Baruch Minke Lab

ELSC Members

Research Group of TRP Channels in Vision and Pain

My investigations have created a new field of research. I co-discovered a new type of ion channel, which I designated the Transient Receptor Potential or in short the TRP channel, as a result of my studies on phototransduction and vision in fruit flies (Drosophila melanogaster). I investigated the biophysical and biochemical properties of TRP channels in fruit fly eyes and identified together with the late Prof. Zvi Selinger phospholipase C as a crucial component of the Drosophila TRP signaling pathway. The principles that we found are common to numerous sensory (e.g. temperature, pain and taste sensations) and motor systems (properties of Purkinje neurons in the cerebellum), thus laying the foundation for the study of molecules that underlie mechanisms of TRP and pain, originally initiated by Prof. David Julius. Today we have extended our research to the first identified loss of function mutation in human TRPV1 channel that govern at least several of the human body's regulatory processes related inflammatory pain and to noxious heat detection. Our major aim is to decipher the critical roles of TRP channels in invertebrate vision and of TRPV1 in human somatosensory physiology.

Envelope Phone-alt

Baruch Minke

Professor Emeritus

Email: baruchm@ekmd.huji.ac.il
Phone: +972-2-6758407
Fax: +972-2-6439736
Mobile: +972-54-7961151
Baruch Minke CV
Address: Department of Medical Neurobiology, Faculty of Medicine,
Hadassah Ein-Kerem Campus, The Hebrew University of Jerusalem
Research Group of TRP Channels in Vision and Pain

My investigations have created a new field of research. I co-discovered a new type of ion channel, which I designated the Transient Receptor Potential or in short the TRP channel, as a result of my studies on phototransduction and vision in fruit flies (Drosophila melanogaster). I investigated the biophysical and biochemical properties of TRP channels in fruit fly eyes and identified together with the late Prof. Zvi Selinger phospholipase C as a crucial component of the Drosophila TRP signaling pathway. The principles that we found are common to numerous sensory (e.g. temperature, pain and taste sensations) and motor systems (properties of Purkinje neurons in the cerebellum), thus laying the foundation for the study of molecules that underlie mechanisms of TRP and pain, originally initiated by Prof. David Julius. Today we have extended our research to the first identified loss of function mutation in human TRPV1 channel that govern at least several of the human body's regulatory processes related inflammatory pain and to noxious heat detection. Our major aim is to decipher the critical roles of TRP channels in invertebrate vision and of TRPV1 in human somatosensory physiology.

ELSC-Seminars-General
Elisheva Rhodes-Mordov
PhD Student
ELSC-Seminars-General
Rachel Zaguri
PhD Student
ELSC-Seminars-General
Rita Gutotov
PhD Student
ELSC-Seminars-General
Tal Brandwine
PhD Student
Ben Katz
Ben Katz PhD
Research Associate
Brandwine Tal, Ifrah Reut, Bialistoky Tzofia, Zaguri Rachel, Rhodes-Mordov Elisheva, Mizrahi-Meissonnier Liliana, Sharon Dror, Katanaev Vladimir L., Gerlitz Offer, Minke Baruch

Knockdown of Dehydrodolichyl Diphosphate Synthase in the Drosophila Retina Leads to a Unique Pattern of Retinal Degeneration

Frontiers in Molecular Neuroscience (2021)

Katz, B., Pak, W. L., and Minke, B.

TRPC Channels—Insight from the Drosophila Light Sensitive Channels

Oxford University New York, NY 10016, Oxford Handbooks Online (In Press) (2019)

Gutorov R, Peters M, Katz B, Brandwine T, Barbera NA, Levitan I, Minke B

Modulation of Transient Receptor Potential C Channel Activity by Cholesterol

Frontiers in Pharmacology 10, 1487 (2019)

Barbera NA, Minke B, Levitan I

Comparative docking analysis of cholesterol analogs to ion channels to discriminate between stereospecific binding vs. stereospecific response

Channels, Volume 13, Issue 1, Pages 136-146 (2019)

Katz B, Minke B.

The Drosophila light-activated TRP and TRPL channels – Targets of the phosphoinositide signaling cascade.

Progress in Retinal and Eye Research, Volume 66, Pages 200-219 (2018)

Katz, B., Payne, R., and Minke, B.

TRP channels in vision.

