In memoriam: Naftali Tishby Lab

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Prof. Naftali Tishby passes away at the age of 68
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Ruth & Stan Flinkman Family Endowment Fund Chair in Brain Research

Tishby's Lab

NEWS

The 2019 IBT Award in Mathematical Neuroscience – THANKS!

Our Information Bottleneck Theory of Deep Learning has recently been noticed – at last!

See the Quanta-Magazine article on our work and my June 2017 Berlin Deep Learning Workshop talk which triggered it.

A longer talk given at Yandex, Moscow, October 10, 2017.

Recent & popular talks

ACDL, Siena, July 2019
MPI, Gottingen, July 2019
ISIT, Paris, July 2019
CBMM, Italy, June 2019
Gatsby triCenter meeting, London, June 2019
IPAM, Geometry of Big Data, UCLA, May 2019
Columbia University Economics, May 2019
IMVC, Tel-Aviv, April 2019
CERN, Geneva, ML for HEP, April 2019
BrainTech, Tel-Aviv, March 2019
ICERM, Brown University, February 2019
Deep Learning & the Brain, ELSC, Jerusalem, January 2019
Directions in Theoretical Physics, Edinburgh, January 2019
Statistical Physics and Machine Learning: A 30 Year Perspectives, APS Physics Next Workshop, October 2018
Part I of a Mini-Course on The Information Theory of Deep Learning, ICTP, Trieste, November 2018
Part II of a Mini-Course on The Information Theory of Deep Learning, ICTP, Trieste, November 2018
Part III of a Mini-Course on The Information Theory of Deep Learning, ICTP, Trieste, November 2018
“What Makes Us Human: From Genes to Machines”, June 6, 2018, Jerusalem.
A Talk at the Israel Academy of Science, June 6, 2018, Jerusalem
Interview on the future of Artificial Intelligence, The AI Summit, Berlin, June 2018.
Interview at SISSA , Trieste, Italy, before my physics colloquium, May 2018.
Perimeter Institute Physics Colloquium, Waterloo, Canada, April 2018.
S tanford CSE Colloquium, April 4, 2018.
Simons Institute, Berkeley, Public talk, April 9, 2018.
Simons Institute, Berkeley, “Brain & Computation program”, March 2018.
Human creativity, Music & Deep Learning, BIU, Nov. 29, 2017.
The Synergy between Information and Control
שבוע אמנות ומוח 2016 דוד גרוסמן ופרופ’ נפתלי תשבי בדיאלוג על מוח, מחשבה, דמיון ויצירה

My Current Lab:

Selected Research Projects

We work at the interface between computer science, physics, and biology which provides some of the most challenging problems in today’s science and technology. We focus on organizing computational principles that govern information processing in biology, at all levels. To this end, we employ and develop methods that stem from statistical physics, information theory and computational learning theory, to analyze biological data and develop biologically inspired algorithms that can account for the observed performance of biological systems. We hope to find simple yet powerful computational mechanisms that may characterize evolved and adaptive systems, from the molecular level to the whole computational brain and interacting populations. An example is the Information Bottleneck method that provides a general principle for extracting relevant structure in multivariate data, characterizes complex processes, and suggests a general approach for understanding optimal adaptive biological behavior

Stas Tiomkin, Ilya Nemenman, Daniel Polani, Naftali Tishby

Intrinsic Motivation in Dynamical Control Systems

PRX Life (2024)

Nadav Amir, Naftali Tishby, Israel Nelken

A simple model of the attentional blink and its modulation by mental training

PLoS Computational Biology (2022)

Noga Zaslavsky, Karee Garvin, Charles Kemp, Naftali Tishby, Terry Regier

The evolution of color naming reflects pressure for efficiency: Evidence from the recent past

Journal of Language Evolution (2022)

Hagai Rappeport, Irit Levin-Reisman, Naftali Tishby, Nathalie Q. Balaban

Detecting chaos in lineage-trees: A deep learning approach

Physical Review Research (2022)

Nadav Amir, Reut Suliman-Lavie, Maayan Tal, Sagiv Shifman, Naftali Tishby, Israel Nelken

Value-complexity tradeoff explains mouse navigational learning

PLoS Computational Biology (2020)

Hadar Levi-Aharoni, Naftali Tishby

The value–complexity trade-off for reinforcement learning based brain–computer interfaces

Journal of Neural Engineering (2020)

Amichai Painsky, Meir Feder, Naftali Tishby

Nonlinear Canonical Correlation Analysis:A Compressed Representation Approach

Entropy (2020)

Hadar Levi-Aharoni, Oren Shriki, Naftali Tishby

Surprise response as a probe for compressed memory states

PLoS Computational Biology (2020)

Noga Zaslavsky, Terry Regier, Naftali Tishby, Charles Kemp

Semantic Categories of Artifacts and Animals Reflect Efficient Coding

ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (2020)

Ron M. Hecht, Ariel Telpaz, Gila Kamhi, Omer Tsimhoni, Aharon Bar-Hillel, Naftali Tishby

Modeling the Effect of Driver’s Eye Gaze Pattern Under Workload: Gaussian Mixture Approach

eScholarship (California Digital Library) (2020)

Giuseppe Carleo, J. I. Cirac, K. Cranmer, Laurent Daudet, Maria Schuld, Naftali Tishby, Leslie Vogt-Maranto, Lenka Zdeborová

Machine learning and the physical sciences

Reviews of Modern Physics (2019)

