Cholinergic excitation induces activity-dependent electrophysiological and transcriptional responses in hippocampal slices

To explore the correlations between short-term neurophysiological events initiated by over-activation of acetylcholine receptors, and long-lasting changes in brain function, we combined electrophysiology and PCR-based measurements in hippocampal slices or live mice subjected to stress or drug-induced cholinergic activation. Our findings reveal a common cascade of neuronal events resulting in delayed suppression of cholinergic transmission.

Authors: Friedman A, Kaufer D, Pavlovsky L, Soreq H.
Year of publication: 1998
Journal: J Physiol Paris. 1998 Jun-Aug;92(3-4):329-35.

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“Working memory”