Neurobiology of TRP Channels, T. Rosenbaum, Editor, CRC Press/Taylor and Francis Group (2017)

Voolstra O, Rhodes-Mordov E, Katz B, Bartels JP, Oberegelsbacher C, Schotthöfer SK, Yasin B, Tzadok H, Huber A, Minke B.

The Phosphorylation State of the Drosophila TRP Channel Modulates the Frequency Response to Oscillating Light In Vivo.

Journal of Neuroscience, 37 (15) 4213-4224 (2017)

Katz B, Voolstra O, Tzadok H, Yasin B, Rhodes-Modrov E, Bartels JP, Strauch L, Huber A, Minke B.

The latency of the light response is modulated by the phosphorylation state of Drosophila TRP at a specific site.

Channels (Austin), 11(6):678-685. (2017)

Katz B*, Gutorov R*, Rhodes-Mordov E, Hardie RC, Minke B.

Electrophysiological Method for Whole-cell Voltage Clamp Recordings from Drosophila Photoreceptors.

Journal of Visualized Experiments, (124). (2017)

Yasin B, Kohn E, Peters M, Zaguri R, Weiss S, Schopf K, Katz B, Huber A, Minke B.

Ectopic Expression of Mouse Melanopsin in Drosophila Photoreceptors Reveals Fast Response Kinetics and Persistent Dark Excitation.

Journal of Biological Chemistry, 292(9):3624-3636. (2017)

Peters M, Katz B, Lev S, Zaguri R, Gutorov R, Minke B.

Depletion of Membrane Cholesterol Suppresses Drosophila Transient Receptor Potential-Like (TRPL) Channel Activity.

Current Topics in Membranes, 80:233-254. (2017)

Kohn E, Katz B, Yasin B, Peters M, Rhodes E, Zaguri R, Weiss S, Minke B.

Functional cooperation between the IP3 receptor and phospholipase C secures the high sensitivity to light of Drosophila photoreceptors in vivo

J Neurosci. 2015 Feb 11;35(6):2530-46 (2015)

Weiss, S. and Minke B.

A new genetic model for calcium induced autophagy and ER-stress in Drosophila photoreceptor cells

Channels, Volume 9, Issue 1, pages 14-20 (2015)

Katz B, Oberacker T, Richter D, Tzadok H, Peters M, Minke B, Huber A.

Drosophila TRP and TRPL are assembled as homomultimeric channels in vivo

J Cell Sci. 2013 Jul 15;126(Pt 14):3121-33 (2013)

Minke B

The History of the Prolonged Depolarizing Afterpotential (PDA) and Its Role in Genetic Dissection of Drosophila Phototransduction

Journal of Neurogenetics, Volume 26, Issue 2 (2012)

Lev S, Katz B, Minke B

The activity of the TRP-like channel depends on its expression system

Channels, Volume 6, Issue 2 (2012)

Lev S., Katz B, Tzarfaty V. and Minke B

Signal-dependent hydrolysis of phosphatidylinositol 4,5-bisphosphate without activation of phospholipase C: implications on gating of Drosophila TRPL (transient receptor potential-like) channel

The Journal of Biological Chemistry, 287, 1436-1447 (2012)

Katz B. and Minke B

Phospholipase C-Mediated Suppression of Dark Noise Enables Single-Photon Detection in Drosophila Photoreceptors

Journal of Neuroscience, 32 (8) 2722-2733 (2012)

Weiss S, Kohn E, Dadon D, Katz B, Peters M, Lebendiker M, Kosloff M, Colley NJ, Minke B.

Compartmentalization and Ca2+ Buffering Are Essential for Prevention of Light-Induced Retinal Degeneration

J Neurosci. 2012 Oct 17;32(42):14696-708 (2012)

Peters M., Trembovler V., Alexandrovich A., Parnas M., Birnbaumer L., Minke B., Shohami E

Carvacrol Together with TRPC1 Elimination Improve Functional Recovery after Traumatic Brain Injury in Mice

Journal of Neurotrauma, Vol. 29, No. 18 (2012)

Minke B, Peters M

Rhodopsin as Thermosensor?

