Yoav Adam Lab

ELSC Members

Sachs Family Lecturer in Brain Sciences

Adam Lab

We are interested in the mechanistic basis for cognitive processes, focusing on the function of hippocampal circuits in learning and memory. To this end, we are developing and applying cutting-edge technology to record and control brain activity using light. This all-optical technology is based on a combination of protein engineering and state-of-the-art microscopes and it allows us to record and manipulate the fine details of neuronal electrical activity at single-cell resolution, in a non-invasive manner. We use this all-optical electrophysiology approach for detailed mechanistic studies of the function and plasticity of hippocampal circuits during various behavioral tasks.

Shulamit Baror-Sebban, Ph.D

Lab manager

Ayala Radziner

Lab Technician

Rachely Butterman

Ph.D. Student

Gur Aminadav

Ph.D. Student

Efrat Sheinbach

Ph.D. Student

Qixin Yang

Ph.D. Student

Rotem Kipper

Ph.D. Student

Mor Margolin

Ph.D. Student

Miki Meerson

M.Sc. Student

Michal Rubin

Ph.D. student

Gal Shturm

Undergraduate Student

May Atias

Undergraduate Student

Ron Buchnic

Anat Marom-Rotem, Ph.D.

Yahel Gazit

Noa Garty

Rotem Ovadia

Yuval Rom

Yaniv Melamed

Renana Malka

Omer Cooper

Rotem Kipper, Yaniv Melamed, Qixin Yang, Gal Shturm, Shulamit Baror-Sebban, Yoav Adam

Voltage Imaging of CA1 Pyramidal Cells and SST+ Interneurons Reveals Stability and Plasticity Mechanisms of Spatial Firing

bioRxiv (2025)

Qixin Yang, Shulamit Baror-Sebban, Rotem Kipper, Michael London, Yoav Adam

All-optical electrophysiology reveals behavior-dependent dynamics of excitation and inhibition in the hippocampus

bioRxiv (2025)

Adam Y., Livneh Y., Miyamichi K, Groysman M., Luo L., Mizrahi A.

Functional transformations of odor inputs in the mouse olfactory bulb

Frontiers in Neural Circuits (2014)

Livneh Y., Adam Y. Mizrahi A.

Odor Processing by Adult-Born Neurons

Neuron (2014)

Armbruster, M., Naskar, S., Garcia, J.P. Sommer, M., Kim, E., Adam, Y., Haydon, P.G., Boyden, E.S., Cohen, A.E., & Dulla, C.G.

Neuronal activity drives pathway-specific depolarization of peripheral astrocyte processes

Nat Neurosci 25, 607–616 (2022)

Adam, Y., & Mizrahi, A.

Long term imaging reveals dynamic changes in the neuronal composition of the glomerular layer

Journal of Neuroscience (2011)

Adam, Y, Mizrahi A.

Circuit formation and maintenance—perspectives from the mammalian olfactory bulb

Current Opinion in Neurobiology, Volume 20, Issue 1, Pages 134-140 (2010)

Chien MP, Brinks D, Adam Y, Bloxham W, Kheifets S, Cohen AE

Photoactivated voltage imaging in tissue with an archaerhodopsin-derived reporter

Science Advances , Vol. 7, no. 19, eabe3216 (2021)

Michael E. Xie, Yoav Adam, Linlin Z. Fan, Urs L. Böhm, Ian Kinsella, Ding Zhou, Marton Rozsa, Amrita Singh, Karel Svoboda, Liam Paninski, Adam E. Cohen

High-fidelity estimates of spikes and subthreshold waveforms from 1-photon voltage imaging in vivo

Cell Reports, Volume 35, Issue 1, 2021, 108954, ISSN 2211-1247, (2021)

Yoav Adam

All-optical electrophysiology in behaving animals

Journal of Neuroscience Methods, Volume 353, 2021, 109101, ISSN 0165-0270 (2021)

Parot VJ, Sing-Long C, Adam Y, Boehm UL, Fan L, Farhi SL, and Cohen AE

Compressed Hadamard microscopy for high-speed optically sectioned neuronal activity recordings

Journal of Physics D: Applied Physics Volume 52, Number 14 (2019)

Adam, Y., Kim, J.J., Lou, S. et al.

Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics

Nature (2019)

Samouil L. Farhi, Vicente J. Parot, Abhinav Grama, Masahito Yamagata, Ahmed S. Abdelfattah, Yoav Adam, Shan Lou, Jeong Jun Kim, Robert E. Campbell, David D. Cox, Adam E. Cohen

Wide-area all-optical neurophysiology in acute brain slices

Journal of Neuroscience (2019)

Fan LZ, Nehme R, Adam Y, Jung ES, Wu H, Eggan K, Arnold DB, Cohen AE

All-optical synaptic electrophysiology probes mechanism of ketamine-induced disinhibition

Nature Methods, volume 15, pages 823–831 (2018)

Lou S, Adam Y, Weinstein EN, Williams E, Williams K, Parot V, Kavokine N, Liberles S, Madisen L, Zeng H, Cohen AE.

Genetically Targeted All-Optical Electrophysiology with a Transgenic Cre-Dependent Optopatch Mouse

Journal of Neuroscience, 36 (43) 11059-11073 (2016)

Brinks D, Adam Y, Kheifets S, Cohen AE

Painting with Rainbows: Patterning Light in Space, Time, and Wavelength for Multiphoton Optogenetic Sensing and Control

Acc. Chem. Res., 49 (11), pp 2518–2526 (2016)

Yoav Adam, Robert H. Edwards, and Shimon Schuldiner

Expression and function of the rat vesicular monoamine transporter 2

Am J Physiol Cell Physiol (2008)

Steiner-Mordoch S, Soskine M, Solomon D, et al.

Parallel topology of genetically fused EmrE homodimers

EMBO J. (2008)

Adam Y, Tayer N, Rotem D, Schreiber G, Schuldiner S.

The fast release of sticky protons: Kinetics of substrate binding and proton release in a multidrug transporter

Proc Natl Acad Sci U S A (2007)

Soskine M, Adam Y, and Schuldiner S.

Direct Evidence for Substrate-induced Proton Release in Detergent-solubilized EmrE, a Multidrug Transporter

J Biol Chem (2004)

Media:
https://www.haaretz.co.il/science/biology/.premium-1.7193349

https://medium.com/the-spike/what-should-systems-neuroscience-do-next-voltage-imaging-9bfa5d6a4df9

https://eurekalert.org/pub_releases/2019-05/hu-anv042919.php

Public lecture (in Hebrew):
https://www.youtube.com/watch?v=615zLv-E5ZM&feature=youtu.be

Resources:
Adam Lab GitHub page:
https://github.com/yoavadamlab

Lab Life:

Yoav Adam

Assistant Professor

Email: yoav.adam@mail.huji.ac.il

Phone: +972-2-549-4831

Yoav Adam

@YoavAdam

Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 2106, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401

Sachs Family Lecturer in Brain Sciences

Adam Lab

People

David Beniaguev

Post Doc

Adi Kaduri Amichai

PhD Student

Amir Dudai

PhD Student

Benjamin Weiner

PhD Student

Shiran Michael

PhD Student

Stav Hertz

PhD Student

Vitaly Lerner

PhD Student

Yair Deitcher

PhD Student

Neta Zylbermann

Lab Manager

Publications

Hertz S, Weiner B, Perets N, London M.

Temporal structure of mouse courtship vocalizations facilitates syllable labeling

Commun Biol. (2020)

Dudai A, Yayon N, Soreq H, London M.

Cortical VIP+ /ChAT+ interneurons: from genetics to function

J Neurochem (2020)

Dudai D., Yayon N., Lerner V., Tasaka G., Deitcher Y., Niederhoffe N., Mizrahi A., Soreq H., London M.

Functional characterization of cortical ChAT/VIP interneurons and their effect on the circuit in vivo.

PLoS Biology (2020)

Dudai A, Yayon N, Lerner V, Tasaka Gi, Deitcher Y, et al.

