Ami Citri Lab

ELSC Members

Citri lab for Experience-Dependent Plasticity

Life is a steady stream of experiences, from the smallest events perceived by the senses to life-changing dramatic events. Our brain serves to select the relevant sensory information, and encode salient experiences to long-term memory, modifying our behavior in the future.

In the Citri Lab, we have two major research foci: 1) How a small & mysterious region called the claustrum supports the selection of relevant sensory information AND 2) How, subsequent to the selection of relevant sensory information, the brain encodes experiences, forming the basis of habits, compulsions and drug addiction. To this end we implement a variety of tools, studying these mechanisms at the molecular, synaptic, circuit and behavioral levels. 

Envelope Phone-alt

Ami Citri

Associate Professor

Email: ami.citri@mail.huji.ac.il
Phone: +972-2-6584978
Ami Citri
@CitriAmi
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 1106, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
https://www.citrilab.com
Citri lab for Experience-Dependent Plasticity

Life is a steady stream of experiences, from the smallest events perceived by the senses to life-changing dramatic events. Our brain serves to select the relevant sensory information, and encode salient experiences to long-term memory, modifying our behavior in the future.

In the Citri Lab, we have two major research foci: 1) How a small & mysterious region called the claustrum supports the selection of relevant sensory information AND 2) How, subsequent to the selection of relevant sensory information, the brain encodes experiences, forming the basis of habits, compulsions and drug addiction. To this end we implement a variety of tools, studying these mechanisms at the molecular, synaptic, circuit and behavioral levels. 

IMG_1378_crop
David Lipton
Post Doc
Itai_passport_photo
Itay Shalom
Undergraduate Student
imgelsc_website
Daniel Nudelman
Undergraduate Student
IMG_20190214_081545
Reut Fluss
Computational Biologist
0G6A5232
Hagit Turm PhD
Lab Manager
ELSC-Seminars-General
Tal Prinz
Lab Technician
Lior Ziv
Lior Ziv
MSc Student
Rivlin_Noa_photo2-pic
Noa Peretz-Rivlin
PhD Student
gal atlan
Gal Atlan
PhD Student
20190211_123758
Diptendu Mukherjee
PhD Student
Ben G
Ben Gonzales
PhD Student
Anna-Terem-2_Courtesy-Hebrew-University
Anna Terem (Nudler)
PhD Student
Efrat Sheinbach
Efrat Sheinbach
Ph.D. Student
Diptendu Mukherjee, Ben Jerry Gonzales, Reut Ashwal-Fluss, Hagit Turm, Maya Groysman, Ami Citri

Egr2 induction in spiny projection neurons of the ventrolateral striatum contributes to cocaine place preference in mice

eLife 2021;10:e65228 (2021)

Anna Terem, Ben Jerry Gonzales, Noa Peretz-Rivlin, Reut Ashwal-Fluss, Noa Bleistein, Maria del Mar Reus-Garcia, Diptendu Mukherjee, Maya Groysman, Ami Citri

Claustral Neurons Projecting to Frontal Cortex Mediate Contextual Association of Reward

Current Biology ISSN 0960-9822 (2020)

Lipton DM, Gonzales BJ, Citri A

Dorsal Striatal Circuits for Habits, Compulsions and Addictions

Frontiers in Systems Neuroscience 13:28 (2019)

Gonzales BJ, Mukherjee D, Ashwal-Fluss R, Loewenstein Y, Citri A

Subregion-specific rules govern the distribution of neuronal immediate-early gene induction

Proceedings of the National Academy of Sciences (2019)

David F. Clayton, Ina Anreiter, Maria Aristizabal, Paul W. Frankland, Elisabeth B. Binder, and Ami Citri

The role of the genome in experience-dependent plasticity: Extending the analogy of the genomic action potential

PNAS (2019)

Mukherjee D, Ignatowska-Jankowska BM, Itskovits E, Gonzales BJ, Turm H, Izakson L, Haritan D, Bleistein N, Cohen C, Amit I, Shay T, Grueter BA, Zaslaver A and Citri A

Salient Experiences are Represented by Unique Transcriptional Signatures in the Brain

eLife (2018)

Atlan G, Terem A, Peretz-Rivlin N, Sehrawat K, Gonzales BJ, Pozner G, Tasaka G-i, Goll Y, Refaeli R, Zviran O, Lim BK, Groysman M, Goshen I, Mizrahi A, Nelken I, Citri A,

The claustrum supports resilience to distraction

Current Biology, Volume 28, Issue 17, 10 September 2018, Pages 2752-2762 (2018)

Vinograd A, Fuchs-Shlomai Y, Stern M, Mukherjee D, Gao Y, Citri A, Davison I, Mizrahi A.