Science, Vol. 331, Issue 6022, pp. 1272-1273 (2011)

Richter D., Katz B., Oberacker T., Tzarfaty V., Belusic G., Minke B., Huber A

Translocation of the Drosophila Transient Receptor Potential-like (TRPL) Channel Requires Both the N- and C-terminal Regions Together with Sustained Ca2+ Entry

The Journal of Biological Chemistry, 286, 34234-34243 (2011)

Minke B

The History of the Drosophila TRP Channel: The Birth of a New Channel Superfamily

Journal of Neurogenetics, Volume 24, Issue 4 (2010)

Zeevi D. A., Lev S., Frumkin A., Minke B

Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy

J Cell Sci, 123: 3112-3124 (2010)

Lev S. and Minke B

Constitutive Activity of TRP Channels: Methods for Measuring the Activity and Its Outcome

Methods in Enzymology, Volume 484, Pages 591-612 (2010)

Lev S., Zeevi D. A., Frumkin A., Offen-Glasner V., Bach G. and Minke B

Constitutive Activity of the Human TRPML2 Channel Induces Cell Degeneration

The Journal of Biological Chemistry, 285, 2771-2782 (2010)

Dadon D. and Minke B

Cellular functions of Transient Receptor Potential channels

The International Journal of Biochemistry & Cell Biology, Volume 42, Issue 9, Pages 1430-1445 (2010)

Parnas M, Katz B., Lev S., Tzarfaty V., Dadon D., Gordon-Shaag, A., Metzner H., Yaka R. and Minke B

Membrane Lipid Modulations Remove Divalent Open Channel Block from TRP-Like and NMDA Channels

Journal of Neuroscience, 29 (8) 2371-2383 (2009)

Parnas M, Peters M., Minke B

Linoleic acid inhibits TRP channels with intrinsic voltage sensitivity: Implications on the mechanism of linoleic acid action

Channels (Austin), 3(3):164-6 (2009)

Katz B and Minke B

Drosophila photoreceptors and signaling mechanisms

Frontiers in Cellular Neuroscience (2009)

Parnas M., Peters M., Dadon D., Lev S., Vertkin I., Slutsky I. and Minke B

Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels

Cell Calcium, Volume 45, Issue 3, Pages 300-309 (2009)

Frechter S., Elia N., Tzarfaty V., Selinger Z. and Minke B

Translocation of Gqα Mediates Long-Term Adaptation in Drosophila Photoreceptors

Journal of Neuroscience, 27 (21) 5571-5583 (2007)

Parnas M., Katz B. and Minke B

Open Channel Block by Ca2+ Underlies the Voltage Dependence of Drosophila TRPL Channel

The Journal of General Physiology, 129 (1) 17-28 (2007)

Minke B

TRP channels and Ca2+ signaling

Cell Calcium, Volume 40, Issue 3, Pages 261-275 (2006)

Meyer NE, Joel-Almagor T, Frechter S, Minke B, Huber A

Subcellular translocation of the eGFP-tagged TRPL channel in Drosophila photoreceptors requires activation of the phototransduction cascade

Journal of Cell Science, 119: 2592-2603 (2006)

Frechter, S and Minke B

Light-regulated translocation of signaling proteins in Drosophila photoreceptors

Journal of Physiology-Paris Volume 99, Issues 2–3, Pages 133-139 (2006)

Minke B. and M. Parnas

Insights on TRP Channels from In Vivo Studies in Drosophila

Annual Review of Physiology, Volume 68, pp 649-684 (2006)

Chorna-Ornan I. , Tzarfati, V., Ankri-Eliahoo, G., Joel-Almagor, T., Huber A., Payre, F. and B Minke

Light-regulated interaction of Dmoesin with TRP and TRPL channels is required for maintenance of photoreceptors

The Journal of Cell Biology, 171 (1) 143-152 (2005)

Elia, N., Frechter, S., Minke, B, and Selinger, Z

Excess of Gβe over Gqαe in vivo prevents dark, spontaneous activity of Drosophila photoreceptors

The Journal of Cell Biology, 171 (3) 517-526 (2005)

Ikhine , R. Corna-Ornan, I. Zars, T. D. Elagina, R. B. Elia, N. Cheng, Y. Selinger, Z. Minke, B. and Hyde, D. R

Novel Dominant Rhodopsin Mutation Triggers Two Mechanisms of Retinal Degeneration and Photoreceptor Desensitization

Journal of Neuroscience, 24 (10) 2516-2526 (2004)

