Inbal Goshen Lab

ELSC Members

Neurons and Glia in Memory Lab

The Belgian Friends Optogenetics Laboratory

What underlies the transition from recent to remote memory? How does local modulation of neuronal activity by glia cells directly affect plasticity and behavior? To solve these puzzles we employ a variety of research approaches, integrating behavior, calcium imaging, electrophysiology and molecular biology, and apply optogenetics or chemogenetics in all of these levels.

Lab Website

Tamara Salaymeh

Undergrad Researcher

Chen Schieber

Undergrad Researcher

Tirzah Merzel Kreisel PhD

Research Associate

Yael Morose

Ph.D. Student

Lior Naggan

Ph.D. Student

Nechama Novick

Undergrad Researcher

Yaara Aram

M.Sc. Student

Stefano Quaglioni

PhD Student

Shay Meron

PhD Student

Adi Doron

Ron Refaeli

Adi Kol

Adar Adamsky

Refaeli R, Kreisel T, Groysman M, Adamsky A, Goshen I

Engram stability and maturation during systems consolidation

Curr Biol. Sep 25;33(18):3942-3950 (2023)

Refaeli R, Kreisel T, Goshen I

Analyzing engram reactivation and long-range connectivity

STAR Protoc Mar 15;5(1):102840 (2024)

Refaeli R, Kreisel T, Yaish TR, Groysman M, Goshen I

Astrocytes control recent and remote memory strength by affecting the recruitment of the CA1→ACC projection to engrams

Cell Rep. Mar 26;43(3):113943 (2024)

Atlan G. Terem A. Peretz-Rivlin N., Sehrawat, K. Gonzales, B., Goll Y., Pozner G., Tasaka G., Goll Y., Rafaeli R., Zviran O., Lim B., Groysman M., Goshen I, Mizrahi A., Nelken I., Citri A.

The claustrum supports resilience to distraction

Current Biology (2018)

Inbal Goshen, Raz Yirmiya, Adi Kol

Mentoring: A three-generation perspective

Neuron Feb 2;110(3):363-365 (2022)

Ron Refaeli, Inbal Goshen

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains

J Vis Exp. Mar 31;(181). (2022)

Adi Doron, Alon Rubin, Aviya Benmelech-Chovav, Netai Benaim, Tom Carmi, Ron Refaeli, Nechama Novick, Tirzah Kreisel, Yaniv Ziv & Inbal Goshen

Hippocampal astrocytes encode reward location

Nature volume 609, pages772–778 (2022)

Licht, T, Eavri R, Goshen I, Shlomai Y, Mizrahi A, Keshet E.

VEGF is required for dendritogenesis of newly born olfactory bulb interneurons

Development, 137: 261-271 (2010)

Refaeli R*, Doron A*, Benmelech-Chovav A, Groysman M, Kreisel T, Loewenstein Y, Goshen I

Features of hippocampal astrocytic domains and their spatial relation to excitatory and inhibitory neurons

Glia. 12 June (2021)

Kol A, Goshen I

The memory orchestra: the role of astrocytes and oligodendrocytes in parallel to neurons

Current Opinion in Neurobiology, Volume 67 pages 131-137 (2021)

Hirbec H, Déglon N, Foo LC, Goshen I, Grutzendler J, Hangen E, Kreisel T, Linck N, Muffat J, Regio S, Rion S, Escartin C

Emerging technologies to study glial cells

Glia. Sep;68(9):1692-1728 (2020)

Adi Kol, Adar Adamsky, Maya Groysman, Tirzah Kreisel, Michael London & Inbal Goshen

Astrocytes contribute to remote memory formation by modulating hippocampal–cortical communication during learning

Nature Neuroscience (2020)

Adi Doron, Inbal Goshen

Glia: The Glue Holding Memories Together

Neuron Volume 105, Issue 1, Pages 9-11 (2020)

Adamsky A, Goshen I

Astrocytes in Memory Function: Pioneering Findings and Future Directions

Neuroscience, Volume 370, Pages 14-26 (2018)

Adar Adamsky*, Adi Kol*, Tirzah Kreisel, Adi Doron, Nofar Ozeri-Engelhard, Talia Melcer, Ron Refaeli, Henrike Horn, Limor Regev, Maya Groysman, Michael London, Inbal Goshen

Astrocytic activation generates de-novo neuronal potentiation and memory enhancement