Functional Plasticity of Odor Representations during Motherhood

Cell Reports 21(2):351-365 (2017)

Brown S, Mathur B, Olsen S, Luppi PH, Bickford M and Citri A

New Breakthroughs in Understanding the Role of Functional Interactions Between the Neocortex and the Claustrum

Journal of Neuroscience, 8 November 2017, 37 (45) 10877-10881 (2017)

Citri A, Berretta S

Claustral Delusions

Claustrum, Volume 1, 2016 – Issue 1 (2016)

Atlan, G, Terem A, Peretz-Rivlin N, Groysman M, Citri A.

Mapping synaptic cortico-claustral connectivity in the mouse

The Journal of comparative neurology (2016)

Neuner SM, Garfinkel BP, Wilmott LA, Ignatowska-Jankowska BM, Citri A, Orly J, Lu L, Overall RW, Mulligan MK, Kempermann G, Williams RW, O’Connell KM, Kaczorowski CC.

Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging

Neurobiol Aging. 2016 Oct;46:58-67 (2016)

Goll Y, Atlan G and Citri A

Attention: The Claustrum

Trends in Neuroscience, Volume 38, Issue 8, August 2015, Pages 486-495 (2015)

Liu J, Mukherjee D, Haritan D, Ignatowska-Jankowska B, Liu J, Citri A and Pang ZP

High on food: the interaction between the neural circuits for feeding and for reward

Frontiers in Biology, April 2015, Volume 10, Issue 2, pp 165–176 (2015)

Turm H, Mukherjee D, Haritan D, Tahor M and Citri A

Comprehensive analysis of transcription dynamics from brain samples following behavioral experience

Journal of Visualized Experiments (2014)

Citri A, Pang ZP, Südhof TC, Wernig M, Malenka RC.

Comprehensive qPCR profiling of gene expression in single neuronal cells

Nat Protoc. 2011 Dec 22;7(1):118-27 (2011)

Pang ZP, Yang N, Vierbuchen T, Ostermeier A, Fuentes DR, Yang TQ, Citri A, Sebastiano V, Marro S, Südhof TC, Wernig M.

Induction of human neuronal cells by defined transcription factors

Nature. 2011 May 26;476(7359):220-3 (2011)

Shai Berman, Roey Schurr, Gal Atlan, Ami Citri, Aviv A Mezer

Automatic segmentation of the dorsal claustrum in humans using in vivo high-resolution MRI

Cerebral Cortex Communications tgaa062 (2020)

Postdoctoral fellow to study the claustrum using whole-cell slice electrophysiology
Postdoctoral fellow to study the role of the claustrum in attention using in-vivo electrophysiology
Honors:
2015 Adelis prize in Neuroscience
2016 CIFAR Azrieli Global Scholar
2018 Member, Child and Brain Development Program, Canadian Institute for Advanced Research (CIFAR)

Website:
Lab Website

Public lectures:
2018 – Public lecture, AfiRNE, Paris dubbed in French

2017 – Public lecture, Geneva

2015 Lecture Behavioral Transcriptomics

2015 ELSC coverage of Adelis prize

2015 AFHU coverage of Adelis prize

2014 – Public lecture, Monte Sinai center, Mexico City

2013 – Cinema & Brain week, in Hebrew

2012 – Public lecture, AFIRNE, Paris

2012 ELSC seminar

Blog Posts:
https://doi.org/10.25250/thescbr.brk180

https://bold.expert/genes-and-brain-plasticity

Gallery:
Envelope Phone-alt

Ami Citri

Associate Professor

Email: ami.citri@mail.huji.ac.il
Phone: +972-2-6584978
Ami Citri
@CitriAmi
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 1106, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
https://www.citrilab.com

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