Aviv Mezer Lab

ELSC Members

Human Brain Biophysics lab
The Belgian Friends Laboratory for the study of Neurodegenerative Diseases

Research in the lab is focused on in-vivo mapping of human brain structures. We are investigating the relationship between structure, function. Our main research tool is in in-vivo quantitative magnetic resonance imaging – qMRI. We are developing tools to biophysically explain the brain’s MRI signals at different levels and resolutions: from molecular local sources through the cellular organization to the mapping of networks across the entire brain. Using these tools, we are studying brain normal development and aging, as well as characterizing neurological disorders. Our research group’s ultimate goal is to develop an understanding of how individual-specific biological structures influence human cognition, under both normal and pathological conditions.

Envelope Phone-alt

Aviv Mezer

Professor

Email: aviv.mezer@elsc.huji.ac.il
Phone: +972-2-6584617
@AvivMezer
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 2, Room 2202, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
Human Brain Biophysics lab
The Belgian Friends Laboratory for the study of Neurodegenerative Diseases

Research in the lab is focused on in-vivo mapping of human brain structures. We are investigating the relationship between structure, function. Our main research tool is in in-vivo quantitative magnetic resonance imaging – qMRI. We are developing tools to biophysically explain the brain’s MRI signals at different levels and resolutions: from molecular local sources through the cellular organization to the mapping of networks across the entire brain. Using these tools, we are studying brain normal development and aging, as well as characterizing neurological disorders. Our research group’s ultimate goal is to develop an understanding of how individual-specific biological structures influence human cognition, under both normal and pathological conditions.

Lee_Cohen
Lee Cohen
Lab Manager
Rona_ELSC
Dr. Rona Shaharabani
Researcher
Noam 2019
Dr. Noam Saadon-Grosman
Post Doc
ELIOR DRORI
Elior Drori
PhD Student
7d70ed06-2ed6-427d-bd6d-487c45f3fdd2
Oshrat Shtangel
PhD Student
Shachar_Moskovich
Shachar Moskovich
PhD Student
MARYANA
Maryana Pozina
PhD Student
david cohen
David Cohen
MSc Student
IMG-20241106-WA0358~2
Hagit Eliyahu
Undergraduate Student
IMG
Lior Shapira
Undergraduate Student
ELSC-Seminars-General
Inbar Elmaliach
Undergraduate Student
photo_Roey_schurr
Dr. Roey Schurr
ShirFilo
Dr. Shir Filo
Shai_Berman
Dr. Shai Berman
picture1
Dr. Jonathan Bain
asier
Dr. Asier Erramuzpe
ELSC-Seminars-General
Gai Gefen
Amitay_Nachmani
Amitay Nachmani
ניב עמוס
Niv Amos
eden mama
Eden Mama
ELSC-Seminars-General
Batsheva Weisinger
S Moskovich, O Shtangel, AA Mezer

Approximating R1 and R2: a quantitative approach to clinical weighted MRI

Human Brain Mapping (2024)

H Neeb, F Schyboll, R Shaharabani, AA Mezer, O Shtange

A theoretical framework for the assessment of water fraction-dependent longitudinal decay rates and magnetisation transfer in membrane lipid phantoms

arXiv preprint arXiv:2408.17085 (2024)

F Shir, L Cohen, G Yahalom, AA Mezer

A qMRI approach for mapping microscopic water populations and tissue relaxivity in the in vivo human brain

bioRxiv, 2024.08. 09.606771 (2024)

A Mezer, F Shir

Mri based system and method for detecting iron-related entities in a region of interest

US Patent App. 18/286,618 (2024)

O Shtangel, AA Mezer

Testing quantitative magnetization transfer models with membrane lipids

Magnetic Resonance in Medicine (2024)

D Radunsky, C Solomon, N Stern, T Blumenfeld-Katzir, S Filo, A Mezer, …

A comprehensive protocol for quantitative magnetic resonance imaging of the brain at 3 Tesla

Plos one 19 (5), e0297244 (2024)

E Drori, L Cohen, D Arkadir, AA Mezer, G Yahalom

Multiparametric quantitative MRI uncovers putamen microstructural changes in Parkinson’s Disease

bioRxiv, 2024.05. 26.595926 (2024)

A Mezer, E Drori

System and method for using medical imaging devices to perform non-invasive diagnosis of a subject

US Patent App. 18/011,893 (2023)

