My investigations have created a new field of research. I co-discovered a new type of ion channel, which I designated the Transient Receptor Potential or in short the TRP channel, as a result of my studies on phototransduction and vision in fruit flies (Drosophila melanogaster). I investigated the biophysical and biochemical properties of TRP channels in fruit fly eyes and identified together with the late Prof. Zvi Selinger phospholipase C as a crucial component of the Drosophila TRP signaling pathway. The principles that we found are common to numerous sensory (e.g. temperature, pain and taste sensations) and motor systems (properties of Purkinje neurons in the cerebellum), thus laying the foundation for the study of molecules that underlie mechanisms of TRP and pain, originally initiated by Prof. David Julius. Today we have extended our research to the first identified loss of function mutation in human TRPV1 channel that govern at least several of the human body’s regulatory processes related inflammatory pain and to noxious heat detection. Our major aim is to decipher the critical roles of TRP channels in invertebrate vision and of TRPV1 in human somatosensory physiology.
Baruch Minke Lab
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Frontiers in Molecular Neuroscience (2021)
Channels, Volume 13, Issue 1, Pages 136-146 (2019)
Frontiers in Pharmacology 10, 1487 (2019)
Oxford University New York, NY 10016, Oxford Handbooks Online (In Press) (2019)
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Current Topics in Membranes, 80:233-254. (2017)
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Channels (Austin), 11(6):678-685. (2017)
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Neurobiology of TRP Channels, T. Rosenbaum, Editor, CRC Press/Taylor and Francis Group (2017)
Channels, Volume 9, Issue 1, pages 14-20 (2015)
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Channels, Volume 6, Issue 2 (2012)
Journal of Neurogenetics, Volume 26, Issue 2 (2012)
The Journal of Biological Chemistry, 286, 34234-34243 (2011)
The International Journal of Biochemistry & Cell Biology, Volume 42, Issue 9, Pages 1430-1445 (2010)
The Journal of Biological Chemistry, 285, 2771-2782 (2010)
Methods in Enzymology, Volume 484, Pages 591-612 (2010)
J Cell Sci, 123: 3112-3124 (2010)
Journal of Neurogenetics, Volume 24, Issue 4 (2010)
Cell Calcium, Volume 45, Issue 3, Pages 300-309 (2009)
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Channels (Austin), 3(3):164-6 (2009)
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The Journal of General Physiology, 129 (1) 17-28 (2007)
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The EMBO Journal, 22, 459-468 (2003)
Cell Calcium, Volume 33, Issues 5–6, Pages 395-408 (2003)
Neuron, Volume 34, Issue 1, Pages 83-93 (2002)
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The TRP Channel and Phospholipase C-Mediated Signaling
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Journal of Neuroscience, 20 (15) 5748-5755 (2000)
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Signal Transduction in Photoreceptor Cells pp 281-298 (1992)
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Inositol Lipid Cascade of Vision Studied in Mutant Flies
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Vision Research, Volume 26, Issue 5, Pages 679-690 (1986)
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PNAS, 82 (20) 7116-7120 (1985)
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EMET Prize
Prince of Asturias Award (from the current King of Spain)
Baruch Minke
Professor Emeritus
Hadassah Ein-Kerem Campus, The Hebrew University of Jerusalem
bioRxiv (2025)
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Journal of Neuroscience. (2022)
iScience, in press (2023)
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The Journal of Neuroscience (2020)
BMC Biology (2023)
Current Biology (2023)
bioRxiv (2020)
Current Biology (2018)
Current Opinion in Neurobiology (2014)
J Neurosci. (2013)
PLOS Computational Biology, e1010398 (2022)
Journal of Computational Neuroscience volume 50, pages139–143 (2022)
IEEE/ACM Transactions on Audio, Speech, and Language Processing, 29, 2037-2047 (2021)
PLOS Computational Biology 16(12): e1008497 (2020)
Cell Reports 27 (5), 1319-1326. e5 (2019)
Frontiers in neuroscience 14, 926 (2020)
Nature Communications 11 (1), 1-14 (2020)
Current Opinion in Physiology 18, 37-41 (2020)
Oxford Research Encyclopedia of Neuroscience (2017)
Cerebral Cortex 27 (11), 5130-5143 (2016)
Neuron 102 (2), 280-293 (2019)
Artificial Intelligence and Statistics (2013)
Cerebral Cortex 32 (1), 158-175 (2022)
Nat Neurosci. 2010 Mar;13(3):353-60. (2010)
Progress in Neurobiology, Volume 202, 102049, ISSN 0301-0082 (2021)
Cerebral Cortex Volume 30, Issue 8, August 2020, Pages 4465–4480 (2020)
Journal of Cognitive Neuroscience Early Access p.1-17 (2019)
Nat Neurosci (2019)
Journal of Neuroscience Methods Volume 309, Pages 60-70 (2018)
Data Brief. 21:1451-1457 (2018)
Cerebral Cortex, Volume 28, Issue 5, Pages 1645–1655 (2018)
PLoS One. 13(6):e0197678 (2018)
Proc Natl Acad Sci U S A. 114(32):8631-8636 (2017)
Cereb Cortex; 27(6):3254-3271 (2017)
PLoS Comput Biol. 3(3):e1005437 (2017)
Biological Psychology Volume 116, Pages 23-27 (2016)
Proc Natl Acad Sci U S A, 113(29): 8308–8313 (2016)
PLoS Comput Biol 12(8) e1005058 (2016)
PLoS One. 2015 Dec 15;10(12):e0144788. (2015)
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IOS Press (2006)
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Nat Neurosci. 2003 Apr;6(4):391-8. (2003)
1985 The A. Heller prize for excellence in Research Thesis
1991 Fullbright fellowship
1994 The Bergmann Memorial Research Grant (concurrently with BSF grant No. 93-00057)
1999 Research prize of the Faculty of Medicine, Hebrew University – Hadassah Medical School.
2000 Bernard Katz Lecturer for the year 2000
2008 Michael Bruno prize, administered by Yad-Hanadiv foundation
2015 Rector prize for excellence in research and teaching
2016 The Michael Landau prize for the Sciences and Research
2021 Humboldt research prize
Israel Nelken
Professor
The Suzanne and Charles Goodman Brain Sciences Building,
Level 2, Room 1207, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401