Eran Meshorer

Professor

The Arthur Gutterman Chair in Stem Cell Research

Epigenetics, stem cells, & neurons

The Meshorer lab is studying

1. Epigenetic regulation in stem cells and differentiation;
2. Neurodegenerative diseases (e.g. HD) using pluripotent stem cell models;
3. Paleo-epigenetics: reconstructing DNA methylation in archaic genomes.

Honors

2019 ‘Breakthrough of the Year’ Award by Science for Gokhman et al. Cell, 2019

2018 Coordinator, Marie Curie ITN Project award (‘EpiSyStem’)

2016 Gold Medal Award from the 1st Faculty of Medicine, Charles University, Prague, Czech Republic

2016 Named the Arthur Gutterman Chair for Stem Cell Research

2015 Vigevani Research Prize, Israel-Italy (with Prof. Giuseppe Testa, Milano)

2013 Zelman Cowen Award for Biomedical Research, Hebrew University and University of Sydney

2012 Hestrin Prize for an outstanding young researcher, Israel Society for Biochemistry and Molecular Biology

2012 Klachky Prize for the advancement of science, Hebrew University

Recent publications

Lim PSL, Meshorer E.
Dppa2 and Dppa4 safeguard bivalent chromatin in order to establish a pluripotent epigenome, Nat Struct Mol Biol. 2020 Aug;27(8):685-686 (2020)
Yoav Mathov, Daniel Batyrev, Eran Meshorer, Liran Carmel
Harnessing epigenetics to study human evolution, Current Opinion in Genetics & Development Pages 23-29, ISSN 0959-437X (2020)
Imke K. Mandemaker, Di Zhou, Serena T. Bruens, Dick H. Dekkers, Pernette J. Verschure, Raghu R. Edupuganti, Eran Meshorer, Jeroen A. Demmers, Jurgen A. Marteijn
Histone H1 eviction by the histone chaperone SET reduces cell survival following DNA damage, Journal of Cell Science jcs.235473 (2020)
Lim PSL, Meshorer E.
Organization of the Pluripotent Genome, Cold Spring Harb Perspect Biol. 2020 Sep 14:a040204. (2020)
Batyrev D, Lapid E, Carmel L, Meshorer E
Predicted Archaic 3D Genome Organization Reveals Genes Related to Head and Spinal Cord Separating Modern from Archaic Humans, Cells, 9(1), 48 9 (2020)
Lezmi E, Weissbein U, Golan-Lev T, Nissim-Rafinia M, Meshorer E, Benvenisty N.
The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation, Stem Cell Reports 2020;S2213-6711(20)30186-7. (2020)
Goldshtein et al.
Transcription Factor Binding in Embryonic Stem Cells Is Constrained by DNA Sequence Repeat Symmetry, Biophysical Journal 118, 1–12 (2020)
Pattabiraman S, Azad GK, Amen T, Brielle S, Park JE, Sze SK, Meshorer E, Kaganovich D.
Vimentin protects differentiating stem cells from stress, Sci Rep. 2020 Nov 11;10(1):19525 (2020)
Gokhman D, Agranat L, Housman G, Nissim-Rafinia M, Colon MN, Gu H, Ferrando M, Gelabert P, Lipende I, Quillen EE, Meissner A, Stone AC, Pusey AE, Mjungu D, Kandel L, Liebergall M, Prada ME, Vidal JM, Krause J, Yakir B, Reich D, Fox CL, Marques-Bonet T, Eran Meshorer and Liran Carmel
Extensive Regulatory Changes in Genes Affecting Vocal and Facial Anatomy Separate Modern from Archaic Humans, BioRxiv (2019)
Mallm JP, Windisch P, Biran A, Gal Z, Schumacher S, Glass R, Herold-Mende C, Meshorer E, Barbus M, Rippe K
Glioblastoma initiating cells are sensitive to histone demethylase inhibition due to epigenetic deregulation, International Journal of Cancer (2019)
Schlesinger S and Meshorer E