Ron M. Hecht, Aharon Bar-Hillel, Ariel Telpaz, Omer Tsimhoni, Naftali Tishby

Information Constrained Control Analysis of Eye Gaze Distribution Under Workload

IEEE Transactions on Human-Machine Systems (2019)

Noga Zaslavsky, Charles Kemp, Naftali Tishby, Terry Regier

Communicative need in colour naming

Cognitive Neuropsychology (2019)

Noga Zaslavsky, Charles Kemp, Naftali Tishby, Terry Regier

Communicative need and color naming

eScholarship (California Digital Library) (2019)

Noga Zaslavsky, Karee Garvin, Charles Kemp, Naftali Tishby, Terry Regier

Evolution and efficiency in color naming: The case of Nafaanra

eScholarship (California Digital Library) (2019)

Noga Zaslavsky, Charles Kemp, Naftali Tishby, Terry Regier

Color Naming Reflects Both Perceptual Structure and Communicative Need

Topics in Cognitive Science (2018)

Noga Zaslavsky, Charles Kemp, Terry Regier, Naftali Tishby

Efficient compression in color naming and its evolution

Proceedings of the National Academy of Sciences (2018)

Naftali Tishby

The Information Bottleneck Theory of Deep Neural Networks

Bulletin of the American Physical Society (2018)

Amichai Painsky, Naftali Tishby

Gaussian Lower Bound for the Information Bottleneck Limit

Journal of Machine Learning Research (2018)

Noga Zaslavsky, Charles Kemp, Terry Regier, Naftali Tishby

Information-theoretic efficiency and semantic variation: The case of color naming

eScholarship (California Digital Library) (2018)

Siwei Wang, Alexander Borst, Noga Zaslavsky, Naftali Tishby, Idan Segev

Efficient encoding of motion is mediated by gap junctions in the fly visual system

PLoS Computational Biology (2017)

Jonathan E. Rubin, Nachum Ulanovsky, Israel Nelken, Naftali Tishby

The Representation of Prediction Error in Auditory Cortex

PLoS Computational Biology (2016)

Nori Jacoby, Naftali Tishby, Dmitri Tymoczko

An Information Theoretic Approach to Chord Categorization and Functional Harmony

Journal of New Music Research (2015)

Nori Jacoby, Peter E. Keller, Bruno H. Repp, Merav Ahissar, Naftali Tishby

Lower Bound on the Accuracy of Parameter Estimation Methods for Linear Sensorimotor Synchronization Models

Timing & Time Perception (2015)

Nori Jacoby, Naftali Tishby, Bruno H. Repp, Merav Ahissar, Peter E. Keller

Parameter Estimation of Linear Sensorimotor Synchronization Models: Phase Correction, Period Correction, and Ensemble Synchronization

Timing & Time Perception (2015)

Naftali Tishby

Sensing and acting under information constraints – a principled approach to biology and intelligence

cIRcle (University of British Columbia) (2015)

Ron M. Hecht, Εlad Noor, Gil Dobry, Yaniv Zigel, Aharon Bar-Hillel, Naftali Tishby

Effective Model Representation by Information Bottleneck Principle

IEEE Transactions on Audio Speech and Language Processing (2013)

Naama Parush, Naftali Tishby, Hagai Bergman

Dopaminergic Balance between Reward Maximization and Policy Complexity

Frontiers in systems neuroscience (2011)

Simone Calderara, Uri Heinemann, Andrea Prati, Rita Cucchiara, Naftali Tishby

Detecting anomalies in people’s trajectories using spectral graph analysis

Computer Vision and Image Understanding (2011)

Ohad Shamir, Naftali Tishby

Stability and model selection in k-means clustering

Machine Learning (2010)

Ohad Shamir, Sivan Sabato, Naftali Tishby

Learning and generalization with the information bottleneck

Theoretical Computer Science (2010)

Yevgeny Seldin, Naftali Tishby

PAC-Bayesian Analysis of Co-clustering and Beyond

Max Planck Institute for Plasma Physics (2010)

Felix Creutzig, Amir Globerson, Naftali Tishby

Past-future information bottleneck in dynamical systems

Physical Review E (2009)

Yevgeny Seldin, Naftali Tishby

PAC-Bayesian Generalization Bound for Density Estimation with Application to Co-clustering

MPG.PuRe (Max Planck Society) (2009)

Amir Globerson, Eran Stark, Eilon Vaadia, Naftali Tishby

The minimum information principle and its application to neural code analysis

Proceedings of the National Academy of Sciences (2009)

Naama Parush, David Arkadir, Alon Nevet, Genela Morris, Naftali Tishby, Israel Nelken, Hagai Bergman

Encoding by Response Duration in the Basal Ganglia

Journal of Neurophysiology (2008)

Eyal Krupka, Amir Navot, Naftali Tishby

Learning to Select Features using their Properties

Journal of Machine Learning Research (2008)

Eyal Krupka, Naftali Tishby

Generalization from Observed to Unobserved Features by Clustering

Journal of Machine Learning Research (2008)

Naftali Tishby

Extracting Relevant Information from Samples

ISAIM (2008)

Hani Neuvirth, Uwe Heinemann, Daniel Birnbaum, Naftali Tishby, Gideon Schreiber

ProMateus–an open research approach to protein-binding sites analysis

Nucleic Acids Research (2007)

Gal Chechik, Michael J. Anderson, Omer Bar‐Yosef, Eric D. Young, Naftali Tishby, Israel Nelken

Reduction of Information Redundancy in the Ascending Auditory Pathway

Neuron (2006)

