Hagai Bergman Lab

ELSC Members

Simone and Bernard Guttman Chair in Brain Research
The French Friends Parkinson’s Laboratory

Our research group use physiological (multiple electrode) tools to explore the computation physiology of the basal ganglia, their disorders and therapy. We record the activity of several neurons in the different basal ganglia nuclei during behavioral tasks and over the wake-sleep cycle. We do it before and after induction of disease-like state (e.g., Parkinson’s disease, schizophrenia) in animal models and in human patients undergoing deep brain stimulation (DBS) procedures. Our goal is to provide better understanding of the physiology and pathophysiology of the basal ganglia, and to use this understanding to develop better methods for treatment (eg closed-loop DBS).

Envelope Phone-alt

Hagai Bergman

Professor

Email: hagaibe@ekmd.huji.ac.il
Phone: +972-2-6757388
Fax: +972-2-6439736
Hagai Bergman
@hb_cell
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 3, Room 1304 Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
https://basalganglia.huji.ac.il
Simone and Bernard Guttman Chair in Brain Research
The French Friends Parkinson’s Laboratory

Our research group use physiological (multiple electrode) tools to explore the computation physiology of the basal ganglia, their disorders and therapy. We record the activity of several neurons in the different basal ganglia nuclei during behavioral tasks and over the wake-sleep cycle. We do it before and after induction of disease-like state (e.g., Parkinson’s disease, schizophrenia) in animal models and in human patients undergoing deep brain stimulation (DBS) procedures. Our goal is to provide better understanding of the physiology and pathophysiology of the basal ganglia, and to use this understanding to develop better methods for treatment (eg closed-loop DBS).

ELSC-Seminars-General
Nadav Amir
Undergraduate Student
ELSC-Seminars-General
Shiran Katabi
PhD Student
HalenBaker_IMG_1363---Pic
Halen Baker
MSc Student
ELSC-Seminars-General
Salam Qukal
MSc Student
student aviv - hagai to website
Aviv Mizrahi-Kliger
MD-PhD Student
NirAsh_photo
Nir Asch
MD-PhD Student
photo
Orilia Ben Yishay Nizri
MD-PhD Student
ELSC-Seminars-General
Sharon Friman PhD
Managing and Administration
UWR_2015-09-14-20h44m06_crop_260
Uri Werner-Reiss
Lab Manager
SH_תמונת פספורט
Shai Heiman Grosberg
PhD Student
ELSC-Seminars-General
Pnina Rapel
PhD Student
GennadieFonar_IMG-20180522-WA0003
Gennadiy Fonar
Post Doc
JG_photo
Jing Guang
Post Doc
IMG_4586a Lily Iskhakova Headshot
Lily Iskhakova
Post Doc
AK_Phote
Alexander Kaplan
PhD Student
DV_ photo1
Dan Valsky
PhD Student
Version 2
Daniel Sand
PhD Student
ELSC-Seminars-General
Noa Rahamim
PhD Student
ELSC-Seminars-General
Odeya Marmor
PhD Student
ELSC-Seminars-General
Shimon Firman
Jing Guang, Halen Baker, Orilia Ben-Yishay Nizri, Shimon Firman, Uri Werner-Reiss, Vadim Kapuller, Zvi Israel & Hagai Bergman

Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity

npj Parkinson’s Disease (2021)

L. Iskhakova, P. Rappel, M. Deffains, G. Fonar, O. Marmor, R. Paz, Z. Israel, R. Eitan & H. Bergman

Modulation of dopamine tone induces frequency shifts in cortico-basal ganglia beta oscillations

Nat Commun 12, 7026 (2021)

Iskhakova, L. P. Rappel, G. Fonar , O. Marmor, R. Paz , Z. Israel , R. Eitan, H. Bergman

Frequency matters: Up- and Down-Regulation of Dopamine Tone Induces Similar Frequency Shifts in Cortico-Basal Ganglia Beta Oscillations

bioRxiv (2021)

Sand D, Arkadir D, Abu Snineh M, Marmor O, Israel Z, Bergman H, Hassin-Baer S, Israeli-Korn S, Peremen Z, Geva AB, Eitan R.