Cell, Volume 174, Issue 1, 28 June 2018, Pages 59-71 (2018)

Doron A, Goshen I

Investigating the transition from recent to remote memory using advanced tools

Brain Research Bulletin, Volume 141, Pages 35-43 (2018)

Milshtein-Parush H, Frere S, Regev L, Lahav C, Benbenishty A, Ben-Eliyahu S, Goshen I, Slutsky I

Sensory Deprivation Triggers Synaptic and Intrinsic Plasticity in the Hippocampus

Cerebral Cortex, Volume 27, Issue 6, Pages 3457–3470 (2017)

Daadi MM, Klausner JQ, Bajar B, Goshen I, Lee-Messer C, Lee SY, Winge MC, Ramakrishnan C, Lo M, Sun G, Deisseroth K, Steinberg GK.

Optogenetic Stimulation of Neural Grafts Enhances Neurotransmission and Downregulates the Inflammatory Response in Experimental Stroke Model

Cell Transplantation, Vol 25, Issue 7 (2016)

Goshen I.

The optogenetic revolution in memory research

Trends in Neurosciences, Volume 37, Issue 9, Pages 511-522 (2014)

Prakash R, Yizhar O, Grewe B, Ramakrishnan C, Wang N, Goshen I, Packer AM, Peterka DS, Yuste R, Schnitzer MJ, Deisseroth K.

Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation

Nature Methods, volume 9, pages 1171–1179 (2012)

Ben Menachem-Zidon O, Avital A, Ben-Menahem Y, Goshen I, Kreisel T, Shmueli EM, Segal M, Ben Hur T, Yirmiya R.

Astrocytes support hippocampal-dependent memory and long-term potentiation via interleukin-1 signaling

Brain, Behavior, and Immunity, Volume 25, Issue 5, Pages 1008-1016 (2011)

Goshen I, Brodsky M, Prakash R, Wallace J, Gradinaru V, Ramakrishnan C, Deisseroth K.

Dynamics of Retrieval Strategies for Remote Memories

Cell, Volume 147, Issue 3, Pages 678-689 (2011)

Yirmiya R, Goshen I.

Immune modulation of learning, memory, neural plasticity and neurogenesis

Brain, Behavior, and Immunity, Volume 25, Issue 2, Pages 181-213 (2011)

Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O'Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, Deisseroth K.

Neocortical excitation/inhibition balance in information processing and social dysfunction

Nature, volume 477, pages 171–178 (2011)

Anikeeva P, Andalman AS, Witten IB, Warden MR, Goshen I, Grosenick L, Gunaydin LA, Frank LM, Deisseroth K.

Optetrode: a multichannel readout for optogenetic control in freely moving mice

Nature Neuroscience, volume 15, pages 163–170 (2011)

Licht T*, Goshen I*, Avital A, Kreisel T, Zubedat S, Eavri R, Segal M, Yirmiya R, Keshet E.

Reversible modulations of neuronal plasticity by VEGF

PNAS, 108 (12) 5081-5086 (2011)

Lee JH, Durand R, Gradinaru V, Zhang F, Goshen I, Kim DS, Fenno, LE, Ramakrishnan C, Deisseroth K.

Global and local fMRI signals driven by neurons defined optogenetically by type and wiring

Nature, volume 465, pages 788–792 (2010)

Gradinaru V, Zhang F, Ramakrishnan C, Mattis J, Prakash R, Diester I, Goshen I, Thompson KR, Deisseroth K.

Molecular and Cellular Approaches for Diversifying and Extending Optogenetics

Cell, Volume 141, Issue 1, Pages 154-165 (2010)

Goshen I, Avital A, Kreisel T, Licht T, Segal M, Yirmiya R.

Environmental Enrichment Restores Memory Functioning in Mice with Impaired IL-1 Signaling via Reinstatement of Long-Term Potentiation and Spine Size Enlargement

Journal of Neuroscience, 29 (11) 3395-3403 (2009)

Goshen I, Yirmiya R

Interleukin-1 (IL-1): A central regulator of stress responses

Frontiers in Neuroendocrinology, Volume 30, Issue 1, Pages 30-45 (2009)

Ounallah-Saad H, Beeri R, Goshen I, Yirmiya R, Renbaum P, Levy-Lahad E

Transcriptional regulation of the murine Presenilin-2 gene reveals similarities and differences to its human orthologue

Gene, Volume 446, Issue 2, Pages 81-89 (2009)

Goshen I, Kreisel T, Ben-Menachem-Zidon O, Licht T, Weidenfeld, J., Ben-Hur T and Yirmiya R.

Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

Molecular Psychiatry, volume 13, pages 717–728 (2008)

Ben Menachem-Zidon O, Goshen I, Kreisel T, Ben Menahem Y, Reinhartz E, Ben Hur T, Yirmiya R.

Intrahippocampal Transplantation of Transgenic Neural Precursor Cells Overexpressing Interleukin-1 Receptor Antagonist Blocks Chronic Isolation-Induced Impairment in Memory and Neurogenesis

Neuropsychopharmacology, volume 33, pages 2251–2262 (2008)

Goshen I, Kreisel T, Ounallah-Saad H, Renbaum P, Zalzstein Y, Ben-Hur T, Levy-Lahad, E, Yirmiya R.

A dual role for interleukin-1 in hippocampal-dependent memory processes

Psychoneuroendocrinology, Volume 32, Issues 8–10, Pages 1106-1115 (2007)

Wolf G, Yirmiya R, Kreisel T, Goshen I, Weidenfeld J, Poole S, Shavit Y.

Interleukin-1 signaling modulates stress-induced analgesia

Brain, Behavior, and Immunity, Volume 21, Issue 5, Pages 652-659 (2007)

Yirmiya R, Goshen I, Bajayo A, Kreisel T, Feldman S, Tam J, Trembovler V, Csernus V, Shohami E, Bab I.

Depression induces bone loss through stimulation of the sympathetic nervous system

PNAS, 103 (45) 16876-16881 (2006)

Bajayo A*, Goshen I*, Feldman S, Csernus V, Iverfeldt K, Shohami E, Yirmiya R, Bab I.

Central IL-1 receptor signaling regulates bone growth and mass

PNAS, 102 (36) 12956-12961 (2005)

Shavit Y, Wolf G, Goshen I, Livshits D, Yirmiya R.

Interleukin-1 antagonizes morphine analgesia and underlies morphine tolerance

Pain Volume 115, Issues 1–2, Pages 50-59 (2005)

Weidenfeld J, Itzik A, Goshen I, Yirmiya R, Ben-Hur T.

Role of the Central Amygdala in Modulating the Pituitary-Adrenocortical and Clinical Responses in Experimental Herpes Simplex Virus-1 Encephalitis

Neuroendocrinology, 81:267–272 (2005)

Avital A*, Goshen I*, Kamsler A*, Segal M, Iverfeldt K, Richter-Levin G, Yirmiya R.

Impaired interleukin‐1 signaling is associated with deficits in hippocampal memory processes and neural plasticity

Hippocampus, Volume 13, Issue 7, Pages 826-834 (2003)

Wolf G, Yirmiya R, Goshen I, Iverfeldt K, Holmlund L, Takeda K, Shavit Y.

Impairment of interleukin-1 (IL-1) signaling reduces basal pain sensitivity in mice: genetic, pharmacological and developmental aspects

Pain, Volume 104 - Issue 3 - p 471–480 (2003)

Goshen I, Yirmiya R, Iverfeldt K, Weidenfeld J.

The Role of Endogenous Interleukin-1 in Stress-Induced Adrenal Activation and Adrenalectomy-Induced Adrenocorticotropic Hormone Hypersecretion

Endocrinology, Volume 144, Issue 10, Pages 4453–4458 (2003)

Pollak Y, Ovadia H, Goshen I, Gurevich R, Monsa K, Avitsur R, Yirmiya R.

Behavioral aspects of experimental autoimmune encephalomyelitis

Journal of Neuroimmunology, Volume 104, Issue 1, Pages 31-36 (2002)

Yirmiya R, Winocur G, Goshen I.

Brain Interleukin-1 Is Involved in Spatial Memory and Passive Avoidance Conditioning

Neurobiology of Learning and Memory, Volume 78, Issue 2, Pages 379-389 (2002)

Pollak Y, Orion E, Goshen I, Ovadia H, Yirmiya R.