Agam, K., Frechter, S. and Minke, B

Activation of the Drosophila TRP and TRPL channels requires both Ca2+ and protein dephosphorylation

Cell Calcium, Volume 35, Issue 2, Pages 87-105 (2004)

Minke, B. and Agam, K

TRP gating is linked to the metabolic state and maintenance of the Drosophila photoreceptor cells

Cell Calcium, Volume 33, Issues 5–6, Pages 395-408 (2003)

Kosloff, M. Elia, N. Joel-Almagor, T. Timberg, R. Zars T. D. Hyde, D. R. Minke, B. and Selinger, Z

Regulation of light‐dependent Gqα translocation and morphological changes in fly photoreceptors

The EMBO Journal, 22, 459-468 (2003)

Minke, B. and Cook, B

TRP Channel Proteins and Signal Transduction

Physiol. Rev. 82:429-472 (2002)

Bähner, M., Frechter, S., Da Silva, N., Minke, B., Paulsen, R. and Huber, A

Light-Regulated Subcellular Translocation of Drosophila TRPL Channels Induces Long-Term Adaptation and Modifies the Light-Induced Current

Neuron, Volume 34, Issue 1, Pages 83-93 (2002)

Minke, B

The TRP Channel and Phospholipase C-Mediated Signaling

Cellular and Molecular Neurobiology, Volume 21, Issue 6, pp 629–643 (2001)

Chorna-Ornan, I., Joel-Almagor, T., Cohen Ben-Ami, H., Frechter, S., Gillo, B., Selinger, Z., Gill, D.L. , and Minke, B

A Common Mechanism Underlies Vertebrate Calcium Signaling and Drosophila Phototransduction

Journal of Neuroscience, 21 (8) 2622-2629 (2001)

Cook B, Bar-Yaacov M, Cohen Ben-Ami H, Goldstein R.E., Paroush Z, Selinger Z and Minke B

Phospholipase C and termination of G-protein-mediated signalling in vivo

Nature Cell Biology, volume 2, pages 296–301 (2000)

Yoon J, Cohen Ben-Ami H, Hong YS, Park S, Strong LLR, Bowman J, Geng C, Baek K, Minke B, Pak WL

Novel Mechanism of Massive Photoreceptor Degeneration Caused by Mutations in the trp Gene of Drosophila

Journal of Neuroscience, 20 (2) 649-659 (2000)

Agam, K., M. von-Campenhausen, S. Levy, H. Cohen Ben-Ami, B. Cook, K. Kirschfeld and B. Minke

Metabolic Stress Reversibly Activates the Drosophila Light-Sensitive Channels TRP and TRPL In Vivo

Journal of Neuroscience, 20 (15) 5748-5755 (2000)

Cook, B and Minke, B

TRP and calcium stores in Drosophila phototransduction

Cell Calcium, Volume 25, Issue 2, Pages 161-171 (1999)

Arnon, A., Cook, B.,Gillo, B., Montell, C., Selinger, Z. and Minke, B

Calmodulin regulation of light adaptation and store-operated dark current in Drosophila photoreceptors

PNAS, 94 (11) 5894-5899 (1997)

Arnon, A., Cook, B., Montell, C., Selinger, Z. and Minke, B

Calmodulin Regulation of Calcium Stores in Phototransduction of Drosophila

Science, Vol. 275, Issue 5303, pp. 1119-1121 (1997)

Minke, B. and Selinger, Z

The roles of trp and calcium in regulating photoreceptor function in Drosophila

Current Opinion in Neurobiology, Volume 6, Issue 4, Pages 459-466 (1996)

Minke, B. and Selinger, Z

Role of Drosophila TRP in inositide-mediated Ca2+ entry

Molecular Neurobiology, Volume 12, Issue 2, pp 163–180 (1996)

Gillo, B., Sealfon, S.C. and Minke, B

Pharmacology of a capacitative Ca2+ entry in Xenopus oocyte

Journal of Photochemistry and Photobiology B: Biology, Volume 35, Issues 1–2, Pages 77-82 (1996)

Ben-Oren, I., Peleg, G., Lewis, A., Minke, B. and Loew, L

Infrared nonlinear optical measurements of membrane potential in photoreceptor cells

Biophysical Journal, Volume 71, Issue 3, Pages 1616-1620 (1996)