Deep Brain Stimulation Can Differentiate Subregions of the Human Subthalamic Nucleus Area by EEG Biomarkers

Front Syst Neurosci. (2021)

Liu X, Xu Y, Bergman H, Li S, Wang W.

A systematic review of Twiddler’s syndrome: a hardware-related complication of deep brain stimulation

Neurosurg Rev. (2021)

Kaplan, A., Mizrahi-Kliger, A.D., Israel, Z. et al.

Dissociable roles of ventral pallidum neurons in the basal ganglia reinforcement learning network

Nat Neurosci 23, 556–564 (2020)

Benady A, Zadik S, Eimerl D, Heymann S, Bergman H, Israel Z, Raz A.

Sedative drugs modulate the neuronal activity in the subthalamic nucleus of parkinsonian patients

Sci Rep. (2020)

Nir Asch, Yehuda Herschman, Rotem Maoz, Carmel Aurbach-Asch, Dan Valsky, Muneer Abu-Snineh, David Arkadir, Eduard Linetsky, Renana Eitan, Odeya Marmor, Hagai Bergman and Zvi Israel;

Independently Together: Subthalamic Theta and Beta Opposite Roles in Predicting Parkinson’s Tremor

Brain communications (2020)

Valsky D, Heiman Grosberg S, Israel Z, Boraud T, Bergman H, Deffains M.

What is the true discharge rate and pattern of the striatal projection neurons in Parkinson’s disease and Dystonia?

Elife (2020)

Mizrahi-Kliger, A. D., A. Kaplan, Z. Israel, M. Deffains, and H. Bergman.

‘Basal ganglia beta oscillations during sleep underlie Parkinsonian insomnia

Proc Natl Acad Sci U S A. (2020)

Rappel P, Grosberg S, Arkadir D, Linetsky E, Abu Snineh M, Bick AS, Tamir I, Valsky D, Marmor O, Abo Foul Y, Peled O, Gilad M, Daudi C, Ben-Naim S, Bergman H, Israel Z, Eitan R.

Theta‐alpha oscillations characterize emotional subregion in the human ventral subthalamic nucleus

Movement Disorders (2019) (2019)

Valsky D, Blackwell K, Tamir I, Eitan R, Bergman H, Israel Z

Real-time machine learning classification of pallidal borders during deep brain stimulation surgery

Journal of Neural Engineering (2019)

Marc Deffains, Hagai Bergma

Parkinsonism-related β oscillations in the primate basal ganglia networks – Recent advances and clinical implications

Parkinsonism & Related Disorders (2019)

Ben Engelhard, Ran Darshan, Nofar Ozeri-Engelhard, Zvi Israel, Uri Werner-Reiss, David Hansel, Hagai Bergman, Eilon Vaadia

Neuronal activity and learning in local cortical networks are modulated by the action-perception state

bioRxiv (2019)

Marmor O, Rappel P, Valsky D, Bick AS, Arkadir D, Linetzky E, Peled O, Tamir I, Bergman H, Israel Z, Eitan R

Movement context modulates neuronal activity in motor and limbic-associative domains of the human parkinsonian subthalamic nucleus

Neurobiology of Disease, 104716 (2019)

Shamir RR, Duchin Y, Kim J, Patriat R, Marmor O, Bergman H, Vitek JL, Sapiro G, Bick A, Eliahou R, Eitan R, Israel Z, Harel N

Microelectrode Recordings Validate the Clinical Visualization of Subthalamic-Nucleus Based on 7T Magnetic Resonance Imaging and Machine Learning for Deep Brain Stimulation Surgery

Neurosurgery, 84, no. 3, 749–757 (2019)

Eitan R, Arkadir D, Linetsky E, Bick AS, Gilad M, Freedman S, Bergman H, Israel Z

Deep brain stimulation for obsessive compulsive disorder: case report of the first OCD patient in Israel

Harefua, Issue 158, Volume 7, Pages 418-422 (2019)

Snineh MA, Hajyahya A, Linetsky E, Eitan R, Bergman H, Israel Z, Arkadir D

A Real-Life Search for the Optimal Set of Conversion Factors to Levodopa-Equivalent-Dose in Parkinson’s Disease Patients on Polytherapy

Journal of Parkinson’s Disease (2019)

Menchón, J.M., Real, E., Alonso, P. et al.

