Eran Meshorer Lab

ELSC Members

Arthur Gutterman Family Chair in Stem Cell Biology Endowment Fund
Epigenetics, stem cells, & neurons

The Meshorer lab is studying

1. Epigenetic regulation in stem cells and differentiation;
2. Neurodegenerative diseases (e.g. HD) using pluripotent stem cell models;
3. Paleo-epigenetics: reconstructing DNA methylation in archaic genomes.

Envelope Phone-alt

Eran Meshorer

Professor

Email: eran.meshorer@mail.huji.ac.il
Phone: +972-2-6585161
Eran Meshorer CV
Eran Meshorer
@meshorer1
Address: Department of Genetics, The Institute of Life Sciences, Silberman Building, Room 2-541. The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram. Yael Riback, Lab administrator, 02-6585144
http://meshorerlab.huji.ac.il/
Arthur Gutterman Family Chair in Stem Cell Biology Endowment Fund
Epigenetics, stem cells, & neurons

The Meshorer lab is studying

1. Epigenetic regulation in stem cells and differentiation;
2. Neurodegenerative diseases (e.g. HD) using pluripotent stem cell models;
3. Paleo-epigenetics: reconstructing DNA methylation in archaic genomes.

Tzukit_Jan2022
Tzukit Tal
Joint student with TEVA
ShalhevetMar22
Shalhevet Klemfner
Graduate student
Ayelet-Hashahar
Ayelet – Hashahar Cohen
Research Associate (Teacher-Researcher)
Daniel_Dec2017
Daniel Batyrev
PhD Student
Juliane_Sep2018
Juliane Oliveira Viegas
PhD Student
Lea_head
Lea Cohen
PhD Student
Moria2016
Moria Ben Yishay
PhD Student
Patrick_Oct2018
Siang Lin Lim
PhD Student
Tamar_May2018
Tamar Segal
PhD Student
ww (1)
Walaa Oweis
PhD Student
pasportpicj
Malka Nissim-Rafinia PhD
Lab Manager
Thabat-Khatib---photo
Thabat Khatib
Post Doc
Bar S, Vershkov D, Keshet G, Lezmi E, Meller N, Yilmaz A, Yanuka O, Nissim-RafiniaM, Meshorer E, Eldar-Geva T, Benvenisty N.

Identifying regulators of parental imprinting by CRISPR/Cas9 screening in haploid human embryonic stem cells

Nat Commun. (2021)

Leader Y, Lev Maor G, Sorek M, Shayevitch R, Hussein M, Hameiri O, Tammer L, Zonszain J, Keydar I, Hollander D, Meshorer E, Ast G.

The upstream 5′ splice site remains associated to the transcription machinery during intron synthesis

Nat Commun. (2021)

Pablo Aurelio Gómez-García, Stephanie Portillo-Ledesma, Maria Victoria Neguembor, Martina Pesaresi, Walaa Oweis, Talia Rohrlich, Stefan Wieser, Eran Meshorer, Tamar Schlick, Maria Pia Cosma, Melike Lakadamyali

Mesoscale Modeling and Single-Nucleosome Tracking Reveal Remodeling of Clutch Folding and Dynamics in Stem Cell Differentiation

Cell Reports, Volume 34, Issue 2, 2021, 108614, ISSN 2211-1247 (2021)

Sorek, M., Oweis, W., Nissim-Rafinia, M. Maman M, Simon S, Hession CC, Adiconis X, Simmons SK, Sanjana NE, Shi X, Lu C, Pan JQ, Xu X, Pouladi MA, Ellerby LM, Zhang F, Levin JZ, Meshorer E.

Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity

Genome Biol 22, 73 (2021)

Danny Bavli, Xue Sun, Chen Kozulin, Dena Ennis, Alex Motzik, Alva Biran, Shlomi Brielle, Adi Alajem, Eran Meshorer, Amnon Buxboim, Oren Ram

CloneSeq: A highly sensitive analysis platform for the characterization of 3D-cultured single-cell-derived clones

Developmental Cell, ISSN 1534-5807, (2021)

Ben-Ami R, Klochendler A, Seidel M, Sido T, Gurel-Gurevich O, Yassour M, Meshorer E, Benedek G, Fogel I, Oiknine-Djian E, Gertler A, Rotstein Z, Lavi B, Dor Y, Wolf DG, Salton M, Drier Y; Hebrew University-Hadassah COVID-19 diagnosis team

Large-scale implementation of pooled RNA extraction and RT-PCR for SARSCoV-2 detection

Clin Microbiol Infect. (2020)

Harikumar A, Lim PSL, Nissim-Rafinia M, Park JE, Sze SK, Meshorer E.

