Israel Nelken Lab

ELSC Members

Israel Nelken

Professor

Phone: +972-2-6584229
Fax: +972-2-6586077
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 2, Room 1207, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
Milton and Brindell Gottlieb Chair in Brain Science
Laboratory of Auditory Neurophysiology

We study the auditory system using a combination of behavioral, electrophysiological and imaging techniques, mostly in animal models but also in humans.

Sounds and the Brain

We investigate the transformation of sound from a physical phenomenon to a perceptual experience. Initial neural representations in the ascending auditory system closely correlate with the momentary physical characteristics of sounds. However, by the time signals reach the midbrain, they begin to integrate increasingly rich contextual information. In the primary auditory cortex, sound responses are profoundly influenced not only by spectro-temporal context but also by the animal’s actions, the specific task at hand, and the level of attention and engagement.

We propose that these representations form part of an inner model of the world, which is essential for decision-making in sound-guided behaviors and serves as the foundation for the perception of sounds. 

Here is a sample of our recent and ongoing projects:

Context-dependent sound representations in auditory cortex >>

Early sound exposure and sound preferences in mice     >>

Sound-guided behavior and neural dynamics in auditory cortex of freely-moving rats >>

Representation of actions in auditory cortex: insights from reinforcement learning and deep neural networks >>

Robert Reiner
Robert Reiner
Lab Manager
Haneen Rajabi
Haneen Rajabi
PhD student
Jonathan Schwarcz
Jonathan Schwarcz
PhD student
adria dym
Adria Dym
PhD student
Gabrielle Marmur
Gabrielle Marmur
PhD student
Shai Yellinek
Shai Yellinek
PhD student
Itai Wasserman
Itai Wasserman
PhD student
Ala Shaloudy
Ala Shaloudy
PhD Student
ELSC-Seminars-General
Josue Zini
ELSC-Seminars-General
Moran Moradi
ELSC-Seminars-General
Gon Ishay
ELSC-Seminars-General
Zhe Liu
ELSC-Seminars-General
Shahar Haim
Adi Hovav-Lixenberg, Yirat Henshke, Tirzah Kreisel, Eran Lottem, Mati Joshua

Nature Communications (2026)

Silvana C Araujo, B. Lacoste, Luis Moreira, Oihane Horno, Eran Lottem, Joaquim Alves da Silva, Boris Gutkin, Christian K. Machens, Susana Q. Lima

bioRxiv (Cold Spring Harbor Laboratory) (2026)

Haimson, B., Gilday, O.D., Lavi-Rudel, A., Sagi, H., Lottem, E., Mizrahi, A.

Sci Adv. (2024)

Haim, S., Ofir, N., Deouell, L.Y., Landau, A.N., Lottem, E.

J Neurosci. (2025)

Liu, Z., Reiner, R., Loewenstein, Y., Lottem, E.

Biol Psychiatry. (2025)

Vertechi, P., Lottem, E., Sarra, D., Godinho, B., Treves, I., Quendera, T., Lohuis, M.N.O, Mainen, Z.F.

Neuron.  (2020)

Lottem, E., Banerjeem, D., Vertechi, P., Sarra, D., Lohuis, M.O, Mainen, Z.F.

Nature Communications. (2018)

Matias, S., Lottem, E., Dugué, G.P., Mainen, Z.F.

Elife. (2017)

Correia, P.A., Lottem, E., Banerjee, D., Machado, A.S., Carey, M.R., Mainen, Z.F.

Elife. (2017)

Dugué, G.P., Lörincz, M.L., Lottem, E., Audero, E., Matias, S., Correia, P.A., Léna, C., Mainen, Z.F.

PLoS One. (2014)

Lottem, E., Gugig, E., Azouz, R.

J Neurophysiol. (2014)

Lottem, E., Azouz, R.

J Neurophysiol. (2008)

We are looking for talented, creative and motivated students and postdocs to join our team.

Eran Lottem

Assistant Professor

Phone: +972-52-7450155
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 2104, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401

“Working memory”