A prospective international multi-center study on safety and efficacy of deep brain stimulation for resistant obsessive-compulsive disorder

Mol Psychiatry (2019)

Deffains M, Iskhakova L, Katabi S, Israel Z, Bergman H.

Longer β oscillatory episodes reliably identify pathological subthalamic activity in Parkinsonism

Movement disorders. 33(10):1609-1618 (2018)

Mizrahi-Kliger, Kaplan, Israel and Bergman

De-synchronization of slow oscillations in the basal ganglia during natural sleep

PNAS, 115 (18) E4274-E4283 (2018)

Wichmann T, Bergman H, DeLong MR

Basal ganglia, movement disorders and deep brain stimulation: advances made through non-human primate research

Journal of Neural Transmission, Volume 125, Issue 3, pp 419–430 (2018)

Marmor O, Valsky D, Joshua M, Bick AS, Arkadir D, Tamir I, Bergman H, Israel Z, Eitan R.

Local vs. volume conductance activity of field potentials in the human subthalamic nucleus

Journal of Neurophysiology 117(6):2140-2151 (2017)

Ashkan K, Rogers P, Bergman H, Ughratdar I

Insights into the mechanisms of deep brain stimulation

Nature Reviews Neurology, volume 13, pages 548–554 (2017)

Deffains, Iskhakova, Katabi, Haber, Israel & Bergman

Subthalamic, not striatal, activity correlates with basal ganglia downstream activity in normal and parkinsonian monkeys

eLife 2016;5:e16443 (2016)

Deffains, M, Iskhakova L, Bergman H.

Stop and Think about Basal Ganglia Functional Organization: The Pallido-Striatal “Stop” Route.

Neuron, Volume 89, Issue 2, Pages 237-239 (2016)

Schechtman, E, Noblejas M I, Mizrahi AD, Dauber O, Bergman H.

Pallidal spiking activity reflects learning dynamics and predicts performance.

PNAS, 113 (41) E6281-E6289 (2016)

Israel, Z, Bergman H.

Location, location, location: Validating the position of deep brain stimulation electrodes.

Movement disorders, Volume 31, Issue 3, Pages 259-259 (2016)

Soreq, L., Salomonis, N., Guffanti, A., Bergman, H., Israel, Z. and Soreq, H.

Whole transcriptome RNA sequencing data from blood leukocytes derived from Parkinson’s disease patients prior to and following deep brain stimulation treatment

Genomics Data, Volume 3, Pages 57-60 (2015)

Soreq, L., Guffanti, A., Salomonis, N., Simchovitz, A., Israel, Z., Bergman, H. and Soreq, H.

Long Non-Coding RNA and Alternative Splicing Modulations in Parkinson’s Leukocytes Identified by RNA Sequencing

Plos computational biology, 10(3):e1003517 (2014)

Soreq, L., Salomonis, N., Bronstein, M., Greenberg, D.S., Israel, Z. Bergman, H. and Soreq, H.

Small RNA sequencing-microarray analyses in Parkinson leukocytes reveal deep brain stimulation-induced splicing changes that classify brain region transcriptomes

Frontiers in Molecular Neuroscience, 6, article 10, 20 pp (2013)

Engelhard B, Ozeri N, Israel Z, Bergman H, Vaadia E.

Inducing Gamma Oscillations and Precise Spike Synchrony by Operant Conditioning via Brain-Machine Interface

Neuron; 77(2):361-75 (2013)

Adler A, Finkes I, Katabi S, Prut Y, Bergman H

Encoding by Synchronization in the Primate Striatum

Journal of Neuroscience, 33 (11) 4854-4866 (2013)

Adler A, Katabi S, Finkes I, Prut Y, Bergman H

Different correlation patterns of cholinergic and GABAergic interneurons with striatal projection neurons

Frontiers in Systems Neuroscience, 7:47 (2013)

Soreq, L., Bergman, H., Israel, Z. and Soreq, H.

Deep brain stimulation modulates nonsense-mediated RNA decay in Parkinson’s patients leukocytes

BMC Genomics, 14:478 (2013)

Adler A, Katabi S, Finkes I, Israel Z, Prut Y, Bergman H.