Embryonic Stem Cell Differentiation Is Regulated by SET through Interactions with p53 and β-Catenin

Stem Cell Reports (2020)

Lim PSL, Meshorer E.

Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome

Nat Struct Mol Biol. (2020)

Lim PSL, Meshorer E.

Organization of the Pluripotent Genome

Cold Spring Harb Perspect Biol (2020)

Meshorer E, Plath K.

Chromatin and Nuclear Architecture in Stem Cells

Stem Cell Reports (2020)

Pattabiraman S, Azad GK, Amen T, Brielle S, Park JE, Sze SK, Meshorer E, Kaganovich D.

Vimentin protects differentiating stem cells from stress

Sci Rep. (2020)

Gokhman, D., M. Nissim-Rafinia, L. Agranat-Tamir, G. Housman, R. Garcia-Perez, E. Lizano, O. Cheronet, S. Mallick, M. A. Nieves-Colon, H. Li, S. Alpaslan-Roodenberg, M. Novak, H. Gu, J. M. Osinski, M. Ferrando-Bernal, P. Gelabert, I. Lipende, D. Mjungu, I. Kondova, R. Bontrop, O. Kullmer, G. Weber, T. Shahar, M. Dvir-Ginzberg, M. Faerman, E. E. Quillen, A. Meissner, Y. Lahav, L. Kandel, M. Liebergall, M. E. Prada, J. M. Vidal, R. M. Gronostajski, A. C. Stone, B. Yakir, C. Lalueza-Fox, R. Pinhasi, D. Reich, T. Marques-Bonet, E. Meshorer, and L. Carmel.

Differential DNA methylation of vocal and facial anatomy genes in modern humans

Nat Commun (2020)

Goldshtein et al.

Transcription Factor Binding in Embryonic Stem Cells Is Constrained by DNA Sequence Repeat Symmetry

Biophysical Journal (2020)

Lezmi E, Weissbein U, Golan-Lev T, Nissim-Rafinia M, Meshorer E, Benvenisty N.

The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation

Stem Cell Reports 2020;S2213-6711(20)30186-7. (2020)

Batyrev D, Lapid E, Carmel L, Meshorer E

Predicted Archaic 3D Genome Organization Reveals Genes Related to Head and Spinal Cord Separating Modern from Archaic Humans

Cells, 9(1), 48 (2020)

Imke K. Mandemaker, Di Zhou, Serena T. Bruens, Dick H. Dekkers, Pernette J. Verschure, Raghu R. Edupuganti, Eran Meshorer, Jeroen A. Demmers, Jurgen A. Marteijn

Histone H1 eviction by the histone chaperone SET reduces cell survival following DNA damage

Journal of Cell Science jcs.235473 (2020)

Yoav Mathov, Daniel Batyrev, Eran Meshorer, Liran Carmel

Harnessing epigenetics to study human evolution

Current Opinion in Genetics & Development Pages 23-29, ISSN 0959-437X (2020)

Hanan, M., Simchovitz, A., Yayon, N., Vaknine, S., Cohen-Fultheim, R., Karmon, M., Madrer, N., Rohrlich, T.M., Maman, M., Bennett, E.R., Greenberg, D.S., Meshorer, E., Levanon, E.Y., Soreq, H. & Kadener, S.

