Adi Mizrahi Lab

ELSC Members

The Eric Roland Chair in Brain Sciences
The NeuroPlasticity lab

Learning related plasticity in the auditory system

We aim to understand the neuronal basis of learning and memory in the auditory system, focusing on cortical circuits. We study perceptual learning and category learning as two lifelong processes that shape brain function and behavior in adults. To study the mechanisms of these types of learning we use mice. We developed automated behavioral systems to train groups of mice on complex behavioral tasks like perceptual learning and categorization. We use a variety of techniques, including electrophysiology, multi-unit arrays recording and imaging to follow single neurons as mice learn, memorize and behave.

And in Olfaction – We have similar interests in olfaction and related olfactory circuits.

Parental plasticity

Parental plasticity is manifested by hormonal and physiological changes across the body including in the brain. We study parental plasticity in the context of auditory and olfactory perceptions. We use the mouse as a model to study how pup vocalizations and pup odors are recognized by their parents. We track how these cues are processed and perceived along the neural circuits responsible. Anatomical, physiological and behavioral methods are integrated to solve the complexity underlying sensory-driven parental behaviors.

How do adult born neurons shape olfaction?

The mammalian brain maintains few neurogenic niches in adulthood. One of these regions is the subventricular zone, which is supplying new inhibitory neurons to the olfactory bulb. The functional role of this unique form of network plasticity remains unknown. We use various tools including mouse genetics combined with imaging to study how these new-born neurons shape the neuronal code in the olfactory system.

Adi Mizrahi

Professor

Phone: +972-2-6585163
Lab Phone: +972-2-6585163
Office Phone: +972-2-6586460
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 2, Room 1204, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
The Eric Roland Chair in Brain Sciences
The NeuroPlasticity lab

Learning related plasticity in the auditory system

We aim to understand the neuronal basis of learning and memory in the auditory system, focusing on cortical circuits. We study perceptual learning and category learning as two lifelong processes that shape brain function and behavior in adults. To study the mechanisms of these types of learning we use mice. We developed automated behavioral systems to train groups of mice on complex behavioral tasks like perceptual learning and categorization. We use a variety of techniques, including electrophysiology, multi-unit arrays recording and imaging to follow single neurons as mice learn, memorize and behave.

And in Olfaction – We have similar interests in olfaction and related olfactory circuits.

Parental plasticity

Parental plasticity is manifested by hormonal and physiological changes across the body including in the brain. We study parental plasticity in the context of auditory and olfactory perceptions. We use the mouse as a model to study how pup vocalizations and pup odors are recognized by their parents. We track how these cues are processed and perceived along the neural circuits responsible. Anatomical, physiological and behavioral methods are integrated to solve the complexity underlying sensory-driven parental behaviors.

How do adult born neurons shape olfaction?

The mammalian brain maintains few neurogenic niches in adulthood. One of these regions is the subventricular zone, which is supplying new inhibitory neurons to the olfactory bulb. The functional role of this unique form of network plasticity remains unknown. We use various tools including mouse genetics combined with imaging to study how these new-born neurons shape the neuronal code in the olfactory system.

