Inbal Goshen

Assistant Professor

Neurons and Glia in Memory Lab

The Belgian Friends Optogenetics Laboratory

What underlies the transition from recent to remote memory? How does local modulation of neuronal activity by glia cells directly affect plasticity and behavior? To solve these puzzles we employ a variety of research approaches, integrating behavior, calcium imaging, electrophysiology and molecular biology, and apply optogenetics or chemogenetics in all of these levels.

LAB WEBSITE

Recent publications

Adi Doron, Inbal Goshen
Glia: The Glue Holding Memories Together, Neuron Volume 105, Issue 1, Pages 9-11 (2020)
Adamsky A, Goshen I
Astrocytes in Memory Function: Pioneering Findings and Future Directions, Neuroscience, Volume 370, Pages 14-26 (2018)
Adar Adamsky, Adi Kol, Tirzah Kreisel, Adi Doron, Nofar Ozeri-Engelhard, Talia Melcer, Ron Refaeli, Henrike Horn, Limor Regev, Maya Groysman, Michael London, Inbal Goshen
Astrocytic activation generates de-novo neuronal potentiation and memory enhancement, Cell, Volume 174, Issue 1, 28 June 2018, Pages 59-71 (2018)
Doron A, Goshen I
Investigating the transition from recent to remote memory using advanced tools, Brain Research Bulletin, Volume 141, Pages 35-43 (2018)
Atlan G, Terem A, Peretz-Rivlin N, Sehrawat K, Gonzales BJ, Pozner G, Tasaka G-i, Goll Y, Refaeli R, Zviran O, Lim BK, Groysman M, Goshen I, Mizrahi A, Nelken I, Citri A,
The claustrum supports resilience to distraction, Current Biology, Volume 28, Issue 17, 10 September 2018, Pages 2752-2762 (2018)
Milshtein-Parush H, Frere S, Regev L, Lahav C, Benbenishty A, Ben-Eliyahu S, Goshen I, Slutsky I
Sensory Deprivation Triggers Synaptic and Intrinsic Plasticity in the Hippocampus, Cerebral Cortex, Volume 27, Issue 6, Pages 3457–3470 (2017)
Daadi MM, Klausner JQ, Bajar B, Goshen I, Lee-Messer C, Lee SY, Winge MC, Ramakrishnan C, Lo M, Sun G, Deisseroth K, Steinberg GK.
Optogenetic Stimulation of Neural Grafts Enhances Neurotransmission and Downregulates the Inflammatory Response in Experimental Stroke Model, Cell Transplantation, Vol 25, Issue 7 (2016)
Goshen I.
The optogenetic revolution in memory research, Trends in Neurosciences, Volume 37, Issue 9, Pages 511-522 (2014)
Prakash R, Yizhar O, Grewe B, Ramakrishnan C, Wang N, Goshen I, Packer AM, Peterka DS, Yuste R, Schnitzer MJ, Deisseroth K.
Two-photon optogenetic toolbox for fast inhibition, excitation and bistable modulation, Nature Methods, volume 9, pages 1171–1179 (2012)
Ben Menachem-Zidon O, Avital A, Ben-Menahem Y, Goshen I, Kreisel T, Shmueli EM, Segal M, Ben Hur T, Yirmiya R.
Astrocytes support hippocampal-dependent memory and long-term potentiation via interleukin-1 signaling, Brain, Behavior, and Immunity, Volume 25, Issue 5, Pages 1008-1016 (2011)
Goshen I, Brodsky M, Prakash R, Wallace J, Gradinaru V, Ramakrishnan C, Deisseroth K.
Dynamics of Retrieval Strategies for Remote Memories, Cell, Volume 147, Issue 3, Pages 678-689 (2011)
Yirmiya R, Goshen I.
Immune modulation of learning, memory, neural plasticity and neurogenesis, Brain, Behavior, and Immunity, Volume 25, Issue 2, Pages 181-213 (2011)
Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O'Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, Deisseroth K.
Neocortical excitation/inhibition balance in information processing and social dysfunction, Nature, volume 477, pages 171–178 (2011)
Anikeeva P, Andalman AS, Witten IB, Warden MR, Goshen I, Grosenick L, Gunaydin LA, Frank LM, Deisseroth K.
Optetrode: a multichannel readout for optogenetic control in freely moving mice, Nature Neuroscience, volume 15, pages 163–170 (2011)
Licht T*, Goshen I*, Avital A, Kreisel T, Zubedat S, Eavri R, Segal M, Yirmiya R, Keshet E.
Reversible modulations of neuronal plasticity by VEGF, PNAS, 108 (12) 5081-5086 (2011)
Lee JH, Durand R, Gradinaru V, Zhang F, Goshen I, Kim DS, Fenno, LE, Ramakrishnan C, Deisseroth K.
Global and local fMRI signals driven by neurons defined optogenetically by type and wiring, Nature, volume 465, pages 788–792 (2010)
Gradinaru V, Zhang F, Ramakrishnan C, Mattis J, Prakash R, Diester I, Goshen I, Thompson KR, Deisseroth K.
Molecular and Cellular Approaches for Diversifying and Extending Optogenetics, Cell, Volume 141, Issue 1, Pages 154-165 (2010)
Licht, T, Eavri R, Goshen I, Shlomai Y, Mizrahi A, Keshet E.
VEGF is required for dendritogenesis of newly born olfactory bulb interneurons, Development, 137: 261-271 (2010)
Goshen I, Avital A, Kreisel T, Licht T, Segal M, Yirmiya R.
Environmental Enrichment Restores Memory Functioning in Mice with Impaired IL-1 Signaling via Reinstatement of Long-Term Potentiation and Spine Size Enlargement, Journal of Neuroscience, 29 (11) 3395-3403 (2009)
Goshen I, Yirmiya R
Interleukin-1 (IL-1): A central regulator of stress responses, Frontiers in Neuroendocrinology, Volume 30, Issue 1, Pages 30-45 (2009)

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Lab Members

Cato de Vos

Visiting Graduate Student

Aviya Benmelech-Chovav

Undergrad Researcher

Undergrad Researcher

Undergrad Researcher

PhD Student

PhD Student

PhD Student

PhD Student

Tirzah Merzel Kreisel PhD

Associate researcher

Websites

Lab Website

Contact information

E-mail: inbal.goshen@elsc.huji.ac.il
Phone: +972-2-6585716

Edmond and Lily Safra Center for Brain Sciences
The Suzanne and and Charles Goodman Brain Sciences Building, North Wing, 1st Floor, Lab 1104
Edmond J. Safra Campus, The Hebrew University
Jerusalem, 9190401