Mati Joshua Lab

ELSC Members

The Joshua lab

The drive to seek reward controls almost every aspect of our behavior, from stereotypical reflexive behaviors, to complex voluntary actions such as choosing where to look, how to reach for a cup of coffee, or what companies to invest in. It is not surprising, therefore, that the symptomatology of neurological disorders that interrupt reward processing – such as those stemming from drug-abuse and depression – include deficits in the capacity to make even simple movements.

Our lab studies how what we want guides what we do, in particular we investigate how the brain uses reward to drive and shape behavior.

Our approach is to study the control of eye movements using neural recordings in animals as they behave. We study the activity of single neurons and neural networks while they operate in real time to produce behavior. Our lab’s research focuses on two major subcortical networks: the basal ganglia and the cerebellum. Both structures are essential for normal movements and impairment to either loop leads to devastating motor disorders. Of particular interest is elucidating the specific role of the basal ganglia and cerebellum in the control of movement. The goal of our research is to understand how the subcortical networks interact with the cerebral cortex to drive behavior that is guided by rewards.

Mati Joshua

Associate Professor

Phone: +972-54-7550566
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 3, Room 1306 Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
The Joshua lab

The drive to seek reward controls almost every aspect of our behavior, from stereotypical reflexive behaviors, to complex voluntary actions such as choosing where to look, how to reach for a cup of coffee, or what companies to invest in. It is not surprising, therefore, that the symptomatology of neurological disorders that interrupt reward processing – such as those stemming from drug-abuse and depression – include deficits in the capacity to make even simple movements.

Our lab studies how what we want guides what we do, in particular we investigate how the brain uses reward to drive and shape behavior.

Our approach is to study the control of eye movements using neural recordings in animals as they behave. We study the activity of single neurons and neural networks while they operate in real time to produce behavior. Our lab’s research focuses on two major subcortical networks: the basal ganglia and the cerebellum. Both structures are essential for normal movements and impairment to either loop leads to devastating motor disorders. Of particular interest is elucidating the specific role of the basal ganglia and cerebellum in the control of movement. The goal of our research is to understand how the subcortical networks interact with the cerebral cortex to drive behavior that is guided by rewards.

ELSC-Seminars-General
Indrajeet Indrajeet
Post Doc
ELSC-Seminars-General
Adi Lixenberg
PhD Student
ELSC-Seminars-General
Gil Zur
PhD Student
ELSC-Seminars-General
Matan Cain
PhD Student
ELSC-Seminars-General
Noga Larry
PhD Student
ELSC-Seminars-General
Yudith Botschko
Lab Manager
ELSC-Seminars-General
Gabi Stemp
MSc student
ELSC-background-010
Yirat Henske
MSc student
Nadav Ben-Shushan, Nimrod Shaham, Mati Joshua & Yoram Burak

Nature Communications 13, 1697 (2022) (2022)

Nashef A, Mitelman R, Harel R, Joshua M, Prut Y.

Proc Natl Acad Sci U S A. Feb 9;118(6):e2012658118. (2021)

Cain M, Botschko Y, Joshua M.

eNeuro. Mar 22;8(2):ENEURO.0232-20.2020. (2021)

Adi Lixenberg, Merav Yarkoni, Yehudit Botschko, and Mati Joshua

J Neurophysiol 123: 786–799 (2020)

Larry N, Yarkoni M, Lixenberg A, Joshua M

eLife (2019)

Botschko, Y, Yarkoni M, Joshua M.

Frontiers in systems neuroscience, Volume: 12 (2018)

Lixenberg, A, Joshua M.

Journal of Neuroscience, 38 (49) 10515-10524 (2018)

Heffley, W, Song E Y, Xu Z, Taylor BN, Hughes M A, McKinney A, Joshua M, Hull C.

Nature neuroscience, Volume: 21, Issue: 10, pp: 1431-1441 (2018)

Marmor O, Valsky D, Joshua M, Bick AS, Arkadir D, Tamir I, Bergman H, Israel Z, Eitan R.

Journal of Neurophysiology 117(6):2140-2151 (2017)

Raghavan, RT, Joshua M.

Journal of Neurophysiology, Volume 118, Issue 4, Pages 2216-2231 (2017)

Lee, J, Joshua M, Medina JF, Lisberger SG.

Neuron, Volume 90, Issue 1, Pages 165-176 (2016)

Joshua, M. Tokiyama, S. Lisberger, S.G.

Journal of Neurophysiology 114(5):2616-24. (2015)

Joshua, M and Lisberger, S.G.

Neuroscience Jun 18;296:80-91 (2015)

Chaisanguanthum, K.S.* Joshua, M*. Medina, J.F. Bialek, W. and Lisberger, S.G.

eNeuro (2014)

Woolley, S.C. Rajan, R. Joshua, M. and Doupe, A.J.

Neuron 82:208–223 (2014)

Joshua, M. Medina, J.F. and Lisberger, S.G.

Journal of Neuroscience 33(15):6633-6647 (2013)

Joshua, M. and Lisberger, S.G.

Journal of Neuroscience 32(8):2856-67 (2012)

Shalit, U, Zinger N, Joshua M, Prut Y.

Cerebral Cortex, Volume 22, Issue 8, Pages 1904–1914 (2011)

Joshua, M. Adler, A. and Bergman, H.

Frontiers in Systems Neuroscience 8;3:2 (2010)

Adler, A, Joshua M, Rivlin-Etzion M, Mitelman R, Marmor O, Prut Y, Bergman H.

Journal of neurophysiology. 103(1):346-59 (2010)

Joshua, M, Adler, A. and Bergman, H.

Current Opinion in Neurobiology, Volume 19, Issue 6, Pages 615-620 (2009)

Joshua M, Adler A, Prut Y, Vaadia E, Wickens JR, Bergman H.

Neuron. 62(5):695-704 (2009)

Joshua, M, Adler A, Rosin B, Vaadia E, Bergman H.

Journal of neurophysiology, Volume 101, Issue 2, Pages 758-772 (2009)

Mitelman, R, Joshua M, Adler A, Bergman H.

Journal of Neuroscience Methods, Volume 178, Issue 2, Pages 350-356 (2009)

Elias, S, Joshua M, Goldberg JA, Heimer G, Arkadir D, Morris G, Bergman H.

Journal of Neuroscience, 27 (10) 2525-2538 (2007)

Joshua, M, Elias S, Levine O, Bergman H.

Journal of Neuroscience Methods, Volume 163, Issue 2, Pages 267-282 (2007)

We are looking for doctoral and postdoctoral students.
Please contact mati.joshua@mail.huji.ac.il

Mati Joshua

Associate Professor

Phone: +972-54-7550566
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 3, Room 1306 Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401

“Working memory”