Ido_Maor
Ido Maor
Research Associate
Elham_Taha_Israel
Elham Taha
Post Doc
omrigilday2
Omri Gilday
PhD Student
Claudia_Maggi
Claudia Maggi
MSc Student
Or_Yudco
Or Yudco
MSc Student
Benne_Praegel
Benne Praegel
PhD student
Meirav_Givon
Meirav Givon
Lab Technician
ELSC-Baruch-Haimson
Baruch Haimson
Post Doc student
raz_cohen_mizrahi_lab
Raz Cohen
Undergraduate Student
ELSC-Seminars-General
Ido Saar
Undergraduate Student
ELSC-Seminars-General
Gideon Rothschild
Haran_Shani_2
Haran Shani Narkiss
ELSC-Seminars-General
Itamar Landau
ELSC-Seminars-General
Gilead Raday
ELSC-Seminars-General
Natan Gold
ELSC-Seminars-General
Rachel Nissim
ELSC-Seminars-General
Libi Feigin
ELSC-Seminars-General
Hagit Kopel
ELSC-Faculty-Yoav-Adam
Yoav Adam
ELSC-Seminars-General
Yoav Livneh
ELSC-Seminars-General
Yael Shlomai
ELSC-Seminars-General
Ido Maor
ELSC-Seminars-General
Amit Vinograd
ELSC-Seminars-General
Ronen Eavry
ELSC-Seminars-General
Lior Cohen
ELSC-Seminars-General
Maya Groysman
ELSC-Seminars-General
Hadas Lapid
ELSC-Seminars-General
Yishai Elyada
ELSC-Seminars-General
Gen-ichi Tasaka
ELSC-Seminars-General
Ariel Gilad
ELSC-Seminars-General
Elena Kudryavitslaya
Tohar Sion Yarden 001
Tohar Sion Yarden
L Feigin, G Tasaka, I Maor and A Mizrahi

Journal of Neuroscience (2021)

Feigin, L and Tasaka, G and Maor, I and Mizrahi, A

Society for Neuroscience, Journal of Neuroscience, 0270-6474 (2021)

Katayun Cohen-Kashi Malina, Emmanouil Tsivourakis, Dahlia Kushinsky, Daniella Apelblat, Stav Shtiglitz, Eran Zohar, Michael Sokoletsky, Gen-ichi Tasaka, Adi Mizrahi, Ilan Lampl, Ivo Spiegel

Neuron, 2021, 109, 1-15, ISSN 0896-6273 (2021)

Elena Kudryavitskaya, Eran Marom, Haran Shani-Narkiss, David Pash, Adi Mizrahi

Current Biology, Volume 31, Issue 8, 2021, Pages 1616-1631.e4, ISSN 0960-9822 (2021)

Kameron K. Clayton, Ross S. Williamson, Kenneth E. Hancock, Gen-ichi Tasaka, Adi Mizrahi, Troy A. Hackett, Daniel B. Polley

Current Biology, Volume 31, Issue 2, Pages 310-321.e5, ISSN 0960-9822 (2021)

Shani Narkiss H., Vingrad A., Landau I.D., Tasaka G., Yayun N., Terlestky S., Groysman M., Maor I., Sompolinsky H., and Mizrahi. A

Nature Communications (2020)

Dudai A, Yayon N, Lerner V, Tasaka Gi, Deitcher Y, et al.

PLOS Biology 18(2): e3000613 (2020)

GILAD A., MAOR I. AND MIZRAHI. A.

eLife 9:e56307 (2020)

Maor Ido, Shwartz-Ziv Ravid, Feigin Libi, Elyada Yishai, Sompolinsky Haim, Mizrahi Adi

Frontiers in Neural Circuits VOLUME=13,PAGES=82 (2020)

Gen-ichi Tasaka, Libi Feigin, Ido Maor, Maya Groysman, Laura A. DeNardo, Jennifer K. Schiavo, Robert C. Froemke, Liqun Luo, Adi Mizrahi

Neuron ISSN 0896-6273 (2020)

Witkowski ED, Gao Y, Gavsyuk AF, Maor I, DeWalt GJ, Eldred WD, Mizrahi A, Davison IG

Front. Cell. Neurosci. 13:166 (2019)

Amit Vinograd, Gen-ichi Tasaka, Lena Kreines, Yair Weiss, Adi Mizrahi

Frontiers in Neuroanatomy, volume 13 article 58 (2019)

Tasaka, G-ichi, Guenthner CJ, Shalev A, Gilday O, Luo L, Mizrahi A.

Nat Commun (2018)

Atlan G, Terem A, Peretz-Rivlin N, Sehrawat K, Gonzales BJ, Pozner G, Tasaka G-i, Goll Y, Refaeli R, Zviran O, Lim BK, Groysman M, Goshen I, Mizrahi A, Nelken I, Citri A,

Current Biology, Volume 28, Issue 17, 10 September 2018, Pages 2752-2762 (2018)

Adi Mizrahi

Trends in Neurosciences Volume 41, Issue 12, Pages 872-874 (2018)

Vinograd A, Fuchs-Shlomai Y, Stern M, Mukherjee D, Gao Y, Citri A, Davison I, Mizrahi A.

