Adi Mizrahi Lab

ELSC Members

Adi Mizrahi

Professor

Phone: +972-2-6585163
Lab Phone: +972-2-6585163
Office Phone: +972-2-6586460
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 2, Room 1204, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
The Eric Roland Chair in Brain Sciences
The NeuroPlasticity lab

Our lab is interested in how the brain we are born with meets the world we grow into. We study the interplay between innate and learned aspects of behavior, asking how experience reshapes neural circuits that support core behaviors such as categorizing stimuli, caring for offspring, and choosing mates. We use the auditory and olfactory systems as our main windows into the brain, because they are tightly linked to ethologically meaningful behaviors – from recognizing a pup’s call to discriminating a predator odor or a potential partner.

A central theme in the lab is development, with a particular focus on adolescence as a transitional period where brain and behavior are not always in sync. We ask how sound and odor categories are formed and refined across development, how parental experience sculpts auditory and olfactory representations, and how social and sexual cues are integrated by cortical circuits. Across these projects, we are especially interested in how “hard-wired” predispositions (for example, to respond to pups, conspecifics or threats) interact with learning to produce flexible, context-dependent behavior.

To address these questions, we combine systems neuroscience and behavior: multi-neuron recordings and imaging in defined circuits, targeted circuit manipulations, and carefully designed behavioral paradigms that probe discrimination, category learning and natural behaviors such as parenting. By following neural activity and behavior over time, we aim to understand how circuits change as animals learn, grow up, and transition between life stages – and how these changes allow the same brain to support both stable instincts and lifelong learning.

Robert Reiner
Robert Reiner
Lab Manager
Haneen Rajabi
Haneen Rajabi
PhD student
Jonathan Schwarcz
Jonathan Schwarcz
PhD student
adria dym
Adria Dym
PhD student
Gabrielle Marmur
Gabrielle Marmur
PhD student
Shai Yellinek
Shai Yellinek
PhD student
Itai Wasserman
Itai Wasserman
PhD student
Ala Shaloudy
Ala Shaloudy
PhD Student
ELSC-Seminars-General
Josue Zini
ELSC-Seminars-General
Moran Moradi
ELSC-Seminars-General
Gon Ishay
ELSC-Seminars-General
Zhe Liu
ELSC-Seminars-General
Shahar Haim
Adi Hovav-Lixenberg, Yirat Henshke, Tirzah Kreisel, Eran Lottem, Mati Joshua

Nature Communications (2026)

Silvana C Araujo, B. Lacoste, Luis Moreira, Oihane Horno, Eran Lottem, Joaquim Alves da Silva, Boris Gutkin, Christian K. Machens, Susana Q. Lima

bioRxiv (Cold Spring Harbor Laboratory) (2026)

Haimson, B., Gilday, O.D., Lavi-Rudel, A., Sagi, H., Lottem, E., Mizrahi, A.

Sci Adv. (2024)

Haim, S., Ofir, N., Deouell, L.Y., Landau, A.N., Lottem, E.

J Neurosci. (2025)

Liu, Z., Reiner, R., Loewenstein, Y., Lottem, E.

Biol Psychiatry. (2025)

Vertechi, P., Lottem, E., Sarra, D., Godinho, B., Treves, I., Quendera, T., Lohuis, M.N.O, Mainen, Z.F.

Neuron.  (2020)

Lottem, E., Banerjeem, D., Vertechi, P., Sarra, D., Lohuis, M.O, Mainen, Z.F.

Nature Communications. (2018)

Matias, S., Lottem, E., Dugué, G.P., Mainen, Z.F.

Elife. (2017)

Correia, P.A., Lottem, E., Banerjee, D., Machado, A.S., Carey, M.R., Mainen, Z.F.

Elife. (2017)

Dugué, G.P., Lörincz, M.L., Lottem, E., Audero, E., Matias, S., Correia, P.A., Léna, C., Mainen, Z.F.

PLoS One. (2014)

Lottem, E., Gugig, E., Azouz, R.

J Neurophysiol. (2014)

Lottem, E., Azouz, R.

J Neurophysiol. (2008)

We are looking for talented, creative and motivated students and postdocs to join our team.

Eran Lottem

Assistant Professor

Phone: +972-52-7450155
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 2104, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401

“Working memory”