Article of the Month, July 2017 (Mezer's lab)

July 3, 2017


Evaluating g-ratio weighted changes in the corpus callosum as a function of age and sex

Authors: Berman et al. (Mezer's lab)

Published in NeuroImage, June 2017


Recent developments in quantitative and diffusion MRI, have made it possible to estimate the axonal g-ratio in human white-matter in-vivo. g-Ratio is the ratio between the inner and outer radii of the myelin sheath wrapped around the axon. We suggest a simplified measurement of g-ratio incorporating proton density mapping, and implement it in the corpus-callosum of 92subjects (ages 8-80). We find the g-ratio values to agree with previously published results. Furthermore, g-ratio values are stable over the lifespan and between the sexes. These results converge with theoretical evidence suggesting g-ratio has an optimal value for white-matter function.


Full article at: http://www.sciencedirect.com/science/article/pii/S1053811917305475