ELSC Seminar Series

Neocortical neurons receive myriad inputs woven throughout the dendritic trees. To study their structural and functional properties we primarily use in vivo two-photon calcium imaging of populations of dendritic spines, the recipients of excitatory synaptic inputs. Our work has uncovered functional diversity, the prevalence of small functional clusters, and begun to understand the unique properties of synapses within individual neurons. We further aim to understand the development, dynamics, and dysfunction of the organization of synaptic inputs.