ELSC Seminar: Inna Slutsky - Dec. 07th, 2017 at 17:00

December 7, 2017

ELSC cordially invites you to the lecture given by:

  

Prof. Inna Slutsky


Sackler School of Medicine, Tel Aviv University

 

On the topic of: 

"Maintaining the balance between stability and plasticity in hippocampal circuits" 

 

The lecture will be held on Thursday, December 7th, at 17:00

at ELSC: Silberman Bldg., 3rd Wing, 6th Floor,

 Edmond J. Safra Campus

 

Light refreshments at 16:45

 

Abstract

How neuronal circuits maintain the balance between stability and plasticity in a constantly changing environment remains a fundamental question in neuroscience. Empirical and theoretical studies suggest that homeostatic negative feedback mechanisms operate to stabilize the function of a system at a set point level of activity. While extensive research uncovered diverse homeostatic mechanisms that maintain activity of neural circuits at extended timescales, several key questions remain open. In my talk, I will discuss two of them: (1) What are the basic principles underlying invariant population dynamics of neural circuits, composed from intrinsically unstable activity patterns of individual neurons? (2) Does homeostatic regulation fail in Alzheimer’s disease? I will analyze the main types of possible homeostatic failures and provide the conceptual framework for examining the causal link between dysregulation of firing homeostasis, aberrant neural circuit activity and memory-related plasticity impairments associated with early-stage Alzheimer’s disease.