Events

ELSC Special Seminar: Prof. Jonathan Kipnis - Dec. 24th, 2018

December 24, 2018

ELSC cordially invites you to the lecture given by:

 

Prof. Jonathan Kipnis 

University of Virginia 

 

On the topic of: 

“Neuromodulatory functions of immune cells and molecules”

  

The lecture will be held on Monday, December 24th, at 14:00

at ELSC: Becker Auditorium, Goodman Brain Sciences Building

Edmond J. Safra Campus

 

Light refreshments at 13:45

 

 

Jonathan Kipnis

Center for Brain Immunology and Glia (BIG), Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA

 

Immune cells and their derived molecules have major impact on brain function. Mice deficient in adaptive immunity have impaired cognitive and social functions compared to that of wild-type mice. Importantly, replenishment of the T cell compartment in immune deficient mice restores proper brain function. Despite the robust influence on brain function, majority of the immune cells are not found within the brain parenchyma, a fact that only adds more mystery into these enigmatic interactions between immunity and the brain. Our results suggest that meningeal space, surrounding the brain, is the site where CNS-associated immune activity takes place. We have recently discovered meningeal lymphatic vessels that regulate CSF perfusion through the parenchyma and allow meningeal cytokines to access the brain. This communication between the CNS and the immunity is affecting neuronal function and may represent a ‘neuromodulatory’ aspect of the immune system.