Prof. Hermona Soreq

Ester (Estelle) R. Bennett

PhD


My present research focuses on understanding the role of the innate immune system in the development of neuro-inflammatory processes in Alzheimer’s disease (AD). Specifically, we are studying the intracellular signaling pathways that are involved in TLR-activated inflammatory responses in microglia, the innate immune cells of the central nervous system, and how this response can be modulated by the cholinergic system. We use primary murine microglia cultures as well as murine microglia lines, and study their immune response to various insults such as amyloid beta, which has a central role in AD etiology.

 

My past research has been mainly in the field of membrane proteins: my doctoral thesis focused on the structure and function of the GABA transporter and my postdoctoral studies on the expression of viral membrane proteins in bacteria. In addition, I have studied the role of protein-protein and protein-peptide interactions in various human disease states.

Publications

  • Astrahan P‭, ‬Flitman-Tene R‭, ‬Bennett ER‭, ‬Krugliak M‭, ‬Gilon C‭, ‬Arkin IT. (2011)‭.‬
  • Shenhar-Tsarfaty S‭, ‬Bruck T‭, ‬Bennett ER‭, ‬Bravman T‭, ‬Ben Aassayag E‭, ‬Waiskopf
  • Podoly E‭, ‬Shalev DE‭, ‬Shenhar-Tsarfaty S‭, ‬Bennett ER‭, ‬Ben Assayag E‭, ‬Wilgus H‭, ‬
  • Arkin IT‭, ‬Xu H‭, ‬Jensen MØ‭, ‬Arbely E‭, ‬Bennett ER‭, ‬Bowers KJ‭, ‬Chow E‭, ‬Dror RO‭,‬
  • Zhou Y, Bennett ER, Kanner BI. (2004) The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 is modulated by its ligands. J Biol Chem. 279(14):13800-8.
  • Bennett ER, Su H, Kanner BI. (2000) Mutation of arginine-44 of GAT-1, a
  • Bennett ER, Kanner BI. (1997) The membrane topology of GAT-1, a (Na+ + Cl-)-coupled g-aminobutyric acid transporter from rat brain. J Biol Chem. 272(2):1203-10.