Noam Slonim, Nir Friedman, Naftali Tishby

Multivariate Information Bottleneck

Neural Computation (2006)

Amir Globerson, Gal Chechik, Fernando Pereira, Naftali Tishby

Euclidean Embedding of Co-Occurrence Data

Journal of Machine Learning Research (2004)

Gill Bejerano, Nir Friedman, Naftali Tishby

Efficient Exact p-Value Computation for Small Sample, Sparse, and Surprising Categorical Data

Journal of Computational Biology (2004)

Gill Bejerano, Nir Friedman, Naftali Tishby

Efficient Exact p -Value Computation for Small Sample, Sparse, and Surprising Categorical Data

Journal of Computational Biology (2004)

Rivka Adar, Yaakov Benenson, Gregory Linshiz, Amit Rosner, Naftali Tishby, Ehud Shapiro

Stochastic computing with biomolecular automata

Proceedings of the National Academy of Sciences (2004)

Ron Bekkerman, Ran El‐Yaniv, Naftali Tishby, Yoad Winter

Distributional word clusters vs. words for text categorization

Journal of Machine Learning Research (2003)

Amir Globerson, Naftali Tishby

Sufficient dimensionality reduction

Journal of Machine Learning Research (2003)

Noam Slonim, Gill Bejerano, Shai Fine, Naftali Tishby

Discriminative Feature Selection via Multiclass Variable Memory Markov Model

EURASIP Journal on Advances in Signal Processing (2003)

Shlomo Dubnov, Ran El‐Yaniv, Yoram Gdalyahu, Elad Schneidman, Naftali Tishby, Golan Yona

A New Nonparametric Pairwise Clustering Algorithm Based on Iterative Estimation of Distance Profiles

Machine Learning (2002)

Itay Gat, Naftali Tishby

Spotting Neural Spike Patterns Using an Adversary Background Model

Neural Computation (2001)

William Bialek, Ilya Nemenman, Naftali Tishby

Predictability, Complexity, and Learning

Neural Computation (2001)

Gill Bejerano, Yevgeny Seldin, Hanah Margalit, Naftali Tishby

Markovian domain fingerprinting: statistical segmentation of protein sequences

Bioinformatics (2001)

Yevgeny Seldin, Gill Bejerano, Naftali Tishby

Unsupervised Sequence Segmentation by a Mixture of Switching Variable Memory Markov Sources

MPG.PuRe (Max Planck Society) (2001)

Yevgeny Seldin, Gill Bejerano, Naftali Tishby

Unsupervised Segmentation and Classification of Mixtures of Markovian Sources

MPG.PuRe (Max Planck Society) (2001)

Bernhard Schölkopf, Smola Williamson R, John Shawe‐Taylor, Joachim M. Buhmann, Wolfgang Maaß, H. Ritter, Naftali Tishby

Single-class Support Vector Machines

MPG.PuRe (Max Planck Society) (1999)

Joachim M. Buhmann, Wolfgang Maass, Helge Ritter, Naftali Tishby

Unsupervised Learning (Dagstuhl Seminar 99121)

DROPS (Schloss Dagstuhl – Leibniz Center for Informatics) (1999)

Shai Fine, Yoram Singer, Naftali Tishby

The Hierarchical Hidden Markov Model: Analysis and Applications

Machine Learning (1998)

Dana Ron, Yoram Singer, Naftali Tishby

On the Learnability and Usage of Acyclic Probabilistic Finite Automata

Journal of Computer and System Sciences (1998)

Shlomo Dubnov, Naftali Tishby, Dalia Cohen

Polyspectra as measures of sound texture and timbre*

Journal of New Music Research (1997)

Itay Gat, Naftali Tishby, Micha Abeles

Comparative study of supervised detection methods of simultaneously recorded spike trains

Neuroscience Letters (1997)

Yoav Freund, H. Sebastian Seung, Eli Shamir, Naftali Tishby

Selective Sampling Using the Query by Committee Algorithm

Machine Learning (1997)

M Linial, N Linial, N Tishby, G Yona

Global self-organization of all known protein sequences reveals inherent biological signatures

Journal of molecular biology (1997)

David Haussler, Michael Kearns, H. Sebastian Seung, Naftali Tishby

Rigorous learning curve bounds from statistical mechanics

Machine Learning (1997)

Itay Gat, Naftali Tishby, Moshe Abeles

Hidden Markov modelling of simultaneously recorded cells in the associative cortex of behaving monkeys

Network Computation in Neural Systems (1997)

Dana Ron, Yoram Singer, Naftali Tishby

The power of amnesia: Learning probabilistic automata with variable memory length

Machine Learning (1997)

Shlomo Dubnov, Naftali Tishby

Testing for Gaussianity and Non Linearity in the sustained portion of musical sounds

HAL (Le Centre pour la Communication Scientifique Directe) (1996)

Shlomo Dubnov, Naftali Tishby, Dalia Cohen

Influence of Frequency Modulating Jitter on Higher Order Moments of Sound Residual with Applications to Synthesis and Classification

The Journal of the Abraham Lincoln Association (1996)

Shlomo Dubnov, Naftali Tishby, Dalia Cohen

Hearing beyond the spectrum

Journal of New Music Research (1995)

Micha Abeles, H. C. Bergman, Itai Gat, Isaac Meilijson, Eyal Seidemann, Naftali Tishby, Eilon Vaadia

Cortical activity flips among quasi-stationary states

Proceedings of the National Academy of Sciences (1995)

