ELSC Special Seminar: Leenoy Meshulam - Jan. 24th, 2017

January 24, 2018

ELSC cordially invites you to the lecture given by: 


Leenoy Meshulam 

Princeton University


On the topic of:


Simplified models for the activity of (very) large populations of neurons underlying mice behavior in virtual reality



The lecture will be held on Tuesday, January 24th, at 16:00

at ELSC: Silberman Bldg., 3rd Wing, 6th Floor

Edmond J. Safra Campus


Light refreshments at 15:45


Recent technological progress has dramatically increased our access to the neural activity underlying memory-related tasks. These complex high-dimensional data call for theories that allow us to identify signatures of collective activity in the networks that are crucial for the emergence of cognitive functions. As an example, we study the neural activity in dorsal hippocampus as a mouse runs along a virtual linear track. One of the dominant features of this data is the activity of place cells, which fire when the animal visits particular locations. During the first stage of our work we used a maximum entropy framework to characterize the probability distribution of the joint activity patterns observed across ensembles of up to 100 cells. These models make surprisingly accurate predictions for the activity of individual neurons given the state of the rest of the network, and this is true both for place cells and for non-place cells.  For the second stage of our work we study networks of ~ 1500 neurons. To address this much larger system, we use different coarse graining methods, in the spirit of the renormalization group, to uncover macroscopic features the network.  We see hints of scaling and of behavior that is controlled by a non-trivial fixed point. Perhaps, then, there is emergent simplicity even in these very complex systems of real neurons in the brain.