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Paper of the Month, March 2020 (Soreq’s Lab)

Soreq's Lab: A lncRNA survey finds increases in neuroprotective LINC‐PINT in Parkinson’s disease substantia nigra

Alon Simchovitz, Mor Hanan, Nadav Yayon, Songhua Lee, Estelle R. Bennett, David S. Greenberg, Sebastian Kadener, Hermona Soreq

A lncRNA survey finds increases in neuroprotective LINC‐PINT in Parkinson’s disease substantia nigra

Aging Cell. 2020; 19:e13115. (2019)

Lay summary:

Parkinson’s disease is the most common motor neurodegenerative disorder, resulting from the selective destruction of dopamine-secreting nerve cells in a brain region called substantia nigra. However, why those neurons die, is still unknown. The recently discovered class of genes called long noncoding RNAs (lncRNAs), play a role in many physiological and pathological conditions. We studied how lncRNA changes in the substantia nigra by analyzing post-mortem brain tissue from Parkinson’s disease patients. We discovered the accumulation of the LINC-PINT lncRNA in the substantia nigra of Parkinson’s patientsas well as in several other models of Parkinson’s disease. LINC-PINT is expressed in neurons, and its levels are correlated with the complexity of the neuronal network. By knocking down LINC-PINT in cultured neurons, we found a protective role for these molecules against oxidative stress, a known phenomenon in Parkinson’s disease. Taken together, our findings suggest a protective role for LINC-PINT in Parkinson’s disease, as well as in other neurodegenerative diseases.

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