Chaya Kalcheim Lab

ELSC Members

Siegfried and Alice Menkes Chair in Cancer Research and Experimental Medicine
Developmental Neurobiology lab

Our laboratory aims at elucidating basic processes that concern the embryonic development of the nervous system. We focus on three main subjects: first, the development of the peripheral nervous system (PNS) from the neural crest. Second, the cellular and molecular basis underlying the transition from the neural crest state (PNS) to the definitive roof plate of the CNS. Third, the molecular signals that mediate interactions between mesoderm and nervous system, found to be of significance for neural patterning and differentiation.

Our lab has a rich academic record in avian embryology and molecular techniques that include in ovo microsurgery and grafting, targeted gene missexpression in embryos, in vitro explants and culture systems, sophisticated imaging and RNAseq techniques. We collaborated in the past with experts in mouse transgenesis that complement our expertise, and currently hold an active interaction with the team of Dr Quenten Schwarz in Adelaide, Australia.

Chaya Kalcheim

Professor

Phone: +972-2-6758438
Fax: +972-2-6757441
Address: Dept. of Medical Neurobiology. IMRIC and ELSC - Faculty of Medicine,
4th floor, room 28, Ein Karem Campus,
The Hebrew University of Jerusalem
Siegfried and Alice Menkes Chair in Cancer Research and Experimental Medicine
Developmental Neurobiology lab

Our laboratory aims at elucidating basic processes that concern the embryonic development of the nervous system. We focus on three main subjects: first, the development of the peripheral nervous system (PNS) from the neural crest. Second, the cellular and molecular basis underlying the transition from the neural crest state (PNS) to the definitive roof plate of the CNS. Third, the molecular signals that mediate interactions between mesoderm and nervous system, found to be of significance for neural patterning and differentiation.

Our lab has a rich academic record in avian embryology and molecular techniques that include in ovo microsurgery and grafting, targeted gene missexpression in embryos, in vitro explants and culture systems, sophisticated imaging and RNAseq techniques. We collaborated in the past with experts in mouse transgenesis that complement our expertise, and currently hold an active interaction with the team of Dr Quenten Schwarz in Adelaide, Australia.

ELSC-Seminars-General
Natali Cohen
Undergraduate Student
ELSC-Seminars-General
Yoni Arndt
Undergraduate Student
ELSC-Seminars-General
Sari Kagan
Researcher
Nitza_Kahane
Nitza Kahane
Scientist
Dina_Rekler
Dina Rekler
PhD student
Shai_Ofek
Shai Ofek
PhD student
ELSC-Seminars-General
Olena Landa
Undergraduate student
Ofek, S, Wiszniak, S, Kagan, S, Tondl, M, Schwarz, Q, and Kalcheim, C

BMC Biol 19, 84 (2021)

Rekler D, Kalcheim C

International Journal of Molecular Sciences. 2021; 22(8):3911 (2021)

Yang, J, Antin, P, Berx, B, Blanpain, C, Brabletz, T, Bronner, M, Campbell, K, Cano, A, Casanova, J, Christofori, G, Dedhar, S, Derynck, R, Ford, H,L, Fuxe, J, de Herreros, AG, Goodall, G.J, HadjantonakisA-K, Huang, R.J.Y, Kalcheim, C, Kalluri, R, Kang, Y, Goodall, Y.K, Levine, H, Liu, J, Longmore, G.D, Mani, S.A, Massagué, J, Mayor, R, McClay, D, Mostov, K.E, Newgreen, D.F, Nieto, M.A, Puisieux, A, Runyan, R, Savagner, P, Stanger, B, Stemmler, M.P, Takahashi, Y, Takeichi, M, Thiery, J.P, Thompson, E.W, Weinberg, R.A , Elizaeth Williams, E, Xing, J, Zhou, B.P, Sheng, G.

Nature Reviews Molecular Cell Biology (2020)

Yang, J., Antin, P., Berx, G. et al.

Nat Rev Mol Cell Biol 21, 341–352 (2020)

Kalcheim, C

Encyclopedia of Life Sciences eLS (2019)

Kalcheim C

Neural Crest Cells. Methods in Molecular Biology, vol 1976. Humana Press, New York, NY (2019)

Kalcheim, C.

eLS, John Wiley & Sons, Ltd (Ed.) (2019)

Deepak Kumar, Erez Nitzan and Chaya Kalcheim

Cell Communication and Signaling, 17:69 (2019)

Kalcheim, C

Genesis (2018)

Kalcheim, C. and Kumar, D

The International Journal of Developmental Biology, 61: 195 – 203 (2017)

Nitzan, E; Avraham, O., Kahane, N., Ofek, S., Kumar, D., and Kalcheim, C

BMC Biology, 14:23 (2016)

Kalcheim, C

Journal of Clinical Medicine, Volume 5, Issue 1 (2016)

Carmel MS, Kahane N, Oberman F, Miloslavski R, Sela-Donenfeld D, Kalcheim C, Yisraeli JK.

PLoS One. 2015 Aug 28;10(8):e0136408 (2015)

Applebaum M, Kalcheim C.

Results and problems in cell differentiation 56:77-98 (2015)

Kalcheim, C. and Rohrer, H

Science, 04 Jul 2014: Vol. 345, Issue 6192, pp. 32-33 (2014)

Applebaum, M, Ben-Yair, R., and Kalcheim, C

BMC Biology, 12: 53 (2014)

Nitzan E, Krispin S, Pfaltzgraff ER, Klar A, Labosky PA, Kalcheim C

Development, 140, 2269-79 (2013)

Nitzan, E., Pfaltzgraff, E.R., Labosky, P.R., and Kalcheim, C

PNAS July 30, 2013 110 (31), 12709-12714 (2013)

Shtukmaster, S., Schier. M., Huber, K., Krispin, S., Kalcheim, C and Unsicker K

Neural Development, 8:12 (2013)

We search for excellent PhD and post-doctoral fellows interested in Developmental aspects of the nervous system.
Honors:
2018 Career Award, Israeli Society for Developmental Biology.
2017- Prusiner-Abramsky prize in Neurosciences
2010-2013: FRIAS Fellow. Freiburg Institute for Advanced Studies and LifeNet

Website:
Lab Website

Chaya Kalcheim

Professor

Phone: +972-2-6758438
Fax: +972-2-6757441
Address: Dept. of Medical Neurobiology. IMRIC and ELSC - Faculty of Medicine,
4th floor, room 28, Ein Karem Campus,
The Hebrew University of Jerusalem

Winners announced for the ELSC photography competition