Gillo, B, Chorna, I., Cohen, H., Cook, B., Manistersky, I, Chorev, M., Arnon, A., Pollock, A., Selinger, Z. and Minke, B

Coexpression of Drosophila TRP and TRP-like proteins in Xenopus oocytes reconstitutes capacitative Ca2+ entry

PNAS, 93 (24) 14146-14151 (1996)

Pollock, J., Arnon, A., Peretz, A., Nichols, D., Mojet, M.H., Hardie, R.C. and Minke, B

TRP, a protein essential for inositide-mediated Ca2+ influx is localized adjacent to the calcium stores in Drosophila photoreceptors

Journal of Neuroscience, 15 (5) 3747-3760 (1995)

Hardie, R.C. and Minke, B

Phosphoinositide-mediated phototransduction in Drosophila photoreceptors: the role of Ca2+ and trp

Cell Calcium Volume 18, Issue 4, Pages 256-274 (1995)

Porter, J.A., Minke, B. and Montell, C

Calmodulin binding to Drosophila NinaC required for termination of phototransduction

The EMBO Journal, Volume 14, Issue 18, Pages 4450-4459 (1995)

Barash, S. and Minke, B

Is the receptor potential of fly photoreceptors a summation of single-photon responses?

Comments in Theoretical Biology. 3: 229-263 (1994)

Peretz, A., Suss-Toby, E., Rom-Glas, A., Arnon, A., Payne, R. and Minke, B

The light response of drosophila photoreceptors is accompanied by an increase in cellular calcium: Effects of specific mutations

Neuron, Volume 12, Issue 6, p1257-1267 (1994)

Hardie, R.C. and Minke, B

Spontaneous activation of light-sensitive channels in Drosophila photoreceptors.

Journal of General Physiology, vol. 103 no. 3 389-407 (1994)

Peretz, A., Sandler, C., Kirschfeld, K., Hardie, R.C. and Minke B

Genetic dissection of light-induced Ca2+ influx into Drosophila photoreceptors.

Journal of General Physiology, vol. 104 no. 6 1057-1077 (1994)

Hardie, R.C. and Minke, B

Calcium-dependent inactivation of light-sensitive channels in Drosophila photoreceptors.

Journal of General Physiology, vol. 103 no. 3 409-427 (1994)

Sahly, I., Schroder, W. Zierold, A. and Minke, B

Accumulation of calcium in degenerating photoreceptors of several Drosophila mutants

Visual Neuroscience, Volume 11, pp. 763-772 (1994)

Selinger, Z. Doza, Y.N. and Minke, B

Mechanisms and genetics of photoreceptors desensitization in Drosophila flies

Biochimica et Biophysica Acta (BBA) – Molecular Cell Research, Volume 1179, Issue 3, Pages 283-299 (1993)

Byk, T., M. Bar-Yaacov, Y. Doza, B. Minke and Z. Selinger

Regulatory arrestin cycle secures the fidelity and maintenance of the fly photoreceptor cell.

PNAS, 90 (5) 1907-1911 (1993)

Hardie, R.C., Suss-Toby, E., Rom-Glas, A., Peretz, A., Selinger, Z. and Minke, B

Protein kinase C is required for light adaptation in Drosophila photoreceptors

Nature, 363, 634–637 (1993)

Hardie, R.C. and Minke, B

Novel Ca2+ channels underlying transduction in Drosophila photoreceptors: implications for phosphoinositide-mediated Ca2+ mobilization

Trends in Neurosciences, Volume 16, Issue 9,, Pages 371-376 (1993)

Hardie, R.C., Peretz, A., Pollock, J.A., and Minke, B

Ca2+ limits the development of the light response in Drosophila photoreceptors

Proceedings of the Royal Society B, Volume 252, Issue 1335 (1993)

Minke, B. and Z. Selinger

The inositol-lipid pathway is necessary for light excitation in fly photoreceptors.

Soc Gen Physiol Ser. 47:201-17. (1992)

Hardie, R.C. and B. Minke

The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors

Neuron, Volume 8, Issue 4, Pages 643-651 (1992)

Rom-Glas, A., C. Sandler, K. Kirschfeld, and B. Minke

The nss mutation or lanthanum inhibits light-induced Ca2+ influx into fly photoreceptors.