A Parkinson’s disease CircRNAs Resource reveals a link between circSLC8A1 and oxidative stress

EMBO Mol Med (2020)

Viegas JO, Meshorer E

The Princess and the P: Pluripotent Stem Cells and P-Bodies

Cell Stem Cell (2019), Volume 25, Issue 5, Pages 589-591 (2019)

Gold A, Eini L, Nissim-Rafinia M, Viner R, Ezer S, Erez K, Aqaqe N, Hanania R, Milyavsky M, Meshorer E, Goldberg M

Spironolactone inhibits the growth of cancer stem cells by impairing DNA damage response

Oncogene, volume 38, pages 3103–3118 (2019)

Gokhman D, Mishol N, de Manuel M, de Juan D, Shuqrun J, Meshorer E, Marques-Bonet T, Rak Y, Carmel L.

Reconstructing Denisovan Anatomy Using DNA Methylation Maps

Cell, Volume 179, Issue 1, Pages 180-192.e10 (2019)

Cohen-Carmon D, Sorek M, Lerner V, Nissim-Rafinia M, Yarom Y, Meshorer E

Progerin-Induced Transcriptional Changes in Huntington’s Disease Human Pluripotent Stem Cell-Derived Neurons

Molecular Neurobiology (2019)

Schlesinger S and Meshorer E

Open chromatin, epigenetic plasticity and nuclear organization in pluripotency

Developmental Cell, Volume 48, Issue 2, 28 January 2019, Pages 135-150 (2019)

Mallm JP, Windisch P, Biran A, Gal Z, Schumacher S, Glass R, Herold-Mende C, Meshorer E, Barbus M, Rippe K

Glioblastoma initiating cells are sensitive to histone demethylase inhibition due to epigenetic deregulation

International Journal of Cancer (2019)

Gokhman D, Agranat L, Housman G, Nissim-Rafinia M, Colon MN, Gu H, Ferrando M, Gelabert P, Lipende I, Quillen EE, Meissner A, Stone AC, Pusey AE, Mjungu D, Kandel L, Liebergall M, Prada ME, Vidal JM, Krause J, Yakir B, Reich D, Fox CL, Marques-Bonet T, Eran Meshorer and Liran Carmel

Extensive Regulatory Changes in Genes Affecting Vocal and Facial Anatomy Separate Modern from Archaic Humans

BioRxiv (2019)

Azad GK, Ito K, Sailaja BS, Biran A, Nissim-Rafinia M, Brown DT, Takizawa T and Meshorer E

PARP1-dependent eviction of the linker histone H1 mediates immediate early gene expression during neuronal activation

Journal of Cell Biology, 217(2):473-481 (2018)

Harikumar A, Edupuganti RR, Sorek M, Azad GK, Markoulaki S, Sehnalová P, Legartová S, Bártová E, Farkash-Amar S, Jaenisch R, Alon U and Meshorer E

An endogenously tagged fluorescent fusion protein library in mouse embryonic stem cells

Stem Cell Reports, Volume 9, Issue 4, 10 October 2017, Pages 1304-1314 (2017)

Edupuganti RR, Harikumar A, Aaronson Y, Biran A, Sailaja BS, Nissim-Rafinia M, Azad GK, Cohen MM, Park JE, Shivalila CS, Markoulaki S, Sze SK, Jaenisch R and Meshorer E

Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation

Stem Cell Reports, Volume 9, Issue 4, Pages 1291-1303 (2017)

Schlesinger S, Kaffe B, Melcer S, Aguilera JDA, Mundackal DS, Kaplan T and Meshorer E

A hyperdynamic H3.3 nucleosome marks promoter regions in pluripotent embryonic stem cells

Nucleic Acids Research, Volume 45, Issue 21, 1 December 2017, Pages 12181–12194 (2017)

Torres CM, Biran A,S, Burney MJ, Patel H, Henser-Brownhill T, Cohen AS, Li Y, Ben Hamo R, Nye E, Spencer-Dene B, Chakravarty P, Efroni S, Matthews N, Misteli T, Meshorer E and Scaffidi P

The linker histone H1.0 determines epigenetic and functional intratumor heterogeneity

Science, Vol 353, Issue 6307 30 September 2016 (2016)

Aaronson, Y, Livyatan I, Gokhman D, Meshorer E.

Systematic identification of gene family regulators in mouse and human embryonic stem cells.

Nucleic Acids Research, Volume 44, Issue 9, Pages 4080–4089 (2016)

Gokhman, D, Meshorer E, Carmel L.

