Events

ELSC Seminar: Noam Ziv - Nov. 23rd, 2017 at 17:00

November 23, 2017

ELSC cordially invites you to the lecture given by:

 

Noam Ziv

Technion - Israel Institute of Technology

 

On the topic of:

"Synaptic tenacity: When everything changes, do things really stay the same?"

 

The lecture will be held on Thursday November 23rd, 2017 at 17:00

at ELSC: Silberman Bldg., 3rd Wing, 6th Floor,

 Edmond J. Safra Campus  

Light refreshments served at 16:45

 

Abstract:

Activity-dependent modifications to synaptic connections - synaptic plasticity – is widely believed to represent a fundamental mechanism for altering network function. This belief also implies, however, that synapses, when not driven to change their properties by physiologically relevant stimuli, should retain these properties over time. Otherwise, physiologically relevant modifications would be gradually lost amidst spurious changes and spontaneous drift. We refer to the expected tendency of synapses to hold onto their properties as "synaptic tenacity".Imaging studies reveal that synapses are not truly structures in a strict sense, and are better thought of as dynamic assemblies of molecules that move in, out and between synaptic sites over time scales of seconds to hours. The seminar will focus on these dynamics, their effects on synaptic tenacity, the significant spontaneous remodeling they seem to induce, the effects of spontaneous synaptic remodeling on synaptic size distributions and synaptic configurations, and compare their relative contributions to synaptic remodeling attributable to specific activity histories.