My investigations have created a new field of research. I co-discovered a new type of ion channel, which I designated the Transient Receptor Potential or in short the TRP channel, as a result of my studies on phototransduction and vision in fruit flies (Drosophila melanogaster). I investigated the biophysical and biochemical properties of TRP channels in fruit fly eyes and identified together with the late Prof. Zvi Selinger phospholipase C as a crucial component of the Drosophila TRP signaling pathway. The principles that we found are common to numerous sensory (e.g. temperature, pain and taste sensations) and motor systems (properties of Purkinje neurons in the cerebellum), thus laying the foundation for the study of molecules that underlie mechanisms of TRP and pain, originally initiated by Prof. David Julius. Today we have extended our research to the first identified loss of function mutation in human TRPV1 channel that govern at least several of the human body’s regulatory processes related inflammatory pain and to noxious heat detection. Our major aim is to decipher the critical roles of TRP channels in invertebrate vision and of TRPV1 in human somatosensory physiology.
Baruch Minke Lab
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Frontiers in Molecular Neuroscience (2021)
Channels, Volume 13, Issue 1, Pages 136-146 (2019)
Frontiers in Pharmacology 10, 1487 (2019)
Oxford University New York, NY 10016, Oxford Handbooks Online (In Press) (2019)
Progress in Retinal and Eye Research, Volume 66, Pages 200-219 (2018)
Current Topics in Membranes, 80:233-254. (2017)
Journal of Biological Chemistry, 292(9):3624-3636. (2017)
Journal of Visualized Experiments, (124). (2017)
Channels (Austin), 11(6):678-685. (2017)
Journal of Neuroscience, 37 (15) 4213-4224 (2017)
Neurobiology of TRP Channels, T. Rosenbaum, Editor, CRC Press/Taylor and Francis Group (2017)
Channels, Volume 9, Issue 1, pages 14-20 (2015)
J Neurosci. 2015 Feb 11;35(6):2530-46 (2015)
J Cell Sci. 2013 Jul 15;126(Pt 14):3121-33 (2013)
Journal of Neurotrauma, Vol. 29, No. 18 (2012)
J Neurosci. 2012 Oct 17;32(42):14696-708 (2012)
Journal of Neuroscience, 32 (8) 2722-2733 (2012)
The Journal of Biological Chemistry, 287, 1436-1447 (2012)
Channels, Volume 6, Issue 2 (2012)
Journal of Neurogenetics, Volume 26, Issue 2 (2012)
The Journal of Biological Chemistry, 286, 34234-34243 (2011)
The International Journal of Biochemistry & Cell Biology, Volume 42, Issue 9, Pages 1430-1445 (2010)
The Journal of Biological Chemistry, 285, 2771-2782 (2010)
Methods in Enzymology, Volume 484, Pages 591-612 (2010)
J Cell Sci, 123: 3112-3124 (2010)
Journal of Neurogenetics, Volume 24, Issue 4 (2010)
Cell Calcium, Volume 45, Issue 3, Pages 300-309 (2009)
Frontiers in Cellular Neuroscience (2009)
Channels (Austin), 3(3):164-6 (2009)
Journal of Neuroscience, 29 (8) 2371-2383 (2009)
The Journal of General Physiology, 129 (1) 17-28 (2007)
Journal of Neuroscience, 27 (21) 5571-5583 (2007)
Annual Review of Physiology, Volume 68, pp 649-684 (2006)
Journal of Physiology-Paris Volume 99, Issues 2–3, Pages 133-139 (2006)
Journal of Cell Science, 119: 2592-2603 (2006)
The Journal of Cell Biology, 171 (3) 517-526 (2005)
The Journal of Cell Biology, 171 (1) 143-152 (2005)
Cell Calcium, Volume 35, Issue 2, Pages 87-105 (2004)
Journal of Neuroscience, 24 (10) 2516-2526 (2004)
The EMBO Journal, 22, 459-468 (2003)
Cell Calcium, Volume 33, Issues 5–6, Pages 395-408 (2003)
Neuron, Volume 34, Issue 1, Pages 83-93 (2002)
Journal of Neuroscience, 21 (8) 2622-2629 (2001)
The TRP Channel and Phospholipase C-Mediated Signaling
Cellular and Molecular Neurobiology, Volume 21, Issue 6, pp 629–643 (2001)
Journal of Neuroscience, 20 (15) 5748-5755 (2000)
Journal of Neuroscience, 20 (2) 649-659 (2000)
Nature Cell Biology, volume 2, pages 296–301 (2000)
Cell Calcium, Volume 25, Issue 2, Pages 161-171 (1999)
Science, Vol. 275, Issue 5303, pp. 1119-1121 (1997)
PNAS, 94 (11) 5894-5899 (1997)
PNAS, 93 (24) 14146-14151 (1996)
Biophysical Journal, Volume 71, Issue 3, Pages 1616-1620 (1996)
Journal of Photochemistry and Photobiology B: Biology, Volume 35, Issues 1–2, Pages 77-82 (1996)
Molecular Neurobiology, Volume 12, Issue 2, pp 163–180 (1996)
Current Opinion in Neurobiology, Volume 6, Issue 4, Pages 459-466 (1996)
The EMBO Journal, Volume 14, Issue 18, Pages 4450-4459 (1995)
Cell Calcium Volume 18, Issue 4, Pages 256-274 (1995)
Journal of Neuroscience, 15 (5) 3747-3760 (1995)
Visual Neuroscience, Volume 11, pp. 763-772 (1994)
Journal of General Physiology, vol. 103 no. 3 409-427 (1994)
Journal of General Physiology, vol. 104 no. 6 1057-1077 (1994)
Is the receptor potential of fly photoreceptors a summation of single-photon responses?
