Reut Fluss

Reut Fluss

Computational biologist

I am interested in understanding the transcriptional networks involved in the formation of drug addiction. I am using RNA-seq and single molecule FISH data to assess the circuit wide transcriptional changes associated with drug exposure in multiple brain regions as well as in single-cell resolution.

CV

Supervisors

Contact information

Goodman Building, room 1106

The Safra Campus of the Hebrew University, Givat-Ram, Jerusalem

Recent publications

Wittenbrink N, Ananthasubramaniam B, Münch M, Koller B, Maier B, Weschke C, Bes F, de Zeeuw J, Nowozin C, Wahnschaffe A, Wisniewski S, Zaleska M, Bartok O, Ashwal-Fluss R, Lammert H, Herzel H, Hummel M, Kadener S, Kunz D, Kramer A. "High-accuracy determination of internal circadian time from a single blood sample". J Clin Invest. (2018 Aug 31;128(9):3826-3839)

Buchumenski I, Bartok O, Ashwal-Fluss R, Pandey V, Porath HT, Levanon EY, Kadener S. "Dynamic hyper-editing underlies temperature adaptation in Drosophila". PLoS Genet. (2017 Jul 26;13(7))

Pamudurti NR*, Bartok O*, Jens M*, Ashwal-Fluss R*, Stottmeister C, Ruhe L, Hanan M, Wyler E, Perez-Hernandez D, Ramberger E, Shenzis S, Samson M, Dittmar G, Landthaler M, Chekulaeva M, Rajewsky N, Kadener S. "Translation of CircRNAs". Molecular Cell (2017 Apr 6;66(1):9-21)

Cohen-Hadad Y, Altarescu G, Eldar-Geva T, Levi-Lahad E, Zhang M, Rogaeva E, Gotkine M, Bartok O, Ashwal-Fluss R, Kadener S, Epsztejn-Litman S, Eiges R."Marked Differences in C9orf72 Methylation Status and Isoform Expression between C9/ALS Human Embryonic and Induced Pluripotent Stem Cells". Stem Cell Reports. (2016 Nov 8;7(5):927-940)

Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, Herzog M, Schreyer L, Papavasileiou P, Ivanov A, Öhman M, Refojo D, Kadener S, Rajewsky N. "Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed". Molecular Cell (2015 Jun 4;58(5):870-85)

Bartok O, Teesalu M, Ashwall-Fluss R, Pandey V et al. "The transcription factor Cabut coordinates energy metabolism and the circadian clock in response to sugar sensing". EMBO J 2015 (Jun 3;34(11):1538-53)

Ashwal-Fluss R.*, Meyer M.*, Pamudurti NR*, Ivanov A., Bartok O., Hanan M., Evantal N., Memczak S., Rajewsky N., Kadener S."circRNA Biogenesis Competes with Pre-mRNA Splicing". Molecular Cell (2014 Oct 2;56(1):55-66).

Mezan S.*, Ashwal-Fluss R.*, Shenhav R., Garber M., Kadener S. "Genome-wide assessment of post-transcriptional control demonstrates a central role for miRNAs in the fly brain". Frontiers in Molecular Neuroscience (2013 Dec 9;6:49)

Lustig Y, Barhod E, Ashwal-Fluss R, Gordin R, Shomron N, Umanski K, Groner Y, Hemi R, Karasik A, Kanety H. "RNA binding protein PTB in conjunction with microRNA-221 regulates AdipoR1 translation and adiponectin signaling". Diabetes (2014 Feb;63(2):433-45)

Melamed Z, Levy A, Ashwal-Fluss R, Lev-Maor G, Mekahel K, Atias N, Gilad S, Sharan R, Levy C, Kadener S*, and Ast G*. "Alternative Splicing Regulates Biogenesis of miRNAs Located Across Exon-Intron Junctions". Molecular Cell (2013 Jun 27;50(6):869-81)

Ashwal R, Hemi R, Tirosh A, Gordin R, Yissachar E, Cohen-Dayag A, Rosenberg A, Karasik A, Blüher M, Kanety H. "Differential expression of novel adiponectin receptor-1 transcripts in skeletal muscle of normoglycemic and type 2 diabetic patients". Diabetes (2011 Mar;60(3):936-46)