Experimental autoimmune encephalomyelitis-associated behavioral syndrome as a model of ‘depression due to multiple sclerosis’

Brain, Behavior, and Immunity, Volume 16, Issue 5, Pages 533-543 (2002)

Barak O, Weidenfeld J, Goshen I, Ben-Hur T, Taylor AN, Yirmiya R.

Intracerebral HIV-1 glycoprotein 120 produces sickness behavior and pituitary–adrenal activation in rats: Role of prostaglandins

Brain, Behavior, and Immunity, Volume 16, Issue 6, Pages 720-735 (2002)

Barak O, Goshen I, Ben-Hur T, Weidenfeld J, Taylor AN, Yirmiya R.

Involvement of brain cytokines in the neurobehavioral disturbances induced by HIV-1 glycoprotein120

Brain Research, Volume 933, Issue 2, Pages 98-108 (2002)

We are always happy to add talented and motivated students to our group!

Graduate Students
We are looking for highly motivated and creative students who are passionate about neuroscience, and would like to be involved in multidisciplinary research examining the role of glia cells and neurons in behavior. Students will have the opportunity to acquire a variety of techniques, from molecular biology and electrophysiology, to imaging and behavior.

Postdocs
Postdoc candidates with experience in imaging / electrophysiology / behavior are welcome to send their CV, along with contact information for 2-3 references.

Undergraduate Students
The lab is happy to offer undergraduate students the opportunity to experience science first hand. Each student is first mentored by a Ph.D. student, and then expected to run their own project independently. Relevant majors: Biology, Physics, Cognitive Sciences, Computer Sciences, Chemistry.

Website:
Lab Website

מאמרים
פריצת דרך ישראלית: המחקר שעשוי לתת תקווה לחולי אלצהיימר, עיתון מעריב

פרופ' ענבל גושן והדוקטורנטית עדי קול גילו את המנגנון במוח שבורר חוויות משמעותיות בחיים שלנו ומייצר מהם זיכרונות ארוכי טווח, אתר האוניברסיטה העברית

תאי המוח שמחליטים מה נזכור גם בעוד שנים, גלובס

המחקר מעמיק והסברה מתחזקת: ייתכן שזיכרון בכלל לא אמור לדייק, הארץ

חשבנו שהנוירונים אחרים לכל התהליכים החשובים במוח. ייתכן שלגמרי טעינו? - על מחקריה החלוציים של פרופ' ענבל גושן, עיתון הארץ

Youtube
פרופ' ענבל גושן
הכוכבים החדשים בשיפור זיכרון

עדי קול
Open Box Science

רון רפאלי
CNS*2021, Workshop

Inbal Goshen

Professor

Email: inbal.goshen@elsc.huji.ac.il

Phone: +972-2-6585716

@GoshenInbal

Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 1104, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401

https://www.goshenlab.com

Neurons and Glia in Memory Lab

The Belgian Friends Optogenetics Laboratory

People

David Beniaguev

Post Doc

Adi Kaduri Amichai

PhD Student

Amir Dudai

PhD Student

Benjamin Weiner

PhD Student

Shiran Michael

PhD Student

Stav Hertz

PhD Student

Vitaly Lerner

PhD Student

Yair Deitcher

PhD Student

Neta Zylbermann

Lab Manager

Publications

Hertz S, Weiner B, Perets N, London M.

Temporal structure of mouse courtship vocalizations facilitates syllable labeling

Commun Biol. (2020)

Dudai A, Yayon N, Soreq H, London M.

Cortical VIP+ /ChAT+ interneurons: from genetics to function

J Neurochem (2020)

Dudai D., Yayon N., Lerner V., Tasaka G., Deitcher Y., Niederhoffe N., Mizrahi A., Soreq H., London M.

Functional characterization of cortical ChAT/VIP interneurons and their effect on the circuit in vivo.

PLoS Biology (2020)

Dudai A, Yayon N, Lerner V, Tasaka Gi, Deitcher Y, et al.