Journal of General Physiology, vol. 100 no. 5 767-781 (1992)

Minke, B., C. Rubinstein, I. Sahly, S. Bar-Nachum, E. Suss, J. Kleiman, T. Byke, and Z. Selinger

The Molecular Mechanism of Retinal Degeneration in the Retinal Degeneration B (rdgB) Mutant of Drosophila

Signal Transduction in Photoreceptor Cells pp 281-298 (1992)

Minke, B. and Z. Selinger

Intracellular Messengers in Invertebrate Photoreceptors Studied in Mutant Flies

Intracellular Messengers pp 517-563 (1992)

Doza, N.Y., B. Minke and Z. Selinger

Characterization of fly rhodopsin kinase

European Journal of Biochemistry, Volume 209, Issue 3, Pages 1035-1040 (1992)

Werner, U., E. Suss-Toby, A. Rom and B. Minke

Calcium is necessary for light excitation in barnacle photoreceptors

Journal of Comparative Physiology A, Volume 170, Issue 4, pp 427–434 (1992)

Sahly, I., S. Bar-Nachum, E. Suss-Toby, A. Rom, A. Peretz, J. Kleiman, T. Byke, Z. Selinger and B. Minke

Calcium channel blockers inhibit retinal degeneration in the retinal-degeneration-B mutant of Drosophila

PNAS, 89 (1) 435-439 (1992)

Minke, B. and Z. Selinger

Chapter 5 Inositol lipid pathway in fly photoreceptors: Excitation, calcium mobilization and retinal degeneration

Progress in Retinal Research, Volume 11, Pages 99-124 (1991)

Minke, B. and R. Payne

Spatial restriction of light adaptation and mutation-induced inactivation in fly photoreceptors

Journal of Neuroscience, 11 (4) 900-909 (1991)

Suss-Toby, E., Z. Selinger, and B. Minke

Lanthanum reduces the excitation efficiency in fly photoreceptors.

Journal of General Physiology, vol. 98 no. 4 849-868 (1991)

Minke, B., C. Rubinstein, I. Sahly, S. Bar-Nachum, R. Timberg and Z. Selinger

Phorbol ester induces photoreceptor-specific degeneration in a Drosophila mutant

PNAS, 87 (1) 113-117 (1990)

Rubinstein, C., S. Bar-Nachum, Z. Selinger, and B. Minke

Light-induced retinal degeneration in rdgB (retinal degeneration B) mutant of Drosophila: Electrophysiological and morphological manifestations of degeneration

Visual Neuroscience, Volume 2, Issue 6, pp. 529-539 (1989)

Rubinstein, C., S. Bar-Nachum, Z. Selinger, and B. Minke

Chemically induced retinal degeneration in the rdgB (retinal degeneration B) mutant of Drosophila

Visual Neuroscience, Volume 2, Issue 6, pp. 541-551 (1989)

Suss, E., S. Barash, D.G. Stavenga, H. Stieve, Z. Selinger, and B. Minke

Chemical excitation and inactivation in photoreceptors of the fly mutants trp and nss.

Journal of General Physiology, vol. 94 no. 3 465-491 (1989)

Selinger, Z. and B. Minke

Inositol Lipid Cascade of Vision Studied in Mutant Flies

Cold Spring Harb Symp Quant Biol. 53: 333-341 (1988)

Barash, S., E. Suss, D.G. Stavenga, Z. Selinger, C. Rubinstein, and B. Minke

Light reduces the excitation efficiency in the nss mutant of the sheep blowfly Lucilia.

Journal of General Physiology, vol. 92 no. 3 307-330 (1988)

Selinger, A., O. Devary, A. Blumenfeld, O. Heichal, S. Barash and B. Minke

Light-dependent phospholipase C activity in Musca eye membranes and excitation of photoreceptor cells by inositol triphosphate and 2,3 diphosphoglycerate.

Prog Clin Biol Res. 249:169-78. (1987)

Devary, O., O. Heichal, A. Blumenfeld, D. Cassel, E. Suss, S. Barash, C. Rubinstein, B. Minke and Z. Selinger

Coupling of photoexcited rhodopsin to inositol phospholipid hydrolysis in fly photoreceptors

PNAS, 84 (19) 6939-6943 (1987)

Minke, B

Bleaching adaptation in photoreceptors.

