Naomi Habib Lab

ELSC Members

Goren-Khazzam Lecturer in Brain Sciences
Cognitive decline and resilience lab

We are interested in solving the secret of cognitive resilience. The cellular microenvironment in the brain is composed of multiple cell types, including neurons, astrocytes, microglia, vascular and other cells, and we are studying how interactions between different cell types in the brain are contributing to cognitive decline and to cognitive resilience, in particular in the context of aging-related pathologies. We also study how interactions between the brain and other systems in the aging body, such as immune and metabolic signaling, are mediating aging-related pathologies. The work is done using human brain tissue, animal models and cell cultures, combining cutting-edge technologies in the fields of genomics, imaging, molecular biology, and genome engineering, with advanced computational analysis and modeling. Specifically, we are pioneering the development and application of single nucleus RNA-sequencing technologies.

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Naomi Habib

Associate Professor

Email: naomi.habib@elsc.huji.ac.il
Phone: +972-2-5494818
Naomi Habib
@naomi_habib
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 2, Room 2207, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
Goren-Khazzam Lecturer in Brain Sciences
Cognitive decline and resilience lab

We are interested in solving the secret of cognitive resilience. The cellular microenvironment in the brain is composed of multiple cell types, including neurons, astrocytes, microglia, vascular and other cells, and we are studying how interactions between different cell types in the brain are contributing to cognitive decline and to cognitive resilience, in particular in the context of aging-related pathologies. We also study how interactions between the brain and other systems in the aging body, such as immune and metabolic signaling, are mediating aging-related pathologies. The work is done using human brain tissue, animal models and cell cultures, combining cutting-edge technologies in the fields of genomics, imaging, molecular biology, and genome engineering, with advanced computational analysis and modeling. Specifically, we are pioneering the development and application of single nucleus RNA-sequencing technologies.

David photo website 2025
David Beniaguev
Post Doc
adi
Adi Kaduri Amichai
PhD Student
Amir_website
Amir Dudai
PhD Student
Ben
Benjamin Weiner
PhD Student
Shiran (2)
Shiran Michael
PhD Student
stav
Stav Hertz
PhD Student
PASS
Vitaly Lerner
PhD Student
Yair
Yair Deitcher
PhD Student
neta
Neta Zylbermann
Lab Manager
David Beniaguev, Sapir Shapira, Idan Segev, Michael London

Dendro-plexing of Single Input Spikes via Multiple Synaptic Contacts Can Enhance Cortical Neuron Computation and Reduce Axonal Wiring

The Journal of neuroscience : the official journal of the Society for Neuroscience (2026)

Bradley C Rauscher, Natalie Fomin-Thunemann, Sreekanth Kura, Patrick R Doran, Pablo D Perez, Kıvılcım Kılıç, Emily A Martin, Dora Balog, Nathan X Chai, Francesca A Froio, Patrick F Bloniasz, Kate E Herrema, Rockwell P Tang, Scott G Knudstrup, Andrew Garcia, John X Jiang, Jeffrey P Gavornik, Michael London, David Kleinfeld, Michael E Hasselmo, Laura D Lewis, Sava Sakadzic, Lei Tian, Gal Mishne, Emily P Stephen, Martin Thunemann, David A Boas, Anna Devor

The neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions

Nature neuroscience (2026)

Qixin Yang, Shulamit Baror-Sebban, Rotem Kipper, Michael London, Yoav Adam

All-optical electrophysiology reveals behavior-dependent dynamics of excitation and inhibition in the hippocampus

Neuron (2026)

Hertz S, Weiner B, Perets N, London M.

Temporal structure of mouse courtship vocalizations facilitates syllable labeling

Commun Biol. (2020)

Dudai A, Yayon N, Soreq H, London M.

Cortical VIP+ /ChAT+ interneurons: from genetics to function

J Neurochem (2020)

Dudai D., Yayon N., Lerner V., Tasaka G., Deitcher Y., Niederhoffe N., Mizrahi A., Soreq H., London M.

Functional characterization of cortical ChAT/VIP interneurons and their effect on the circuit in vivo.

PLoS Biology (2020)

Dudai A, Yayon N, Lerner V, Tasaka Gi, Deitcher Y, et al.