S Filo, R Shaharabani, D Bar Hanin, M Adam, E Ben-David, H Schoffman, …

Non-invasive assessment of normal and impaired iron homeostasis in the brain

Nature Communications 14 (1), 5467 (2023)

Shai Berman, Elior Drori, Aviv A. Mezer

Spatial profiles provide sensitive MRI measures of the midbrain micro- and macrostructure

NeuroImage, Volume 264, 119660, ISSN 1053-8119 (2022)

Edith Brignoni-Pérez, Sarah E. Dubner, Michal Ben-Shachar, Shai Berman, Aviv A. Mezer, Heidi M. Feldman, Katherine E. Travis

White matter properties underlying reading abilities differ in 8-year-old children born full term and preterm: A multi-modal approach

NeuroImage, Volume 256, 2022, 119240, ISSN 1053-8119 (2022)

Elior Drori, Shai Berman, Aviv A. Mezer

Mapping microstructural gradients of the human striatum in normal aging and Parkinson’s disease

SCIENCE ADVANCES, Vol 8, Issue 28 (2022)

Shir Filo, Rona Shaharabani, Daniel Bar Hanin, Masha Adam, Eliel Ben-David, Hanan Schoffman, Nevo Margalit, Naomi Habib, Tal Shahar, Aviv Mezer

Uncovering molecular iron compounds in the living human brain

bioRxiv 2022.05.02.490254 (2022)

Roey Schurr, Aviv A. Mezer

The glial framework reveals white-matter fiber architecture in human and primate brains

Science  (2021)

Elizabeth Huber, Aviv Mezer, Jason D. Yeatman

Neurobiological underpinnings of rapid white matter plasticity during intensive reading instruction

NeuroImage 243, 118453 (2021)

Vaidehi S. Natu, Mona Rosenke, Hua Wu, Francesca R. Querdasi, Holly Kular, Nancy Lopez-Alvarez, Mareike Grotheer, Shai Berman, Aviv A. Mezer & Kalanit Grill-Spector

Infants’ cortex undergoes microstructural growth coupled with myelination during development

Communications Biology 4, 1191 (2021)

A Erramuzpe, R Schurr, J D Yeatman, I H Gotlib, M D Sacchet, K E Travis, H M Feldman, A A Mezer

A Comparison of Quantitative R1 and Cortical Thickness in Identifying Age, Lifespan Dynamics, and Disease States of the Human Cortex

Cerebral Cortex, Volume 31, Issue 2, February, Pages 1211–1226 (2021)

SE Dubner, M Ben-Shachar, A Mezer, HM Feldman, KE Travis

Associations of reading skills and properties of cerebral white matter pathways in 8-year-old children born preterm

medRxiv (2020)

Bruckert, L., Travis, K.E., Mezer, A.A. et al.

Associations of Reading Efficiency with White Matter Properties of the Cerebellar Peduncles in Children

Cerebellum (2020)

Shai Berman, Yael Backner, Ronnie Krupnik, Friedemann Paul, Panayiota Petrou, Dimitrios Karussis, Netta Levin, Aviv A. Mezer

Conduction Delays in the Visual Pathways of Progressive Multiple Sclerosis Patients Covary with Brain Structure

NeuroImage 117204, ISSN 1053-8119 (2020)

Shtangel O, Mezer AA

A phantom system for assessing the effects of membrane lipids on water proton relaxation

NMR in Biomedicine e4209 (2020)

Schurr R, Zelman A, Mezer AA

Subdividing the superior longitudinal fasciculus using local quantitative MRI

NeuroImage Volume 208, 116439 (2020)

Shai Berman, Roey Schurr, Gal Atlan, Ami Citri, Aviv A Mezer

Automatic segmentation of the dorsal claustrum in humans using in vivo high-resolution MRI

Cerebral Cortex Communications tgaa062 (2020)

Bain JS, Filo S, Mezer AA

The robust and independent nature of structural STS asymmetries

Brain Structure and Function, pp 1-12 (2019)

Amitay Nachmani, Roey Schurr, Leo Joskowicz, Aviv A Mezer

The effect of motion correction interpolation on quantitative T1 mapping with MRI

Medical image analysis (2019)

Schurr R, Filo S, Mezer AA

Tractography delineation of the vertical occipital fasciculus using quantitative T1 mapping

NeuroImage (2019)

Bain JS, Yeatman JD, Schurr R, Rokem A, Mezer AA

Evaluating arcuate fasciculus laterality measurements across dataset and tractography pipelines

Human Brain Mapping (2019)