Isr J Med Sci. 23(1-2):61-8. (1987)

Almagor, E., P. Hillman and B. Minke

Spatial properties of the prolonged depolarizing afterpotential in barnacle photoreceptors. II. Antagonistic interactions.

Journal of General Physiology, vol. 87 no. 3 407-423 (1986)

Almagor, E., P. Hillman and B. Minke

Spatial properties of the prolonged depolarizing afterpotential in barnacle photoreceptors. I. The induction process.

Journal of General Physiology, vol. 87 no. 3 391-405 (1986)

Minke, B

Photopigment-dependent Adaptation in Invertebrates — Implications for Vertebrates

Dahlem Workshop Reports (Life Sciences Research Report), vol 34, pp 241-265 (1986)

Minke, B. and M. Tsacopoulos

Light induced sodium dependent accumulation of calcium and potassium in the extracellular space of bee retina

Vision Research, Volume 26, Issue 5, Pages 679-690 (1986)

Minke, B. and R.S. Stephenson

The characteristics of chemically induced noise in Musca photoreceptors

Journal of Comparative Physiology A, Volume 156, Issue 3, pp 339–356 (1985)

Blumenfeld, A., J. Erusalimsky, O. Heichal, Z. Selinger, and B. Minke

Light-activated guanosinetriphosphatase in Musca eye membranes resembles the prolonged depolarizing afterpotential in photoreceptor cells

PNAS, 82 (20) 7116-7120 (1985)

Minke, B. and K. Kirschfeld

Non-local interactions between light induced processes in Calliphora photoreceptors

Journal of Comparative Physiology A, Volume 154, Issue 2, pp 175–187 (1984)

Minke, B. and E. Armon

Activation of electrogenic Na-Ca exchange by light in fly photoreceptors

Vision Research, Volume 24, Issue 2, Pages 109-115 (1984)

Hillman, P., S. Hochstein and B. Minke

Transduction in invertebrate photoreceptors: role of pigment bistability.

Physiological Reviews, Volume 63, Pages 668-772 (1983)

Minke, B

The trp is a Drosophila mutant sensitive to developmental temperature

Journal of comparative physiology, Volume 151, Issue 4, pp 483–486 (1983)

Armon, E. and B. Minke

Light activated electrogenic Na+-Ca2+-exchange in fly photoreceptors: Modulation by Na+/K+-pump activity

Biophysics of structure and mechanism, Volume 9, Issue 4, pp 349–357 (1983)

Minke, B

Light-induced reduction in excitation efficiency in the trp mutant of Drosophila.

Journal of General Physiology, vol. 79 no. 3 361-385 (1982)

Franceschini, N., K. Kirschfeld and B. Minke

Fluorescence of photoreceptor cells observed in vivo

Science, Vol. 213, Issue 4513, pp. 1264-1267 (1981)

Minke, B. and E. Armon

Intermediate processes in phototransduction. A study in Drosophila mutants

Photochemistry and Photobiology, Volume 32, Issue 4, Pages 553-562 (1980)

Minke, B. and K. Kirschfeld

Fast electrical potentials arising from activation of metarhodopsin in the fly.

Journal of General Physiology, vol. 75 no. 4 381-402 (1980)

Almagor, E., P. Hillman, and B. Minke

Upper limit on translational diffusion of visual pigment in intact unfixed barnacle photoreceptors

Biophysics of structure and mechanism, Volume 5, Issue 2–3, pp 243–248 (1979)

Minke, B

Transduction in photoreceptors with bistable pigments: Intermediate processes

Biophysics of structure and mechanism, Volume 5, Issue 2–3, pp 163–174 (1979)

Minke, B. and K. Kirschfeld

The contribution of a sensitizing pigment to the photosensitivity spectra of fly rhodopsin and metarhodopsin.

Journal of General Physiology, vol. 73 no. 5 517-540 (1979)

Kirschfeld, K., R. Feiler and B. Minke

The Kinetics of Formation of Metarhodopsin in Intact Photoreceptors of the Fly

Zeitschrift für Naturforschung C, Volume 33, Issue 11-12, Pages 1009–1010 (1978)

Minke, B., S. Hochstein and P. Hillman

The kinetics of visual pigment systems: II. Application to measurements on a bistable pigment system

Biological Cybernetics, Volume 30, Issue 1, pp 33–43 (1978)

Hochstein, S., B. Minke, P. Hillman and B. Knight

The kinetics of visual pigment systems: I. Mathematical analysis

Biological Cybernetic, Volume 30, Issue 1, pp 23–32 (1978)

Minke, B. and K. Kirschfeld

Microspectrophotometric evidence for two photointerconvertible states of visual pigment in the barnacle lateral eye.

