2. (2013)

Nelken I, Yaron A, Polterovich A, Hershenhoren I.

Stimulus-specific adaptation beyond pure tones

Adv Exp Med Biol. 2013;787:411-8. (2013)

Eitan Globerson, and Israel Nelken

The neuro-pianist

Front Syst Neurosci. 2013; 7: 35. (2013)

Chechik G, Nelken I.

Auditory abstraction from spectro-temporal features to coding auditory entities

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18968-73. (2012)

Nelken I.

Predictive information processing in the brain: the neural perspective

Int J Psychophysiol. 2012 Feb;83(2):253-5. (2012)

Yaron A, Hershenhoren I, Nelken I.

Sensitivity to Complex Statistical Regularities in Rat Auditory Cortex

Neuron. 2012 Nov 8;76(3):603-15. (2012)

Grienberger C, Adelsberger H, Stroh A, Milos RI, Garaschuk O, Schierloh A, Nelken I, Konnerth A.

Sound-evoked network calcium transients in mouse auditory cortex in vivo

J Physiol. 2012 Feb 15;590(4):899-918. (2012)

Zohar O, Shackleton TM, Nelken I, Palmer AR, Shamir M.

First spike latency code for interaural phase difference discrimination in the guinea pig inferior colliculus

J Neurosci. 2011 Jun 22;31(25):9192-204. (2011)

Chen X, Leischner U, Rochefort NL, Nelken I, Konnerth A.

Functional mapping of single spines in cortical neurons in vivo

Nature. 2011 Jun 26;475(7357):501-5. (2011)

Israel Nelken

Music and the auditory brain: where is the connection?

Front Hum Neurosci. 2011; 5: 106. (2011)

Taaseh N, Yaron A, Nelken I.

Stimulus-specific adaptation and deviance detection in the rat auditory cortex

PLoS One. 2011;6(8):e23369. (2011)

Asadollahi A, Endler F, Nelken I, Wagner H.

Neural correlates of binaural masking level difference in the inferior colliculus of the barn owl (Tyto alba)

Eur J Neurosci. 2010 Aug;32(4):606-18. (2010)

Nahum M, Nelken I, Ahissar M.

Stimulus uncertainty and perceptual learning: similar principles govern auditory and visual learning

Vision Res. 2010 Feb 22;50(4):391-401. (2010)

Antunes FM, Nelken I, Covey E, Malmierca MS.

Stimulus-specific adaptation in the auditory thalamus of the anesthetized rat

PLoS One. 2010 Nov 19;5(11):e14071. (2010)

Nelken I.

Inhibitory plasticity in auditory cortex

Neuron. 2009 Jun 11;62(5):605-7. (2009)

Winkler I, Denham SL, Nelken I.

Modeling the auditory scene: predictive regularity representations and perceptual objects

Trends Cogn Sci. 2009 Dec;13(12):532-40. (2009)

Merav Ahissar , Mor Nahum , Israel Nelken and Shaul Hochstein

Reverse hierarchies and sensory learning

Philosophical transactions of the Royal Society of London. Series B, Biological sciences (2009)

Andrew J King, Israel Nelken

Unraveling the principles of auditory cortical processing: can we learn from the visual system?

Nature Neuroscience volume 12, pages 698–701 (2009) (2009)

Parush N, Arkadir D, Nevet A, Morris G, Tishby N, Nelken I, Bergman H.

Encoding by response duration in the basal ganglia

J Neurophysiol. 2008 Dec;100(6):3244-52. (2008)

Las L, Shapira AH, Nelken I.

Functional gradients of auditory sensitivity along the anterior ectosylvian sulcus of the cat

J Neurosci. 2008 Apr 2;28(14):3657-67. (2008)

Nahum M, Nelken I, Ahissar M.

Low-level information and high-level perception: the case of speech in noise

PLoS Biol. 2008 May 20;6(5):e126. (2008)

Israel Nelken and Omer Bar-Yosef

Neurons and objects: the case of auditory cortex

Front Neurosci. 2008 Jul; 2(1): 107–113. (2008)

Nelken I, Bizley JK, Nodal FR, Ahmed B, King AJ, Schnupp JW.

Responses of auditory cortex to complex stimuli: functional organization revealed using intrinsic optical signals

J Neurophysiol. 2008 Apr;99(4):1928-41. (2008)

Gordon N, Shackleton TM, Palmer AR, Nelken I.

Responses of neurons in the inferior colliculus to binaural disparities: Insights from the use of Fisher information and mutual information

J Neurosci Methods. 2008 Apr 30;169(2):391-404. (2008)

Yuval-Greenberg S, Tomer O, Keren AS, Nelken I, Deouell LY.

Transient induced gamma-band response in EEG as a manifestation of miniature saccades

Neuron. 2008 May 8;58(3):429-41. (2008)

Y. Bitterman, R. Mukamel, R. Malach, I. Fried & I. Nelken

Ultra-fine frequency tuning revealed in single neurons of human auditory cortex

Nature volume 451, pages 197–201 (10 January 2008) (2008)

Nelken I, Chechik G.