Comments in Theoretical Biology. 3: 229-263 (1994)
Journal of General Physiology, vol. 103 no. 3 389-407 (1994)
Neuron, Volume 12, Issue 6, p1257-1267 (1994)
Proceedings of the Royal Society B, Volume 252, Issue 1335 (1993)
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1179, Issue 3, Pages 283-299 (1993)
Trends in Neurosciences, Volume 16, Issue 9,, Pages 371-376 (1993)
Nature, 363, 634–637 (1993)
PNAS, 90 (5) 1907-1911 (1993)
PNAS, 89 (1) 435-439 (1992)
Journal of Comparative Physiology A, Volume 170, Issue 4, pp 427–434 (1992)
European Journal of Biochemistry, Volume 209, Issue 3, Pages 1035-1040 (1992)
Intracellular Messengers pp 517-563 (1992)
The inositol-lipid pathway is necessary for light excitation in fly photoreceptors.
Soc Gen Physiol Ser. 47:201-17. (1992)
Signal Transduction in Photoreceptor Cells pp 281-298 (1992)
Journal of General Physiology, vol. 100 no. 5 767-781 (1992)
Neuron, Volume 8, Issue 4, Pages 643-651 (1992)
Progress in Retinal Research, Volume 11, Pages 99-124 (1991)
Journal of General Physiology, vol. 98 no. 4 849-868 (1991)
Journal of Neuroscience, 11 (4) 900-909 (1991)
PNAS, 87 (1) 113-117 (1990)
Journal of General Physiology, vol. 94 no. 3 465-491 (1989)
Visual Neuroscience, Volume 2, Issue 6, pp. 541-551 (1989)
Visual Neuroscience, Volume 2, Issue 6, pp. 529-539 (1989)
Inositol Lipid Cascade of Vision Studied in Mutant Flies
Cold Spring Harb Symp Quant Biol. 53: 333-341 (1988)
Journal of General Physiology, vol. 92 no. 3 307-330 (1988)
Bleaching adaptation in photoreceptors.
Isr J Med Sci. 23(1-2):61-8. (1987)
PNAS, 84 (19) 6939-6943 (1987)
Light-dependent phospholipase C activity in Musca eye membranes and excitation of photoreceptor cells by inositol triphosphate and 2,3 diphosphoglycerate.
Prog Clin Biol Res. 249:169-78. (1987)
Vision Research, Volume 26, Issue 5, Pages 679-690 (1986)
Dahlem Workshop Reports (Life Sciences Research Report), vol 34, pp 241-265 (1986)
Journal of General Physiology, vol. 87 no. 3 391-405 (1986)
Journal of General Physiology, vol. 87 no. 3 407-423 (1986)
PNAS, 82 (20) 7116-7120 (1985)
Journal of Comparative Physiology A, Volume 156, Issue 3, pp 339–356 (1985)
Vision Research, Volume 24, Issue 2, Pages 109-115 (1984)
Journal of Comparative Physiology A, Volume 154, Issue 2, pp 175–187 (1984)
EMET Prize
Prince of Asturias Award (from the current King of Spain)
Baruch Minke
Professor Emeritus
Hadassah Ein-Kerem Campus, The Hebrew University of Jerusalem
Commun Biol. (2020)
J Neurochem (2020)
PLoS Biology (2020)
PLoS Biology (2020)
Journal of Neuroscience, JN-RM-1470-21 (2021)
Neuron, ISSN 0896-6273 (2021)
bioRxiv preprint first posted online May. 31, 2019 (2019)
bioRxiv preprint first posted online Apr. 18, 2019; (2019)
Cell reports 23 (4), 1034-1044 (2018)
Cell, Volume 174, Issue 1, 28 June 2018, Pages 59-71 (2018)
Scientific Reports, volume 8, Article number: 4311 (2018)
Molecular autism 9 (1), 57 (2018)
Cytotherapy 20 (5), S23 (2018)
US Patent App. 15/755,138 (2018)
Behavioural Brain Research Volume 331, Pages 254-260 (2017)
Nature Neuroscience, VOLUME 20 | NUMBER 7 | JULY 2017 (2017)
Scientific Reports volume 6, Article number: 29080 (2016)
Frontiers in Behavioral Neuroscience, 10:236 (2016)
Nat Neurosci. 2002 Apr;5(4):332-40. (2002)
J Comput Neurosci. 2000 Sep-Oct;9(2):133-48. (2000)
Science. 2000 Oct 27;290(5492):744-50 (2000)
Journal of Neuroscience 1 October 1999, 19 (19) 8219-8233 (1999)
Michael London
Associate Professor
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 2103, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401