Barrel cortex VIP/ChAT interneurons suppress sensory responses in vivo

PLoS Biology (2020)

Amir Dudai, Michael Doron, Idan Segev and Michael London

Synaptic input and ACh modulation regulate dendritic Ca2+ spike duration in pyramidal neurons, directly affecting their somatic output

Journal of Neuroscience, JN-RM-1470-21 (2021)

David Beniaguev, Idan Segev, Michael London

Single cortical neurons as deep artificial neural networks

Neuron, ISSN 0896-6273 (2021)

Eyal Gal, Rodrigo Perin, Henry Markram, Michael London, Idan Segev

Neuron Geometry Underlies a Universal Local Architecture in Neuronal Networks

bioRxiv preprint first posted online May. 31, 2019 (2019)

David Beniaguev, Idan Segev, Michael London

Single Cortical Neurons as Deep Artificial Neural Networks

bioRxiv preprint first posted online Apr. 18, 2019; (2019)

Christina Labarrera, Yair Deitcher, Amir Dudai, Benjamin Weiner, Adi Kaduri Amichai, Neta Zylbermann, Michael London

Adrenergic Modulation Regulates the Dendritic Excitability of Layer 5 Pyramidal Neurons In Vivo

Cell reports 23 (4), 1034-1044 (2018)

Adar Adamsky*, Adi Kol*, Tirzah Kreisel, Adi Doron, Nofar Ozeri-Engelhard, Talia Melcer, Ron Refaeli, Henrike Horn, Limor Regev, Maya Groysman, Michael London, Inbal Goshen

Astrocytic activation generates de-novo neuronal potentiation and memory enhancement

Cell, Volume 174, Issue 1, 28 June 2018, Pages 59-71 (2018)

N Yayon, A Dudai, N Vrieler, O Amsalem, M London, H Soreq

Intensify3D: Normalizing signal intensity in large heterogenic image stacks

Scientific Reports, volume 8, Article number: 4311 (2018)

N Perets, S Hertz, M London, D Offen

Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice

Molecular autism 9 (1), 57 (2018)

D Offen, N Perets, S Hertz, M London

Intranasal administration of exosomes derived from mesenchymal stem cells improves autistic-like behaviors of BTBR mice

Cytotherapy 20 (5), S23 (2018)

Z Zalevsky, M London, E Cohen, A Shemer, D Malka

Multi optically-coupled channels module and related methods of computation

US Patent App. 15/755,138 (2018)

Perets N, Segal-Gavish H, Gothelf Y, Barzilay R, Barhum Y, Abramov N, Hertz S, Morozov D, London M, Offen D

Long term beneficial effect of neurotrophic factors-secreting mesenchymal stem cells transplantation in the BTBR mouse model of autism

Behavioural Brain Research Volume 331, Pages 254-260 (2017)

Eyal Gal, Michael London, Amir Globerson, Srikanth Ramaswamy, Michael W Reimann, Eilif Muller, Henry Markram & Idan Segev

Rich cell-type-specific network topology in neocortical microcircuitry

Nature Neuroscience, VOLUME 20 | NUMBER 7 | JULY 2017 (2017)

Cohen E, Malka D, Shemer A, Zalevsky Z and London M

Neural networks within multi-core optic fibers

Scientific Reports volume 6, Article number: 29080 (2016)

Weiner B, Hertz S, Perets N, London M

Social Ultrasonic Vocalization in Awake Head-Restrained Mouse

Frontiers in Behavioral Neuroscience, 10:236 (2016)

London M, Segev I.

synaptic music in dendrites

Nat Neurosci. 2004 Sep;7(9):904-5. (2004)

London M, Segev I.

Synaptic scaling in vitro and in vivo

Nat Neurosci. 2001 Sep;4(9):853-5. (2002)

London M, Schreibman A, Häusser M, Larkum ME, Segev I.

The information efficacy of a synapse

Nat Neurosci. 2002 Apr;5(4):332-40. (2002)

Steinmetz PN, Manwani A, Koch C, London M, Segev I.

Subthreshold voltage noise due to channel fluctuations in active neuronal membranes

J Comput Neurosci. 2000 Sep-Oct;9(2):133-48. (2000)

Segev I, London M.

Untangling dendrites with quantitative models

Science. 2000 Oct 27;290(5492):744-50 (2000)

Michael London, Claude Meunier and Idan Segev

Signal transfer in passive dendrites with non-uniform membrane conductance

Journal of Neuroscience 1 October 1999, 19 (19) 8219-8233 (1999)

Open Positions

At this time there are no available positions in the lab.

Additional Information

Website:
Lab Website
ELSC Program in Theoretical Neuroscience

Michael London

Associate Professor

Email: mickey.london@mail.huji.ac.il

Phone: +972-2-6586337

Michael London CV

@mikilon

Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 2103, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401

https://www.mikilon.org