Information theory in auditory research

Hear Res. 2007 Jul;229(1-2):94-105. (2007)

Israel Nelken, Nachum Ulanovsky

Mismatch negativity and stimulus-specific adaptation in animal models

Journal of Psychophysiology 21(3-4):214-223 (2007)

Bizley JK, Nodal FR, Bajo VM, Nelken I, King AJ.

Physiological and anatomical evidence for multisensory interactions in auditory cortex

Cereb Cortex. 2007 Sep;17(9):2172-89. (2007)

Alex Loebel, Israel Nelken, and Misha Tsodyks

Processing of sounds by population spikes in a model of primary auditory cortex

Front Neurosci. 2007 Nov; 1(1): 197–209. (2007)

Omer Bar-Yosef and Israel Nelken

The Effects of Background Noise on the Neural Responses to Natural Sounds in Cat Primary Auditory Cortex

Front Comput Neurosci. 2007; 1: 3. (2007)

Israel Nelken, Merav Ahissar

High-Level and Low-Level Processing in the Auditory System: The Role of Primary Auditory Cortex

IOS Press (2006)

Chechik G, Anderson MJ, Bar-Yosef O, Young ED, Tishby N, Nelken I.

Reduction of information redundancy in the ascending auditory pathway

Neuron. 2006 Aug 3;51(3):359-68. (2006)

Moshitch D, Las L, Ulanovsky N, Bar-Yosef O, Nelken I.

Responses of neurons in primary auditory cortex (A1) to pure tones in the halothane-anesthetized cat

J Neurophysiol. 2006 Jun;95(6):3756-69. (2006)

Nelken I, Chechik G, Mrsic-Flogel TD, King AJ, Schnupp JW.

Encoding stimulus information by spike numbers and mean response time in primary auditory cortex

J Comput Neurosci. 2005 Oct;19(2):199-221. (2005)

Bizley JK, Nodal FR, Nelken I, King AJ.

Functional Organization of Ferret Auditory Cortex

Cereb Cortex. 2005 Oct;15(10):1637-53. (2005)

Liora Las, Edward A. Stern and Israel Nelken

Representation of tone in fluctuating maskers in the ascending auditory system

Journal of Neuroscience 9 February 2005, 25 (6) 1503-1513; (2005)

Griffiths TD, Warren JD, Scott SK, Nelken I, King AJ.

Cortical processing of complex sound: a way forward?

Trends Neurosci. 2004 Apr;27(4):181-5. (2004)

Nelken I, Bizley JK, Nodal FR, Ahmed B, Schnupp JW, King AJ.

Large-scale organization of ferret auditory cortex revealed using continuous acquisition of intrinsic optical signals

J Neurophysiol. 2004 Oct;92(4):2574-88. (2004)

Nachum Ulanovsky, Liora Las, Dina Farkas and Israel Nelken

Multiple time scales of adaptation in auditory cortex neurons

Journal of Neuroscience 17 November 2004, 24 (46) 10440-10453; (2004)

Nelken I.

Processing of complex stimuli and natural scenes in the auditory cortex

Curr Opin Neurobiol. 2004 Aug;14(4):474-80. (2004)

Fishbach A, Yeshurun Y, Nelken I.

Neural model for physiological responses to frequency and amplitude transitions uncovers topographical order in the auditory cortex

J Neurophysiol. 2003 Dec;90(6):3663-78. (2003)

Israel Nelken, Alon FishbachLiora LasNachum UlanovskyDina Farkas

Primary auditory cortex of cats: feature detection or something else?

Biological Cybernetics November 2003, Volume 89, Issue 5, pp 397–406 (2003)

Ulanovsky N, Las L, Nelken I.

Processing of low-probability sounds by cortical neurons

Nat Neurosci. 2003 Apr;6(4):391-8. (2003)

Open Positions

A postdoctoral position is available in the field of auditory perception under the supervision of Prof. Israel Nelken. Click here for more information.

Additional Information

Honors:
1985 The A. Heller prize for excellence in Research Thesis
1991 Fullbright fellowship
1994 The Bergmann Memorial Research Grant (concurrently with BSF grant No. 93-00057)
1999 Research prize of the Faculty of Medicine, Hebrew University – Hadassah Medical School.
2000 Bernard Katz Lecturer for the year 2000
2008 Michael Bruno prize, administered by Yad-Hanadiv foundation
2015 Rector prize for excellence in research and teaching
2016 The Michael Landau prize for the Sciences and Research
2021 Humboldt research prize

Israel Nelken

Professor

Email: israel.nelken@mail.huji.ac.il

Phone: +972-2-6584229

Fax: +972-2-6586077

Israel Nelken

Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 2, Room 1207, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401