Shlomo Dubnov, Naftali Tishby

Clustering Musical Sounds Using Polyspectral Distance Measures

The Journal of the Abraham Lincoln Association (1995)

Yaron Singer, Naftali Tishby

Dynamical encoding of cursive handwriting

Biological Cybernetics (1994)

Naftali Tishby, Allen L. Gorin

Algebraic learning of statistical associations for language acquisition

Computer Speech & Language (1994)

HS Seung, H Sompolinsky, N Tishby

Statistical mechanics of learning from examples

Physical review. A, Atomic, molecular, and optical physics (1992)

Haim Sompolinsky, Naftali Tishby

Learning in a Two-Layer Neural Network of Edge Detectors

Europhysics Letters (EPL) (1990)

Haim Sompolinsky, Naftali Tishby, H. Sebastian Seung

Learning from examples in large neural networks

Physical Review Letters (1990)

G. Györgyi, Naftali Tishby

Path Integrals in Hamiltonian Systems: Breakup of the Last Kolmogorov-Arnold-Moser Torus Due to Random Forces

Physical Review Letters (1989)

Naftali Tishby

Nonlinear dynamical modeling of speech using neural networks

Neural Networks (1988)

G. Györgyi, Naftali Tishby

Destabilization of islands in noisy Hamiltonian systems

Physical Review A (1987)

Naftali Tishby

Text-independent speaker verification using linear predictive hidden Markov models

The Journal of the Acoustical Society of America (1987)

G. Györgyi, Naftali Tishby

Scaling in stochastic Hamiltonian systems: A renormalization approach

Physical Review Letters (1987)

Yoel Tikochinsky, Naftali Tishby, R. D. Levine

Tikochinsky, Tishby, and Levine Respond

Physical Review Letters (1985)

Yoel Tikochinsky, Naftali Tishby, R. D. Levine

Alternative approach to maximum-entropy inference

Physical Review A (1984)

Naftali Tishby, R. D. Levine

Time evolution via a self-consistent maximal-entropy propagation: The reversible case

Physical Review A (1984)

Yoel Tikochinsky, Naftali Tishby, R. D. Levine

Consistent Inference of Probabilities for Reproducible Experiments

Physical Review Letters (1984)

Naftali Tishby, R. D. Levine

A self-consistent field procedure for stationary states using an algebraic approach and the maximum entropy formalism

Chemical Physics Letters (1984)

Naftali Tishby, R. D. Levine

Surprisal analysis derived from a variational principle for mechanical systems

Chemical Physics Letters (1983)

In memoriam: Naftali Tishby

Professor

https://naftali-tishby.mystrikingly.com

Prof. Naftali Tishby passes away at the age of 68
Read More

Ruth & Stan Flinkman Family Endowment Fund Chair in Brain Research

Tishby's Lab

NEWS

The 2019 IBT Award in Mathematical Neuroscience – THANKS!

Our Information Bottleneck Theory of Deep Learning has recently been noticed – at last!

See the Quanta-Magazine article on our work and my June 2017 Berlin Deep Learning Workshop talk which triggered it.

A longer talk given at Yandex, Moscow, October 10, 2017.

Recent & popular talks

My Current Lab:

Selected Research Projects

People

Ben Katz PhD

Research Associate

Elisheva Rhodes-Mordov

PhD Student

Rachel Zaguri

PhD Student

Rita Gutotov

PhD Student

Tal Brandwine

PhD Student

Publications

Ben Katz, Rachel Zaguri, Simon Edvardson, Channa Maayan, Orly Elpeleg, Shaya Lev, Elyad Davidson, Maximilian Peters, Shlomit Kfir-erenfeld, Esther Berger, Shifa Ghazalin, Alexander M. Binshtok, Baruch Minke

Addendum to Nociception and pain in humans lacking a functional TRPV1 channel

Journal of Clinical Investigation (2026)

Tal Brandwine-Shemmer, Nicolas Barbera, Irena Levitan, Baruch Minke

Cholesterol inhibits capsaicin activation of the TRPV1 channel

Channels (2026)

Ben Katz, Rachel Zaguri, Rita Gutorov, Baruch Minke

How a Boy Who Loved Hot Peppers Contributed to Pain Research

Frontiers for Young Minds (2025)

Ben Katz, Rita Gutorov, Channa Maayan, Rachel Zaguri, Baruch Minke

Human Mutations in the TRPV1 Channel: Implications for Noxious Cold Sensation

The Annual Review of Pharmacology and Toxicology (2025)

Tal Brandwine-Shemmer, Baruch Minke, Irena Levitan

Inhibition of TRPV1 by an antagonist in clinical trials is dependent on cholesterol binding

Cell Calcium (2024)

Baruch Minke

The pioneering use of the PDA phenotype by Bill Pak for screening a network of phototransduction genes and the associated signaling pathways

Journal of Neurogenetics (2024)

Rita Gutorov, Ben Katz, Maximilian Peters, Baruch Minke

Membrane lipid modulations by methyl-β-cyclodextrin uncouple the Drosophila light-activated phospholipase C from TRP and TRPL channel gating

Journal of Biological Chemistry (2023)

Sarah C. Stanhope, Tal Brandwine-Shemmer, Hannah R. Blum, Emma H. Doud, Amber Jannasch, Amber L. Mosley, Baruch Minke, Vikki M. Weake

Proteome-wide quantitative analysis of redox cysteine availability in the Drosophila melanogaster eye reveals oxidation of phototransduction machinery during blue light exposure and age

Redox Biology (2023)

