Events

ELSC Seminar: Genela Morris - Apr. 10th, 2018 at 13:00

April 10, 2018

 ELSC cordially invites you to the lecture given by: 

 

 

 Dr. Genela Morris 
Sagol Department of Neurobiology, University of Haifa 

 

On the topic of: 

“Goal-relevant representation of the hippocampal cognitive map is shaped by local dopaminergic innervation”

 

 

The lecture will be held on Tuesday, April 10th, at 13:00

at ELSC: Silberman Bldg., 3rd Wing, 6th Floor,

 Edmond J. Safra Campus

 

Light refreshments at 12:45

 

 

Abstract:

The hippocampus may be viewed as the internal model for goal-directed behavior. We asked whether it learns to selectively represent goal-relevant input dimensions, and what is the role of local dopaminergic signals in dorsal CA1 in this process. In a series of experiments in rats, different sensory dimensions were manipulated such that only subsets of those were relevant for goal achievement. Animals mapped their environment according to the reward-relevant dimensions in a motivation dependent manner. The shift in behavioral mapping was paralleled by a shift in parameter coding by place cells in dCA1, such that by the end of learning, cell activity represented only the relevant dimensions. Both behavioral mapping and reorganization of neural representation depended on dopamine secreted locally in the dCA1. Finally, to identify the source of the local dopaminergic signal necessary for the goal-relevant map formation, we performed pathway-specific pharmacogenetic experiments. Preliminary results highlight a dissociation between attention and plasticity effects mediated differentially by VTA and LC.