Mati Joshua Lab

ELSC Members

Mati Joshua

Associate Professor

Phone: +972-54-7550566
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 3, Room 1306 Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
The Joshua lab

The drive to seek reward controls almost every aspect of our behavior, from stereotypical reflexive behaviors, to complex voluntary actions such as choosing where to look, how to reach for a cup of coffee, or what companies to invest in. It is not surprising, therefore, that the symptomatology of neurological disorders that interrupt reward processing – such as those stemming from drug-abuse and depression – include deficits in the capacity to make even simple movements.

Our lab studies how what we want guides what we do, in particular we investigate how the brain uses reward to drive and shape behavior.

Our approach is to study the control of eye movements using neural recordings in animals as they behave. We study the activity of single neurons and neural networks while they operate in real time to produce behavior. Our lab’s research focuses on two major subcortical networks: the basal ganglia and the cerebellum. Both structures are essential for normal movements and impairment to either loop leads to devastating motor disorders. Of particular interest is elucidating the specific role of the basal ganglia and cerebellum in the control of movement. The goal of our research is to understand how the subcortical networks interact with the cerebral cortex to drive behavior that is guided by rewards.

Abeer Karmi Hallak
Abeer Karmi Hallak, Ph.D.
Lab Manager
Imri_Lifshitz
Imri Lifshitz
Ph.D. Student
Shai_Tishby
Shai Tishby
Ph.D. Student
YoavRubinstein
Yoav Rubinstein
Ph.D. Student
Maayan_Moshkovitz
Maayan Moshkovitz
PhD Student
Netta Livneh
Netta Livneh
PhD Student
ADMIN PHOTO
Asia Prag
MSc Student
ADMIN PHOTO
Or Nathan
Undergraduate Student
unnamed
Hila Topaz
Undergraduate Student
Shai Tishby Tamari, Yoav Rubinstein, Netta Livneh, Maayan Moshkovitz, Abeer Karmi, Lilach Avitan

Nature Communications (2026)

Imri Lifshitz, Asia Prag, Netta Livneh, Maayan Moshkovitz, Abeer Karmi, Lilach Avitan

Nature Communications (2026)

Y Rubinstein, M Moshkovitz, I Ottenheimer, S Shapira, S Tiomkin, L Avitan

iScience (2025)

Suárez, Rodrigo, Tobias Bluett, Michael H. McCullough, Lilach Avitan, Dylan A. Black, Annalisa Paolino, Laura R. Fenlon, Geoffrey J. Goodhill, and Linda J. Richards.

Proc. Natl. Acad. Sci.  (2023)

Zhu, Shuyu I., Michael H. McCullough, Zac Pujic, Jordan Sibberas, Biao Sun, Thomas Darveniza, Bianca Bucknall, Lilach Avitan, and Geoffrey J. Goodhill

Journal of Neuroscience (2023)

Triplett MA, Pujic Z, Sun B, Avitan L, Goodhill GJ.

PLoS Comput Biol. (2020)

Avitan L, Pujic Z, Mölter J, Zhu S, Sun B, Goodhill GJ

Elife, 19;10:e61942 (2021)

Marcus A. Triplett , Lilach Avitan , and Geoffrey J. Goodhill

Computational Biology (2020)

Avitan, L., Pujic, Z., Molter, J., Sun, B., Myhre,A.E., Goodhill, G.J.

Current Biology (2020)

Avitan L. and Goodhill G.J.

Trends in Neurosciences (2018)

Mölter, J., Avitan, L. & Goodhill, G.

BMC Biol (2018)

Triplett, M., Avitan, L. and Goodhill, G.J.

PLoS Computational Biology, 14(9):e1006421 (2018)

Marachlian, E., Avitan, L., Goodhill, G.J., and Sumbre, G.

Frontiers in Neural Circuits, 12, 46 (2018)

Avitan L., Pujic Z., Mölter J., Sun B., Van De Poll1 M., Teng H.,Amor R., Scott E.K., and Goodhill G.J.

Current Biology, Volume 27, Issue 16, Pages 2407-2419.e4 (2017)

Avitan, L., Pujic Z., Hughes J.N., Scott E.K. and Goodhill J.G.

Journal of Neuroscience, 36(19):5385–5396 (2016)

Suarez, R., Fenlon, L., Marek, R., Avitan, L., Sah, P., Goodhill, G.J. and Richards, L.J.

Neuron, Volume 82, Issue 6, Pages 1289-1298 (2014)

Avitan L., Teicher M., and Abeles M.

Journal of Neurophysiology, 102: 3046-3059 (2009)

Avitan L., Teicher M., and Abeles M.

Biological Cybernetics, 98(1):49-59 (2008)

We are looking for bright and highly motivated doctoral and postdoctoral students.

Lilach Avitan

Assistant Professor

Phone: +972-2-5494829
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 2, Room 1203, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401

“Working memory”