Epigenetics: It’s Getting Old. Past Meets Future in Paleoepigenetics.

Trends in Ecology & Evolution, Volume 31, Issue 4, Pages 290-300 (2016)

Kfir N, Glaich O, Lev-Maor G, Alajem A, Datta A, Sze SK, Meshorer E and Ast G

SF3B1 Association with Chromatin Determines Splicing Outcomes

Cell Reports, Volume 11, Issue 4, Pages 618-629 (2015)

Yearim A, Gelfman S, Shayevitch R, Melcer S, Glaich O, Mallm JP, Nissim-Rafinia M, Cohen A, Rippe K, Meshorer E and Ast G

HP1 Is Involved in Regulating the Global Impact of DNA Methylation on Alternative Splicing

Cell Reports Volume 10, Issue 7, Pages 1122-1134 (2015)

Moussaieff A, Rouleau M, Kitsberg D, Cohen M, Levy G, Barasch D, Nemirovski A, Shen-Orr S, Laevsky I, Amit M, Bomze D, Elena-Herrmann B, Scherf T, Nissim-Rafinia M, Kempa S, Itskovitz-Eldor J, Meshorer E, Aberdam D, Nahmias Y.

Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells

Cell Metabolism, Volume 21, Issue 3, Pages 392-402 (2015)

Alajem A, Biran A, Harikumar A, Sailaja BS, Aaronson Y, Livyatan I, Nissim-Rafinia M, Sommer AG, Mostoslavsky G, Gerbasi VR, Golden DE, Datta A, Sze SK and Meshorer E

Differential Association of Chromatin Proteins Identifies BAF60a/SMARCD1 as a regulator of embryonic stem cell differentiation.

Cell Reports, Volume 10, Issue 12, 31 March 2015, Pages 2019-2031 (2015)

Harikumar A and Meshorer E

Chromatin remodeling and bivalent histone modifications in embryonic stem cells

EMBO reports, 16, 1609-1619 (2015)

Livyatan I, Aaronson Y, Gokhman D, Ashkenazi R and Meshorer E

BindDB: an integrated database and webtool platform for “reverse-ChIP” epigenomic analysis

Cell Stem Cell, LETTER| VOLUME 17, ISSUE 6, P647-648, DECEMBER 03, 2015 (2015)

Ben-David U, Biran A, Scaffidi P, Herold-Mende C, Boehringer M, Meshorer E and Benvenisty N

Elimination of undifferentiated cancer cells by pluripotent stem cell inhibitors

Journal of Molecular Cell Biology, Volume 6, Issue 3, Pages 267–269 (2014)

Blumberg A, Sailaja BS, Kundaje A, Levin L, Dadon S, Shmorak S, Shaulian S, Meshorer E and Mishmar D

Transcription Factors Bind Negatively Selected Sites within Human mtDNA Genes

Genome Biology and Evolution, Volume 6, Issue 10, Pages 2634–2646 (2014)

Alvarez-Saavedra M, De Repentigny Y, Lagali P, Ram EV, Yan K, Hashem E, Ivanochko D, Huh M, Doo Y, Mears A, Todd M, Corcoran C, Bassett E, Tokarew N, Kokavec J, Majumder R, Ioshikhes I, Wallace V, Kothary R, Meshorer E, Stopka T, Skoultchi A and Picketts D

Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation

Nature Communications, volume 5, Article number: 4181 (2014)

Gokhman D, Lavi E, Prüfer K, Fraga MF, Riancho JA, Kelso J, Pääbo S, Meshorer E* and Carmel L*

Reconstructing the DNA methylation maps of the Neandertal and the Denisovan

Science, Vol 344, Issue 6183 02 May 2014 (2014)

Raviv S, Bharti K, Rencus-Lazar S, Cohen-Tayar Y, Schyr R, Evantal N, Meshorer E, Zilberberg A, Grebe R, Rosin-Arbesfeld R, Lauderdale J, Lutty G, Arnheiter H and Ashery-Padan R

PAX6 Regulates Melanogenesis in the Retinal Pigmented Epithelium through Feed-Forward Regulatory Interactions with MITF

PLoS Genetics, 10(5):e1004360 (2014)