Journal of General Physiology, vol. 71 no. 1 37-45 (1978)

Kirschfeld, K., N. Franceschini and B. Minke

Evidence for a sensitising pigment in fly photoreceptors

Nature, 269, 386–390 (1977)

Minke, B

Drosophila mutant with a transducer defect

Biophysics of structure and mechanism, Volume 3, Issue 1, pp 59–64 (1977)

Hillman, P.S. Hochstein, and B. Minke

Nonlocal interactions in the photoreceptor transduction process.

Journal of General Physiology, vol. 68 no. 2 227-245 (1976)

Minke, B., C.-F. Wu and W.L. Pak

Isolation of light-induced response of the central retinula cells from the electroretinogram of Drosophila

Journal of comparative physiology, Volume 98, Issue 4, pp 345–355 (1975)

Minke, B., C-F, Wu, and W.L. Pak

Induction of photoreceptor voltage noise in the dark in Drosophila mutant

Nature, 258, 84–87 (1975)

Minke, B., S. Hochstein, and P. Hillman

Derivation of a Quantitative Kinetic Model for a Visual Pigment from Observations of Early Receptor Potential

Biophysical Journal, Volume 14, Issue 6, Pages 490-512 (1974)

Hillman, P., F.A. Dodge, Jr., S. Hochstein, B. Knight and B. Minke

Rapid Dark Recovery of the Invertebrate Early Receptor Potential

Journal of General Physiology, vol. 62 no. 1 77-86 (1973)

Minke, B., S. Hochstein and P. Hillman

Antagonistic Process as Source of Visible-Light Suppression of Afterpotential in Limulus UV Photoreceptors

Journal of General Physiology, vol. 62 no. 6 787-791 (1973)

Minke, B., S. Hochstein, and P. Hillman

Early Receptor Potential Evidence for the Existence of Two Thermally Stable States in the Barnacle Visual Pigment

Journal of General Physiology, vol. 62 no. 1 87-104 (1973)

Hochstein, S., B. Minke, and P. Hillman

Antagonistic Components of the Late Receptor Potential in the Barnacle Photoreceptor Arising from Different Stages of the Pigment Process

Journal of General Physiology, vol. 62 no. 1 105-128 (1973)

Hochstein, S., B. Minke and P. Hillman

Receptor Potentials from a Visual Pigment with Two Thermally Stable States

The Visual System pp 65-73 (1972)

Minke, B., and E. Auerbach

Latencies and correlation in single units and visual evoked potentials in the cat striate cortex following monocular and binocular stimulations

Experimental Brain Research, Volume 14, Issue 4, pp 409–422 (1972)

Hillman, P., S. Hochstein and B. Minke

A Visual Pigment with Two Physiologically Active Stable States

Science, Vol. 175, Issue 4029, pp. 1486-1488 (1972)

At this time there are no available positions in the lab.
Honors:
EMET Prize
Prince of Asturias Award (from the current King of Spain)
Envelope Phone-alt

Baruch Minke

Professor Emeritus

Email: baruchm@ekmd.huji.ac.il
Phone: +972-2-6758407
Fax: +972-2-6439736
Mobile: +972-54-7961151
Baruch Minke CV
Address: Department of Medical Neurobiology, Faculty of Medicine,
Hadassah Ein-Kerem Campus, The Hebrew University of Jerusalem

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ELSC - The Edmond and Lily Safra Center for Brain Sciences

The Edmond & Lily Safra Center for Brain Sciences (ELSC) aims to develop a thriving interface between theory and experimentation across levels – cognitive, biological, and computational neuroscience – paving the way to innovative discovery in brain research.

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פיתוח ועיצוב אתר: סטודיו שדה

לחצו למעבר להרשמה

“Working memory”

New exhibition titled “Working memory” by the artist Alon kedem and in collaboration with ELSC Prof. Leon Deouell. In the picture: Moshe Lion, the mayor of Jerusalem and Prof. Asher Cohen, the president of The Hebrew University of Jerusalem.