Elisheva Rhodes-Mordov, Tal Brandwine-Shemmer, Rachel Zaguri, Rita Gutorov, Maximilian Peters, Baruch Minke

Diacylglycerol Activates the Drosophila Light Sensitive Channel TRPL Expressed in HEK Cells

International Journal of Molecular Sciences (2023)

Ben Katz, Baruch Minke

Methods for Studying the Optics, Physiology, and Biochemistry of the Fly Compound Eye

Journal of Visualized Experiments (2023)

Ben Katz, Rachel Zaguri, Simon Edvardson, Channa Maayan, Orly Elpeleg, Shaya Lev, Elyad Davidson, Maximilian Peters, Shlomit Kfir‐Erenfeld, Esther Berger, Shifa Ghazalin, Alexander M. Binshtok, Baruch Minke

Nociception and pain in humans lacking a functional TRPV1 channel

Journal of Clinical Investigation (2022)

Baruch Minke, William L. Pak

The light-activated TRP channel: the founding member of the TRP channel superfamily

Journal of Neurogenetics (2022)

Rita Gutorov, Ben Z. Katz, Baruch Minke

Electrophysiological Methods for Measuring Photopigment Levels in Drosophila Photoreceptors

Journal of Visualized Experiments (2022)

Rita Gutorov, Ben Katz, Elisheva Rhodes-Mordov, Rachel Zaguri, Tal Brandwine-Shemmer, Baruch Minke

The Role of Membrane Lipids in Light-Activation of Drosophila TRP Channels

Biomolecules (2022)

Tal Brandwine, Reut Ifrah, Tzofia Bialistoky, Rachel Zaguri, Elisheva Rhodes-Mordov, Liliana Mizrahi‐Meissonnier, Dror Sharon, Vladimir L. Katanaev, Offer Gerlitz, Baruch Minke

Knockdown of Dehydrodolichyl Diphosphate Synthase in the Drosophila Retina Leads to a Unique Pattern of Retinal Degeneration

Frontiers in Molecular Neuroscience (2021)

Reut Ifrah, Tal Brandwine, Liliana Mizrahi‐Meissonnier, Rachel Zaguri, Tzofia Bialistoky, Vladimir L. Katanaev, Dror Sharon, Offer Gerlitz, Baruch Minke

A Drosophila model for a Dehydrodolichyl Diphosphate Synthase (DHDDS) mutation causing Retinitis Pigmentosa in humans

Investigative Ophthalmology & Visual Science (2020)

Rita Gutorov, Maximilian Peters, Ben Katz, Tal Brandwine, Nicolas Barbera, Irena Levitan, Baruch Minke

Modulation of Transient Receptor Potential C Channel Activity by Cholesterol

Frontiers in Pharmacology (2019)

Nicolas A Barbera, Baruch Minke, Irena Levitan

Comparative docking analysis of cholesterol analogs to ion channels to discriminate between stereospecific binding vs. stereospecific response

Channels (Austin, Tex.) (2019)

Ben Katz, Baruch Minke

The Drosophila light-activated TRP and TRPL channels – Targets of the phosphoinositide signaling cascade

Progress in Retinal and Eye Research (2018)

Ben Katz, Olaf Voolstra, Hanan Tzadok, Bushra Yasin, Elisheva Rhodes-Modrov, Jonas-Peter Bartels, Lisa Strauch, Armin Huber, Baruch Minke

The latency of the light response is modulated by the phosphorylation state of Drosophila TRP at a specific site

Channels (2017)

Maximilian Peters, Ben Katz, Shaya Lev, Rachel Zaguri, Rita Gutorov, Baruch Minke

Depletion of Membrane Cholesterol Suppresses Drosophila Transient Receptor Potential-Like (TRPL) Channel Activity

Current topics in membranes (2017)

Ben Katz, Rita Gutorov, Elisheva Rhodes-Mordov, Roger Hardie, Baruch Minke

Electrophysiological Method for Whole-cell Voltage Clamp Recordings from Drosophila Photoreceptors

Journal of Visualized Experiments (2017)

Olaf Voolstra, Elisheva Rhodes-Mordov, Ben Katz, Jonas-Peter Bartels, Claudia Oberegelsbacher, Susanne Katharina Schotthöfer, Bushra Yasin, Hanan Tzadok, Armin Huber, Baruch Minke

The Phosphorylation State of the Drosophila TRP Channel Modulates the Frequency Response to Oscillating Light In Vivo

Journal of Neuroscience (2017)

Bushra Yasin, Elkana Kohn, Maximilian Peters, Rachel Zaguri, Shirley Weiss, Krystina Schopf, Ben Katz, Armin Huber, Baruch Minke

Ectopic Expression of Mouse Melanopsin in Drosophila Photoreceptors Reveals Fast Response Kinetics and Persistent Dark Excitation

Journal of Biological Chemistry (2017)

Liliana Mizrahi‐Meissonnier, Rachel Zaguri, Elisheva Rhodes, Vladimir L. Katanaev, Baruch Minke, Dror Sharon

Molecular, physiological and morphological effects of DHDDS knockdown in photoreceptors of Drosophila

Investigative Ophthalmology & Visual Science (2015)

Elkana Kohn, Ben Katz, Bushra Yasin, Maximilian Peters, Elisheva Rhodes, Rachel Zaguri, Shirley Weiss, Baruch Minke

Functional Cooperation between the IP3 Receptor and Phospholipase C Secures the High Sensitivity to Light of Drosophila Photoreceptors In Vivo