Bošković A, Eid A, Pontabry J, Ishiuchi T, Spiegelhalter C, Ram EVS, Meshorer E and Torres-Padilla ME

Higher chromatin mobility supports totipotency and precedes pluripotency in vivo

Genes & Dev. 28: 1042-1047 (2014)

Bodaker M, Meshorer E, Mitrani E and Louzoun Y

Genes related to differentiation are correlated with the gene regulatory network structure

Bioinformatics, Volume 30, Issue 3, Pages 406–413 (2014)

Schlesinger S, Meshorer E and Goff SP

Asynchronous transcriptional silencing of individual retroviral genomes in embryonic cells

Retrovirology, 11:31 (2014)

Shahar OD, Kalousi A, Eini L, Fisher B, Weiss A, Darr J, Mazina O, Bramson S, Kupiec M, Eden A, Meshorer E, Mazin AV, Brino L, Goldberg M and Soutoglou E

A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair

Nucleic Acids Research, Volume 42, Issue 9, Pages 5689–5701 (2014)

Efroni S, Meerzaman D, Schaefer CF, Greenblum S, Soo-Lyu M, Hu Y, Cultraro C, Meshorer E, Buetow KH

Systems analysis utilising pathway interactions identifies sonic hedgehog pathway as a primary biomarker and oncogenic target in hepatocellular carcinoma

IET Systems Biology, Volume: 7 , Issue: 6, Pages: 243 – 251 (2013)

Livyatan I, Harikumar A, Nissim-Rafinia M, Duttagupta R, Gingeras TR and Meshorer E

Non-polyadenylated transcription in embryonic stem cells reveals novel non-coding RNA related to pluripotency and differentiation

Nucleic Acids Research, Volume 41, Issue 12, Pages 6300–6315 (2013)

Gokhman D, Livyatan I, Sailaja BS, Melcer S and Meshorer E

Multilayered chromatin analysis reveals E2f, Smad and Zfx as transcriptional regulators of histones

Nature Structural & Molecular Biology, volume 20, pages 119–126 (2013)

Deng T, Zhu I, Zhang S, Leng F, Cherukuri S, Hansen L, Mariño-Ramírez L, Meshorer E, Landsman D and Bustin M

HMGN1 Modulates Nucleosome Occupancy and DNase I Hypersensitivity at the CpG Island Promoters of Embryonic Stem Cells

Molecular and Cellular Biology, 33(16):3377-89 (2013)

Farkash-Amar S, David Y, Polten A, Hezroni H, Eldar Y, Meshorer E, Yakhini Z and Simon I

Systematic Determination of Replication Activity Type Highlights Interconnections between Replication, Chromatin Structure and Nuclear Localization

PLoS ONE 7(11): e48986 (2012)

Sailaja BS, Cohen-Carmon D, Zimmerman G, Soreq H and Meshorer E

Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4

PNAS, 109 (52) E3687-E3695 (2012)

Sommer CA, Christodoulou C, Gianotti-Sommer A, Shen SS, Sailaja BS, Hezroni H, Meshorer E, Kotton DN and Mostoslavsky G.

Residual Expression of Reprogramming Factors Affects the Transcriptional Program and Epigenetic Signatures of Induced Pluripotent Stem Cells

PLoS ONE 7(12): e51711 (2012)

Cohen-Carmon D and Meshorer E

Polyglutamine (polyQ) disorders The chromatin connection

Nucleus, Volume 3, Issue 5, Pages 433-441 (2012)

Shahar O, Raghu Ram EVS, Shimshoni E, Hareli S, Meshorer E and Goldberg M

Live imaging of induced and controlled DNA double-strand break formation reveals extremely low repair by homologous recombination in human cells

Oncogene, volume 31, pages 3495–3504 (2012)

Melcer S, Hezroni H, Rand E, Nissim-Rafinia M, Stewart C, Skoultchi A, Bustin M and Meshorer E

Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation

Nature Communications volume 3, Article number: 910 (2012)

Dutta B, Adav SS, Koh CG, Lim SK, Meshorer E and Sze SK

Elucidating the temporal dynamics of chromatin-associated protein release upon DNA digestion by quantitative proteomic approach