Open chromatin, epigenetic plasticity and nuclear organization in pluripotency, Developmental Cell, Volume 48, Issue 2, 28 January 2019, Pages 135-150 (2019)
Cohen-Carmon D, Sorek M, Lerner V, Nissim-Rafinia M, Yarom Y, Meshorer E
Progerin-Induced Transcriptional Changes in Huntington’s Disease Human Pluripotent Stem Cell-Derived Neurons, Molecular Neurobiology (2019)
Gokhman D, Mishol N, de Manuel M, de Juan D, Shuqrun J, Meshorer E, Marques-Bonet T, Rak Y, Carmel L.
Reconstructing Denisovan Anatomy Using DNA Methylation Maps, Cell, Volume 179, Issue 1, Pages 180-192.e10 (2019)
Gold A, Eini L, Nissim-Rafinia M, Viner R, Ezer S, Erez K, Aqaqe N, Hanania R, Milyavsky M, Meshorer E, Goldberg M
Spironolactone inhibits the growth of cancer stem cells by impairing DNA damage response, Oncogene, volume 38, pages 3103–3118 (2019)
Viegas JO, Meshorer E
The Princess and the P: Pluripotent Stem Cells and P-Bodies, Cell Stem Cell (2019), Volume 25, Issue 5, Pages 589-591 (2019)
Azad GK, Ito K, Sailaja BS, Biran A, Nissim-Rafinia M, Brown DT, Takizawa T and Meshorer E
PARP1-dependent eviction of the linker histone H1 mediates immediate early gene expression during neuronal activation, Journal of Cell Biology, 217(2):473-481 (2018)
Schlesinger S, Kaffe B, Melcer S, Aguilera JDA, Mundackal DS, Kaplan T and Meshorer E
A hyperdynamic H3.3 nucleosome marks promoter regions in pluripotent embryonic stem cells, Nucleic Acids Research, Volume 45, Issue 21, 1 December 2017, Pages 12181–12194 (2017)
Edupuganti RR, Harikumar A, Aaronson Y, Biran A, Sailaja BS, Nissim-Rafinia M, Azad GK, Cohen MM, Park JE, Shivalila CS, Markoulaki S, Sze SK, Jaenisch R and Meshorer E
Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation, Stem Cell Reports, Volume 9, Issue 4, Pages 1291-1303 (2017)
Harikumar A, Edupuganti RR, Sorek M, Azad GK, Markoulaki S, Sehnalová P, Legartová S, Bártová E, Farkash-Amar S, Jaenisch R, Alon U and Meshorer E
An endogenously tagged fluorescent fusion protein library in mouse embryonic stem cells, Stem Cell Reports, Volume 9, Issue 4, 10 October 2017, Pages 1304-1314 (2017)
Gokhman, D, Meshorer E, Carmel L.
Epigenetics: It's Getting Old. Past Meets Future in Paleoepigenetics., Trends in Ecology & Evolution, Volume 31, Issue 4, Pages 290-300 (2016)

View All Publications

CV

Eran Meshorer CV

Lab Members

Ayelet- Hashahar Cohen

Research Associate (Teacher-Researcher)

Postdoctoral researcher

PhD Student

PhD Student

Juliane Oliveira Viegas

PhD Student

PhD Student

Moria Ben Yishay

PhD Student

PhD Student

PhD Student

PhD Student

MSc student

Malka Nissim-Rafinia PhD

Lab manager

Eitan Segev PhD

EpiSyStem ITN manager

Websites

Lab Facebook Page

Media

Live imaging of primary dopaminergic neurons

DNA double-strand break induction and repair by homologous recombination

Eran’s talk on stem cells, reprogramming and cloning at the MADUA series of lectures, 2015

Eran’s talk at the Brain & Cinema week, 2013

Eran’s talk on the 2012 Nobel Prize in Physiology or Medicine (Gurdon / Yamanaka)

Contact information

E-mail: eran.meshorer@mail.huji.ac.il

Phone: 02-6585161

Fax: 02-6586073

Address: Department of Genetics, The Institute of Life Sciences, Silberman Building, Room 2-541. The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram.

Yael Riback, Lab administrator, 02-6585144