Barrel cortex VIP/ChAT interneurons suppress sensory responses in vivo

PLoS Biology (2020)

Amir Dudai, Michael Doron, Idan Segev and Michael London

Synaptic input and ACh modulation regulate dendritic Ca2+ spike duration in pyramidal neurons, directly affecting their somatic output

Journal of Neuroscience, JN-RM-1470-21 (2021)

David Beniaguev, Idan Segev, Michael London

Single cortical neurons as deep artificial neural networks

Neuron, ISSN 0896-6273 (2021)

Eyal Gal, Rodrigo Perin, Henry Markram, Michael London, Idan Segev

Neuron Geometry Underlies a Universal Local Architecture in Neuronal Networks

bioRxiv preprint first posted online May. 31, 2019 (2019)

David Beniaguev, Idan Segev, Michael London

Single Cortical Neurons as Deep Artificial Neural Networks

bioRxiv preprint first posted online Apr. 18, 2019; (2019)

Christina Labarrera, Yair Deitcher, Amir Dudai, Benjamin Weiner, Adi Kaduri Amichai, Neta Zylbermann, Michael London

Adrenergic Modulation Regulates the Dendritic Excitability of Layer 5 Pyramidal Neurons In Vivo

Cell reports 23 (4), 1034-1044 (2018)

Adar Adamsky*, Adi Kol*, Tirzah Kreisel, Adi Doron, Nofar Ozeri-Engelhard, Talia Melcer, Ron Refaeli, Henrike Horn, Limor Regev, Maya Groysman, Michael London, Inbal Goshen

Astrocytic activation generates de-novo neuronal potentiation and memory enhancement

Cell, Volume 174, Issue 1, 28 June 2018, Pages 59-71 (2018)

N Yayon, A Dudai, N Vrieler, O Amsalem, M London, H Soreq

Intensify3D: Normalizing signal intensity in large heterogenic image stacks

Scientific Reports, volume 8, Article number: 4311 (2018)

N Perets, S Hertz, M London, D Offen

Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice

Molecular autism 9 (1), 57 (2018)

D Offen, N Perets, S Hertz, M London

Intranasal administration of exosomes derived from mesenchymal stem cells improves autistic-like behaviors of BTBR mice

Cytotherapy 20 (5), S23 (2018)

Z Zalevsky, M London, E Cohen, A Shemer, D Malka

Multi optically-coupled channels module and related methods of computation

US Patent App. 15/755,138 (2018)

Perets N, Segal-Gavish H, Gothelf Y, Barzilay R, Barhum Y, Abramov N, Hertz S, Morozov D, London M, Offen D

Long term beneficial effect of neurotrophic factors-secreting mesenchymal stem cells transplantation in the BTBR mouse model of autism

Behavioural Brain Research Volume 331, Pages 254-260 (2017)

Eyal Gal, Michael London, Amir Globerson, Srikanth Ramaswamy, Michael W Reimann, Eilif Muller, Henry Markram & Idan Segev

Rich cell-type-specific network topology in neocortical microcircuitry

Nature Neuroscience, VOLUME 20 | NUMBER 7 | JULY 2017 (2017)

Cohen E, Malka D, Shemer A, Zalevsky Z and London M

Neural networks within multi-core optic fibers

Scientific Reports volume 6, Article number: 29080 (2016)

Weiner B, Hertz S, Perets N, London M

Social Ultrasonic Vocalization in Awake Head-Restrained Mouse

Frontiers in Behavioral Neuroscience, 10:236 (2016)

London M, Segev I.

synaptic music in dendrites

Nat Neurosci. 2004 Sep;7(9):904-5. (2004)

London M, Segev I.

Synaptic scaling in vitro and in vivo

Nat Neurosci. 2001 Sep;4(9):853-5. (2002)

London M, Schreibman A, Häusser M, Larkum ME, Segev I.

The information efficacy of a synapse

Nat Neurosci. 2002 Apr;5(4):332-40. (2002)

Steinmetz PN, Manwani A, Koch C, London M, Segev I.

Subthreshold voltage noise due to channel fluctuations in active neuronal membranes

J Comput Neurosci. 2000 Sep-Oct;9(2):133-48. (2000)

Segev I, London M.

Untangling dendrites with quantitative models

Science. 2000 Oct 27;290(5492):744-50 (2000)

Michael London, Claude Meunier and Idan Segev

Signal transfer in passive dendrites with non-uniform membrane conductance

Journal of Neuroscience 1 October 1999, 19 (19) 8219-8233 (1999)

At this time there are no available positions in the lab.
Website:
Lab Website
ELSC Program in Theoretical Neuroscience
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Michael London

Associate Professor

Email: mickey.london@mail.huji.ac.il
Phone: +972-2-6586337
Michael London CV
@mikilon
Address: The Edmond and Lily Safra Center for Brain Sciences
The Suzanne and Charles Goodman Brain Sciences Building,
Level 1, Room 2103, Edmond J. Safra Campus,
The Hebrew University of Jerusalem, 9190401
https://www.mikilon.org
לחצו למעבר להרשמה

“Working memory”

New exhibition titled “Working memory” by the artist Alon kedem and in collaboration with ELSC Prof. Leon Deouell. In the picture: Moshe Lion, the mayor of Jerusalem and Prof. Asher Cohen, the president of The Hebrew University of Jerusalem.