Chaya Kalcheim Lab

ELSC Members

Chaya Kalcheim


Phone: +972-2-6758438
Fax: +972-2-6757441
Address: Dept. of Medical Neurobiology. IMRIC and ELSC - Faculty of Medicine,
4th floor, room 28, Ein Karem Campus,
The Hebrew University of Jerusalem
Siegfried and Alice Menkes Chair in Cancer Research and Experimental Medicine
Developmental Neurobiology lab

Our laboratory aims at elucidating basic processes that concern the embryonic development of the nervous system. We focus on three main subjects: first, the development of the peripheral nervous system (PNS) from the neural crest. Second, the cellular and molecular basis underlying the transition from the neural crest state (PNS) to the definitive roof plate of the CNS. Third, the molecular signals that mediate interactions between mesoderm and nervous system, found to be of significance for neural patterning and differentiation.

Our lab has a rich academic record in avian embryology and molecular techniques that include in ovo microsurgery and grafting, targeted gene missexpression in embryos, in vitro explants and culture systems, sophisticated imaging and RNAseq techniques. We collaborated in the past with experts in mouse transgenesis that complement our expertise, and currently hold an active interaction with the team of Dr Quenten Schwarz in Adelaide, Australia.

Susanna Ventriglia
Susanna Ventriglia
MSc Student
Nitza Kahane
Dina Rekler
PhD student
Shai Ofek
PhD student
Olena Landa
Undergraduate student
Yoni Arndt
Undergraduate Student
Sari Kagan
Rekler D, Kalcheim C

International Journal of Molecular Sciences. 2021; 22(8):3911 (2021)

Ofek, S, Wiszniak, S, Kagan, S, Tondl, M, Schwarz, Q, and Kalcheim, C

BMC Biol 19, 84 (2021)

Yang, J., Antin, P., Berx, G. et al.

Nat Rev Mol Cell Biol 21, 341–352 (2020)

Yang, J, Antin, P, Berx, B, Blanpain, C, Brabletz, T, Bronner, M, Campbell, K, Cano, A, Casanova, J, Christofori, G, Dedhar, S, Derynck, R, Ford, H,L, Fuxe, J, de Herreros, AG, Goodall, G.J, HadjantonakisA-K, Huang, R.J.Y, Kalcheim, C, Kalluri, R, Kang, Y, Goodall, Y.K, Levine, H, Liu, J, Longmore, G.D, Mani, S.A, Massagué, J, Mayor, R, McClay, D, Mostov, K.E, Newgreen, D.F, Nieto, M.A, Puisieux, A, Runyan, R, Savagner, P, Stanger, B, Stemmler, M.P, Takahashi, Y, Takeichi, M, Thiery, J.P, Thompson, E.W, Weinberg, R.A , Elizaeth Williams, E, Xing, J, Zhou, B.P, Sheng, G.

Nature Reviews Molecular Cell Biology (2020)

Deepak Kumar, Erez Nitzan and Chaya Kalcheim

Cell Communication and Signaling, 17:69 (2019)

Kalcheim, C.

eLS, John Wiley & Sons, Ltd (Ed.) (2019)

Kalcheim C

Neural Crest Cells. Methods in Molecular Biology, vol 1976. Humana Press, New York, NY (2019)

Kalcheim, C

Encyclopedia of Life Sciences eLS (2019)

Kalcheim, C

Genesis (2018)

Kalcheim, C. and Kumar, D

The International Journal of Developmental Biology, 61: 195 – 203 (2017)

Kalcheim, C

Journal of Clinical Medicine, Volume 5, Issue 1 (2016)

Nitzan, E; Avraham, O., Kahane, N., Ofek, S., Kumar, D., and Kalcheim, C

BMC Biology, 14:23 (2016)

Applebaum M, Kalcheim C.

Results and problems in cell differentiation 56:77-98 (2015)

Carmel MS, Kahane N, Oberman F, Miloslavski R, Sela-Donenfeld D, Kalcheim C, Yisraeli JK.

PLoS One. 2015 Aug 28;10(8):e0136408 (2015)

Applebaum, M, Ben-Yair, R., and Kalcheim, C

BMC Biology, 12: 53 (2014)

Kalcheim, C. and Rohrer, H

Science, 04 Jul 2014: Vol. 345, Issue 6192, pp. 32-33 (2014)

Shtukmaster, S., Schier. M., Huber, K., Krispin, S., Kalcheim, C and Unsicker K

Neural Development, 8:12 (2013)

Nitzan, E., Pfaltzgraff, E.R., Labosky, P.R., and Kalcheim, C

PNAS July 30, 2013 110 (31), 12709-12714 (2013)

Nitzan E, Krispin S, Pfaltzgraff ER, Klar A, Labosky PA, Kalcheim C

Development, 140, 2269-79 (2013)

We search for excellent PhD and post-doctoral fellows interested in Developmental aspects of the nervous system.
2018 Career Award, Israeli Society for Developmental Biology.
2017- Prusiner-Abramsky prize in Neurosciences
2010-2013: FRIAS Fellow. Freiburg Institute for Advanced Studies and LifeNet

Lab Website

Chaya Kalcheim


Phone: +972-2-6758438
Fax: +972-2-6757441
Address: Dept. of Medical Neurobiology. IMRIC and ELSC - Faculty of Medicine,
4th floor, room 28, Ein Karem Campus,
The Hebrew University of Jerusalem

“Working memory”