Paper of the Month, August 2020(Habib's Lab)

Disease-associated astrocytes in Alzheimer’s disease and aging

Authors: Habib, N., McCabe, C., Medina, S. et al.


Published: Nat Neurosci 23, 701–706 (2020)



The role of non-neuronal cells in Alzheimer’s disease progression has not been fully elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-associated astrocytes in an Alzheimer’s disease mouse model. These disease-associated astrocytes appeared at early disease stages and increased in abundance with disease progression. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors.


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