We are interested in the mechanistic basis for cognitive processes, focusing on the function of hippocampal circuits in learning and memory. To this end, we are developing and applying cutting-edge technology to record and control brain activity using light. This all-optical technology is based on a combination of protein engineering and state-of-the-art microscopes and it allows us to record and manipulate the fine details of neuronal electrical activity at single-cell resolution, in a non-invasive manner. We use this all-optical electrophysiology approach for detailed mechanistic studies of the function and plasticity of hippocampal circuits during various behavioral tasks.
Yoav Adam Lab
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Sachs Family Lecturer in Brain Sciences
Adam Lab
Qixin Yang, Shulamit Baror-Sebban, Rotem Kipper, Michael London, Yoav Adam
Neuron (2026)
Rotem Kipper, Yaniv Melamed, Qixin Yang, Gal Shturm, Shulamit Baror-Sebban, Yoav Adam
bioRxiv (2025)
Qixin Yang, Shulamit Baror-Sebban, Rotem Kipper, Michael London, Yoav Adam
bioRxiv (2025)
Adam Y., Livneh Y., Miyamichi K, Groysman M., Luo L., Mizrahi A.
Frontiers in Neural Circuits (2014)
Armbruster, M., Naskar, S., Garcia, J.P. Sommer, M., Kim, E., Adam, Y., Haydon, P.G., Boyden, E.S., Cohen, A.E., & Dulla, C.G.
Nat Neurosci 25, 607–616 (2022)
Adam, Y., & Mizrahi, A.
Journal of Neuroscience (2011)
Adam, Y, Mizrahi A.
Current Opinion in Neurobiology, Volume 20, Issue 1, Pages 134-140 (2010)
Chien MP, Brinks D, Adam Y, Bloxham W, Kheifets S, Cohen AE
Science Advances , Vol. 7, no. 19, eabe3216 (2021)
Michael E. Xie, Yoav Adam, Linlin Z. Fan, Urs L. Böhm, Ian Kinsella, Ding Zhou, Marton Rozsa, Amrita Singh, Karel Svoboda, Liam Paninski, Adam E. Cohen
Cell Reports, Volume 35, Issue 1, 2021, 108954, ISSN 2211-1247, (2021)
Yoav Adam
Journal of Neuroscience Methods, Volume 353, 2021, 109101, ISSN 0165-0270 (2021)
Parot VJ, Sing-Long C, Adam Y, Boehm UL, Fan L, Farhi SL, and Cohen AE
Journal of Physics D: Applied Physics Volume 52, Number 14 (2019)
Adam, Y., Kim, J.J., Lou, S. et al.
Nature (2019)
Samouil L. Farhi, Vicente J. Parot, Abhinav Grama, Masahito Yamagata, Ahmed S. Abdelfattah, Yoav Adam, Shan Lou, Jeong Jun Kim, Robert E. Campbell, David D. Cox, Adam E. Cohen
Journal of Neuroscience (2019)
Fan LZ, Nehme R, Adam Y, Jung ES, Wu H, Eggan K, Arnold DB, Cohen AE
Nature Methods, volume 15, pages 823–831 (2018)
Lou S, Adam Y, Weinstein EN, Williams E, Williams K, Parot V, Kavokine N, Liberles S, Madisen L, Zeng H, Cohen AE.
Journal of Neuroscience, 36 (43) 11059-11073 (2016)
Brinks D, Adam Y, Kheifets S, Cohen AE
Acc. Chem. Res., 49 (11), pp 2518–2526 (2016)
Yoav Adam, Robert H. Edwards, and Shimon Schuldiner
Am J Physiol Cell Physiol (2008)
Steiner-Mordoch S, Soskine M, Solomon D, et al.
EMBO J. (2008)
Adam Y, Tayer N, Rotem D, Schreiber G, Schuldiner S.
Proc Natl Acad Sci U S A (2007)
Soskine M, Adam Y, and Schuldiner S.
