We show that odor representations by olfactory bulb mitral cells (MC) are highly flexible and correlate with behavioral meaning. We trained mice to classify odor stimuli in a multiple decision boundary task and imaged MC activity using two-photon imaging during behavior. We found that MC representations change flexibly based on odor value following category learning. In addition, we found that behavioral choice is a strong component in MC responses. Learning related changes in MCs were particularly evident as increase in suppressive response profiles suggesting an inhibitory mechanism of learning related changes.
Paper of the month
Mizrahi’s Lab: Flexible categorization in the mouse olfactory bulb
Current Biology, 2021, ISSN 0960-9822 (2021)