Filo S, Shtangel O, Salamon N, Kol A, Weisinger B, Shifman S, Mezer AA

Disentangling molecular alterations from water-content changes in the aging human brain using quantitative MRI

Nature Communications (2019)

S. Berman, S. Filo, AA Mezer

Modeling conduction delays in the corpus callosum using MRI-measured g-ratio

NeuroImage (2019)

Hiromasa Takemura, Shumpei Ogawa, Aviv A. Mezer, Hiroshi Horiguchi, Atsushi Miyazaki, Kenji Matsumoto, Keigo Shikishima, Tadashi Nakano, Yoichiro Masuda

Diffusivity and quantitative T1 profile of human visual white matter tracts after retinal ganglion cell damage

NeuroImage: Clinical (2019)

Travis KE, Castro MRH, Berman S, Dodson CK, Mezer AA, Ben-Shachar M, Feldman HM.

More than myelin: Probing white matter differences in prematurity with quantitative T1 and diffusion MRI

Neuroimage Clin. 2019 Mar 12;22:101756 (2019)

Berman, S, West KL, Does MD, Yeatman JD, Mezer AA.

Evaluating g-ratio weighted changes in the corpus callosum as a function of age and sex.

NeuroImage 182, 304-313 (2018)

Schurr, R, Duan Y, Norcia AM, Ogawa S, Yeatman JD, Mezer AA.

Tractography optimization using quantitative t1 mapping in the human optic radiation

NeuroImage (2018)

Shtangel, O., & Mezer, A. A.

A Phantom System Designed to Assess the Effects of Membrane Lipids on Water Proton Relaxation

bioRxiv (2018)

Mezer AA., Filo S.

PD: Proton Density of Tissue Water

Quantitative MRI of the Brain, 55-72 (2018)

Lévy, S., Guertin, M. C., Khatibi, A., Mezer, A., Martinu, K., Chen, J. I., … & Cohen-Adad, J.

Test-retest reliability of myelin imaging in the human spinal cord: Measurement errors versus region-and aging-induced variations

PloS one (2018)

Duval, T, Lévy S, Stikov N, Campbell J, Mezer A, Witzel T, Keil B, Smith V, Wald LL, Klawiter E, Cohen-Adad J.

g-Ratio weighted imaging of the human spinal cord in vivo.

NeuroImage (2017)

Gomez, J, Barnett MA, Natu V, Mezer A, Palomero-Gallagher N, Weiner KS, Amunts K, Zilles K, Grill-Spector K.

Microstructural proliferation in human cortex is coupled with the development of face processing

Science (2017)

Mezer, A, Rokem A, Berman S, Hastie T, Wandell BA.

Evaluating quantitative proton-density-mapping methods

Hum Brain Mapp (2016)

Travis KE, Golden NH, Feldman HM, Solomon M, Nguyen J, Mezer A, Yeatman JD, Dougherty RF.

Abnormal white matter properties in adolescent girls with anorexia nervosa

Neuroimage Clin. 2015 Oct 23;9:648-59 (2015)

Duan Y, Norcia AM, Yeatman JD, Mezer A.

The Structural Properties of Major White Matter Tracts in Strabismic Amblyopia

Invest Ophthalmol Vis Sci. (2015)

Rokem A, Yeatman JD, Pestilli F, Kay KN, Mezer A, van der Walt S, Wandell BA.

Evaluating the accuracy of diffusion MRI models in white matter

PLoS One. 2015 Apr 16;10(4):e0123272 (2015)

Our Lab is now recruiting students and postdocs interested in human brain imaging. Background in MR, biophysics, computer-science, engineering or other related fields can be advantageous.

We are also looking for post-docs or researchers (full/part time) with background in MR-physics.

Please send CV, a short research interests statement, and names of potential references to: aviv.mezer@elsc.huji.ac.il
Lab software:
https://github.com/mezera/mrQ

https://github.com/MezerLab

Media:
In the news: (English)
https://www.usnews.com/news/healthcare-of-tomorrow/articles/2020-01-14/commentary-a-better-mri-test-to-study-aging-in-the-brain.

In the news: (Hebrew):
https://www.haaretz.co.il/science/.premium-1.7606717

TV: (French)
https://www.youtube.com/watch?v=Nj5clh3u-hs&app=desktop&ab_channel=i24NEWSFran%C3%A7ais

Gallery:












Envelope Phone-alt

Aviv Mezer

Professor

Email: aviv.mezer@elsc.huji.ac.il
Phone: +972-2-6584617
@AvivMezer
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 2, Room 2202, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401

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