ELSC News

Article of the Month, June 2018 (Bergman's lab)

June 1, 2018

 

Desynchronization of slow oscillations in the basal ganglia during natural sleep

Authors:  Aviv D. Mizrahi-KligerAlexander KaplanZvi Israel, and Hagai Bergman
Published in PNAS on April 2018
AOM_Bergman-062018

 

Summary:

Slow-wave sleep is widely associated with synchronized slow oscillations recorded in the cortical mantle and elsewhere in the brain. In this study, we focused on the basal ganglia, a group of interconnected subcortical nuclei implicated in habit learning and in common neurological disorders(e.g., Parkinson’s disease). We show that unlike cortical circuits, where slow oscillation is locally synchronized, slow oscillations of firing rates within each basal ganglia nucleus are not phase-locked between adjacent neurons, and are decoupled from the local field potential. Our results establish that neuronal slow oscillations and synchrony do not always co-occur, and highlight decorrelation as a key feature of basal ganglia circuitry that persists even in the most synchronized physiological conditions.