In the developing nervous system, special cells called ‘neural crest progenitors’ are born and develop into most components of the peripheral nervous system (PNS). In this work we identified a protein, called Yes-associated-protein (YAP), which is necessary and sufficient for the onset of migration of neural crest progenitors and for their subsequent development. Furthermore, we characterized the molecular pathway by which YAP exerts its activity. This work advances our understanding of the molecular network responsible for the ontogeny of the PNS.
Paper of the month
Kalcheim's Lab: YAP promotes neural crest emigration through interactions with BMP and Wnt activities
Deepak Kumar, Erez Nitzan and Chaya Kalcheim
Cell Communication and Signaling on June (2019)