Temporal convergence of dynamic cell assemblies in the striato-pallidal network

Journal of Neuroscience, 32 (7) 2473-2484; (2012)

R.R. Shamir, A. Zaidel, L. Joskowicz, H. Bergan, Z. Israel

Microelectrode Recording Duration and Spatial Density Constraints for Automatic Targeting of the Subthalamic Nucleus

Stereotactic and Functional Neurosurgery 90(5):325-335 (2012)

Soreq, L., Ben-Shaul, Y., Israel, Z., Bergman, H. and Soreq, H.

Meta-analysis of genetic and environmental Parkinson’s disease models reveals a common role of mitochondrial protection pathways

Neurobiology of Disease, Volume 45, Issue 3, Pages 1018-1030 (2012)

Soreq, L., Greenberg, D.S., Bergman, H., Israel, Z. and Soreq, H.

Exon Arrays Reveal Alternative Splicing Aberrations in Parkinson’s Disease Leukocytes

Neurodegenerative Disease 10, 203-206 (2012)

Soreq, L., Israel, Z., Greenberg, D.S., Bergman, H. and Soreq, H.

Deep brain stimulation induces rapidly reversible transcript changes in Parkinson’s leucocytes

Journal of cellular and molecular medicine 16, 1496-1507 (2012)

BenMoyal-Segal, L., Soreq, L., Ben-Shaul, Y., Ben-Ari, S., Ben-Moshe, T., Aviel, S., Bergman, H. and Soreq, H.

Adaptive Alternative Splicing Correlates with Less Environmental Risk of Parkinsonism

Neurodegenerative Disease 9, 87-98 (2012)

Rosin B, Slovik M, Mitelman R, Rivlin-Etzion M, Haber SN, Israel Z, Vaadia E, Bergman H.

Closed-loop deep brain stimulation is superior in ameliorating Parkinsonism

Neuron, 72(2), 370-384 (2011)

Zaidel A, Spivak A, Grieb B, Bergman H, Israel Z.

Subthalamic span of beta-oscillations predicts deep brain stimulation efficacy for Parkinson’s patients

Brain. 133(Pt 7):2007-21 (2010)

Joshua, M. Adler, A. and Bergman, H.

Novelty encoding by the output neurons of the basal ganglia

Frontiers in Systems Neuroscience 8;3:2 (2010)

Adler, A, Joshua M, Rivlin-Etzion M, Mitelman R, Marmor O, Prut Y, Bergman H.

Neurons in both pallidal segments change their firing properties similarly prior to closure of the eyes.

Journal of neurophysiology. 103(1):346-59 (2010)

Joshua, M, Adler, A. and Bergman, H.

The dynamics of dopamine in control of motor behavior

Current Opinion in Neurobiology, Volume 19, Issue 6, Pages 615-620 (2009)

Joshua M, Adler A, Prut Y, Vaadia E, Wickens JR, Bergman H.

Synchronization of midbrain dopaminergic neurons is enhanced by rewarding events

Neuron. 62(5):695-704 (2009)

Joshua, M, Adler A, Rosin B, Vaadia E, Bergman H.

Encoding of probabilistic rewarding and aversive events by pallidal and nigral neurons.

Journal of neurophysiology, Volume 101, Issue 2, Pages 758-772 (2009)

Mitelman, R, Joshua M, Adler A, Bergman H.

A noninvasive, fast and inexpensive tool for the detection of eye open/closed state in primates

Journal of Neuroscience Methods, Volume 178, Issue 2, Pages 350-356 (2009)

Joshua, M, Adler A, Mitelman R, Vaadia E, Bergman H.

Midbrain dopaminergic neurons and striatal cholinergic interneurons encode the difference between reward and aversive events at different epochs of probabilistic classical conditioning trials.

Journal of Neuroscience, 28 (45) 11673-11684 (2008)

At this time there are no available positions in the lab.
Honors:
Michael Bruno Memorial Award in 2003

Baruch Rapport prize for excellence in bio-medical research in 2013

the Rotchild prize in life science 2016

Website:
https://basalganglia.huji.ac.il

Gallery:
Envelope Phone-alt

Hagai Bergman

Professor

Email: hagaibe@ekmd.huji.ac.il
Phone: +972-2-6757388
Fax: +972-2-6439736
Hagai Bergman
@hb_cell
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 3, Room 1304 Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
https://basalganglia.huji.ac.il

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