Yoav Adam Lab

ELSC Members

Sachs Family Lecturer in Brain Sciences
Adam Lab

We are interested in the mechanistic basis for cognitive processes, focusing on the function of hippocampal circuits in learning and memory. To this end, we are developing and applying cutting-edge technology to record and control brain activity using light. This all-optical technology is based on a combination of protein engineering and state-of-the-art microscopes and it allows us to record and manipulate the fine details of neuronal electrical activity at single-cell resolution, in a non-invasive manner. We use this all-optical electrophysiology approach for detailed mechanistic studies of the function and plasticity of hippocampal circuits during various behavioral tasks.

Envelope Phone-alt

Yoav Adam

Assistant Professor

Email: yoav.adam@mail.huji.ac.il
Phone: +972-2-549-4831
Yoav Adam
@YoavAdam
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 2106, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
Sachs Family Lecturer in Brain Sciences
Adam Lab
Mor Margolin
Mor Margolin
Ph.D. Student
Renana Malka
Renana Malka
M.Sc. Student
Liam Aisenberg
Liam Aisenberg
Undergraduate student
Gur Aminadav
Gur Aminadav
Ph.D. Student
Omer Cooper
Omer Cooper
Undergraduate Student
shulamit
Shulamit Baror-Sebban, Ph.D
Lab manager
Michal Rubin
Michal Rubin
M.Sc. Student
Efrat Sheinbach
Efrat Sheinbach
Ph.D. Student
Qixin Yang_Cropped
Qixin Yang
Ph.D. Student
Rottem_Kipper
Rotem Kipper
Ph.D. Student
Gal Shturm
Gal Shturm
Undergraduate Student
Ron_Buchnic
Ron Buchnic
Anat-Marom_0
Anat Marom-Rotem, Ph.D.
Yahel Gazit_Cropped
Yahel Gazit
Noa_Garty
Noa Garty
Rotem Ovadia
Rotem Ovadia
Yuval Rom
Yuval Rom
Yanive Melamed
Yaniv Melamed
Armbruster, M., Naskar, S., Garcia, J.P. Sommer, M., Kim, E., Adam, Y., Haydon, P.G., Boyden, E.S., Cohen, A.E., & Dulla, C.G.

Neuronal activity drives pathway-specific depolarization of peripheral astrocyte processes

Nat Neurosci 25, 607–616  (2022)

Adam, Y., & Mizrahi, A.

Long term imaging reveals dynamic changes in the neuronal composition of the glomerular layer

Journal of Neuroscience, 31(22), 7967-7973. (2011)

Chien MP, Brinks D, Adam Y, Bloxham W, Kheifets S, Cohen AE

Photoactivated voltage imaging in tissue with an archaerhodopsin-derived reporter

Science Advances , Vol. 7, no. 19, eabe3216 (2021)

Michael E. Xie, Yoav Adam, Linlin Z. Fan, Urs L. Böhm, Ian Kinsella, Ding Zhou, Marton Rozsa, Amrita Singh, Karel Svoboda, Liam Paninski, Adam E. Cohen

High-fidelity estimates of spikes and subthreshold waveforms from 1-photon voltage imaging in vivo

Cell Reports, Volume 35, Issue 1, 2021, 108954, ISSN 2211-1247, (2021)

Yoav Adam

All-optical electrophysiology in behaving animals

Journal of Neuroscience Methods, Volume 353, 2021, 109101, ISSN 0165-0270 (2021)

Parot VJ, Sing-Long C, Adam Y, Boehm UL, Fan L, Farhi SL, and Cohen AE

Compressed Hadamard microscopy for high-speed optically sectioned neuronal activity recordings

Journal of Physics D: Applied Physics Volume 52, Number 14 (2019)

Adam, Y., Kim, J.J., Lou, S. et al.

Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics

Nature (2019)

Samouil L. Farhi, Vicente J. Parot, Abhinav Grama, Masahito Yamagata, Ahmed S. Abdelfattah, Yoav Adam, Shan Lou, Jeong Jun Kim, Robert E. Campbell, David D. Cox, Adam E. Cohen

Wide-area all-optical neurophysiology in acute brain slices

Journal of Neuroscience (2019)

Fan LZ, Nehme R, Adam Y, Jung ES, Wu H, Eggan K, Arnold DB, Cohen AE

All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition

Nature Methods, volume 15, pages 823–831 (2018)

Lou S, Adam Y, Weinstein EN, Williams E, Williams K, Parot V, Kavokine N, Liberles S, Madisen L, Zeng H, Cohen AE.

Genetically Targeted All-Optical Electrophysiology with a Transgenic Cre-Dependent Optopatch Mouse

Journal of Neuroscience, 36 (43) 11059-11073 (2016)

Brinks D, Adam Y, Kheifets S, Cohen AE

Painting with Rainbows: Patterning Light in Space, Time, and Wavelength for Multiphoton Optogenetic Sensing and Control

Acc. Chem. Res., 49 (11), pp 2518–2526 (2016)

Livneh Y, Adam Y, Mizrahi A.

Odor Processing by Adult-Born Neurons

Neuron. 2014 Mar 5;81(5):1097-1110 (2014)

Adam Y, Livneh Y, Miyamichi K, Groysman M, Luo L, Mizrahi A.

Functional transformations of odor inputs in the mouse olfactory bulb

Front Neural Circuits. 2014; 8: 129. (2014)

Adam, Y, Mizrahi A.

Long-Term Imaging Reveals Dynamic Changes in the Neuronal Composition of the Glomerular Layer

Journal of Neuroscience, 31 (22) 7967-7973 (2011)

Adam, Y, Mizrahi A.

Circuit formation and maintenance—perspectives from the mammalian olfactory bulb

Current Opinion in Neurobiology, Volume 20, Issue 1, Pages 134-140 (2010)

Yoav Adam, Robert H. Edwards, and Shimon Schuldiner

Expression and function of the rat vesicular monoamine transporter 2

Am J Physiol Cell Physiol (2008)

Steiner-Mordoch S, Soskine M, Solomon D, et al.

Parallel topology of genetically fused EmrE homodimers

EMBO J. (2008)

Adam Y, Tayer N, Rotem D, Schreiber G, Schuldiner S.

The fast release of sticky protons: Kinetics of substrate binding and proton release in a multidrug transporter

Proc Natl Acad Sci U S A (2007)

Soskine M, Adam Y, and Schuldiner S.

Direct Evidence for Substrate-induced Proton Release in Detergent-solubilized EmrE, a Multidrug Transporter

J Biol Chem (2004)

We are looking for curious and highly-motivated students and postdocs to join our team
Media:
https://www.haaretz.co.il/science/biology/.premium-1.7193349

https://medium.com/the-spike/what-should-systems-neuroscience-do-next-voltage-imaging-9bfa5d6a4df9

https://eurekalert.org/pub_releases/2019-05/hu-anv042919.php

Public lecture (in Hebrew):
https://www.youtube.com/watch?v=615zLv-E5ZM&feature=youtu.be

Resources:
Adam Lab GitHub page:
https://github.com/yoavadamlab

Lab Life:
Envelope Phone-alt

Yoav Adam

Assistant Professor

Email: yoav.adam@mail.huji.ac.il
Phone: +972-2-549-4831
Yoav Adam
@YoavAdam
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 2106, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401

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“Working memory”

New exhibition titled “Working memory” by the artist Alon kedem and in collaboration with ELSC Prof. Leon Deouell. In the picture: Moshe Lion, the mayor of Jerusalem and Prof. Asher Cohen, the president of The Hebrew University of Jerusalem.

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