J Biol Chem (2004)
We are looking for curious and highly-motivated students and postdocs to join our team
Media:
https://www.haaretz.co.il/science/biology/.premium-1.7193349
https://medium.com/the-spike/what-should-systems-neuroscience-do-next-voltage-imaging-9bfa5d6a4df9
https://eurekalert.org/pub_releases/2019-05/hu-anv042919.php
Public lecture (in Hebrew):
https://www.youtube.com/watch?v=615zLv-E5ZM&feature=youtu.be
Resources:
Adam Lab GitHub page:
https://github.com/yoavadamlab
Lab Life:
https://www.haaretz.co.il/science/biology/.premium-1.7193349
https://medium.com/the-spike/what-should-systems-neuroscience-do-next-voltage-imaging-9bfa5d6a4df9
https://eurekalert.org/pub_releases/2019-05/hu-anv042919.php
Public lecture (in Hebrew):
https://www.youtube.com/watch?v=615zLv-E5ZM&feature=youtu.be
Resources:
Adam Lab GitHub page:
https://github.com/yoavadamlab
Lab Life:
Yoav Adam
Assistant Professor
Email: yoav.adam@mail.huji.ac.il
Phone: +972-2-549-4831
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 2106, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 2106, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
Sachs Family Lecturer in Brain Sciences
Adam Lab
Shai Tishby Tamari, Yoav Rubinstein, Netta Livneh, Maayan Moshkovitz, Abeer Karmi, Lilach Avitan
Nature Communications (2026)
Imri Lifshitz, Asia Prag, Netta Livneh, Maayan Moshkovitz, Abeer Karmi, Lilach Avitan
Nature Communications (2026)
Y Rubinstein, M Moshkovitz, I Ottenheimer, S Shapira, S Tiomkin, L Avitan
iScience (2025)
Suárez, Rodrigo, Tobias Bluett, Michael H. McCullough, Lilach Avitan, Dylan A. Black, Annalisa Paolino, Laura R. Fenlon, Geoffrey J. Goodhill, and Linda J. Richards.
Proc. Natl. Acad. Sci. (2023)
Zhu, Shuyu I., Michael H. McCullough, Zac Pujic, Jordan Sibberas, Biao Sun, Thomas Darveniza, Bianca Bucknall, Lilach Avitan, and Geoffrey J. Goodhill
Journal of Neuroscience (2023)
Triplett MA, Pujic Z, Sun B, Avitan L, Goodhill GJ.
PLoS Comput Biol. (2020)
Avitan L, Pujic Z, Mölter J, Zhu S, Sun B, Goodhill GJ
Elife, 19;10:e61942 (2021)
Lilach Avitan, Carsen Stringer
Neuron (2022)
Marcus A. Triplett , Lilach Avitan , and Geoffrey J. Goodhill
Emergence of spontaneous assembly activity in developing neural networks without afferent input.
Computational Biology (2020)
Avitan, L., Pujic, Z., Molter, J., Sun, B., Myhre,A.E., Goodhill, G.J.
Current Biology (2020)
Avitan L. and Goodhill G.J.
Trends in Neurosciences (2018)
Mölter, J., Avitan, L. & Goodhill, G.
BMC Biol (2018)
Triplett, M., Avitan, L. and Goodhill, G.J.
PLoS Computational Biology, 14(9):e1006421 (2018)
Marachlian, E., Avitan, L., Goodhill, G.J., and Sumbre, G.
Frontiers in Neural Circuits, 12, 46 (2018)
Avitan L., Pujic Z., Mölter J., Sun B., Van De Poll1 M., Teng H.,Amor R., Scott E.K., and Goodhill G.J.
Current Biology, Volume 27, Issue 16, Pages 2407-2419.e4 (2017)
Avitan, L., Pujic Z., Hughes J.N., Scott E.K. and Goodhill J.G.
Journal of Neuroscience, 36(19):5385–5396 (2016)
Suarez, R., Fenlon, L., Marek, R., Avitan, L., Sah, P., Goodhill, G.J. and Richards, L.J.
Neuron, Volume 82, Issue 6, Pages 1289-1298 (2014)
Avitan L., Teicher M., and Abeles M.
Journal of Neurophysiology, 102: 3046-3059 (2009)
Avitan L., Teicher M., and Abeles M.
Biological Cybernetics, 98(1):49-59 (2008)
We are looking for bright and highly motivated doctoral and postdoctoral students.
Lilach Avitan
Assistant Professor
Phone: +972-2-5494829
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 2, Room 1203, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
The Suzanne and Charles Goodman Brain Sciences Building,
Level 2, Room 1203, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401