Journal of Proteomics, Volume 75, Issue 17, Pages 5493-5506 (2012)

Biran A and Meshorer E

Chromatin and Genome Organization in Reprogramming

Stem Cells, Volume 30, Issue 9, Pages 1793-1799 (2012)

Hezroni H, Sailaja BS and Meshorer E

Pluripotency-related, Valproic Acid (VPA)-induced Genome-wide Histone H3 Lysine 9 (H3K9) Acetylation Patterns in Embryonic Stem Cells

The Journal of Biological Chemistry, 286, 35977-35988 (2011)

Nissim-Rafinia M and Meshorer E

Photobleaching Assays (FRAP & FLIP) to Measure Chromatin Protein Dynamics in Living Embryonic Stem Cells

J. Vis. Exp. (52), e2696 (2011)

Gaspar-Maia A, Alajem A, Meshorer E and Ramalho-Santos M

Open chromatin in pluripotency and reprogramming

Nature Reviews Molecular Cell Biology, volume 12, pages 36–47 (2011)

Hezroni H, Tzchori I, Davidi A, Mattout A, Biran A, Nissim-Rafinia M, Westphal H and Meshorer E

H3K9 histone acetylation predicts pluripotency and reprogramming capacity of ES cells

Nucleus, Volume 2, Issue 4, Pages 300-309 (2011)

Mattout A, Biran A and Meshorer E

Global epigenetic changes during somatic cell reprogramming to iPS cell

Journal of Molecular Cell Biology, Volume 3, Issue 6, Pages 341–350 (2011)

Mattout, A and Meshorer E

Chromatin plasticity and genome organization in pluripotent embryonic stem cells

Current Opinion in Cell Biology, Volume 22, Issue 3, Pages 334-341 (2010)

Prokocimer M, Davidovich M, Nissim-Rafinia M, Wiesel-Motiuk N, Bar D, Barkan R, Meshorer E and Gruenbaum Y

Nuclear lamins: key regulators of nuclear structure and activities

Journal of Cellular and Molecular Medicine, Volume 13, Issue 6, Pages 1059-1085 (2009)

Efroni, S, Melcer S, Nissim-Rafinia M and Meshorer E

Stem cells do play with dice: A statistical physics view of transcription

Cell Cycle, Volume 8, Issue 1, Pages 43-48 (2009)

Raghu Ram EVS and Meshorer E

Transcriptional competence in pluripotency

Genes & Dev. 23: 2793-2798 (2009)

Schwartz S, Meshorer E and Ast G

Chromatin organization marks exon-intron structure

Nature Structural & Molecular Biology volume 16, pages 990–995 (2009)

Gaspar-Maia A, Alajem A, Polesso F, Sridharan R, Mason MJ, Heidersbach A, Ramalho-Santos J, McManus MT, Plath K, Meshorer E, Ramalho-Santos M

Chd1 regulates open chromatin and pluripotency of embryonic stem cells

Nature, volume 460, pages 863–868 (2009)

Meshorer E and Gruenbaum Y

Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging

Journal of Cell Biology, vol. 181 no. 1 9-13 (2008)

Meshorer E

Imaging chromatin in embryonic stem cells

StemBook (2008)

Efroni S, Duttagupta R, Cheng J, Dehghani H, Hoeppner DJ, Dash C, Bazett-Jones DP, Le Grice S, McKay RDG, Buetow KH, Gingeras TR, Misteli T, Meshorer E

Global Transcription in Pluripotent Embryonic Stem Cells

Cell Stem Cell, Volume 2, Issue 5, Pages 437-447 (2008)

Takizawa T and Meshorer E

Chromatin and nuclear architecture in the nervous system

Trends in Neurosciences, Volume 31, Issue 7, Pages 343-352 (2008)

Meshorer E

Chromatin in embryonic stem cell neuronal differentiation

Histology and Histopathology, 22, 311-319 (2007)

Meshorer E and Soreq H

Virtues and woes of AChE alternative splicing in stress-related neuropathologies

Trends in Neurosciences,Volume 29, Issue 4, Pages 216-224 (2006)

Meshorer E, Yellajoshula D, George E, Scambler PJ, Brown D and Misteli T

Hyperdynamic Plasticity of Chromatin Proteins in Pluripotent Embryonic Stem Cells

Developmental Cell, Volume 10, Issue 1, Pages 105-116 (2006)

Meshorer E, Bryk B, Toiber D, Cohen J, Podoly E, Dori A and Soreq H

SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA

Molecular Psychiatry, 10, 985–997 (2005)

Salmon A1, Erb C, Meshorer E, Ginzberg D, Adani Y, Rabinovitz I, Amitai G, Soreq H.