Cell Reports 21(2):351-365 (2017)

Vinograd A, Livneh Y, Mizrahi A.

Journal of Neuroscience, 37 (49) 12018-12030; (2017)

Ronen Reshef, Elena Kudryavitskaya, Haran Shani-Narkiss, Batya Isaacson, Neta Rimmerman, Adi Mizrahi, Raz Yirmiya

eLife 2017;6:e30809 (2017)

Elyada YM, Mizrahi A.

Curr Opin Neurobiol. 2015 Dec;35:49-56. (2015)

Rothschild G, Mizrahi A.

Annu Rev Neurosci. 2015 Jul 8;38:247-68 (2015)

Livneh Y, Adam Y, Mizrahi A.

Neuron. 2014 Mar 5;81(5):1097-1110 (2014)

Adi Mizrahi, Amos Shalev, Israel Nelken

Current Opinion in Neurobiology. 24:103-110 (2014)

Adam Y, Livneh Y, Miyamichi K, Groysman M, Luo L, Mizrahi A.

Front Neural Circuits. 2014; 8: 129. (2014)

Miyamichi K, Shlomai-Fuchs Y, Shu M, Weissbourd BC, Luo L, Mizrahi A.

Neuron. 2013 Dec 4;80(5):1232-45. (2013)

Rothschild G, Cohen L, Mizrahi A, Nelken I.

J Neurosci. 2013 Jul 31;33(31):12851-61 (2013)

Kopel H, Schechtman E, Groysman M, Mizrahi A.

J Neurosci. 2012 May 30;32(22):7519-27 (2012)

Livneh, Y, Mizrahi A.

Nature Neuroscience, volume 15, pages 26–28 (2011)

Adam, Y, Mizrahi A.

Journal of Neuroscience, 31 (22) 7967-7973 (2011)

Livneh, Y, Mizrahi A.

The Journal of Comparative Neurology, Volume 519, Issue 11, Pages 2212-2224 (2011)

Cohen, L, Rothschild G, Mizrahi A.

Neuron, Volume 72, Issue 2, Pages 357-369 (2011)

Livneh, Y, Mizrahi A.

Frontiers in systems neuroscience, 3:17 (2010)

Adam, Y, Mizrahi A.

Current Opinion in Neurobiology, Volume 20, Issue 1, Pages 134-140 (2010)

Rothschild G, Nelken I, Mizrahi A.

Nat Neurosci. 2010 Mar;13(3):353-60. (2010)

Licht, T, Eavri R, Goshen I, Shlomai Y, Mizrahi A, Keshet E.

Development, 137: 261-271 (2010)

Livneh, Y, Feinstein N, Klein M, Mizrahi A.

Journal of Neuroscience, 29 (1) 86-97 (2009)

Kopel, H, Meshulam M, Mizrahi A.

Journal of Neuroscience Methods, Volume 182, Issue 2, Pages 189-194 (2009)

Positions are available for 2021:
– MSc student position.
– PhD student position.
– Postdoctoral trainee position.

The Mizrahi lab is using state of the art imaging, electrophysiological and behavioral tools to study neural correlates and neural/cellular mechanisms of learning, as well as during social interactions.

We accept students through several graduate programs of the Hebrew University. Our students come from various backgrounds in one or more of these areas – Biology, Psychology, Cognitive Sciences, Computer Science, Physics, Chemistry.

Further details: For more information, please contact: Adi Mizrahi: mizrahi.adi@mail.huji.ac.il
Honors:
Eric Roland Professor in Brain Sciences

Adi Mizrahi

Professor

Phone: +972-2-6585163
Lab Phone: +972-2-6585163
Office Phone: +972-2-6586460
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 2, Room 1204, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401

Winners announced for the ELSC photography competition