Journal of Neuroscience (2015)

Shirley Weiss, Baruch Minke

A new genetic model for calcium induced autophagy and ER-stress in Drosophila photoreceptor cells

Channels (2015)

Elisheva Rhodes-Mordov, Hadar Samra, Baruch Minke

Electroretinogram (ERG) Recordings from Drosophila

BIO-PROTOCOL (2015)

Ben Katz, Tina Oberacker, David Richter, Hanan Tzadok, Maximilian Peters, Baruch Minke, Armin Huber

Drosophila TRP and TRPL are assembled as homomultimeric channels in vivo

Journal of cell science (2013)

Shirley Weiss, Elkana Kohn, Daniela Dadon, Ben Katz, Maximilian Peters, Mario Lebendiker, Mickey Kosloff, Nansi Jo Colley, Baruch Minke

Compartmentalization and Ca2+Buffering Are Essential for Prevention of Light-Induced Retinal Degeneration

Journal of Neuroscience (2012)

Maximilian Peters, Victoria Trembovler, Alexander Alexandrovich, Moshe Parnas, Lutz Birnbaumer, Baruch Minke, Esther Shohami

Carvacrol Together with TRPC1 Elimination Improve Functional Recovery after Traumatic Brain Injury in Mice

Journal of Neurotrauma (2012)

Baruch Minke

The History of the Prolonged Depolarizing Afterpotential (PDA) and Its Role in Genetic Dissection of Drosophila Phototransduction

Journal of Neurogenetics (2012)

Shaya Lev, Ben Katz, Baruch Minke

The activity of the TRP-like channel depends on its expression system

Channels (2012)

Ben Katz, Baruch Minke

Phospholipase C-Mediated Suppression of Dark Noise Enables Single-Photon Detection in Drosophila Photoreceptors

Journal of Neuroscience (2012)

Shaya Lev, Ben Katz, Vered Tzarfaty, Baruch Minke

Signal-dependent Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate without Activation of Phospholipase C

Journal of Biological Chemistry (2011)

David Richter, Ben Katz, Tina Oberacker, Vered Tzarfaty, Gregor Belušič, Baruch Minke, Armin Huber

Translocation of the Drosophila Transient Receptor Potential-like (TRPL) Channel Requires Both the N- and C-terminal Regions Together with Sustained Ca2+ Entry

Journal of Biological Chemistry (2011)

Baruch Minke, Maximilian Peters

Cell biology. Rhodopsin as thermosensor

Science (New York, N.Y.) (2011)

Baruch Minke

The History of the Drosophila TRP Channel: The Birth of a New Channel Superfamily

Journal of Neurogenetics (2010)

David A. Zeevi, Shaya Lev, Ayala Frumkin, Baruch Minke, Gideon Bach

Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy

Journal of Cell Science (2010)

Daniela Dadon, Baruch Minke

Cellular functions of Transient Receptor Potential channels

The International Journal of Biochemistry & Cell Biology (2010)

Shaya Lev, Baruch Minke

Constitutive activity of TRP channels methods for measuring the activity and its outcome

Methods in enzymology (2010)

Shaya Lev, David A. Zeevi, Ayala Frumkin, Vered Offen‐Glasner, Gideon Bach, Baruch Minke

Constitutive Activity of the Human TRPML2 Channel Induces Cell Degeneration

Journal of Biological Chemistry (2009)

Ben Katz, Baruch Minke

Drosophila photoreceptors and signaling mechanisms

Frontiers in cellular neuroscience (2009)

Moshe Parnas, Maximilian Peters, Baruch Minke

Linoleic acid inhibits TRP channels with intrinsic voltage sensitivity: Implications on the mechanism of linoleic acid action

Channels (2009)

Moshe Parnas, Ben Katz, Shaya Lev, Vered Tzarfaty, Daniela Dadon, Ariela Gordon‐Shaag, Henry Metzner, Rami Yaka, Baruch Minke

Membrane Lipid Modulations Remove Divalent Open Channel Block from TRP-Like and NMDA Channels

Journal of Neuroscience (2009)

Moshe Parnas, Maximilian Peters, Daniela Dadon, Shaya Lev, Irena Vertkin, Inna Slutsky, Baruch Minke

Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels

Cell Calcium (2009)

Shahar Frechter, Natalie Elia, Vered Tzarfaty, Zvi Selinger, Baruch Minke

Translocation of Gqα Mediates Long-Term Adaptation in Drosophila Photoreceptors

Journal of Neuroscience (2007)

Moshe Parnas, Ben Katz, Baruch Minke

Open Channel Block by Ca2+ Underlies the Voltage Dependence of Drosophila TRPL Channel

The Journal of General Physiology (2006)

Baruch Minke

TRP channels and Ca2+ signaling

Cell Calcium (2006)

Nina Meyer, Tamar Joel-Almagor, Shahar Frechter, Baruch Minke, Armin Huber

Subcellular translocation of the eGFP-tagged TRPL channel in Drosophilaphotoreceptors requires activation of the phototransduction cascade

Journal of Cell Science (2006)

Shahar Frechter, Baruch Minke

Light-regulated translocation of signaling proteins in Drosophila photoreceptors

Journal of Physiology-Paris (2006)

Natalie Elia, Shahar Frechter, Yinon Gedi, Baruch Minke, Zvi Selinger

Excess of Gβe over Gqαe in vivo prevents dark, spontaneous activity of Drosophila photoreceptors

The Journal of Cell Biology (2005)