Muscarinic modulations of neuronal anticholinesterase responses

Chem Biol Interact. 2005 Dec 15;157-158:105-13. Epub 2005 Nov 11. (2005)

Meshorer E, Biton I, Ben-Shaul Y, Assaf Y, Soreq H and Cohen Y

Chronic cholinergic imbalances promote brain diffusion and transport abnormalities

The FASEB Journal, Vol. 19, No. 8 (2005)

Meshorer E, Toiber D, Zurel D, Sahly I, Dori A, Cagnano E, Schreiber L, Grisaru D, Tronche F and Soreq H

Combinatorial Complexity of 5′ Alternative Acetylcholinesterase Transcripts and Protein Products

The Journal of Biological Chemistry, 279, 29740-29751 (2004)

Meshorer E and Soreq H

Pre‐mRNA splicing modulations in senescence

Aging Cell, Volume 1, Issue 1, Pages 10-16 (2002)

Stoilov P, Meshorer E, Gencheva M, Glick D, Soreq H and Stamm S

Defects in Pre-mRNA Processing as Causes of and Predisposition to Diseases

DNA and Cell Biology, Vol. 21, No. 11 (2002)

Meshorer E, Erb C, Gazit R, Pavlovsky L, Kaufer D, Friedman A, Glick D, Ben-Arie N and Soreq H

Alternative Splicing and Neuritic mRNA Translocation Under Long-Term Neuronal Hypersensitivity

Science, Vol. 295, Issue 5554, pp. 508-512 (2002)

Sigalevich P, Meshorer E, Helman Y and Cohen Y

Transition from Anaerobic to Aerobic Growth Conditions for the Sulfate-Reducing Bacterium Desulfovibrio oxyclinae Results in Flocculation

Appl. Environ. Microbiol. 66:5005-5012 (2000)

Lev-Lehman E, Evron T, Broide RS, Meshorer E, Ariel I, Seidman S and Soreq H

Synaptogenesis and myopathy under acetylcholinesterase overexpression

Journal of Molecular Neuroscience, Volume 14, Issue 1–2, pp 93–105 (2000)

At this time there are no available positions in the lab.
Honors:
2019 ‘Breakthrough of the Year’ Award by Science for Gokhman et al. Cell, 2019

2018 Coordinator, Marie Curie ITN Project award (‘EpiSyStem’)

2016 Gold Medal Award from the 1st Faculty of Medicine, Charles University, Prague, Czech Republic

2016 Named the Arthur Gutterman Chair for Stem Cell Research

2015 Vigevani Research Prize, Israel-Italy (with Prof. Giuseppe Testa, Milano)

2013 Zelman Cowen Award for Biomedical Research, Hebrew University and University of Sydney

2012 Hestrin Prize for an outstanding young researcher, Israel Society for Biochemistry and Molecular Biology

2012 Klachky Prize for the advancement of science, Hebrew University

Website:
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Eran Meshorer

Professor

Email: eran.meshorer@mail.huji.ac.il
Phone: +972-2-6585161
Eran Meshorer CV
Eran Meshorer
@meshorer1
Address: Department of Genetics, The Institute of Life Sciences, Silberman Building, Room 2-541. The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram. Yael Riback, Lab administrator, 02-6585144
http://meshorerlab.huji.ac.il/

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פיתוח ועיצוב אתר: סטודיו שדה

לחצו למעבר להרשמה

“Working memory”

New exhibition titled “Working memory” by the artist Alon kedem and in collaboration with ELSC Prof. Leon Deouell. In the picture: Moshe Lion, the mayor of Jerusalem and Prof. Asher Cohen, the president of The Hebrew University of Jerusalem.