We are interested in the mechanistic basis for cognitive processes, focusing on the function of hippocampal circuits in learning and memory. To this end, we are developing and applying cutting-edge technology to record and control brain activity using light. This all-optical technology is based on a combination of protein engineering and state-of-the-art microscopes and it allows us to record and manipulate the fine details of neuronal electrical activity at single-cell resolution, in a non-invasive manner. We use this all-optical electrophysiology approach for detailed mechanistic studies of the function and plasticity of hippocampal circuits during various behavioral tasks.
Yoav Adam Lab
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Additional Information
Sachs Family Lecturer in Brain Sciences
Adam Lab
Yoav Adam
Assistant Professor
Email: yoav.adam@mail.huji.ac.il
Phone: +972-2-549-4831
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 2106, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 2106, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
Sachs Family Lecturer in Brain Sciences
Adam Lab
We are interested in the mechanistic basis for cognitive processes, focusing on the function of hippocampal circuits in learning and memory. To this end, we are developing and applying cutting-edge technology to record and control brain activity using light. This all-optical technology is based on a combination of protein engineering and state-of-the-art microscopes and it allows us to record and manipulate the fine details of neuronal electrical activity at single-cell resolution, in a non-invasive manner. We use this all-optical electrophysiology approach for detailed mechanistic studies of the function and plasticity of hippocampal circuits during various behavioral tasks.
Armbruster, M., Naskar, S., Garcia, J.P. Sommer, M., Kim, E., Adam, Y., Haydon, P.G., Boyden, E.S., Cohen, A.E., & Dulla, C.G.
Nat Neurosci 25, 607–616 (2022)
Yoav Adam
Journal of Neuroscience Methods, Volume 353, 2021, 109101, ISSN 0165-0270 (2021)
Michael E. Xie, Yoav Adam, Linlin Z. Fan, Urs L. Böhm, Ian Kinsella, Ding Zhou, Marton Rozsa, Amrita Singh, Karel Svoboda, Liam Paninski, Adam E. Cohen
Cell Reports, Volume 35, Issue 1, 2021, 108954, ISSN 2211-1247, (2021)
Chien MP, Brinks D, Adam Y, Bloxham W, Kheifets S, Cohen AE
Science Advances , Vol. 7, no. 19, eabe3216 (2021)
Samouil L. Farhi, Vicente J. Parot, Abhinav Grama, Masahito Yamagata, Ahmed S. Abdelfattah, Yoav Adam, Shan Lou, Jeong Jun Kim, Robert E. Campbell, David D. Cox, Adam E. Cohen
Journal of Neuroscience (2019)
Adam, Y., Kim, J.J., Lou, S. et al.
Nature (2019)
Parot VJ, Sing-Long C, Adam Y, Boehm UL, Fan L, Farhi SL, and Cohen AE
Journal of Physics D: Applied Physics Volume 52, Number 14 (2019)
Fan LZ, Nehme R, Adam Y, Jung ES, Wu H, Eggan K, Arnold DB, Cohen AE
Nature Methods, volume 15, pages 823–831 (2018)
Brinks D, Adam Y, Kheifets S, Cohen AE
Acc. Chem. Res., 49 (11), pp 2518–2526 (2016)
Lou S, Adam Y, Weinstein EN, Williams E, Williams K, Parot V, Kavokine N, Liberles S, Madisen L, Zeng H, Cohen AE.
Journal of Neuroscience, 36 (43) 11059-11073 (2016)
Adam Y, Livneh Y, Miyamichi K, Groysman M, Luo L, Mizrahi A.
Front Neural Circuits. 2014; 8: 129. (2014)
Livneh Y, Adam Y, Mizrahi A.
Neuron. 2014 Mar 5;81(5):1097-1110 (2014)
Adam, Y, Mizrahi A.
Journal of Neuroscience, 31 (22) 7967-7973 (2011)
Adam, Y., & Mizrahi, A.
Journal of Neuroscience, 31(22), 7967-7973. (2011)
Adam, Y, Mizrahi A.
Current Opinion in Neurobiology, Volume 20, Issue 1, Pages 134-140 (2010)
Steiner-Mordoch S, Soskine M, Solomon D, et al.
EMBO J. (2008)
Yoav Adam, Robert H. Edwards, and Shimon Schuldiner
Am J Physiol Cell Physiol (2008)
Adam Y, Tayer N, Rotem D, Schreiber G, Schuldiner S.
Proc Natl Acad Sci U S A (2007)
Soskine M, Adam Y, and Schuldiner S.
J Biol Chem (2004)
We are looking for curious and highly-motivated students and postdocs to join our team
Media:
https://www.haaretz.co.il/science/biology/.premium-1.7193349
https://medium.com/the-spike/what-should-systems-neuroscience-do-next-voltage-imaging-9bfa5d6a4df9
https://eurekalert.org/pub_releases/2019-05/hu-anv042919.php
Public lecture (in Hebrew):
https://www.youtube.com/watch?v=615zLv-E5ZM&feature=youtu.be
Resources:
Adam Lab GitHub page:
https://github.com/yoavadamlab
Lab Life:
https://www.haaretz.co.il/science/biology/.premium-1.7193349
https://medium.com/the-spike/what-should-systems-neuroscience-do-next-voltage-imaging-9bfa5d6a4df9
https://eurekalert.org/pub_releases/2019-05/hu-anv042919.php
Public lecture (in Hebrew):
https://www.youtube.com/watch?v=615zLv-E5ZM&feature=youtu.be
Resources:
Adam Lab GitHub page:
https://github.com/yoavadamlab
Lab Life:
Yoav Adam
Assistant Professor
Email: yoav.adam@mail.huji.ac.il
Phone: +972-2-549-4831
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 2106, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 2106, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