Irit Chorna-Ornan, Vered Tzarfaty, Galit Ankri-Eliahoo, Tamar Joel-Almagor, Nina Meyer, Armin Huber, François Payre, Baruch Minke

Light-regulated interaction of Dmoesin with TRP and TRPL channels is required for maintenance of photoreceptors

The Journal of Cell Biology (2005)

Baruch Minke, Moshe Parnas

INSIGHTS ON TRP CHANNELS FROM IN VIVO STUDIES IN DROSOPHILA

Annual Review of Physiology (2005)

Roustem Iakhine, Irit Chorna-Ornan, Troy Zars, Natalie Elia, Yan Cheng, Zvi Selinger, Baruch Minke, David R. Hyde

Novel Dominant Rhodopsin Mutation Triggers Two Mechanisms of Retinal Degeneration and Photoreceptor Desensitization

Journal of Neuroscience (2004)

Keren Agam, Shahar Frechter, Baruch Minke

Activation of the Drosophila TRP and TRPL channels requires both Ca2+ and protein dephosphorylation

Cell Calcium (2003)

Baruch Minke, Keren Agam

TRP gating is linked to the metabolic state and maintenance of the Drosophila photoreceptor cells

Cell Calcium (2003)

Mickey Kosloff, Natalie Elia, Tamar Joel-Almagor, Rina Timberg, Troy D Zars, David R Hyde, Baruch Minke, Zvi Selinger

Regulation of light-dependent Gqalpha translocation and morphological changes in fly photoreceptors

The EMBO journal (2003)

Baruch Minke, Shahar Frechter

Long-term Adaptation Largely Modifies the Quantum Efficiency of Single Photon Response in Drosophila

Investigative Ophthalmology & Visual Science (2002)

Baruch Minke, Boaz Cook

TRP Channel Proteins and Signal Transduction

Physiological Reviews (2002)

Monika Bähner, Shahar Frechter, Noel Da Silva, Baruch Minke, Reinhard Paulsen, Armin Huber

Light-Regulated Subcellular Translocation of Drosophila TRPL Channels Induces Long-Term Adaptation and Modifies the Light-Induced Current

Neuron (2002)

Baruch Minke

The TRP calcium channel and retinal degeneration

Advances in experimental medicine and biology (2002)

Baruch Minke

The TRP Channel and Phospholipase C-Mediated Signaling

Cellular and Molecular Neurobiology (2001)

Irit Chorna-Ornan, Tamar Joel-Almagor, Hagit Cohen Ben-Ami, Shahar Frechter, Boaz Gillo, Zvi Selinger, Donald L. Gill, Baruch Minke

A Common Mechanism Underlies Vertebrate Calcium Signaling and Drosophila Phototransduction

Journal of Neuroscience (2001)

Keren Agam, Mark von Campenhausen, S. Levy, Hagit Cohen Ben-Ami, Boaz Cook, K Kirschfeld, Baruch Minke

Metabolic Stress Reversibly Activates the Drosophila Light-Sensitive Channels TRP and TRPLIn Vivo

Journal of Neuroscience (2000)

B Cook, M Bar-Yaacov, H Cohen Ben-Ami, R E Goldstein, Z Paroush, Z Selinger, B Minke

Phospholipase C and termination of G-protein-mediated signalling in vivo

Nature cell biology (2000)

Jaeseung Yoon, Hagit Cohen Ben-Ami, Young Seok Hong, Soyeon Park, Lydia L. R. Strong, John D. Bowman, Chaoxian Geng, Kwanghee Baek, Baruch Minke, William L. Pak

Novel Mechanism of Massive Photoreceptor Degeneration Caused by Mutations in thetrp Gene of Drosophila

Journal of Neuroscience (2000)

Boaz Cook, Baruch Minke

TRP and calcium stores inDrosophilaphototransduction

Cell Calcium (1999)

Assaf Arnon, Boaz Cook, Boaz Gillo, Craig Montell, Zvi Selinger, Baruch Minke

Calmodulin regulation of light adaptation and store-operated dark current in Drosophila photoreceptors

Proceedings of the National Academy of Sciences (1997)

Assaf Arnon, Boaz Cook, Craig Montell, Zvi Selinger, Baruch Minke

Calmodulin Regulation of Calcium Stores in Phototransduction of Drosophila

Science (1997)

B Gillo, I Chorna, H Cohen, B Cook, I Manistersky, M Chorev, A Arnon, J A Pollock, Z Selinger, B Minke

Coexpression of Drosophila TRP and TRP-like proteins in Xenopus oocytes reconstitutes capacitative Ca2+ entry

Proceedings of the National Academy of Sciences of the United States of America (1996)

I. Ben-Oren, Gadi Peleg, A. Lewis, Baruch Minke, Leslie M. Loew

Infrared nonlinear optical measurements of membrane potential in photoreceptor cells

Biophysical Journal (1996)

Boaz Gillo, Stuart C. Sealfon, Baruch Minke

Pharmacology of a capacitative Ca2+ entry in Xenopus oocyte

Journal of Photochemistry and Photobiology B Biology (1996)

Baruch Minke, Zvi Selinger

The roles of trp and calcium in regulating photoreceptor function in Drosophila

Current Opinion in Neurobiology (1996)

Baruch Minke, Zvi Selinger

Role ofDrosophila TRP in inositide-mediated Ca2+ entry

Molecular Neurobiology (1996)

Roger Hardie, Baruch Minke

Phosphoinositide-mediated phototransduction in Drosophila photoreceptors: the role of Ca2+ and trp

