Our laboratory aims at elucidating basic processes that concern the embryonic development of the nervous system. We focus on three main subjects: first, the development of the peripheral nervous system (PNS) from the neural crest. Second, the cellular and molecular basis underlying the transition from the neural crest state (PNS) to the definitive roof plate of the CNS. Third, the molecular signals that mediate interactions between mesoderm and nervous system, found to be of significance for neural patterning and differentiation.
Our lab has a rich academic record in avian embryology and molecular techniques that include in ovo microsurgery and grafting, targeted gene missexpression in embryos, in vitro explants and culture systems, sophisticated imaging and RNAseq techniques. We collaborated in the past with experts in mouse transgenesis that complement our expertise, and currently hold an active interaction with the team of Dr Quenten Schwarz in Adelaide, Australia.