Events

ELSC Special Seminar: Dr. Jonatan Aljadeff - Oct. 1st, 2017 at 14:00

October 1, 2017

ELSC cordially invites you to the lecture given by:

 

Dr. Jonatan Aljadeff

University of Chicago

 

On the topic of:


 Modulation of STDP by extracellular calcium and implications for memory”

 

  The lecture will be held on Sunday, October 1, at 14:00

at ELSC: Silberman Bldg., 3rd Wing, 6th Floor

Edmond J. Safra Campus

 Light refreshments at 13:45



Abstract: In classical STDP, a pre- before post spike leads to LTP and the reverse timing induces LTD. While previous measurements of STDP used non-physiologically high extracellular calcium concentrations, a lower concentration is thought to correspond to smaller calcium transients and is expected to modify STDP. Our collaborators measured STDP at the CA1-CA3 synapse and found that its sign and magnitude depend strongly on the extracellular calcium concentration. At physiological levels a protocol with a single pre and postsynaptic spike did not yield LTP.
We constructed a calcium based synaptic plasticity model where depression and potentiation depend on the transient postsynaptic calcium. A crucial component of the model that allows it to quantitatively account for the entire dataset is the contribution of the NMDA nonlinearity, endowed with a long timescale, to the transient calcium concentration.
We also studied the memory retention properties implied by our model and found that the strong nonlinearity ensures a resiliency to noise, especially when firing-rate correlations are weak.
Joint work with Yanis Inglebert, Dominique Debanne and Nicolas Brunel