Cell Calcium (1995)

J A Porter, B Minke, C Montell

Calmodulin binding to Drosophila NinaC required for termination of phototransduction

The EMBO journal (1995)

J A Pollock, A Assaf, A Peretz, C D Nichols, M H Mojet, R C Hardie, B Minke

TRP, a protein essential for inositide-mediated Ca2+ influx is localized adjacent to the calcium stores in Drosophila photoreceptors

The Journal of neuroscience : the official journal of the Society for Neuroscience (1995)

Asher Peretz, C. Sandler, K Kirschfeld, Roger Hardie, Baruch Minke

Genetic dissection of light-induced Ca2+ influx into Drosophila photoreceptors

The Journal of General Physiology (1994)

Iman Sahly, W. H. Schröder, Karl Zierold, Baruch Minke

Accumulation of calcium in degenerating photoreceptors of several Drosophilamutants

Visual Neuroscience (1994)

A Peretz, E Suss-Toby, A Rom-Glas, A Arnon, R Payne, B Minke

The light response of Drosophila photoreceptors is accompanied by an increase in cellular calcium: effects of specific mutations

Neuron (1994)

Roger Hardie, Baruch Minke

Calcium-dependent inactivation of light-sensitive channels in Drosophila photoreceptors

The Journal of General Physiology (1994)

R C Hardie, B Minke

Spontaneous activation of light-sensitive channels in Drosophila photoreceptors

The Journal of general physiology (1994)

Asher Peretz, T Claus Sandler, K Kirschfeld, Roger C. Hardie, Baruch Minke

Genetic dissection of light-induced Ca 2� influx into Drosophila photoreceptors

MPG.PuRe (Max Planck Society) (1994)

Z Selinger, Y N Doza, B Minke

Mechanisms and genetics of photoreceptors desensitization in Drosophila flies

Biochimica et biophysica acta (1993)

Roger Hardie, Baruch Minke

Novel Ca2+ channels underlying transduction in Drosophila photoreceptors: implications for phosphoinositide-mediated Ca2+ mobilization

Trends in Neurosciences (1993)

Roger Hardie, Asher Peretz, John A. Pollock, Baruch Minke

Ca2+limits the development of the light response in Drosophilaphotoreceptors

Proceedings of the Royal Society B Biological Sciences (1993)

R C Hardie, A Peretz, E Suss-Toby, A Rom-Glas, S A Bishop, Z Selinger, B Minke

Protein kinase C is required for light adaptation in Drosophila photoreceptors

Nature (1993)

Tamara Byk, Margalit Bar-Yaacov, Yair N. Doza, Baruch Minke, Zvi Selinger

Regulatory arrestin cycle secures the fidelity and maintenance of the fly photoreceptor cell

Proceedings of the National Academy of Sciences (1993)

Yair N. Doza, Baruch Minke, Michael Chorev, Zvi Selinger

Characterization of fly rhodopsin kinase

European Journal of Biochemistry (1992)

A. Rom-Glas, C. Sandler, K Kirschfeld, Baruch Minke

The nss mutation or lanthanum inhibits light-induced Ca2+ influx into fly photoreceptors

The Journal of General Physiology (1992)

Uri Werner, Edith Suss-Toby, Ayelet Rom, Baruch Minke

Calcium is necessary for light excitation in barnacle photoreceptors

Journal of Comparative Physiology A (1992)

Roger Hardie, Baruch Minke

The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors

Neuron (1992)

Iman Sahly, S Bar Nachum, Edith Suss-Toby, Ayelet Rom, Asher Peretz, J. Kleiman, Tamara Byk, Zvi Selinger, Baruch Minke

Calcium channel blockers inhibit retinal degeneration in the retinal-degeneration-B mutant of Drosophila

Proceedings of the National Academy of Sciences (1992)

Baruch Minke, Zvi Selinger

The inositol-lipid pathway is necessary for light excitation in fly photoreceptors

PubMed (1992)

Edith Suss-Toby, Zvi Selinger, Baruch Minke

Lanthanum reduces the excitation efficiency in fly photoreceptors

The Journal of General Physiology (1991)

Baruch Minke, Richard Payne

Spatial restriction of light adaptation and mutation-induced inactivation in fly photoreceptors

Journal of Neuroscience (1991)

Baruch Minke, Zvi Selinger

Chapter 5 Inositol lipid pathway in fly photoreceptors: Excitation, calcium mobilization and retinal degeneration

Progress in Retinal Research (1991)

Baruch Minke, C T Rubinstein, Iman Sahly, Shoshana Bar-Nachum, Rina Timberg, Zvi Selinger

Phorbol ester induces photoreceptor-specific degeneration in a Drosophila mutant

Proceedings of the National Academy of Sciences (1990)

E Suss, S Barash, Doekele G. Stavenga, H. Stieve, Zvi Selinger, Baruch Minke

Chemical excitation and inactivation in photoreceptors of the fly mutants trp and nss

The Journal of General Physiology (1989)

Open Positions

At this time there are no available positions in the lab.

Additional Information

Honors:
EMET Prize
Prince of Asturias Award (from the current King of Spain)

Baruch Minke

Professor Emeritus

Email: baruchm@ekmd.huji.ac.il

Phone: +972-2-6758407

Fax: +972-2-6439736

Mobile: +972-54-7961151

Baruch Minke CV

Address: Department of Medical Neurobiology, Faculty of Medicine,
Hadassah Ein-Kerem Campus, The Hebrew University of Jerusalem