Barrel cortex VIP/ChAT interneurons suppress sensory responses in vivo

PLoS Biology (2020)

Amir Dudai, Michael Doron, Idan Segev and Michael London

Synaptic input and ACh modulation regulate dendritic Ca2+ spike duration in pyramidal neurons, directly affecting their somatic output

Journal of Neuroscience, JN-RM-1470-21 (2021)

David Beniaguev, Idan Segev, Michael London

Single cortical neurons as deep artificial neural networks

Neuron, ISSN 0896-6273 (2021)

Eyal Gal, Rodrigo Perin, Henry Markram, Michael London, Idan Segev

Neuron Geometry Underlies a Universal Local Architecture in Neuronal Networks

bioRxiv preprint first posted online May. 31, 2019 (2019)

David Beniaguev, Idan Segev, Michael London

Single Cortical Neurons as Deep Artificial Neural Networks

bioRxiv preprint first posted online Apr. 18, 2019; (2019)

Christina Labarrera, Yair Deitcher, Amir Dudai, Benjamin Weiner, Adi Kaduri Amichai, Neta Zylbermann, Michael London

Adrenergic Modulation Regulates the Dendritic Excitability of Layer 5 Pyramidal Neurons In Vivo

Cell reports 23 (4), 1034-1044 (2018)

Adar Adamsky*, Adi Kol*, Tirzah Kreisel, Adi Doron, Nofar Ozeri-Engelhard, Talia Melcer, Ron Refaeli, Henrike Horn, Limor Regev, Maya Groysman, Michael London, Inbal Goshen

Astrocytic activation generates de-novo neuronal potentiation and memory enhancement

Cell, Volume 174, Issue 1, 28 June 2018, Pages 59-71 (2018)

N Yayon, A Dudai, N Vrieler, O Amsalem, M London, H Soreq

Intensify3D: Normalizing signal intensity in large heterogenic image stacks

Scientific Reports, volume 8, Article number: 4311 (2018)

N Perets, S Hertz, M London, D Offen

Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice

Molecular autism 9 (1), 57 (2018)

D Offen, N Perets, S Hertz, M London

Intranasal administration of exosomes derived from mesenchymal stem cells improves autistic-like behaviors of BTBR mice

Cytotherapy 20 (5), S23 (2018)

Z Zalevsky, M London, E Cohen, A Shemer, D Malka

Multi optically-coupled channels module and related methods of computation

US Patent App. 15/755,138 (2018)

Perets N, Segal-Gavish H, Gothelf Y, Barzilay R, Barhum Y, Abramov N, Hertz S, Morozov D, London M, Offen D

Long term beneficial effect of neurotrophic factors-secreting mesenchymal stem cells transplantation in the BTBR mouse model of autism

Behavioural Brain Research Volume 331, Pages 254-260 (2017)

Eyal Gal, Michael London, Amir Globerson, Srikanth Ramaswamy, Michael W Reimann, Eilif Muller, Henry Markram & Idan Segev

Rich cell-type-specific network topology in neocortical microcircuitry

Nature Neuroscience, VOLUME 20 | NUMBER 7 | JULY 2017 (2017)

Cohen E, Malka D, Shemer A, Zalevsky Z and London M

Neural networks within multi-core optic fibers

Scientific Reports volume 6, Article number: 29080 (2016)

Weiner B, Hertz S, Perets N, London M

Social Ultrasonic Vocalization in Awake Head-Restrained Mouse

Frontiers in Behavioral Neuroscience, 10:236 (2016)

London M, Segev I.

synaptic music in dendrites

Nat Neurosci. 2004 Sep;7(9):904-5. (2004)

London M, Segev I.

Synaptic scaling in vitro and in vivo

Nat Neurosci. 2001 Sep;4(9):853-5. (2002)

London M, Schreibman A, Häusser M, Larkum ME, Segev I.

The information efficacy of a synapse

Nat Neurosci. 2002 Apr;5(4):332-40. (2002)

Steinmetz PN, Manwani A, Koch C, London M, Segev I.

Subthreshold voltage noise due to channel fluctuations in active neuronal membranes

J Comput Neurosci. 2000 Sep-Oct;9(2):133-48. (2000)

Segev I, London M.

Untangling dendrites with quantitative models

Science. 2000 Oct 27;290(5492):744-50 (2000)

Michael London, Claude Meunier and Idan Segev

Signal transfer in passive dendrites with non-uniform membrane conductance

Journal of Neuroscience 1 October 1999, 19 (19) 8219-8233 (1999)

Open Positions

At this time there are no available positions in the lab.

Additional Information

Website:
Lab Website
ELSC Program in Theoretical Neuroscience

Michael London

Associate Professor

Email: mickey.london@mail.huji.ac.il

Phone: +972-2-6586337

Michael London CV

@mikilon

Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 2103, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401

https://www.mikilon.org