A possible role of olivary gap-junctions in the generation of physiological and pathological tremors

Tremor is a potentially disabling pathology that affects millions of people. The inferior olive (IO) has been implicated in several types of tremor.1,2 In particular, electrical synapses have been shown to be essential for the generation of oscillatory activity in the IO,3 which may manifest as tremor. In a recent paper,4 we described how the electrical coupling of non-oscillating cells can generate oscillatory network behavior. Here we apply this dynamic mechanism to the IO and discuss the possible clinical applications…

Authors: Loewenstein Y.
Year of publication: 2002
Journal: Mol Psychiatry. 2002;7(2):129-31.

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“Working memory”